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Carsten Müller
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Journal Articles

Germ line DDX41 mutations define a unique subtype of myeloid neoplasms

Hideki Makishima, Ryunosuke Saiki, Yasuhito Nannya, Sophia Korotev, Carmelo Gurnari, June Takeda, Yukihide Momozawa, Steve Best, Pramila Krishnamurthy, Tetsuichi Yoshizato, Yoshiko Atsuta, Yusuke Shiozawa, Yuka Iijima-Yamashita, Kenichi Yoshida, Yuichi Shiraishi, Yasunobu Nagata, Nobuyuki Kakiuchi, Makoto Onizuka, Kenichi Chiba, Hiroko Tanaka, Ayana Kon, Yotaro Ochi, Masahiro M. Nakagawa, Rurika Okuda, Takuto Mori, Akinori Yoda, Hidehiro Itonaga, Yasushi Miyazaki, Masashi Sanada, Takayuki Ishikawa, Shigeru Chiba, Hisashi Tsurumi, Senji Kasahara, Carsten Müller-Tidow, Akifumi Takaori-Kondo, Kazuma Ohyashiki, Toru Kiguchi, Fumihiko Matsuda, Joop H. Jansen, Chantana Polprasert, Piers Blombery, Yoichiro Kamatani, Satoru Miyano, Luca Malcovati, Torsten Haferlach, Michiaki Kubo, Mario Cazzola, Austin G. Kulasekararaj, Lucy A. Godley, Jaroslaw P. Maciejewski, Seishi Ogawa
Journal: Blood
Blood (2023) 141 (5): 534–549.
DOI: https://doi.org/10.1182/blood.2022018221
Published: 2023
Includes: Supplemental data
Journal Articles

A phase II clinical trial of combined BRAF/MEK inhibition for BRAF V600E -mutated multiple myeloma

Clinical Trials & Observations
Nicola Giesen, Manik Chatterjee, Christof Scheid, Alexandra M Poos, Britta Besemer, Kaya Miah, Axel Benner, Nicole Becker, Thomas Moehler, Ivana Metzler, Cyrus Khandanpour, Andrea Seidel-Glaetzer, Karolin Trautmann-Grill, K. Martin Kortüm, Carsten Müller-Tidow, Gunhild Mechtersheimer, Benjamin Goeppert, Albrecht Stenzinger, Niels Weinhold, Hartmut Goldschmidt, Katja C. Weisel, Marc S. Raab
Journal: Blood
Blood blood.2022017789.
DOI: https://doi.org/10.1182/blood.2022017789
Published: 2023
Includes: Supplemental data
Journal Articles

Venetoclax synergizes with gilteritinib in FLT3 wild-type high-risk acute myeloid leukemia by suppressing MCL-1

Maike Janssen, Christina Schmidt, Peter-Martin Bruch, Maximilian F. Blank, Christian Rohde, Alexander Waclawiczek, Daniel Heid, Simon Renders, Stefanie Göllner, Lisa Vierbaum, Birgit Besenbeck, Sophie A. Herbst, Mareike Knoll, Carolin Kolb, Adriana Przybylla, Katharina Weidenauer, Anne Kathrin Ludwig, Margarete Fabre, Muxin Gu, Richard F. Schlenk, Friedrich Stölzel, Martin Bornhäuser, Christoph Röllig, Uwe Platzbecker, Claudia Baldus, Hubert Serve, Tim Sauer, Simon Raffel, Caroline Pabst, George Vassiliou, Binje Vick, Irmela Jeremias, Andreas Trumpp, Jeroen Krijgsveld, Carsten Müller-Tidow, Sascha Dietrich
Journal: Blood
Blood (2022) 140 (24): 2594–2610.
DOI: https://doi.org/10.1182/blood.2021014241
Published: 2022
Includes: Supplemental data
Journal Articles

Overlapping features of therapy-related and de novo NPM1 -mutated AML

Jad Othman, Manja Meggendorfer, Enrico Tiacci, Christian Thiede, Richard F. Schlenk, Richard Dillon, Sebastian Stasik, Alessandra Venanzi, Sarah Bertoli, Eric Delabesse, Pierre-yves Dumas, Arnaud Pigneux, Audrey Bidet, Amanda Frances Gilkes, Ian Thomas, Maria Teresa Voso, Alessandro Rambaldi, Lorenzo Brunetti, Vincenzo Maria Perriello, Vibeke Andresen, Bjorn T Gjertsen, Maria Paola Martelli, Christian Récher, Hubert Serve, Carsten Müller-Tidow, Claudia D. Baldus, Torsten Haferlach, Nigel H. Russell, Brunangelo Falini
Journal: Blood
Blood blood.2022018108.
DOI: https://doi.org/10.1182/blood.2022018108
Published: 2022
Includes: Supplemental data
Journal Articles

Macs - a Leukemic Stem Cell- Based Predictor of Clinical Response to Venetoclax and Other BH3 Mimetics for Acute Myeloid Leukemia

Simon Renders, Alexander Waclawiczek, Aino-Maija Leppä, Cecilia Reyneri, Barbara Betz, Karolin Stumpf, Maike Janssen, Julia M. Unglaub, Elisa Donato, Rabia Shahswar, Simon Raffel, Michael Heuser, Richard F. Schlenk, Michael Hundemer, Tim Sauer, Carsten Müller-Tidow, Andreas Trumpp
Journal: Blood
Blood (2022) 140 (Supplement 1): 2023–2024.
DOI: https://doi.org/10.1182/blood-2022-164831
Published: 2022
Journal Articles

Bone Marrow Immune Signatures in Multiple Myeloma Are Linked to Tumor Heterogeneity and Treatment Outcome

Simon Steiger, Raphael Lutz, Nina Prokoph, Subarna Palit, Stephan M Tirier, Philipp Reichert, Anja Baumann, Nadine Hefner, Sabrina Schumacher, Dominik Vonficht, Florian Grünschläger, Alexandra M Poos, Lukas John, Laleh Haghverdi, Jan-Philipp Mallm, Elias K Mai, Mirco Friedrich, Katharina Kriegsmann, Mohamed H.S. Awwad, Anna Jauch, Uta Bertsch, Diana Tichy, Carsten Müller-Tidow, Roland Schroers, Hans Salwender, Britta Besemer, Roland Fenk, Katja Weisel, Hartmut Goldschmidt, Stefanie Huhn, Michael Hundemer, Karsten Rippe, Simon Haas, Niels Weinhold, Marc S Raab
Journal: Blood
Blood (2022) 140 (Supplement 1): 2083–2085.
DOI: https://doi.org/10.1182/blood-2022-168685
Published: 2022
Journal Articles

Discovery of Tumor Reactive T Cell Receptors in Newly Diagnosed Multiple Myeloma

Mirco Friedrich, Niklas Kehl, Simon Steiger, Tim Robin Wagner, Katharina Lindner, Michael Kilian, Julius Michel, Sebastian Uhrig, Raphael Lutz, Nina Prokoph, Alexandra M Poos, Lukas John, Lilli Sophie Sester, Niels Weinhold, Stefan Fröhling, Edward W Green, Lukas Bunse, Paola Neri, Nizar Jacques Bahlis, Karsten Rippe, Stefan Eichmüller, Carsten Müller-Tidow, Hartmut Goldschmidt, Michael Platten, Marc S Raab
Journal: Blood
Blood (2022) 140 (Supplement 1): 604–605.
DOI: https://doi.org/10.1182/blood-2022-169721
Published: 2022
Journal Articles

Differential Engraftment of CEBPA Mutated Acute Myeloid Leukemia Cells in NSGS Mice

Philomina Sona Peramangalam, Sridevi Surapally, Sridhar Rao, Carsten Müller-Tidow, John Anto Pulikkan
Journal: Blood
Blood (2022) 140 (Supplement 1): 12655–12656.
DOI: https://doi.org/10.1182/blood-2022-170448
Published: 2022
Journal Articles

Single Versus Double Induction with "7+3" Containing 60 Versus 90 Mg Daunorubicin for Newly Diagnosed AML: Results from the Randomized Controlled SAL Dauno-Double Trial

Christoph Röllig, Björn Steffen, Christoph Schliemann, Jan-Henrik Mikesch, Nael Alakel, Regina Herbst, Mathias Haenel, Richard Noppeney, Maher Hanoun, Martin Kaufmann, Zdenek Racil, Kerstin Schäfer-Eckart, Tim Sauer, Andreas Neubauer, Claudia D. Baldus, Jolana Mertova, Edgar Jost, Dirk Niemann, Jan Novak, Stefan W. Krause, Sebastian Scholl, Andreas Hochhaus, Gerhard Held, Tomáš Szotkowski, Christoph Schmid, Andreas Rank, Lars Fransecky, Michael Kramer, Frank Fiebig, Annett Haake, Friedrich Stoelzel, Johannes Schetelig, Jan Moritz Middeke, Uwe Platzbecker, Christian Thiede, Carsten Müller-Tidow, Wolfgang E. Berdel, Hubert Serve, Gerhard Ehninger, Jiří Mayer, Martin Bornhaeuser
Journal: Blood
Blood (2022) 140 (Supplement 1): 523–525.
DOI: https://doi.org/10.1182/blood-2022-157126
Published: 2022
Journal Articles

Germline Risks and Clinical Impacts of DDX41 Mutations in Myeloid Malignancies

Hideki Makishima, Ryunosuke Saiki, Yasuhito Nannya, Sophia C. Korotev, Carmelo Gurnari, June Takeda, Yukihide Momozawa, Steve Best, Pramila Krishnamurthy, Tetsuichi Yoshizato, Yoshiko Atsuta, Yusuke Shiozawa, Yuka Iijima-Yamashita, Kenichi Yoshida, Yuichi Shiraishi, Yasunobu Nagata, Nobuyuki Kakiuchi, Makoto Onizuka, Kenichi Chiba, Hiroko Tanaka, Ayana Kon, Yotaro Ochi, Masahiro Marshall Nakagawa, Rurika Okuda, Takuto Mori, Akinori Yoda, Hidehiro Itonaga, Yasushi Miyazaki, Masashi Sanada, Takayuki Ishikawa, Shigeru Chiba, Hisashi Tsurumi, Senji Kasahara, Carsten Müller-Tidow, Akifumi Takaori-Kondo, Kazuma Ohyashiki, Toru Kiguchi, Fumihiko Matsuda, Joop H. Jansen, Chantana Polprasert, Piers Blombery, Yoichiro Kamatani, Satoru Miyano, Luca Malcovati, Torsten Haferlach, Michiaki Kubo, Mario Cazzola, Austin Kulasekararaj, Lucy A. Godley, Jaroslaw P. Maciejewski, Seishi Ogawa
Journal: Blood
Blood (2022) 140 (Supplement 1): 208–210.
DOI: https://doi.org/10.1182/blood-2022-158851
Published: 2022
Journal Articles

Interleukin-12 and Interleukin-18 Associate with Chronic Graft-Versus-Host Disease but with Inverse Clinical Outcomes

Thomas Luft, Salim Oulghazi, Caroline Pabst, Leonard Petry, Richard Huth, Carsten Müller-Tidow, Peter Dreger
Journal: Blood
Blood (2022) 140 (Supplement 1): 7641–7642.
DOI: https://doi.org/10.1182/blood-2022-163269
Published: 2022
Journal Articles

MYCN Regulates Cell Survival Via EIF4G1 in Inv(16) Acute Myeloid Leukemia

Philomina Sona Peramangalam, Sridevi Surapally, Shikan Zheng, Robert Burns, Nan Zhu, Sridhar Rao, Carsten Müller-Tidow, John Anto Pulikkan
Journal: Blood
Blood (2022) 140 (Supplement 1): 9117–9118.
DOI: https://doi.org/10.1182/blood-2022-170112
Published: 2022
Journal Articles

Tandem Duplications of the UBTF gene in Adult AML: A Rare but Recurrent Alteration Associated with Myelodysplasia and Poor Outcome

Julia-Annabell Georgi, Sebastian Stasik, Sven Zukunft, Marita Hartwig, Christoph Röllig, Uta Oelschlaegel, Utz Krug, Tim Sauer, Sebastian Scholl, Andreas Hochhaus, Tim H Brümmendorf, Ralph Naumann, Björn Steffen, Hermann Einsele, Markus Schaich, Andreas Burchert, Andreas Neubauer, Kerstin Schaefer-Eckart, Christoph Schliemann, Stefan W. Krause, Mathias Haenel, Richard Noppeney, Ulrich Kaiser, Claudia D. Baldus, Martin Kaufmann, Carsten Müller-Tidow, Uwe Platzbecker, Wolfgang E. Berdel, Hubert Serve, Gerhard Ehninger, Martin Bornhaeuser, Johannes Schetelig, Frank P. Kroschinsky, Christian Thiede
Journal: Blood
Blood (2022) 140 (Supplement 1): 6262–6264.
DOI: https://doi.org/10.1182/blood-2022-164702
Published: 2022
Journal Articles

Venetoclax-Based Salvage Therapy Improves Outcome in Relapsed/Refractory AML Patients Eligible for Intensive Treatment: A Propensity Score Matching Analysis

Julia M. Unglaub, Richard F. Schlenk, Maher Hanoun, H. Christian Reinhardt, Jan Moritz Middeke, Kerstin Schäfer-Eckart, Björn Steffen, Stefan W. Krause, Christoph Schliemann, Martin Kaufmann, Mathias Haenel, Edgar Jost, Martina Crysandt, Lars Fransecky, Hermann Einsele, Sabrina Kraus, Dirk Niemann, Andreas Neubauer, Ruth Seggewiss-Bernhardt, Sebastian Scholl, Stefan Klein, Christoph Schmid, Markus Schaich, Uwe Platzbecker, Claudia D. Baldus, Martin Bornhaeuser, Hubert Serve, Christoph Röllig, Michael Kramer, Elena Katelari, Maike Janssen, Caroline Pabst, Thomas Luft, Peter Dreger, Carsten Müller-Tidow, Tim Sauer
Journal: Blood
Blood (2022) 140 (Supplement 1): 3317–3319.
DOI: https://doi.org/10.1182/blood-2022-167677
Published: 2022
Journal Articles

CEBPA mutations in 4708 patients with acute myeloid leukemia: differential impact of bZIP and TAD mutations on outcome

Clinical Trials & Observations
Franziska Taube, Julia Annabell Georgi, Michael Kramer, Sebastian Stasik, Jan Moritz Middeke, Christoph Röllig, Utz Krug, Alwin Krämer, Sebastian Scholl, Andreas Hochhaus, Tim H. Brümmendorf, Ralph Naumann, Andreas Petzold, Roger Mulet-Lazaro, Peter J. M. Valk, Björn Steffen, Hermann Einsele, Markus Schaich, Andreas Burchert, Andreas Neubauer, Kerstin Schäfer-Eckart, Christoph Schliemann, Stefan W. Krause, Mathias Hänel, Richard Noppeney, Ulrich Kaiser, Claudia D. Baldus, Martin Kaufmann, Sylvia Herold, Friedrich Stölzel, Katja Sockel, Malte von Bonin, Carsten Müller-Tidow, Uwe Platzbecker, Wolfgang E. Berdel, Hubert Serve, Gerhard Ehninger, Martin Bornhäuser, Johannes Schetelig, Christian Thiede, for the Study Alliance Leukemia (SAL)
Journal: Blood
Blood (2022) 139 (1): 87–103.
DOI: https://doi.org/10.1182/blood.2020009680
Published: 2022
Includes: Supplemental data
Journal Articles

Impact of Body Mass Index on Patient Outcome in Acute Myeloid Leukemia Patients Receiving Intensive Induction Therapy: A Real-World Registry Experience

Julius Christoph Enssle, Sebastian Wolf, Sebastian Scheich, Sarah Weber, Michael Kramer, Leo Ruhnke, Christoph Schliemann, Jan-Henrik Mikesch, Stefan W. Krause, Tim Sauer, Maher Hanoun, Hans Christian Reinhardt, Sabrina Kraus, Martin Kaufmann, Mathias Haenel, Lars Fransecky, Andreas Burchert, Andreas Neubauer, Martina Crysandt, Edgar Jost, Dirk Niemann, Kerstin Schäfer-Eckhard, Gerhard Held, Ulrich Kaiser, Maxi Wass, Markus Schaich, Carsten Müller-Tidow, Uwe Platzbecker, Claudia D. Baldus, Martin Bornhäuser, Christoph Rollig, Hubert Serve, Björn Steffen
Journal: Blood
Blood (2021) 138 (Supplement 1): 3370.
DOI: https://doi.org/10.1182/blood-2021-145917
Published: 2021
Journal Articles

Leukemic Stem Cells of Monocytic AMLs Are Not-Resistant to BCL-2 Inhibition

Simon Renders, Aino-Maija Leppä, Alexander Waclawiczek, Maike Janssen, Elisa Donato, Cecilia Reyneri, Julia M. Unglaub, Michael Hundemer, Richard F. Schlenk, Simon Raffel, Carsten Müller-Tidow, Tim Sauer, Andreas Trumpp
Journal: Blood
Blood (2021) 138 (Supplement 1): 3469.
DOI: https://doi.org/10.1182/blood-2021-149781
Published: 2021
Journal Articles

Two-Year Evaluation of the German Clinical Amyloidosis Registry

Ute Hegenbart, Niklas Fuhr, Laura Huber, Christoph Kimmich, Kaya Veelken, Tobias Dittrich, Rita Ziehl, Fabian aus dem Siepen, Alexander Carpinteiro, Timon Hansen, Carsten Müller-Tidow, Axel Benner, Stefan Schönland
Journal: Blood
Blood (2021) 138 (Supplement 1): 3780.
DOI: https://doi.org/10.1182/blood-2021-152713
Published: 2021
Journal Articles

The Spatial Heterogeneity in Newly Diagnosed Multiple Myeloma Patients - from Sub-Clonal Architecture to the Immune Microenvironment

Lukas John, Alexandra Poos, Stephan M Tirier, Jan-Philipp Mallm, Nina Prokoph, Alexander Brobeil, Raphael Lutz, Sabrina Schumacher, Simon Steiger, Katharina Bauer, Anja Baumann, Christoph Rehnitz, Carsten Müller-Tidow, Hartmut Goldschmidt, Stefanie Huhn, Karsten Rippe, Marc-Steffen Raab, Sandra Sauer, Niels Weinhold
Journal: Blood
Blood (2021) 138 (Supplement 1): 729.
DOI: https://doi.org/10.1182/blood-2021-150937
Published: 2021
Journal Articles

Prediction of Complete Remission and Survival in Acute Myeloid Leukemia Using Supervised Machine Learning

Jan-Niklas Eckardt, Christoph Rollig, Michael Kramer, Sebastian Stasik, Julia-Annabell Georgi, Peter Heisig, Frank P. Kroschinsky, Johannes Schetelig, Uwe Platzbecker, Carsten Müller-Tidow, Tim Sauer, Hubert Serve, Claudia D. Baldus, Kerstin Schaefer-Eckart, Martin Kaufmann, Stefan W. Krause, Mathias Haenel, Christoph Schliemann, Maher Hanoun, Christian Thiede, Martin Bornhaeuser, Karsten Wendt, Jan Moritz Middeke
Journal: Blood
Blood (2021) 138 (Supplement 1): 108.
DOI: https://doi.org/10.1182/blood-2021-149582
Published: 2021