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Journal Articles

Venetoclax and idasanutlin in relapsed/refractory AML: a nonrandomized, open-label phase 1b trial

Clinical Trials & Observations
Naval G. Daver, Monique Dail, Jacqueline S. Garcia, Brian A. Jonas, Karen W. L. Yee, Kevin R. Kelly, Norbert Vey, Sarit Assouline, Gail J. Roboz, Stefania Paolini, Daniel A. Pollyea, Agostino Tafuri, Joseph M. Brandwein, Arnaud Pigneux, Bayard L. Powell, Pierre Fenaux, Rebecca L. Olin, Giuseppe Visani, Giovanni Martinelli, Maika Onishi, Jue Wang, Weize Huang, Cherie Green, Marion G. Ott, Wan-Jen Hong, Marina Y. Konopleva, Michael Andreeff
Journal: Blood
Blood (2023) 141 (11): 1265–1276.
DOI: https://doi.org/10.1182/blood.2022016362
Published: 2023
Includes: Supplemental data
Journal Articles

Enasidenib vs conventional care in older patients with late-stage mutant- IDH2 relapsed/refractory AML: a randomized phase 3 trial

Clinical Trials & Observations
Stéphane de Botton, Pau Montesinos, Andre C. Schuh, Cristina Papayannidis, Paresh Vyas, Andrew H. Wei, Hans Ommen, Sergey Semochkin, Hee-Je Kim, Richard A. Larson, Jaime Koprivnikar, Olga Frankfurt, Felicitas Thol, Jörg Chromik, Jenny Byrne, Arnaud Pigneux, Xavier Thomas, Olga Salamero, Maria Belen Vidriales, Vadim Doronin, Hartmut Döhner, Amir T. Fathi, Eric Laille, Xin Yu, Maroof Hasan, Patricia Martin-Regueira, Courtney D. DiNardo
Journal: Blood
Blood (2023) 141 (2): 156–167.
DOI: https://doi.org/10.1182/blood.2021014901
Published: 2023
Includes: Supplemental data
Journal Articles

Overlapping features of therapy-related and de novo NPM1 -mutated AML

Jad Othman, Manja Meggendorfer, Enrico Tiacci, Christian Thiede, Richard F. Schlenk, Richard Dillon, Sebastian Stasik, Alessandra Venanzi, Sarah Bertoli, Eric Delabesse, Pierre-yves Dumas, Arnaud Pigneux, Audrey Bidet, Amanda Frances Gilkes, Ian Thomas, Maria Teresa Voso, Alessandro Rambaldi, Lorenzo Brunetti, Vincenzo Maria Perriello, Vibeke Andresen, Bjorn T Gjertsen, Maria Paola Martelli, Christian Récher, Hubert Serve, Carsten Müller-Tidow, Claudia D. Baldus, Torsten Haferlach, Nigel H. Russell, Brunangelo Falini
Journal: Blood
Blood blood.2022018108.
DOI: https://doi.org/10.1182/blood.2022018108
Published: 2022
Includes: Supplemental data
Journal Articles

Epag 2015 : A Phase II Randomized Placebo-Controlled Study to Assess the Impact on Outcome of Eltrombopag Administered to Elderly Patients with Acute Myeloid Leukemia Receiving Induction Chemotherapy. a French Innovative Leukemia Organization (FILO) Study

Arnaud Pigneux, Pierre-Yves Dumas, Marc Bernard, Norbert Vey, Audrey Bidet, Ariane Mineur, Mathilde Hunault, Martin Carre, Mario Ojeda, Anne Banos, Pierre Peterlin, Romain Guieze, Yohan Desbrosses, Gabrielle Roth Guepin, Celestine Simand, Thibaut Leguay, Emmanuel Gyan, Eric Jourdan, Jean-Philippe Vial, Tony Marchand, Yosr Hicheri, Marie C Bene, Jean Francois Hamel, Christian Recher
Journal: Blood
Blood (2022) 140 (Supplement 1): 6142–6144.
DOI: https://doi.org/10.1182/blood-2022-167000
Published: 2022
Journal Articles

Olutasidenib (FT-2102) Induces Durable Complete Remissions in Patients with Relapsed/Refractory mIDH1 Acute Myeloid Leukemia. Results from a Planned Interim Analysis of a Phase 2 Pivotal Clinical Trial

Jorge E. Cortes, Pierre Fenaux, Karen Yee, Christian Recher, Andrew H. Wei, Pau Montesinos, David C Taussig, Arnaud Pigneux, Thorsten Braun, Antonio Curti, Carolyn Grove, Brian A. Jonas, Asim Khwaja, Pierre Peterlin, Olga Polyanskaya, Jennifer Sweeney, Julie Brevard, Emma Barrett, Stephane De Botton
Journal: Blood
Blood (2022) 140 (Supplement 1): 6193–6196.
DOI: https://doi.org/10.1182/blood-2022-167330
Published: 2022
Journal Articles

Gilteritinib Activity in Refractory or Relapsed FLT3 -Mutated Acute Myeloid Leukemia Patients Previously Treated By Intensive Chemotherapy and Midostaurin: A Study from the French AML Intergroup ALFA/Filo

Pierre-Yves Dumas, Emmanuel Raffoux, Emilie Berard, Sarah Bertoli, Marie Anne Hospital, Mael Heiblig, Yohan Desbrosses, Caroline Bonmati, Cecile Pautas, Juliette Lambert, Corentin Orvain, Anne Banos, Florence Pasquier, Pierre Peterlin, Tony Marchand, Madalina Uzunov, Jamilé Frayfer, Pascal Turlure, Thomas Cluzeau, Eric Jourdan, Chantal Himberlin, Emmanuelle Tavernier, Alban Villate, Stéphanie Haiat, Marie-Lorraine Chretien, Martin Carre, Sylvain Chantepie, Iona Vaida, Mathieu Wemeau, Safia Chebrek, Gaëlle Guillerm, Romain Guieze, Houria Debarri, Eve Gehlkopf, Kamel Laribi, Ambroise Marçais, Alberto Santagostino, Marie C Bene, Ariane C Mineur, Arnaud Pigneux, Herve Dombret, Christian Recher
Journal: Blood
Blood (2022) 140 (Supplement 1): 8996–8998.
DOI: https://doi.org/10.1182/blood-2022-159125
Published: 2022
Journal Articles

Initial Results from SELECT-AML-1, a Phase 2 Study of Tamibarotene in Combination with Venetoclax and Azacitidine in RARA-Positive Newly Diagnosed AML Patients Ineligible for Standard Induction Chemotherapy

Suman Kambhampati, Christine M. McMahon, Alireza Eghtedar, Daniel A. Pollyea, Stephane de Botton, Arnaud Pigneux, Mohamad Cherry, Brian J Ball, Gautam Borthakur, Thomas Cluzeau, Gary J. Schiller, Beibei Hu, Angela Volkert, Joanie Aasen Gausman, Graeme Hodgson, David A. Roth, Erica D. Warlick, Michael J. Kelly, Eytan Stein
Journal: Blood
Blood (2022) 140 (Supplement 1): 3333–3335.
DOI: https://doi.org/10.1182/blood-2022-156564
Published: 2022
Journal Articles

Dexaml-02 : A Phase II Study of Dexamethasone Added to Induction and Postremission Therapy in Older Patients with Newly Diagnosed AML. a French Innovative Leukemia Organization (FILO) Study

Christian Recher, Sarah Bertoli, Pierre Peterlin, Romain Guieze, Yohan Desbrosses, Yosr Hicheri, Omar Benbrahim, Martin Carre, Hunault-Berger Mathilde, Anne Banos, Marc Bernard, Emmanuel Gyan, Alain Saad, Safia Chebrek, Gabrielle Roth Guepin, Veronique Dorvaux, Laurence Sanhes, Maria Pilar Gallego Hernanz, Carole Exbrayat, Laure Vincent, Chantal Himberlin, Laetitia Largeaud, Eric Delabesse, Francois Vergez, Norbert Vey, Ariane C Mineur, Célestine Simand, Isabelle Luquet, Arnaud Pigneux
Journal: Blood
Blood (2022) 140 (Supplement 1): 6149–6151.
DOI: https://doi.org/10.1182/blood-2022-158665
Published: 2022
Journal Articles

Prognostic impact of DDX41 germline mutations in intensively treated acute myeloid leukemia patients: an ALFA-FILO study

Clinical Trials & Observations
Nicolas Duployez, Laëtitia Largeaud, Matthieu Duchmann, Rathana Kim, Julie Rieunier, Juliette Lambert, Audrey Bidet, Lise Larcher, Jean Lemoine, François Delhommeau, Pierre Hirsch, Laurène Fenwarth, Olivier Kosmider, Justine Decroocq, Anne Bouvier, Yannick Le Bris, Marlène Ochmann, Alberto Santagostino, Lionel Adès, Pierre Fenaux, Xavier Thomas, Jean-Baptiste Micol, Claude Gardin, Raphael Itzykson, Jean Soulier, Emmanuelle Clappier, Christian Recher, Claude Preudhomme, Arnaud Pigneux, Hervé Dombret, Eric Delabesse, Marie Sébert
Journal: Blood
Blood (2022) 140 (7): 756–768.
DOI: https://doi.org/10.1182/blood.2021015328
Published: 2022
Includes: Supplemental data
Journal Articles

Artificial Intelligence-Based Predictive Models for Acute Myeloid Leukemia

Ibrahim Didi, David Simoncini, Francois Vergez, Pierre-Yves Dumas, Suzanne Tavitian, Laetitia Largeaud, Audrey Bidet, Jean-Baptiste Rieu, Isabelle Luquet, Nicolas Lechevalier, Eric Delabesse, Audrey Sarry, Anne-Charlotte De Grande, Emilie Berard, Arnaud Pigneux, Christian Recher, Jean-Marc Alliot, Sarah Bertoli
Journal: Blood
Blood (2021) 138 (Supplement 1): 3389.
DOI: https://doi.org/10.1182/blood-2021-145122
Published: 2021
Journal Articles

Prognostic Significance of DDX41 Germline Mutations in Intensively Treated AML Patients: An ALFA-Filo Study

Nicolas Duployez, Matthieu Duchmann, Laetitia Largeaud, Juliette Lambert, Audrey Bidet, Emmanuelle Clappier, Xavier Thomas, Stephane de Botton, Claude Gardin, Christian Recher, Arnaud Pigneux, Raphael Itzykson, Claude Preudhomme, Hervé Dombret, Eric Delabesse, Marie Sebert
Journal: Blood
Blood (2021) 138 (Supplement 1): 612.
DOI: https://doi.org/10.1182/blood-2021-148465
Published: 2021
Journal Articles

Molecular Characteristics of Response to Olutasidenib (FT-2102) in Patients with Relapsed/Refractory mIDH1 Acute Myeloid Leukemia

Stephane De Botton, Karen Yee, Christian Recher, Andrew H. Wei, Pau Montesinos, David Taussig, Arnaud Pigneux, Thorsten Braun, Antonio Curti, Jordi Esteve, Carolyn Grove, Brian A. Jonas, Asim Khwaja, Olivier Legrand, Pierre Peterlin, Montserrat Arnan Sangerman, William G. Blum, Daniela Cilloni, Devendra Hiwase, Joseph G. Jurcic, Jürgen Krauter, Xavier Thomas, Justin Watts, Jay Yang, Zihao Xin, Alex Sedkov, Sylvie Guichard, Jennifer Sweeney, Christophe Marzac, Jorge E. Cortes, Pierre Fenaux
Journal: Blood
Blood (2021) 138 (Supplement 1): 2351.
DOI: https://doi.org/10.1182/blood-2021-144912
Published: 2021
Journal Articles

Real Life Study on Allogeneic Hematopoietic Cell Transplantation Practice According to International Guidelines and Its Impact on Survival in Acute Myeloid Leukemia French Population

Loic Abed, Morgane Mounier, Marie Robin, Stephanie Nguyen Quoc, Nicole Raus, Anna Berceanu, Sylvain Chantepie, Arnaud Pigneux, Edouard Forcade, Jacques-Olivier Bay, Sylvie Francois, Gaëlle Guillerm, Jean-Baptiste Mear, Denis Caillot, Mohamad Mohty, Remy Dulery, Nathalie Contentin, Charlotte Jubert, Alain Monnereau, Sebastien Orazio, Xavier Troussard, Edouard Cornet, Mohamad Sobh, Marc Maynadie, Mauricette Michallet
Journal: Blood
Blood (2021) 138 (Supplement 1): 4133.
DOI: https://doi.org/10.1182/blood-2021-152571
Published: 2021
Journal Articles

Long-Term Outcome of Peripheral Blood Autologous Stem Cell Transplantation (AutoSCT) for De Novo Acute Myeloid Leukemia in Patients Achieving First Complete Remission after One Vs Two Induction Courses: A Study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT)

Arnon Nagler, Jacques-Emmanuel Galimard, Myriam Labopin, Didier Blaise, William Arcese, Depei Wu, Gwendolyn Van Gorkom, Marie Thérèse Rubio, Tobias Gedde-Dahl, Anne Huynh, Francesco Lanza, Norbert Claude Gorin, Sr., Mohamad Mohty, Silvia Maria Trisolini, Arnaud Pigneux
Journal: Blood
Blood (2021) 138 (Supplement 1): 1840.
DOI: https://doi.org/10.1182/blood-2021-145031
Published: 2021
Journal Articles

Long-Term Survival after Intensive Chemotherapy or Hypomethylating Agents in AML Patients Aged 70 Years and Older: A Large Patient Data Set Study from Dataml, SAL and Pethema European Registries

Christian Recher, Christoph Rollig, Emilie Berard, Sarah Bertoli, Pierre-Yves Dumas, Suzanne Tavitian, Hubert Serve, Martin Bornhäuser, Uwe Platzbecker, Carsten Müller-Tidow, Claudia D. Baldus, David Martínez-Cuadrón, Josefina Serrano, Pilar Martínez, Eduardo Rodríguez-Arbolí, Cristina Gil, Juan-Miguel Bergua, Teresa Bernal, Adolfo de la Fuente, Eric Delabesse, Audrey Bidet, Arnaud Pigneux, Pau Montesinos, Michael Kramer
Journal: Blood
Blood (2021) 138 (Supplement 1): 872.
DOI: https://doi.org/10.1182/blood-2021-147735
Published: 2021
Journal Articles

Retrospective Analysis of the Outcomes of Patients with Relapsed/Refractory Acute Myeloid Leukemia Included in a Patient Named Program of Gemtuzumab Ozogamicin

Juliette Lambert, Pierre Peterlin, Cecile Pautas, Emmanuel Raffoux, Denis Caillot, Ollivier Legrand, Magalie Joris, Anna Berceanu, Jean Valere Malfuson, Sylvain Chantepie, Marc Bernard, Lauris Gastaud, Arnaud Pigneux, Omar Benbrahim, Caroline Bonmati, Hunault-Berger Mathilde, Hervé Dombret, Philippe Rousselot, Sylvie Chevret, Sylvie Castaigne
Journal: Blood
Blood (2021) 138 (Supplement 1): 876.
DOI: https://doi.org/10.1182/blood-2021-145184
Published: 2021
Journal Articles

Prognostic significance of concurrent gene mutations in intensively treated patients with IDH -mutated AML: an ALFA study

CME Clinical Trials & Observations
Matthieu Duchmann, Jean-Baptiste Micol, Nicolas Duployez, Emmanuel Raffoux, Xavier Thomas, Jean-Pierre Marolleau, Thorsten Braun, Lionel Adès, Sylvain Chantepie, Emilie Lemasle, Céline Berthon, Jean-Valère Malfuson, Cécile Pautas, Juliette Lambert, Nicolas Boissel, Karine Celli-Lebras, Denis Caillot, Pascal Turlure, Norbert Vey, Arnaud Pigneux, Christian Recher, Christine Terré, Claude Gardin, Raphaël Itzykson, Claude Preudhomme, Hervé Dombret, Stéphane de Botton
Journal: Blood
Blood (2021) 137 (20): 2827–2837.
DOI: https://doi.org/10.1182/blood.2020010165
Published: 2021
Includes: Supplemental data
Journal Articles

A personalized approach to guide allogeneic stem cell transplantation in younger adults with acute myeloid leukemia

Clinical Trials & Observations
Laurène Fenwarth, Xavier Thomas, Stéphane de Botton, Nicolas Duployez, Jean-Henri Bourhis, Auriane Lesieur, Gael Fortin, Paul-Arthur Meslin, Ibrahim Yakoub-Agha, Pierre Sujobert, Pierre-Yves Dumas, Christian Récher, Delphine Lebon, Céline Berthon, Mauricette Michallet, Arnaud Pigneux, Stéphanie Nguyen, Sylvain Chantepie, Norbert Vey, Emmanuel Raffoux, Karine Celli-Lebras, Claude Gardin, Juliette Lambert, Jean-Valère Malfuson, Denis Caillot, Sébastien Maury, Benoît Ducourneau, Pascal Turlure, Emilie Lemasle, Cécile Pautas, Sylvie Chevret, Christine Terré, Nicolas Boissel, Gérard Socié, Hervé Dombret, Claude Preudhomme, Raphael Itzykson
Journal: Blood
Blood (2021) 137 (4): 524–532.
DOI: https://doi.org/10.1182/blood.2020005524
Published: 2021
Includes: Supplemental data
Journal Articles

IDH Mutations Identify a Subgroup of NPM1 Patients with a More Favorable Prognosis. a Retrospective Multicenter Study of the Filo Group

Sylvain Garciaz, Marie Anne Hospital, Colombe Saillard, MD, Yosr Hicheri, Evelyne D'Incan, Jerome Rey, Catherine Lacombe, Arnaud Pigneux, MD PhD, Marie-Christine Béné, PharmSciD, PhD, Christian Recher, MD PhD, Marie-Joelle Mozziconacci, Norbert Vey, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39–40.
DOI: https://doi.org/10.1182/blood-2020-141229
Published: 2020
Journal Articles

Pain and Opioid Use in Patients with FLT3 Mutation-Positive Relapsed/Refractory AML: A Subanalysis of Patient-Reported Outcomes from the Admiral Trial

David Cella, PhD, Ellen Ritchie, MD, Arnaud Pigneux, MD PhD, Yoshinobu Kanda, MD PhD, Cristina Ivanescu, PhD, Bhavik J. Pandya, PharmD, Manasee V. Shah, MPH
Journal: Blood
Blood (2020) 136 (Supplement 1): 25–26.
DOI: https://doi.org/10.1182/blood-2020-134389
Published: 2020