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Bachisio Ziccheddu
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Journal Articles

Tracking the Evolution of Therapy-Related Myeloid Neoplasms Using Chemotherapy Signatures

Benjamin T. Diamond, Bachisio Ziccheddu, Kylee H. Maclachlan, Justin Taylor, Eileen Mary Boyle, Juan Esteban Arango Ossa, Thomas Jacob Jahn, Maurizio Affer, Tulasigeri M. Totiger, David G Coffey, Namrata Chandhok, Justin M Watts, Luisa Cimmino, Sydney X Lu, Niccolo Bolli, Kelly L Bolton, Heather J. Landau, Jae H. Park, Karuna Ganesh, Andrew McPherson, Mikkael A. Sekeres, Alexander M Lesokhin, David J. Chung, Yanming Zhang, Caleb Ho, Mikhail Roshal, Jeffrey W Tyner, Stephen D Nimer, Elli Papaemmanuil, Saad Z. Usmani, Gareth J Morgan, Ola Landgren, Francesco Maura
Journal: Blood
Blood blood.2022018244.
DOI: https://doi.org/10.1182/blood.2022018244
Published: 2023
Includes: Supplemental data
Journal Articles

Individualized Treatment-Adjusted Risk Stratification in Newly Diagnosed Multiple Myeloma

Francesco Maura, Arjun Raj Rajanna, Andriy Derkach, Bachisio Ziccheddu, Niels Weinhold, Kylee H Maclachlan, Benjamin Diamond, Faith E. Davies, Eileen Boyle, Brian A. Walker, Alexandra M Poos, Malin Hultcrantz, Ariosto Siqueira Silva, Oliver Hampton, Jamie Teer, Niccolò Bolli, Graham Jackson, Martin F. Kaiser, Charlotte Pawlyn, Gordon Cook, Dennis Verducci, Dickran Kazandjian, Frits van Rhee, Saad Usmani, Ken H. Shain, Marc S Raab, Gareth J. Morgan, Ola Landgren
Journal: Blood
Blood (2022) 140 (Supplement 1): 1561–1563.
DOI: https://doi.org/10.1182/blood-2022-160215
Published: 2022
Journal Articles

Tracking the Earliest Genomic Events in Multiple Myeloma Life-History

Anthony Cirrincione, Bachisio Ziccheddu, Kylee H Maclachlan, Alexandra M. Poos, Monika Chojnacka, Benjamin Diamond, Eileen M Boyle, Patrick Blaney, Dylan Gagler, Yanming Zhang, Ahmet Dogan, Alexander M Lesokhin, Faith E. Davies, Neha Korde, Marc S Raab, Niels Weinhold, Saad Usmani, Gareth J. Morgan, Ola Landgren, Francesco Maura
Journal: Blood
Blood (2022) 140 (Supplement 1): 1553–1555.
DOI: https://doi.org/10.1182/blood-2022-164742
Published: 2022
Journal Articles

Genomic Determinants of Resistance in Newly Diagnosed Multiple Myeloma Treated with Targeted-Immunotherapy

Francesco Maura, Eileen Boyle, David Coffey, Kylee H Maclachlan, Benjamin Diamond, Patrick Blaney, Dylan Gagler, Bachisio Ziccheddu, Hussein Ghamlouch, Yubao Wang, James E. Hoffman, Dickran Kazandjian, Hani Hassoun, Emily Guzman, Sham Mailankody, Urvi A Shah, Carlyn Tan, Malin Hultcrantz, Michael Scordo, Gunjan L. Shah, Heather Landau, David J. Chung, Sergio A. Giralt, Yanming Zhang, Ahmet Dogan, Alexander M Lesokhin, Dennis Verducci, Faith E. Davies, Saad Usmani, Neha Korde, Gareth J. Morgan, Ola Landgren
Journal: Blood
Blood (2022) 140 (Supplement 1): 1137–1139.
DOI: https://doi.org/10.1182/blood-2022-160308
Published: 2022
Journal Articles

Role of TNFRSF17 and GPRC5D Structural and Point Mutations in Resistance to Targeted Immunotherapies in Multiple Myeloma (MM)

Holly Lee, Paola Neri, Sungwoo Ahn, Ranjan Maity, Noemie Leblay, Bachisio Ziccheddu, Monika Chojnacka, Rémi Tilmont, Elie Barakat, Ola Landgren, Francesco Maura, Nizar Jacques Bahlis
Journal: Blood
Blood (2022) 140 (Supplement 1): 252–253.
DOI: https://doi.org/10.1182/blood-2022-167602
Published: 2022
Journal Articles

Variability in Pattern of Mutational Signatures in Multiple Myeloma As a Function of Racial Origin

Patrick Blaney, Eileen M Boyle, Kylee H Maclachlan, Louis S. Williams, Dylan Gagler, Parvathi Sudha, Alexandra M Poos, Yubao Wang, Hussein Ghamlouch, Avital Tenenbaum, Ariel Siegel, Xiaoyi Chen, Gaurav Varma, David Kaminetzsky, Marc Braunstein, David Coffey, Benjamin Diamond, Bachisio Ziccheddu, Dickran Kazandjian, Urvi A Shah, Elizabeth E. Brown, Elisabet E. Manasanch, Alexander M Lesokhin, Niels Weinhold, Brian A. Walker, Saad Usmani, Ola Landgren, Faith E Davies, Francesco Maura, Gareth J. Morgan
Journal: Blood
Blood (2022) 140 (Supplement 1): 430–432.
DOI: https://doi.org/10.1182/blood-2022-167390
Published: 2022
Journal Articles

Impact of Rare Structural Variant Events in Newly Diagnosed Multiple Myeloma

Monika Chojnacka, Benjamin Diamond, Bachisio Ziccheddu, Even Rustad, Eileen Boyle, Kylee H Maclachlan, Patrick Blaney, Saad Usmani, Gareth J. Morgan, Ola Landgren, Francesco Maura
Journal: Blood
Blood (2022) 140 (Supplement 1): 1542–1543.
DOI: https://doi.org/10.1182/blood-2022-160311
Published: 2022
Journal Articles

Vκ*MYC Mouse Model Recapitulates Key Genomic Defining Events in Multiple Myeloma

Francesco Maura, David Coffey, Esteban Braggio, Caleb K Stein, Meaghen E Sharik, Megan T Du, Bachisio Ziccheddu, Gareth J. Morgan, Ola Landgren, P. Leif Bergsagel, Marta Chesi
Journal: Blood
Blood (2022) 140 (Supplement 1): 1540–1541.
DOI: https://doi.org/10.1182/blood-2022-166614
Published: 2022
Journal Articles

Fc-Mediated Antibody Effector Function, Inflammation Resolution and Oligoclonality on TCR Rearrangements Predict Sustained MRD Negativity in Newly Diagnosed Multiple Myeloma Treated with Immunotherapy Regimens

Eileen M Boyle, Francesco Maura, David Coffey, Kylee H Maclachlan, Benjamin Diamond, Hussein Ghamlouch, Dylan Gagler, Patrick Blaney, Bachisio Ziccheddu, Yubao Wang, Emily Guzman, Avital Tenenbaum, Ariel Siegel, Xiaoyi Chen, Gaurav Varma, James E Hoffman, Dickran Kazandjian, Hani Hassoun, Sham Mailankody, Urvi A Shah, Carlyn Tan, Malin Hultcrantz, Michael Scordo, Gunjan L. Shah, Heather Landau, David J. Chung, Sergio A Giralt, Yanming Zhang, Ahmet Dogan, Alexander M Lesokhin, Dennis Verducci, Faith E Davies, Saad Usmani, Neha Korde, Ola Landgren, Gareth J. Morgan
Journal: Blood
Blood (2022) 140 (Supplement 1): 249–251.
DOI: https://doi.org/10.1182/blood-2022-165500
Published: 2022
Journal Articles

Tracking the Evolution of Therapy-Related Myeloid Neoplasms Using Chemotherapy Signatures

Bachisio Ziccheddu, Benjamin Diamond, Kylee H Maclachlan, Justin Taylor, Eileen M Boyle, Juan E. Arango Ossa, Jahn Jacob, Maurizio Affer, Tulasigeri M Totiger, David Coffey, Justin Watts, Sydney X. Lu, Niccolo Bolli, Kelly L Bolton, Jae H Park, Heather Landau, Karuna Ganesh, Andrew McPherson, Mikkael A. Sekeres, Alexander M Lesokhin, David J. Chung, Yanming Zhang, Caleb Ho, Mikhail Roshal, Jeffrey W. Tyner, Stephen D Nimer, Elli Papaemmanuil, Saad Usmani, Gareth J. Morgan, Ola Landgren, Francesco Maura
Journal: Blood
Blood (2022) 140 (Supplement 1): 2088–2090.
DOI: https://doi.org/10.1182/blood-2022-158992
Published: 2022
Journal Articles

The Mutagenic Impact of Radiotherapy in Multiple Myeloma

Benjamin Diamond, Alexandra M Poos, Bachisio Ziccheddu, Kylee H Maclachlan, Yanming Zhang, Saad Usmani, Eileen M Boyle, Faith E Davies, Gareth J. Morgan, Ola Landgren, Marc S Raab, Francesco Maura, Niels Weinhold
Journal: Blood
Blood (2022) 140 (Supplement 1): 7125–7126.
DOI: https://doi.org/10.1182/blood-2022-166531
Published: 2022
Journal Articles

Whole-genome sequencing reveals complex genomic features underlying anti-CD19 CAR T-cell treatment failures in lymphoma

Michael D. Jain, Bachisio Ziccheddu, Caroline A. Coughlin, Rawan Faramand, Anthony J. Griswold, Kayla M. Reid, Meghan Menges, Yonghong Zhang, Ling Cen, Xuefeng Wang, Mohammad Hussaini, Ola Landgren, Marco L. Davila, Jonathan H. Schatz, Frederick L. Locke, Francesco Maura
Journal: Blood
Blood (2022) 140 (5): 491–503.
DOI: https://doi.org/10.1182/blood.2021015008
Published: 2022
Includes: Supplemental data
Journal Articles

Molecular Evolution of Classical Hodgkin Lymphoma Revealed Though Whole Genome Sequencing of Hodgkin and Reed-Sternberg Cells

Francesco Maura, Marcin Imielinski, Jenny Z Xiang, Bhavneet Binder, Kenneth Eng, Manik Uppal, Feng He, Wei Zhang, Qi Gao, Sunita I. Park, Matthew J. Oberley, Elizabeth Ruckdeschel, Megan S. Lim, Gerald Wertheim, Matthew J. Barth, Terzah M. Horton, Bachisio Ziccheddu, Federico Abascal, Kylee H Maclachlan, Venkata D Yellapantula, Ola Landgren, Craig H. Moskowitz, Ethel Cesarman, Mikhail Roshal, Olivier Elemento, Lisa Giulino Roth
Journal: Blood
Blood (2021) 138 (Supplement 1): 805.
DOI: https://doi.org/10.1182/blood-2021-148663
Published: 2021
Journal Articles

Genomic Drivers of Large B-Cell Lymphoma Resistance to CD19 CAR-T Therapy

Michael D. Jain, Bachisio Ziccheddu, Caroline A. Coughlin, Rawan Faramand, Anthony J. Griswold, Kayla M Reid, Ola Landgren, Frederick L. Locke, Francesco Maura, Marco L. Davila, Jonathan H. Schatz
Journal: Blood
Blood (2021) 138 (Supplement 1): 42.
DOI: https://doi.org/10.1182/blood-2021-148605
Published: 2021
Journal Articles

The Genomic Landscape of Waldenström Macroglobulinemia Reveals Sustained Germinal Center Activity and Late-Developing Copy Number Aberrations

Kylee H Maclachlan, Tina Bagratuni, Efstathios Kastritis, Bachisio Ziccheddu, Sydney X. Lu, Venkata D Yellapantula, Christopher Famulare, Benjamin Diamond, Monika Chojnacka, Arjun Raj, Emilia Mason, David G. Coffey, James E. Hoffman, Dickran Kazandjian, Andriy Derkach, Elli Papaemmanuil, Ahmet Dogan, Alexander Lesokhin, Ola Landgren, M. Lia Palomba, Francesco Maura, Meletios-Athanasios Dimopoulos
Journal: Blood
Blood (2021) 138 (Supplement 1): 2394.
DOI: https://doi.org/10.1182/blood-2021-148095
Published: 2021
Journal Articles

Chemotherapy-Related Mutational Signatures Reveal the Origins of Therapy-Related Myeloid Neoplasms

Benjamin Diamond, Bachisio Ziccheddu, Eileen M Boyle, Kylee H Maclachlan, Juan Arango Ossa, Justin Taylor, Justin Watts, Sydney X. Lu, Venkata D Yellapantula, Christopher Famulare, Monika Chojnacka, Arjun Raj Rajanna, Emilia Mason, David G. Coffey, James E. Hoffman, Dickran Kazandjian, Terrence J Bradley, Menglei Zhu, Niccolo Bolli, Elli Papaemmanuil, Kelly L. Bolton, Michael Scordo, Oscar B Lahoud, Eytan M. Stein, Craig S. Sauter, Hani Hassoun, Sham Mailankody, Neha Korde, Malin Hultcrantz, Urvi A Shah, Gunjan L Shah, Jae H Park, Heather J Landau, Karuna Ganesh, Mikkael A. Sekeres, Stephen Nimer, David J. Chung, Caleb Ho, Mikhail Roshal, Alexander Lesokhin, Gareth J. Morgan, Ola Landgren, Francesco Maura
Journal: Blood
Blood (2021) 138 (Supplement 1): 3271.
DOI: https://doi.org/10.1182/blood-2021-145927
Published: 2021
Journal Articles

Genomic and Immune Signatures Predict Sustained MRD Negativity in Newly Diagnosed Multiple Myeloma Patients Treated with Daratumumab, Carfilzomib, Lenalidomide, and Dexamethasone (D-KRd)

Francesco Maura, Eileen M Boyle, Benjamin Diamond, Patrick Blaney, Hussein Ghamlouch, Bachisio Ziccheddu, Yubao Wang, Kylee H Maclachlan, James E. Hoffman, Hani Hassoun, Sham Mailankody, Urvi A Shah, Carlyn Tan, Malin Hultcrantz, Michael Scordo, Dickran Kazandjian, Gunjan L Shah, Heather J Landau, David J. Chung, Sergio Giralt, Benedetto Bruno, Yanming Zhang, Arnaldo A Arbini, Ahmet Dogan, Alexander Lesokhin, Faith E Davies, Neha Korde, Gareth J Morgan, Ola Landgren
Journal: Blood
Blood (2021) 138 (Supplement 1): 325.
DOI: https://doi.org/10.1182/blood-2021-149112
Published: 2021
Journal Articles

Specific targeting of the KRAS mutational landscape in myeloma as a tool to unveil the elicited antitumor activity

Antonio Sacco, Cinzia Federico, Katia Todoerti, Bachisio Ziccheddu, Valentina Palermo, Arianna Giacomini, Cosetta Ravelli, Federica Maccarinelli, Giada Bianchi, Angelo Belotti, Rossella Ribolla, Vanessa Favasuli, Alexey S. Revenko, A. Robert Macleod, Brandon Willis, Hongbo Cai, Joana Hauser, Claire Rooney, Sophie E. Willis, Philip Lloyd Martin, Anna Staniszewska, Helen Ambrose, Lyndsey Hanson, Chiara Cattaneo, Alessandra Tucci, Giuseppe Rossi, Roberto Ronca, Antonino Neri, Stefania Mitola, Niccolò Bolli, Marco Presta, Michele Moschetta, Sarah Ross, Aldo M. Roccaro
Journal: Blood
Blood (2021) 138 (18): 1705–1720.
DOI: https://doi.org/10.1182/blood.2020010572
Published: 2021
Includes: Supplemental data
Journal Articles

Revealing Transcriptome Deregulation upon Genomic Complexity in Multiple Myeloma

Matteo Claudio Da Via', MD, Bachisio Ziccheddu, Matteo Dugo, Marta Lionetti, PhD, Katia Todoerti, PhD, Mattia D'Agostino, MD, Antonino Neri, MD, Luca Baldini, MD PhD, Paolo Corradini, Francesco Maura, MD, Niccolo Bolli, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 3–4.
DOI: https://doi.org/10.1182/blood-2020-136211
Published: 2020
Journal Articles

Timing the Initiation of Multiple Myeloma

Francesco Maura, MD, Even H Rustad, MD, Niccolò Bolli, MD PhD, Venkata Yellapantula, PhD, Daniel A. Leongamornlert, PhD, Ferran Nadeu, BSc, MSc, Nicos Angelopoulos, PhD, Kevin J Dawson, Thomas J Mitchell, Rob Osborne, Bachisio Ziccheddu, PhD, Cristiana Carniti, PhD, Vittorio Montefusco, Paolo Corradini, Kenneth C. Anderson, MD, Philippe Moreau, MD, Elli Papaemmanuil, PhD, Ludmil Alexandrov, Xose S Puente, Elias Campo, Reiner Siebert, PhD, Herve Avet-Loiseau, MD PhD, Nikhil C. Munshi, MD, Peter J Campbell, Ola Landgren, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 573.
DOI: https://doi.org/10.1182/blood-2019-124357
Published: 2019