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Journal Articles

Role of MBD4 Mutation in Neoplastic Evolution of Acute Myeloid Leukemia

Naomi Kawashima, Dongxu Jiang, Divya Jyoti Singh, Dale Grabowski, Carmelo Gurnari, Yasuo Kubota, Mai Aly, Valeria Visconte, Brittany L Griffin, Torsten Haferlach, Jaroslaw P. Maciejewski, Babal K. Jha

Blood (2022) 140 (Supplement 1): 8783–8784.

DOI: https://doi.org/10.1182/blood-2022-163694

Published: 2022

Journal Articles

Demonstration That Loss of TET2 Impairs DNA Mismatch Repair Resulting in Clonally Restricted Genomic Instability

Dongxu Jiang, Feng Pan, Yihong Guan, Xiaorong Gu, Naomi Kawashima, Divya Jyoti Singh, Danai Dima, Guangbo Qu, Edward F Greenberg, Valeria Visconte, Omar Mian, Mingjiang Xu, Jaroslaw P. Maciejewski, Babal K. Jha

Blood (2022) 140 (Supplement 1): 1989–1990.

DOI: https://doi.org/10.1182/blood-2022-169467

Published: 2022

Journal Articles

Heightened Endoplasmic-Reticulum Stress Is a Targetable Vulnerability of Malignant Plasma Cells in Multiple Myeloma

Danai Dima, Metis Hasipek, Divya Jyoti Singh, Dongxu Jiang, Anand D. Tiwari, Dale Grabowski, Yvonne Parker, Daniel J. Lindner, Jianjun Zhao, Kenneth H. Shain, Jack Khouri, Jaroslaw P. Maciejewski, Babal K. Jha

Blood (2022) 140 (Supplement 1): 7100–7101.

DOI: https://doi.org/10.1182/blood-2022-169516

Published: 2022

Journal Articles

Clinical and Mechanistic Relationship of T -Cell Large Granular Lymphocytic Leukemia ( TLGL) and monoclonal Gammopathy of Undetermined Significance (MGUS)

Danai Dima, Fauzia Ullah, Najiullah Omar, Carmelo Gurnari, Puneet Dhillon, Valeria Visconte, Babal K. Jha, Jaroslaw P. Maciejewski

Blood (2022) 140 (Supplement 1): 9402–9403.

DOI: https://doi.org/10.1182/blood-2022-165601

Published: 2022

Journal Articles

The similarity of class II HLA genotypes defines patterns of autoreactivity in idiopathic bone marrow failure disorders

Blood (2021) 138 (26): 2781–2798.

DOI: https://doi.org/10.1182/blood.2021012900

Published: 2021

Includes: Supplemental data

Journal Articles

The Drive to Acquire Biallelic Hits Inversely Correlates with the Functional Impact of the Primary TP53 Lesion: The Complexity of TP53 Role Assessment

Waled Bahaj, Carmelo Gurnari, Tariq Kewan, Suresh Kumar Balasubramanian, Simona Pagliuca, Yogenthiran Saunthararajah, Laila Terkawi, Misam Zawit, Hassan Awada, Babal K. Jha, Valeria Visconte, Betty K. Hamilton, Hetty E. Carraway, Jaroslaw P. Maciejewski

Blood (2021) 138 (Supplement 1): 3322.

DOI: https://doi.org/10.1182/blood-2021-152848

Published: 2021

Journal Articles

Myelodysplastic Syndromes: A More Global 5-Hydroxymethylcytosine Deficiency Disorder Than Suggested By the Presence of TET2 Mutations

Carmelo Gurnari, Simona Pagliuca, Yihong Guan, Courtney E. Hershberger, Ying Ni, Jaymeson Gordon, Hetty E. Carraway, Richard A Padgett, Diego Coutinho, Ilana Zalcberg, Jae-Sook Ahn, Hyeoung-Joon Kim, Dennis Dong Hwan Kim, Sr., Mark D. Minden, Joop H. Jansen, Babal K. Jha, Torsten Haferlach, Jaroslaw P. Maciejewski, Valeria Visconte

Blood (2021) 138 (Supplement 1): 3665.

DOI: https://doi.org/10.1182/blood-2021-145949

Published: 2021

Journal Articles

Germline MPO Variants Predispose to Myeloid Neoplasia: Potential Mechanisms Suggested By In Vivo and in Vitro Studies

Blood (2021) 138 (Supplement 1): 3662.

DOI: https://doi.org/10.1182/blood-2021-149598

Published: 2021

Journal Articles

A Novel Approach to Induce ATRA Mediated Differentiation in NPM1 Mutant Acute Myeloid Leukemia

Metis Hasipek, Yihong Guan, Dale Grabowski, Xiaorong Gu, Jaroslaw P. Maciejewski, Yogenthiran Saunthararajah, Hetty E. Carraway, Babal K. Jha

Blood (2021) 138 (Supplement 1): 786.

DOI: https://doi.org/10.1182/blood-2021-151394

Published: 2021

Journal Articles

Epigenetic Enzyme Mutations in Myeloid Malignancies Are Selected By Chromatin-Remodeling Requirements That Vary By Lineage- and Maturation-Stage

Sunisa Kongkiatkamon, Xiaorong Gu, Kwok Peng Ng, Simona Pagliuca, Vera Adema, Wencke Walter, Yasunobu Nagata, Cassandra M Kerr, Cassandra M Kerr, Manja Meggendorfer, Hassan Awada, Stephan Hutter, Carmelo Gurnari, Claudia Haferlach, Babal K. Jha, Valeria Visconte, Torsten Haferlach, Jaroslaw P. Maciejewski, Yogenthiran Saunthararajah

Blood (2021) 138 (Supplement 1): 1148.

DOI: https://doi.org/10.1182/blood-2021-153618

Published: 2021

Journal Articles

Genomic Landscape of PHD Finger Protein 6 ( PHF6 ) Mutant Myeloid Neoplasia

Laila Terkawi, Carmelo Gurnari, Sunisa Kongkiatkamon, Simona Pagliuca, Minako Mori, Hassan Awada, Ishani Pandit, Christopher Haddad, Tariq Kewan, Waled Bahaj, Misam Zawit, Babal K. Jha, Hetty E. Carraway, Anjali Advani, Jaroslaw P. Maciejewski, Valeria Visconte

Blood (2021) 138 (Supplement 1): 1154.

DOI: https://doi.org/10.1182/blood-2021-153554

Published: 2021

Journal Articles

Spectrum of Molecular Modes of Immune Escape in Idiopathic Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Simona Pagliuca, Carmelo Gurnari, Colin Hercus, Niroshan Nadarajah, Adam Wahida, Laila Terkawi, Sunisa Kongkiatkamon, Misam Zawit, Tariq Kewan, Waled Bahaj, Babal K. Jha, Yihong Guan, Minako Mori, Caiying Zhu, Valeria Visconte, Ping Zhu, Torsten Haferlach, Jaroslaw P. Maciejewski

Blood (2021) 138 (Supplement 1): 603.

DOI: https://doi.org/10.1182/blood-2021-151965

Published: 2021

Journal Articles

Therapeutic Targeting of TET-Dioxygenase Deficiency in Myeloid Malignancies

Yihong Guan, Anand D. Tiwari, Metis Hasipek, Dale Grabowski, Daniel Lindner, James G Phillips, Omar Mian, Mingjiang Xu, Jaroslaw P. Maciejewski, Babal K. Jha

Blood (2021) 138 (Supplement 1): 3985.

DOI: https://doi.org/10.1182/blood-2021-152744

Published: 2021

Journal Articles

TET2 Inhibitory Effects of Eltrombopag Contribute Its Hematopoietic Activity

Yihong Guan, PhD, Metis Hasipek, PhD, Bhumika J. Patel, MD, Dale Grabowski, BS, Anand D. Tiwari, PhD, Sunisa Kongkiatkamon, MD, Cassandra M Kerr, MS, Aziz Nazha, MD, Yogenthiran Saunthararajah, MD, Mikkael A. Sekeres, MD MS, Jaroslaw P. Maciejewski, MD PhD, Babal K. Jha, PhD

Blood (2020) 136 (Supplement 1): 2–3.

DOI: https://doi.org/10.1182/blood-2020-142875

Published: 2020

Journal Articles

Venetoclax Inhibition of Pyrimidine Synthesis Guides Methods for Integration with Decitabine or 5-Azacytidine That Are Non-Myelosuppressive

Xiaorong Gu, PhD, Rita Tohme, PhD, Mendel Goldfinger, MD, Benjamin K. Tomlinson, MD, Nneha Sakre, PhD, Shannon Hanmer, Babal K. Jha, PhD, Jaroslaw P. Maciejewski, MD PhD, Amit Verma, MBBS, Yogenthiran Saunthararajah, MD

Blood (2020) 136 (Supplement 1): 26–27.

DOI: https://doi.org/10.1182/blood-2020-143200

Published: 2020

Journal Articles

Inhibition of Critical DNA Dioxygenase Activity in IDH1/2 Mutant Myeloid Neoplasms

Simona Pagliuca, MD, Yihong Guan, PhD, Anand D. Tiwari, PhD, Dale Grabowski, BS, Carmelo Gurnari, MD, Cassandra M Kerr, MS, Sunisa Kongkiatkamon, MD, Metis Hasipek, PhD, Laila Terkawi, Misam Zawit, MBBS, Hassan Awada, MD, Valeria Visconte, PhD, Yogenthiran Saunthararajah, MD, James G Phillips, PhD, Jaroslaw P. Maciejewski, MD PhD, Babal K. Jha, PhD

Blood (2020) 136 (Supplement 1): 28.

DOI: https://doi.org/10.1182/blood-2020-143094

Published: 2020

Journal Articles

Impact of HLA Evolutionary Divergence on Clinical Features of Patients with Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Simona Pagliuca, MD, Carmelo Gurnari, MD, Diego Chowell, PhD, Chirag Krishna, Bhumika J. Patel, MD, Hassan Awada, MD, Cassandra M Kerr, MS, Sunisa Kongkiatkamon, MD, Ashwin Kishtagari, MBBS, Thomas Laframboise, PhD, Yogenthiran Saunthararajah, MD, Babal K. Jha, PhD, Valeria Visconte, PhD, Timothy Chan, MD PhD, Jaroslaw Maciejewski, PhD

Blood (2020) 136 (Supplement 1): 2–3.

DOI: https://doi.org/10.1182/blood-2020-142693

Published: 2020

Journal Articles

Multicenter Validation of a Personalized Model to Predict Hypomethylating Agent Response in Myelodysplastic Syndromes (MDS)

Nathan Radakovich, BA, David A. Sallman, MD, Rena J. Buckstein, MD FRCPC, Andrew M. Brunner, MD, Sudipto Mukherjee, MD PhD MPH, Rami Komrokji, MD, Najla Al Ali, M.Sc, Jacob Shreve, MD MS, Yazan Rouphail, Cassandra M Kerr, MS, Yihong Guan, PhD, Teodora Kuzmanovic, BA, Metis Hasipek, PhD, Babal K. Jha, PhD, Jaroslaw P. Maciejewski, MD PhD, Mikkael A. Sekeres, MD MS, Aziz Nazha, MD

Blood (2020) 136 (Supplement 1): 54–55.

DOI: https://doi.org/10.1182/blood-2020-139815

Published: 2020

Journal Articles

A Personalized Clinical-Decision Tool to Improve the Diagnostic Accuracy of Myelodysplastic Syndromes

Blood (2020) 136 (Supplement 1): 33–35.

DOI: https://doi.org/10.1182/blood-2020-139412

Published: 2020

Journal Articles

Role of Oligoadenylate Synthetases in Myeloid Neoplasia

Metis Hasipek, PhD, Yihong Guan, PhD, Dale Grabowski, BS, Xiaorong Gu, PhD, Yogenthiran Saunthararajah, MD, Robert Silverman, PhD, George R Stark, PhD, Jaroslaw Maciejewski, PhD, Babal K. Jha, PhD

Blood (2020) 136 (Supplement 1): 29–30.

DOI: https://doi.org/10.1182/blood-2020-142457

Published: 2020

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NARROW

Role of MBD4 Mutation in Neoplastic Evolution of Acute Myeloid Leukemia

Demonstration That Loss of TET2 Impairs DNA Mismatch Repair Resulting in Clonally Restricted Genomic Instability

Heightened Endoplasmic-Reticulum Stress Is a Targetable Vulnerability of Malignant Plasma Cells in Multiple Myeloma

Clinical and Mechanistic Relationship of T -Cell Large Granular Lymphocytic Leukemia ( TLGL) and monoclonal Gammopathy of Undetermined Significance (MGUS)

The similarity of class II HLA genotypes defines patterns of autoreactivity in idiopathic bone marrow failure disorders

The Drive to Acquire Biallelic Hits Inversely Correlates with the Functional Impact of the Primary TP53 Lesion: The Complexity of TP53 Role Assessment

Myelodysplastic Syndromes: A More Global 5-Hydroxymethylcytosine Deficiency Disorder Than Suggested By the Presence of TET2 Mutations

Germline MPO Variants Predispose to Myeloid Neoplasia: Potential Mechanisms Suggested By In Vivo and in Vitro Studies

A Novel Approach to Induce ATRA Mediated Differentiation in NPM1 Mutant Acute Myeloid Leukemia

Epigenetic Enzyme Mutations in Myeloid Malignancies Are Selected By Chromatin-Remodeling Requirements That Vary By Lineage- and Maturation-Stage

Genomic Landscape of PHD Finger Protein 6 ( PHF6 ) Mutant Myeloid Neoplasia

Spectrum of Molecular Modes of Immune Escape in Idiopathic Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Therapeutic Targeting of TET-Dioxygenase Deficiency in Myeloid Malignancies

TET2 Inhibitory Effects of Eltrombopag Contribute Its Hematopoietic Activity

Venetoclax Inhibition of Pyrimidine Synthesis Guides Methods for Integration with Decitabine or 5-Azacytidine That Are Non-Myelosuppressive

Inhibition of Critical DNA Dioxygenase Activity in IDH1/2 Mutant Myeloid Neoplasms

Impact of HLA Evolutionary Divergence on Clinical Features of Patients with Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Multicenter Validation of a Personalized Model to Predict Hypomethylating Agent Response in Myelodysplastic Syndromes (MDS)

A Personalized Clinical-Decision Tool to Improve the Diagnostic Accuracy of Myelodysplastic Syndromes

Role of Oligoadenylate Synthetases in Myeloid Neoplasia

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American Society of Hematology

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American Society of Hematology

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