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Journal Articles

A Multicentre Phase II Study of the Aminopeptidase Inhibitor, CHR- 2797, in the Treatment of Elderly and/or Previously Treated patients with Acute Myeloid Leukemia.

B. Lowenberg, MD, F. Davies, MD, C. Müller-Tidow, MD, Ulrich Dührsen, A. Burnett, MD, FRCP, P. Zachée, MD, PhD, D. Dierickx, MD, C. Jenkins, MD, P. Sonneveld, MD, M. Jongen-Lavrencic, MD, S. Zweegman, MD, G. Morgan, MD, U. Krug, MD, A. Richardson, PhD, L. Hooftman, MD, G. Ossenkoppele, MD, PhD

Blood (2008) 112 (11): 961.

DOI: https://doi.org/10.1182/blood.V112.11.961.961

Published: 2008

Journal Articles

Mutant Wilms’ Tumor 1 ( WT1 ) mRNA with Premature Termination Codons Is Sensitive to Nonsense-Mediated RNA Decay in Acute Myeloid Leukemia (AML)

Saman Abbas, Claudia Erpelinck, Chantal Goudswaard, B. Lowenberg, MD, Peter Valk, PhD

Blood (2008) 112 (11): 2538.

DOI: https://doi.org/10.1182/blood.V112.11.2538.2538

Published: 2008

Journal Articles

Gene Expression Profiles with Signatures of Tumor Biology and Chemotherapy Sensitivity May Provide a Novel Approach to Maximize Response to Induction Therapy in Patients with Acute Myeloid Leukemia.

Arati V Rao, Sascha A Tuchman, Anil Potti, David A. Rizzieri, MD, Hiroyuki Mano, Ruud Delwel, PhD, Peter Valk, B. Lowenberg, MD

Blood (2008) 112 (11): 2252.

DOI: https://doi.org/10.1182/blood.V112.11.2252.2252

Published: 2008

Journal Articles

Distinct Gene Expression Profiling in AML in Elderly Versus Younger Patients

Henk-Marijn de Jonge, Evelina S de Bont, Peter Valk, Jan Jacob Schuringa, Marcel P Kies, Carolien M. Woolthuis, Ruud Delwel, Edo Vellenga, B. Lowenberg, Geert A Huls

Blood (2008) 112 (11): 2546.

DOI: https://doi.org/10.1182/blood.V112.11.2546.2546

Published: 2008

Journal Articles

Fluorouracil selectively spares acute myeloid leukemia cells with long- term growth abilities in immunodeficient mice and in culture

W Terpstra, RE Ploemacher, A Prins, K van Lom, K Pouwels, AW Wognum, G Wagemaker, B Lowenberg, JJ Wielenga

Blood (1996) 88 (6): 1944–1950.

DOI: https://doi.org/10.1182/blood.V88.6.1944.bloodjournal8861944

Published: 1996

Journal Articles

Quality control of multidrug resistance assays in adult acute leukemia: correlation between assays for P-glycoprotein expression and activity

HJ Broxterman, P Sonneveld, N Feller, GJ Ossenkoppele, DC Wahrer, CA Eekman, M Schoester, J Lankelma, HM Pinedo, B Lowenberg, GJ Schuurhuis

Blood (1996) 87 (11): 4809–4816.

DOI: https://doi.org/10.1182/blood.V87.11.4809.bloodjournal87114809

Published: 1996

Journal Articles

Long-term leukemia-initiating capacity of a CD34-subpopulation of acute myeloid leukemia

W Terpstra, A Prins, RE Ploemacher, BW Wognum, G Wagemaker, B Lowenberg, JJ Wielenga

Blood (1996) 87 (6): 2187–2194.

DOI: https://doi.org/10.1182/blood.V87.6.2187.bloodjournal8762187

Published: 1996

Journal Articles

Tryptophan 650 of human granulocyte colony-stimulating factor (G-CSF) receptor, implicated in the activation of JAK2, is also required for G- CSF-mediated activation of signaling complexes of the p21ras route

RM Barge, JP de Koning, K Pouwels, F Dong, B Lowenberg, IP Touw

Blood (1996) 87 (6): 2148–2153.

DOI: https://doi.org/10.1182/blood.V87.6.2148.bloodjournal8762148

Published: 1996

Journal Articles

The membrane-distal cytoplasmic region of human granulocyte colony- stimulating factor receptor is required for STAT3 but not STAT1 homodimer formation

JP de Koning, F Dong, L Smith, AM Schelen, RM Barge, DC van der Plas, LH Hoefsloot, B Lowenberg, IP Touw

Blood (1996) 87 (4): 1335–1342.

DOI: https://doi.org/10.1182/blood.V87.4.1335.bloodjournal8741335

Published: 1996

Journal Articles

Specific involvement of tyrosine 764 of human granulocyte colony- stimulating factor receptor in signal transduction mediated by p145/Shc/GRB2 or p90/GRB2 complexes

JP de Koning, AM Schelen, F Dong, C van Buitenen, BM Burgering, JL Bos, B Lowenberg, IP Touw

Blood (1996) 87 (1): 132–140.

DOI: https://doi.org/10.1182/blood.V87.1.132.132

Published: 1996

Journal Articles

A point mutation in the granulocyte colony-stimulating factor receptor (G-CSF-R) gene in a case of acute myeloid leukemia results in the overexpression of a novel G-CSF-R isoform

F Dong, M van Paassen, C van Buitenen, LH Hoefsloot, B Lowenberg, IP Touw

Blood (1995) 85 (4): 902–911.

DOI: https://doi.org/10.1182/blood.V85.4.902.bloodjournal854902

Published: 1995

Journal Articles

Predominance of functional multidrug resistance (MDR-1) phenotype in CD34+ acute myeloid leukemia cells

PA te Boekhorst, K de Leeuw, M Schoester, S Wittebol, K Nooter, A Hagemeijer, B Lowenberg, P Sonneveld

Blood (1993) 82 (10): 3157–3162.

DOI: https://doi.org/10.1182/blood.V82.10.3157.3157

Published: 1993

Journal Articles

In situ hybridization on May-Grunwald Giemsa-stained bone marrow and blood smears of patients with hematologic disorders allows detection of cell-lineage-specific cytogenetic abnormalities

K van Lom, A Hagemeijer, EM Smit, B Lowenberg

Blood (1993) 82 (3): 884–888.

DOI: https://doi.org/10.1182/blood.V82.3.884.884

Published: 1993

Journal Articles

Hematopoietic growth factors and their receptors in acute leukemia

B Lowenberg, IP Touw

Blood (1993) 81 (2): 281–292.

DOI: https://doi.org/10.1182/blood.V81.2.281.281

Published: 1993

Journal Articles

Involvement of tumor necrosis factor (TNF) receptors p55 and p75 in TNF responses of acute myeloid leukemia blasts in vitro

R Delwel, C van Buitenen, B Lowenberg, I Touw

Blood (1992) 80 (7): 1798–1803.

DOI: https://doi.org/10.1182/blood.V80.7.1798.1798

Published: 1992

Journal Articles

Kit ligand improves in vitro erythropoiesis in myelodysplastic syndrome

B Backx, L Broeders, B Lowenberg

Blood (1992) 80 (5): 1213–1217.

DOI: https://doi.org/10.1182/blood.V80.5.1213.1213

Published: 1992

Journal Articles

Introduction of the human interleukin-6 (IL-6) receptor in murine IL-3- dependent hematopoietic cells restores responsiveness to IL-6

I Touw, R van Gurp, P Schipper, T van Agthoven, B Lowenberg

Blood (1992) 79 (11): 2867–2872.

DOI: https://doi.org/10.1182/blood.V79.11.2867.2867

Published: 1992

Journal Articles

Tumor necrosis factor regulates the expression of granulocyte- macrophage colony-stimulating factor and interleukin-3 receptors on human acute myeloid leukemia cells

O Elbaz, LM Budel, H Hoogerbrugge, IP Touw, R Delwel, LA Mahmoud, B Lowenberg

Blood (1991) 77 (5): 989–995.

DOI: https://doi.org/10.1182/blood.V77.5.989.989

Published: 1991

Journal Articles

Interleukin-6 (IL-6) is an intermediate in IL-1-induced proliferation of leukemic human megakaryoblasts

MA Brach, B Lowenberg, L Mantovani, U Schwulera, R Mertelsmann, F Herrmann

Blood (1990) 76 (10): 1972–1979.

DOI: https://doi.org/10.1182/blood.V76.10.1972.1972

Published: 1990

Journal Articles

Interleukin-1 alpha also induces granulocyte-macrophage colony- stimulating factor in immature normal bone marrow cells

FJ Bot, P Schipper, L Broeders, R Delwel, K Kaushansky, B Lowenberg

Blood (1990) 76 (2): 307–311.

DOI: https://doi.org/10.1182/blood.V76.2.307.307

Published: 1990

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NARROW

A Multicentre Phase II Study of the Aminopeptidase Inhibitor, CHR- 2797, in the Treatment of Elderly and/or Previously Treated patients with Acute Myeloid Leukemia.

Mutant Wilms’ Tumor 1 ( WT1 ) mRNA with Premature Termination Codons Is Sensitive to Nonsense-Mediated RNA Decay in Acute Myeloid Leukemia (AML)

Gene Expression Profiles with Signatures of Tumor Biology and Chemotherapy Sensitivity May Provide a Novel Approach to Maximize Response to Induction Therapy in Patients with Acute Myeloid Leukemia.

Distinct Gene Expression Profiling in AML in Elderly Versus Younger Patients

Fluorouracil selectively spares acute myeloid leukemia cells with long- term growth abilities in immunodeficient mice and in culture

Quality control of multidrug resistance assays in adult acute leukemia: correlation between assays for P-glycoprotein expression and activity

Long-term leukemia-initiating capacity of a CD34-subpopulation of acute myeloid leukemia

Tryptophan 650 of human granulocyte colony-stimulating factor (G-CSF) receptor, implicated in the activation of JAK2, is also required for G- CSF-mediated activation of signaling complexes of the p21ras route

The membrane-distal cytoplasmic region of human granulocyte colony- stimulating factor receptor is required for STAT3 but not STAT1 homodimer formation

Specific involvement of tyrosine 764 of human granulocyte colony- stimulating factor receptor in signal transduction mediated by p145/Shc/GRB2 or p90/GRB2 complexes

A point mutation in the granulocyte colony-stimulating factor receptor (G-CSF-R) gene in a case of acute myeloid leukemia results in the overexpression of a novel G-CSF-R isoform

Predominance of functional multidrug resistance (MDR-1) phenotype in CD34+ acute myeloid leukemia cells

In situ hybridization on May-Grunwald Giemsa-stained bone marrow and blood smears of patients with hematologic disorders allows detection of cell-lineage-specific cytogenetic abnormalities

Hematopoietic growth factors and their receptors in acute leukemia

Involvement of tumor necrosis factor (TNF) receptors p55 and p75 in TNF responses of acute myeloid leukemia blasts in vitro

Kit ligand improves in vitro erythropoiesis in myelodysplastic syndrome

Introduction of the human interleukin-6 (IL-6) receptor in murine IL-3- dependent hematopoietic cells restores responsiveness to IL-6

Tumor necrosis factor regulates the expression of granulocyte- macrophage colony-stimulating factor and interleukin-3 receptors on human acute myeloid leukemia cells

Interleukin-6 (IL-6) is an intermediate in IL-1-induced proliferation of leukemic human megakaryoblasts

Interleukin-1 alpha also induces granulocyte-macrophage colony- stimulating factor in immature normal bone marrow cells

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American Society of Hematology

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ASH Publications

American Society of Hematology

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