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Journal Articles

Upfront Autologous Hematopoietic Stem-Cell Transplantation Improves Overall Survival in Comparison with Bortezomib-Based Intensification Therapy in Newly Diagnosed Multiple Myeloma: Long-Term Follow-up Analysis of the Randomized Phase 3 EMN02/HO95 Study

Michele Cavo, Francesca Gay, MD, Meral Beksac, MD, Meletios A Dimopoulos, Lucia Pantani, MD PhD, Maria Teresa Petrucci, Luca Dozza, MSc, Bronno Van Der Holt, PhD, Sonja Zweegman, MDPhD, Elena Zamagni, Giuseppe A. Palumbo, MD PhD, Francesca Patriarca, Monica Galli, Vladimir Maisnar, MD PhD MBA, Markus Hansson, MD, Angelo Belotti, Ludek Pour, MD, Paula F Ypma, MD PhD, Mariella Grasso, Sandra Croockewit, MD, Massimo Offidani, Renato Zambello, Anna Marina Liberati, MD, Niels Frost Andersen, MD PhD, Annemiek Broyl, MD PhD, Rossella Troia, PharmD, Pellegrino Musto, Heinz Ludwig, MD, Anna Maria Morelli, MD, Roman Hajek, MD, Christoph Driessen, MD, Anders Waage, MD PhD, Peter Gimsing, DO, PhD, Ulf-Henrik Mellqvist, MD PhD, Thilo Zander, MD, Mario Boccadoro, Pieter Sonneveld, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 37–38.
DOI: https://doi.org/10.1182/blood-2020-137575
Published: 2020
Journal Articles

Peripheral Neuropathy in the Cassiopeia Study

Cathelijne Fokkema, MD, Bronno Van Der Holt, PhD, Mark van Duin, PhD, Ruth Wester, MD, Tom Cupedo, PhD, Philippe Moreau, MD, Jessica Vermeulen, MD PhD, Annemiek Broyl, MD PhD, Pieter Sonneveld, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 48.
DOI: https://doi.org/10.1182/blood-2020-137400
Published: 2020
Journal Articles

18 f-FDG PET/CT Baseline Rdiomics Features Improve the Prediction of Treatment Outcome in Diffuse Large B-Cell Lymphoma Patients

Jakoba J Eertink, MSc, Tim van de Brug, PhD, Sanne E Wiegers, MSc, Gerben J.C. Zwezerijnen, MD, Elisabeth Pfaehler, MSc, Pieternella J. Lugtenburg, MD PhD, Bronno van der Holt, PhD, Henrica C.W. de Vet, PhD, Otto S Hoekstra, MD PhD, Ronald Boellaard, PhD, Josée M Zijlstra, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 27–28.
DOI: https://doi.org/10.1182/blood-2020-140245
Published: 2020
Journal Articles

Consolidation Treatment with VRD Followed By Maintenance Therapy Versus Maintenance Alone in Newly Diagnosed, Transplant-Eligible Patients with Multiple Myeloma (MM): A Randomized Phase 3 Trial of the European Myeloma Network (EMN02/HO95)

Pieter Sonneveld, MD PhD, Meral Beksac, MD, Bronno Van Der Holt, PhD, Meletios A Dimopoulos, Angelo Michele Carella, MD, Heinz Ludwig, MD, Sonja Zweegman, MD PhD, Thilo Zander, MD, Ruth Wester, MD, Roman Hajek, MD, Lucia Pantani, MD PhD, Luca Dozza, MSc, Francesca Gay, MD, Anna Maria Cafro, Luca De Rosa, Francesca Fioritoni, MD, Ulf-Henrik Mellqvist, MD PhD, Rossella Troia, PharmD, Niels Frost Andersen, MD PhD, Ka Lung Wu, MD PhD, Christoph Driessen, MD, Susana Carvalho, MD, Alexandra J. Croockewit, MD PhD, Fredrik Schjesvold, MDPhD, Massimo Offidani, Michele Cavo, Mario Boccadoro
Journal: Blood
Blood (2020) 136 (Supplement 1): 46–48.
DOI: https://doi.org/10.1182/blood-2020-139337
Published: 2020
Journal Articles

A New Risk Stratification Model (R2-ISS) in Newly Diagnosed Multiple Myeloma: Analysis of Mature Data from 7077 Patients Collected By European Myeloma Network within Harmony Big Data Platform

Mattia D'Agostino, MD, Juan-José Lahuerta, MD PhD, Ruth Wester, MD, Anders Waage, MD PhD, Uta Bertsch, Elena Zamagni, Maria-Victoria Mateos, MD PhD, Alessandra Larocca, Daniele Dall'Olio, Niels W. C. J. van de Donk, David Cairns, MSc, PhD, Serena Rocchi, Hans Salwender, MD, Joan Blade Creixenti, Bronno van der Holt, PhD, Castellani Gastone, Giovannino Ciccone, Andrea Capra, Jan Dürig, MD, Sara Bringhen, MD, Sonja Zweegman, MDPhD, Michele Cavo, Hartmut Goldschmidt, MD, Gordon Cook, MB ChB, PhD, Jesus Maria Hernández-Rivas, MD PhD, Jesus F. San-Miguel, MD PhD, Mario Boccadoro, Pieter Sonneveld, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 34–37.
DOI: https://doi.org/10.1182/blood-2020-137021
Published: 2020
Journal Articles

Validation and Improvement Opportunities of the Revised International Staging System for Multiple Myeloma: An Analysis on Mature Data from European Clinical Trials within the Harmony Big Data Platform

Mattia D'Agostino, MD, Anders Waage, MD PhD, Juan-José Lahuerta, MD PhD, Uta Bertsch, Elena Zamagni, MD, Lars Bullinger, Alessandra Larocca, Maria-Victoria Mateos, Niels W. C. J. Van De Donk, Hans Jürgen Salwender, MD, Joan Bladé, MD, Bronno van der Holt, PhD, Paola Tacchetti, Giovannino Ciccone, Sonja Zweegman, Hartmut Goldschmidt, Michele Cavo, Jesús San-Miguel, Pieter Sonneveld, Mario Boccadoro, Jesús María Hernández-Rivas, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1773.
DOI: https://doi.org/10.1182/blood-2019-124321
Published: 2019
Journal Articles

Time-Restricted Versus Standard Duration Immunosuppression after Allogeneic Hematopoietic Stem Cell Transplantation: Results from the Prospective Randomized Phase III HOVON-96 Trial

Cornelis N. De Jong, MD, Ellen Meijer, MD PhD, Katerina Bakunina, Erfan Nur, MD PhD, Marinus van Marwijk Kooij, MD PhD, Marco De Groot, MD PhD, Michel Van Gelder, MD PhD, Johan A. Maertens, MD PhD, Jurgen H.E. Kuball, MD PhD, Dries Deeren, MD PhD, Bronno Van Der Holt, PhD, Jan J Cornelissen, MD PhD, Annoek E.C. Broers, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 371.
DOI: https://doi.org/10.1182/blood-2019-130872
Published: 2019
Journal Articles

Higher Expression of Nuclear Cereblon in Bone Marrow Biopsies of Patients with Multiple Myeloma Treated with Imids in the HOVON-87/Nmsg-18 Trial Is Associated with Longer PFS and OS

Ruth Wester, M Duin, King Hong Lam, MD PhD, Suzana Couto, Yan Ren, Maria Wang, Bronno Van Der Holt, PhD, Berna Berna Beverloo, PhD, Heleen Visser-Wisselaar, Alex Nigg, Anjan Thakurta, Sonja Zweegman, Annemiek Broyl, MD PhD, Pieter Sonneveld
Journal: Blood
Blood (2019) 134 (Supplement_1): 3071.
DOI: https://doi.org/10.1182/blood-2019-128584
Published: 2019
Journal Articles

Bortezomib-Based Induction and Maintenance Overcomes the Negative Prognostic Impact of Renal Impairment and del17p in Transplant-Eligible Myeloma Patients: Long Term Results from the Phase III HOVON-65/GMMG-HD4 Study after Median 137 Months Follow up

Christof Scheid, MD, Henk Lokhorst, MD PhD, Igor W Blau, MD PhD, Bronno Van Der Holt, PhD, Uta Bertsch, Sonja Zweegman, MD PhD, Katja Weisel, Edo Vellenga, Marie José Kersten, MD PhD, Sandra Croockewit, Elias K Mai, MD, Reinier Raymakers, MD PhD, Dirk Hose, MD, Anna Jauch, Jens Hillengass, MD, Marian Stevens-Kroef, PhD, Marc S Raab, MD PhD, Kai Neben, Stephan Stilgenbauer, Annemiek Broyl, MD PhD, Hans-Walter Lindemann, MD, Gerard Bos, MD PhD, Peter Brossart, MD, Marinus van Marwijk Kooij, MD PhD, Paula F Ypma, MD PhD, Ulrich Dührsen, Prof, MD PhD, Ron Schaafsma, MD PhD, Thomas Hielscher, Hans Salwender, Hartmut Goldschmidt, MD, Pieter Sonneveld
Journal: Blood
Blood (2019) 134 (Supplement_1): 3308.
DOI: https://doi.org/10.1182/blood-2019-129684
Published: 2019
Journal Articles

Treatment of Primary Plasma Cell Leukemia with Carfilzomib and Lenalidomide-Based Therapy: Results of the First Interim Analysis of the Phase 2 EMN12/HOVON129 Study

Niels W. C. J. Van De Donk, MD PhD, Bronno van der Holt, PhD, Fredrik H. Schjesvold, MD PhD, Ka Lung Wu, MD, Stefano Spada, Annemiek Broyl, MD PhD, Wilfried Roeloffzen, Alain Gaddiseur, Thomas Lund, MD, Monique C. Minnema, Massimo Offidani, Mariella Grasso, Niels Frost Andersen, Jo Caers, MD PhD, Benedetto Bruno, MD, Sonja Zweegman, MD PhD, Pieter Sonneveld, Roman Hajek, Prof, MD PhD, Reuben Benjamin, MD, Francesca Gay, MD, Annette Juul Vangsted, MD PhD, Pellegrino Musto
Journal: Blood
Blood (2019) 134 (Supplement_1): 693.
DOI: https://doi.org/10.1182/blood-2019-125120
Published: 2019
Journal Articles

Post-Transplantation Cyclophosphamide after Allogeneic Hematopoietic Stem Cell Transplantation: Results of the Prospective Randomized HOVON-96 Trial in Recipients of Matched Related and Unrelated Donors

Cornelis N. De Jong, MD, Ellen Meijer, MD PhD, Katerina Bakunina, Erfan Nur, MD PhD, Marinus van Marwijk Kooij, MD PhD, Marco R. de Groot, MD PhD, Michel van Gelder, MD PhD, Johan A. Maertens, MD PhD, Jurgen H.E. Kuball, MD PhD, Dries Deeren, MD PhD, Bronno van der Holt, PhD, Jan J Cornelissen, MD PhD, Annoek E.C. Broers, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1.
DOI: https://doi.org/10.1182/blood-2019-124659
Published: 2019
Journal Articles

Ixazomib-Thalidomide-Low Dose Dexamethasone (ITd) Induction Followed By Maintenance Therapy with Ixazomib or Placebo in Newly Diagnosed Multiple Myeloma Patients Not Eligible for Autologous Stem Cell Transplantation; Results from the Randomized Phase II HOVON-126/Nmsg 21#13 Trial

Sonja Zweegman, MDPhD, Fredrik H. Schjesvold, MDPhD, Bronno van der Holt, PhD, Mark-David Levin, MDPhD, Claudia A.M. Stege, MD, Anders Waage, MD PhD, Maria B.L. Leijs, MD, Saskia K. Klein, MDPhD, Damian L. Szatkowski, MDPhDMSc, Per Axelsson, MD, Trung Hieu Do, MD, Dorota Knut-Bojanovska, Ellen van der Spek, MDPhD, Asta Svirskaite, Pino Poddighe, MDPhD, Marian Stevens-Kroef, MD, Markus Hansson, MD PhD, Niels WCJ van de Donk, MD PhD, Einar Haukas, MD, Pieter Sonneveld, MDPhD, Niels Abildgaard, MDPhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 800.
DOI: https://doi.org/10.1182/blood-2018-99-111650
Published: 2018
Journal Articles

Differential Effect of Upfront Intensification Treatment in Genetically Defined Myeloma Risk Groups - a Combined Analysis of ISS, Del17p and SKY92 Scores in the EMN-02/HOVON-95 MM Trial

Davine Hofste op Bruinink, MD MSc, Mark van Duin, PhD, Meral Beksac, MD, Christoph Driessen, MD, Heinz Ludwig, MD, Michael Vermeulen, BSc, Rowan Kuiper, MSc, Martin H van Vliet, PhD, Bronno van der Holt, PhD, Roman Hajek, MD PhD, Hans Erik Johnsen, MD Professor, Meletios A Dimopoulos, MD, Antonio Palumbo, MD, Michele Cavo, MD, Pieter Sonneveld, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3186.
DOI: https://doi.org/10.1182/blood-2018-99-119873
Published: 2018
Journal Articles

Transcriptomics in Multiple Myeloma Demonstrates an Association between Survival and Expression of T Cell Co-Signaling Ligands in Bone Marrow Derived Myeloma Plasma Cells

Pim Mutsaers, MD, Rowan Kuiper, MSc, Dora Hammerl, Msc, Mark van Duin, PhD, Bronno Van Der Holt, PhD, Sonja Zweegman, MDPhD, Walter M Gregory, Jan J Cornelissen, MD PhD, Annemiek Broyl, MD PhD, Reno Debets, PhD, Pieter Sonneveld, MDPhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 241.
DOI: https://doi.org/10.1182/blood-2018-99-118488
Published: 2018
Journal Articles

Treatment Response and Long-Term Survival in Multiple Myeloma in the GMMG-HD4 Trial - Neither Profit All Molecular Entities Alike, Nor Are Remissions to Different Regimen Equal

Anja Seckinger, Hans Jürgen Salwender, MD, Hans Martin, MD, Christof Scheid, Thomas Hielscher, Uta Bertsch, MD, Manuela Hummel, Anna Jauch, PhD, Wolfgang Knauf, Martina Emde, Susanne Beck, Kai Neben, Henk M. Lokhorst, MD PhD, Bronno van der Holt, PhD, Ulrich Duehrsen, MD, Jan Dürig, Hans-Walter Lindemann, MD, Ingo Schmidt-Wolf, Mathias Haenel, MD, Bernd Lathan, Marc S Raab, MD PhD, Carsten Müller-Tidow, MD, Pieter Sonneveld, MD PhD, Igor Wolfgang Blau, Jens Hillengass, MD, Katja Weisel, MD, Hartmut Goldschmidt, MD, Dirk Hose, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4485.
DOI: https://doi.org/10.1182/blood-2018-99-113284
Published: 2018
Journal Articles

Autologous Stem Cell Transplantation Versus Bortezomib-Melphalan-Prednisone for Newly Diagnosed Multiple Myeloma: Second Interim Analysis of the Phase 3 EMN02/HO95 Study

Michele Cavo, MD, Roman Hájek, MD, Lucia Pantani, MD, Meral Beksac, MD, Stefania Oliva, MD, Luca Dozza, Hans Erik Johnsen, MD Professor, Maria Teresa Petrucci, MD, Ulf-Henrik Mellqvist, MD, Concetta Conticello, MD, Christoph Driessen, MD, Giulia Marzocchi, BSc, Meletios A. Dimopoulos, Sonja Zweegman, MD PhD, Ka Lung Wu, MD, Barbara Gamberi, MD, Claudia Crippa, MD, Bronno van der Holt, Massimo Offidani, MD, Ruth Wester, Iolanda Donatella Vincelli, MD, Rossella Troia, Petra Cornelisse, Mario Boccadoro, MD, Pieter Sonneveld, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 397.
DOI: https://doi.org/10.1182/blood.V130.Suppl_1.397.397
Published: 2017
Journal Articles

Higher Expression of Nuclear Cereblon in Bone Marrow Biopsies of Patients with Multiple Myeloma Included in the HOVON-87/Nmsg-18 Trial May be Associated with Longer PFS and OS

Ruth Wester, King Hong Lam, MD PhD, Mark van Duin, PhD, Suzana Couto, Yan Ren, Maria Wang, PhD, Bronno van der Holt, Berna Beverloo, PhD, Heleen Visser-Wisselaar, Alex Nigg, Max Qian, Anjan Thakurta, PhD, Annemiek Broyl, MD PhD, Sonja Zweegman, MD PhD, Pieter Sonneveld, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3052.
DOI: https://doi.org/10.1182/blood.V130.Suppl_1.3052.3052
Published: 2017
Journal Articles

Frailty Predicts Survival and Toxicity in Newly Diagnosed Multiple Myeloma Patients Ineligible for Autologous Stem Cell Transplantation; Report of the HOVON-87/Nmsg-18 Study Group

Claudia A.M. Stege, MD, Bronno van der Holt, Ulf-Henrik Mellqvist, MD, Mark-David Levin, PhD, Morten Salomo, Niels Abildgaard, MD, Gerard Bos, MDPhD, Heleen Visser-Wisselaar, Markus Hansson, MD PhD, Annette van der Velden, MD, Wendy Deenik, MD, Astrid Gruber, MD PhD, Jules L.L.M. Coenen, MD, Torben Plesner, MD, Saskia Klein, MD, Bea Tanis, MD PhD, Damian L. Szatkowski, MDPhDMSc, Rolf Brouwer, MD PhD, Matthijs Westerman, MD, Maria Berhardina Leijs, MD, Harm Sinnige, Einar Haukaas, Klaas van der Hem, MD PhD, Marc Durian, MD, Vera Mattijssen, MD PhD, Peter Gimsing, DO, PhD, Niels WCJ Van De Donk, Marian Stevens-Kroef, PhD, Pieter Sonneveld, MDPhD, Anders Waage, MD PhD, Sonja Zweegman, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3146.
DOI: https://doi.org/10.1182/blood.V130.Suppl_1.3146.3146
Published: 2017
Journal Articles

Carfilzomib Combined with Thalidomide and Low-Dose Dexamethasone for Remission Induction and Consolidation in Newly Diagnosed, Transplant Eligible Patients with Multiple Myeloma: The Carthadex Trial

Ruth Wester, Bronno van der Holt, Emelie Asselbergs, Sonja Zweegman, MD PhD, Marie José Kersten, MD, Edo Vellenga, MD, Marinus van Marwijk Kooij, MD PhD, Okke de Weerdt, MD, Monique C Minnema, Sarah Lonergan, Antonio Palumbo, MD, Henk M Lokhorst, Annemiek Broyl, MD PhD, Karim Saad Iskander, Pieter Sonneveld, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3141.
DOI: https://doi.org/10.1182/blood.V130.Suppl_1.3141.3141
Published: 2017
Journal Articles

Bortezomib-Based Therapy Overcomes the Adverse Impact of Renal Impairment in Transplant Eligible Patients: An Analysis of the Prospective Randomized EMN02/HO95 Study

Meletios A. Dimopoulos, Efstathios Kastritis, Roman Hajek, Luca Dozza, Meral Beksac, MD, Alessandra Larocca, Hans Erik Johnsen, MD Professor, Ulf-Henrik Mellqvist, MD, Anders Waage, MD PhD, Sonja Zweegman, MD PhD, Heinz Ludwig, MD, Lucia Pantani, MD, Andrew Spencer, MD, Anna Pascarella, Marina Martello, Susana Carvalho, Hlif Steingrimsdottir, MD, Claudia Cellini, MD, Petra Cornelisse, Rossella Troia, Patrizia Tosi, MD, Bronno van der Holt, Mario Boccadoro, Pieter Sonneveld, MDPhD, Michele Cavo, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4545.
DOI: https://doi.org/10.1182/blood.V130.Suppl_1.4545.4545
Published: 2017