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Journal Articles

Cyclosporine May Inhibit the Effect of Extra-Physiologic Oxygen Shock/Stress on Peripheral Blood Stem Cells

Amro Elshoury, MBBChir, Hans Minderman, PhD, Alexis Conway, PhD, Paul K. Wallace, MS, PhD, Charlie Mantel, Joseph Dennis Tario, PhD, Yeong Choi, Kieran O'Loughin, MS, Carlos Cedeno, PhD, Jenna Nichols, Kahteong Soh, MS, Philip L. McCarthy, MD, George Chen, MD

Blood (2018) 132 (Supplement 1): 3346.

https://doi.org/10.1182/blood-2018-99-119329

Published: 2018

Journal Articles

Unique and Unexpected Functional Activities of Hematopoietically Active Cytokines Truncated By Dipeptidylpeptidase-4 (DPP4)

Heather A. O'Leary, PhD, Charlie Mantel, Man Ryul Lee, PhD, Xianyin Lai, PhD, Scott Cooper, BS, Giao Hangoc, DVM, PhD, H. Scott Boswell, MD, Hal E. Broxmeyer, PhD

Blood (2014) 124 (21): 2922.

https://doi.org/10.1182/blood.V124.21.2922.2922

Published: 2014

Journal Articles

Mitigation of a Newly Discovered Phenomenon, Extra Physiologic Oxygen Shock/Stress (EPHOSS), Mediated By the Mitochondria Permeability Transition Pore, Greatly Improves Stem Cell Collection and Transplantation

Charlie Mantel, Heather A. O'Leary, PhD, Brahmananda Reddy Chitteti, PhD, Xinxin Huang, PhD, Scott Cooper, BS, Giao Hangoc, DVM, PhD, Nickolay Brustovetsky, PhD, Edward F. Srour, PhD, Man Ryul Lee, PhD, Steven Messina-Graham, Nadia Falah, MD, Reuben Kapur, PhD, Louis M. Pelus, PhD, Mircea Ivan, MD, PhD, Kye-Seong Kim, PhD, Hal E. Broxmeyer, PhD

Blood (2014) 124 (21): 2905.

https://doi.org/10.1182/blood.V124.21.2905.2905

Published: 2014

Journal Articles

DPP4 (CD26) Truncation Of GM-CSF and IL-3 Alters Their Signaling and Functional Activity In Normal and Leukemic Hematopoietic Stem and Progenitor Cells

Heather A. O'Leary, Ph.D., Charlie Mantel, Xianyin Lai, Ph.D., Scott Cooper, BS, Giao Hangoc, DVM, Ph.D., H. Scott Boswell, M.D., Frank Witzmann, Ph.D., Hal E. Broxmeyer, PhD

Blood (2013) 122 (21): 1206.

https://doi.org/10.1182/blood.V122.21.1206.1206

Published: 2013

Journal Articles

CD26 Truncation of GM-CSF and IL-3 Alters Their Functional Interactions

Heather A. O'Leary, PhD, Charlie Mantel, Scott Cooper, BS, Christina J Walker, BS, Hal E. Broxmeyer, Ph.D.

Blood (2012) 120 (21): 1240.

https://doi.org/10.1182/blood.V120.21.1240.1240

Published: 2012

Journal Articles

Mouse hematopoietic cell–targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging–like phenotype

Charlie Mantel, Steven Messina-Graham, Akira Moh, Scott Cooper, Giao Hangoc, Xin-Yuan Fu, Hal E. Broxmeyer

Blood (2012) 120 (13): 2589–2599.

https://doi.org/10.1182/blood-2012-01-404004

Published: 2012

Includes: Supplemental data

Journal Articles

CD1d expression on and regulation of murine hematopoietic stem and progenitor cells

Hal E. Broxmeyer, Kent Christopherson, Giao Hangoc, Scott Cooper, Charlie Mantel, Gourapura J. Renukaradhya, Randy R. Brutkiewicz

Blood (2012) 119 (24): 5731–5741.

https://doi.org/10.1182/blood-2012-01-404012

Published: 2012

Includes: Supplemental data

Journal Articles

TIP110/p110 nrb /SART3/p110 regulation of hematopoiesis through CMYC

Ying Liu, Khalid Timani, Charlie Mantel, Yan Fan, Giao Hangoc, Scott Cooper, Johnny J. He, Hal E. Broxmeyer

Blood (2011) 117 (21): 5643–5651.

https://doi.org/10.1182/blood-2010-12-325332

Published: 2011

Includes: Supplemental data

Journal Articles

STAT3 Deletion In Hematopoietic Tissue Causes Mitochondrial Dysfunction with Increased ROS Leading to LT-Repopulating Stem Cell Depletion, Erythroid Dysplasia, Peripheral Neutrophilia, and a Rapid Aging-Like Phenotype.

Charlie Mantel, Steve Messina-Graham, Akira Moh, PhD, Xin-Yuan Fu, PhD, Hal E. Broxmeyer, PhD

Blood (2010) 116 (21): 2621.

https://doi.org/10.1182/blood.V116.21.2621.2621

Published: 2010

Journal Articles

The Earliest Stages of Loss of Stem Cell Self-Renewal in-Vivo Is Linked to Upregulated Biosynthesis of “Quiet” Mitochondria and Is Influenced by CXCR4 Activation and STAT3 Gene Deletion.

Charlie Mantel, Steven Messina-Graham, Akira Moh, PhD, Xin-Yuan Fu, PhD, Hal E. Broxmeyer, PhD

Blood (2009) 114 (22): 2546.

https://doi.org/10.1182/blood.V114.22.2546.2546

Published: 2009

Journal Articles

Embryonic Stem Cells Bypass Numerous Cell Cycle Checkpoints; Not Just G1.

Charlie Mantel, Hal E. Broxmeyer, PhD

Blood (2008) 112 (11): 1331.

https://doi.org/10.1182/blood.V112.11.1331.1331

Published: 2008

Journal Articles

Mouse Hematopoietic Stem Cells, Unlike Human and Mouse Embryonic Stem Cells, Exhibit Checkpoint-Apoptosis Coupling.

Sara Rohrabaugh, Charlie Mantel, Hal E. Broxmeyer

Blood (2007) 110 (11): 3357.

https://doi.org/10.1182/blood.V110.11.3357.3357

Published: 2007

Journal Articles

Molecular Mechanisms of Spindle Checkpoint-Apoptosis Linkage and Karyotypic Stability in Stem Cells.

Charlie Mantel, Sara Rhorabough, Ying Guo, Man-Ryul Lee, Myung-Kwan Han, Kye-Seong Kim, Hal E. Broxmeyer

Blood (2007) 110 (11): 3361.

https://doi.org/10.1182/blood.V110.11.3361.3361

Published: 2007

Journal Articles

Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: a source of karyotpic instability

Charlie Mantel, Ying Guo, Man Ryul Lee, Min-Kyoung Kim, Myung-Kwan Han, Hirohiko Shibayama, Seiji Fukuda, Mervin C. Yoder, Louis M. Pelus, Kye-Seong Kim, Hal E. Broxmeyer

Blood (2007) 109 (10): 4518–4527.

https://doi.org/10.1182/blood-2006-10-054247

Published: 2007

Includes: Supplemental data

Journal Articles

Mitotic Arrest Deficiency 2 (Mad2) Is Required for Proliferative Synergy of GM-CSF Plus SCF in Hematopoietic Progenitors Via Effects on Apoptosis and Is Mediated by Ligand-Dependent Association of Mad2 with SCF and GM-CSF Receptors.

Shigeki Ito, MD, PhD, Charlie Mantel, Yoji Ishida, MD,PhD, Hal E. Broxmeyer, PhD

Blood (2006) 108 (11): 4225.

https://doi.org/10.1182/blood.V108.11.4225.4225

Published: 2006

Journal Articles

Oct-4 Is Crucial for Stress-Induced Murine Embryonic Stem Cell Survival/Anti-Apoptosis Mediated by STAT3/Survivin.

Ying Guo, MD, MS, Charlie Mantel, B.S., Robert A. Hromas, M.D., Hal E. Broxmeyer, Ph.D.

Blood (2006) 108 (11): 277.

https://doi.org/10.1182/blood.V108.11.277.277

Published: 2006

Journal Articles

A helical turn makes an attractive inhibitor

Charlie Mantel

Blood (2006) 107 (4): 1245–1246.

https://doi.org/10.1182/blood-2005-11-4644

Published: 2006

Journal Articles

Role of SIRT1 in Proliferation and Self-Renewal of Mouse Embryonic Stem Cells.

Myung-Kwan Han, Charlie Mantel, Ying Guo, Wen Tao, Hal E. Broxmeyer

Blood (2005) 106 (11): 520.

https://doi.org/10.1182/blood.V106.11.520.520

Published: 2005

Journal Articles

Mad2 (Mitotic Arrest Deficiency 2) Is Essential for the Synergistic Proliferation Induced by Stem Cell Factor Combined with GM-CSF in Hematopoietic Progenitor Cells, Effects Reflecting the Association of c-kit with Mad2.

Shigeki Ito, MD, PhD, Charlie Mantel, Myung-Kwan Han, PhD, Seiji Fukuda, MD/PhD, Yoji Ishida, MD/PhD, Robert Benezra, PhD, Hal E. Broxmeyer, PhD

Blood (2005) 106 (11): 71.

https://doi.org/10.1182/blood.V106.11.71.71

Published: 2005

Journal Articles

IL-31 Receptor and IL-31 in the Positive Regulation of Myeloid Progenitor Cell Proliferation/Survival.

Hal E. Broxmeyer, PhD, Nico Ghilardi, PhD, Giao Hangoc, DVM, Scott Cooper, BSc, Wen Tao, PhD, Charlie Mantel, BSc, Barbara Graham-Evans, PhD, Frederic J. deSauvage, PhD

Blood (2005) 106 (11): 1347.

https://doi.org/10.1182/blood.V106.11.1347.1347

Published: 2005

NARROW

Cyclosporine May Inhibit the Effect of Extra-Physiologic Oxygen Shock/Stress on Peripheral Blood Stem Cells

Unique and Unexpected Functional Activities of Hematopoietically Active Cytokines Truncated By Dipeptidylpeptidase-4 (DPP4)

Mitigation of a Newly Discovered Phenomenon, Extra Physiologic Oxygen Shock/Stress (EPHOSS), Mediated By the Mitochondria Permeability Transition Pore, Greatly Improves Stem Cell Collection and Transplantation

DPP4 (CD26) Truncation Of GM-CSF and IL-3 Alters Their Signaling and Functional Activity In Normal and Leukemic Hematopoietic Stem and Progenitor Cells

CD26 Truncation of GM-CSF and IL-3 Alters Their Functional Interactions

Mouse hematopoietic cell–targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging–like phenotype

CD1d expression on and regulation of murine hematopoietic stem and progenitor cells

TIP110/p110 nrb /SART3/p110 regulation of hematopoiesis through CMYC

STAT3 Deletion In Hematopoietic Tissue Causes Mitochondrial Dysfunction with Increased ROS Leading to LT-Repopulating Stem Cell Depletion, Erythroid Dysplasia, Peripheral Neutrophilia, and a Rapid Aging-Like Phenotype.

The Earliest Stages of Loss of Stem Cell Self-Renewal in-Vivo Is Linked to Upregulated Biosynthesis of “Quiet” Mitochondria and Is Influenced by CXCR4 Activation and STAT3 Gene Deletion.

Embryonic Stem Cells Bypass Numerous Cell Cycle Checkpoints; Not Just G1.

Mouse Hematopoietic Stem Cells, Unlike Human and Mouse Embryonic Stem Cells, Exhibit Checkpoint-Apoptosis Coupling.

Molecular Mechanisms of Spindle Checkpoint-Apoptosis Linkage and Karyotypic Stability in Stem Cells.

Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: a source of karyotpic instability

Mitotic Arrest Deficiency 2 (Mad2) Is Required for Proliferative Synergy of GM-CSF Plus SCF in Hematopoietic Progenitors Via Effects on Apoptosis and Is Mediated by Ligand-Dependent Association of Mad2 with SCF and GM-CSF Receptors.

Oct-4 Is Crucial for Stress-Induced Murine Embryonic Stem Cell Survival/Anti-Apoptosis Mediated by STAT3/Survivin.

A helical turn makes an attractive inhibitor

Role of SIRT1 in Proliferation and Self-Renewal of Mouse Embryonic Stem Cells.

Mad2 (Mitotic Arrest Deficiency 2) Is Essential for the Synergistic Proliferation Induced by Stem Cell Factor Combined with GM-CSF in Hematopoietic Progenitor Cells, Effects Reflecting the Association of c-kit with Mad2.

IL-31 Receptor and IL-31 in the Positive Regulation of Myeloid Progenitor Cell Proliferation/Survival.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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