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Journal Articles

Long-Term Efficacy and Safety of Danicopan as Add-On Therapy to Ravulizumab or Eculizumab in PNH With Significant EVH

Clinical Trials & Observations
Austin G Kulasekararaj, Morag Griffin, Caroline I Piatek, Jamile Shammo, Jun-ichi Nishimura, Christopher J Patriquin, Hubert Schrezenmeier, Wilma Barcellini, Jens Peter Panse, Anna Gaya, Yogesh Patel, Peng Liu, Gleb Filippov, Flore Sicre de Fontbrune, Antonio Maria Risitano, Jong Wook Lee
Journal: Blood
Blood blood.2024026299.
https://doi.org/10.1182/blood.2024026299
Published: 2024
Includes: Supplemental data
Journal Articles

Utility of Baseline PET/CT As Surrogate of Molecular Features in Mantle Cell Lymphoma

Amanda Isabel Perez, Cristina Lopez, Sonia Rodriguez, Guillem Clot, Ferran Nadeu, Anna Montaner, Carlos Jimenez-Vicente, Julio Delgado, Laura Magnano, Juan Gonzalo Correa, Pablo Mozas, Andrea Rivero, Anna Gaya, Marta Gómez, Alfredo Rivas-Delgado, Ana Muntañola, Sebastian Casanueva-Eliceiry, Aida Niñerola-Baizan, Gerard Frigola, Elías Campo, Armando Lopez-Guillermo, Xavier Setoain, Silvia Bea, Eva Gine
Journal: Blood
Blood (2024) 144 (Supplement 1): 6222.
https://doi.org/10.1182/blood-2024-205717
Published: 2024
Journal Articles

Phase III Randomized COMMODORE 2 Trial: 2-Year Efficacy and Safety of Crovalimab in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Naive to Complement Inhibition

Alexander Röth, Guangsheng He, Andres Brodsky, Chatree Chai-Adisaksopha, Narcisa Sonia Comia, Anna Gaya, Martin Höglund, Richard J. Kelly, Ahlam Naila Kori, Je-Hwan Lee, Naoshi Obara, Antonio M Risitano, Anita Appius, Leigh Beveridge, Brittany Gentile, Zilu Zhang, Bing Han, Sasha Sreckovic
Journal: Blood
Blood (2024) 144 (Supplement 1): 2687.
https://doi.org/10.1182/blood-2024-208072
Published: 2024
Journal Articles

Danicopan As Add-on Therapy to Ravulizumab or Eculizumab in Patients with Paroxysmal Nocturnal Hemoglobinuria: Long-Term Patient-Reported Outcomes from the Phase 3 ALPHA Trial

Caroline Piatek, Jong Wook Lee, Morag Griffin, Jun-Ichi Nishimura, Christopher Patriquin, Hubert Schrezenmeier, Wilma Barcellini, Jamile Shammo, Anna Gaya, Mohammed Mahdi, Peng Liu, Karl-Johan Myren, Andrew Messali, Flore Sicre de Fontbrune, Jens Panse, Austin G. Kulasekararaj
Journal: Blood
Blood (2024) 144 (Supplement 1): 2692.
https://doi.org/10.1182/blood-2024-199506
Published: 2024
Journal Articles

Patient-Reported Outcomes: Danicopan As Add-on Therapy to Ravulizumab or Eculizumab Versus Placebo in Patients with Paroxysmal Nocturnal Hemoglobinuria and Clinically Significant Extravascular Hemolysis

Caroline I Piatek, Jong-Wook Lee, Morag Griffin, Jun-Ichi Nishimura, Christopher J. Patriquin, Hubert Schrezenmeier, Wilma Barcellini, Jamile Shammo, Anna Gaya, Yogesh Patel, Peng Liu, Karl-Johan Myrén, Flore Sicre De Fontbrune, Jens Panse, Austin Kulasekararaj
Journal: Blood
Blood (2023) 142 (Supplement 1): 1346.
https://doi.org/10.1182/blood-2023-190015
Published: 2023
Journal Articles

Factor B Inhibition with Oral Iptacopan Monotherapy Demonstrates Sustained Long-Term Efficacy and Safety in Anti-C5-Treated Patients (pts) with Paroxysmal Nocturnal Hemoglobinuria (PNH) and Persistent Anemia: Final 48-Week Results from the Multicenter, Phase III APPLY-PNH Trial

Antonio M Risitano, Austin Kulasekararaj, Alexander Roeth, Phillip Scheinberg, Yasutaka Ueda, Carlos de Castro, Eros Di Bona, Morag Griffin, Saskia MC Langemeijer, Hubert Schrezenmeier, Wilma Barcellini, Vitor AQ Mauad, Jens Panse, Philippe Schafhausen, Suzanne Tavitian, Eloise Beggiato, Anna Gaya, Wei-Han Huang, Toshio Kitawaki, Abdullah Kutlar, Jaroslaw P. Maciejewski, Rosario Notaro, Vinod Pullarkat, Jörg Schubert, Louis Terriou, Michihiro Uchiyama, Flore Sicre De Fontbrune, Camilla Frieri, Ferras Alashkar, Shreyans Gandhi, Rakesh Kumar, Christine Thorburn, Samopriyo Maitra, Susan Solar-Yohay, Tomasz Lawniczek, Marion Dahlke, Régis Peffault De Latour
Journal: Blood
Blood (2023) 142 (Supplement 1): 571.
https://doi.org/10.1182/blood-2023-180780
Published: 2023
Journal Articles

Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Treated with Pegcetacoplan: Real Life Experience

Carlos Vallejo, Santiago Bonanad Boix, Fernando Carnicero, Anna Gaya, Ana Pilar Gonzalez, Fernando Ataulfo Gonzalez Fernandez, Esperanza Lavilla, Eduardo José Salido, Piva Sanchez Anton, Míriam Vara
Journal: Blood
Blood (2023) 142 (Supplement 1): 5653.
https://doi.org/10.1182/blood-2023-185570
Published: 2023
Journal Articles

Danicopan As Add-on Therapy to Ravulizumab or Eculizumab Versus Placebo in Patients with Paroxysmal Nocturnal Hemoglobinuria and Clinically Significant Extravascular Hemolysis: Phase 3 Long-Term Data

Austin Kulasekararaj, Morag Griffin, Caroline I Piatek, Jamile Shammo, Jun-Ichi Nishimura, Christopher J. Patriquin, Hubert Schrezenmeier, Anna Gaya, Yogesh Patel, Peng Liu, Gleb Filippov, Flore Sicre De Fontbrune, Antonio M Risitano, Jong-Wook Lee
Journal: Blood
Blood (2023) 142 (Supplement 1): 576.
https://doi.org/10.1182/blood-2023-189863
Published: 2023
Journal Articles

Paradoxical Findings in Patients with Paroxysmal Nocturnal Hemoglobinuria Treated with C5 Inhibitors: Suboptimal Disease Control Perceived As Satisfactory

Anna Gaya, Luis Fernando Fernández Fuertes, Mónica Ballesteros Andrés, Silvia De La Iglesia Íñigo, Rafael Andrés Del Orbe Barreto, Fernando Fernández Fuertes, Ana Pilar Gonzalez, Isidro Jarque, Esperanza Lavilla, Ramiro Nuñez Vasquez, Eduardo José Salido, Maria Vahí, Carlos Vallejo
Journal: Blood
Blood (2023) 142 (Supplement 1): 5645.
https://doi.org/10.1182/blood-2023-185939
Published: 2023
Journal Articles

One-Year Efficacy and Safety from a Phase 3 Trial of Ravulizumab in Adult Patients with Paroxysmal Nocturnal Hemoglobinuria Receiving Prior Eculizumab Treatment

Austin Kulasekararaj, MDMBBS,MRCP,FRCPath, Anita Hill, MD PhD, Saskia Langemeijer, MD PhD, Richard A. Wells, MD DPhil, F. Ataulfo Gonzalez-Fernandez, Anna Gaya, Emilio Ojeda Gutierrez, Caroline I. Piatek, Lindsay D Mitchell, MBChB, MRCP(UK), FRCPath, Kensuke Usuki, Alberto Bosi, Robert A. Brodsky, MD, Masayo Ogawa, MD FAAP, Ji Yu, Stephan Ortiz, RPh, PhD, Alexander Röth, MD PhD, Jong-Wook Lee, MD PhD, Régis Peffault de Latour, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2231.
https://doi.org/10.1182/blood-2019-128746
Published: 2019
Journal Articles

Ravulizumab (ALXN1210) vs eculizumab in C5-inhibitor–experienced adult patients with PNH: the 302 study

Clinical Trials & Observations
Austin G. Kulasekararaj, Anita Hill, Scott T. Rottinghaus, Saskia Langemeijer, Richard Wells, F. Ataulfo Gonzalez-Fernandez, Anna Gaya, Jong Wook Lee, Emilio Ojeda Gutierrez, Caroline I. Piatek, Jeff Szer, Antonio Risitano, Shinji Nakao, Eric Bachman, Lori Shafner, Andrew I. Damokosh, Stephan Ortiz, Alexander Röth, Regis Peffault de Latour
Journal: Blood
Blood (2019) 133 (6): 540–549.
https://doi.org/10.1182/blood-2018-09-876805
Published: 2019
Includes: Supplemental data
Journal Articles

Results from a Phase 3, Multicenter, Non-Inferiority Study of Ravulizumab (ALXN1210) Versus Eculizumab in Adult Patients with Paroxysmal Nocturnal Hemoglobinuria Currently Treated with Eculizumab

Austin G. Kulasekararaj, MBBS, MD MRCP, FRCPath, Anita Hill, MD PhS, Scott T. Rottinghaus, MD, Saskia Langemeijer, MD PhD, Richard A. Wells, MD DPhil, F. Ataulfo Gonzalez-Fernandez, Anna Gaya, Jong-Wook Lee, MD PhD, Emilio Ojeda Gutierrez, Caroline I. Piatek, Jeffrey Szer, MBBS, Antonio M. Risitano, MD PhD, Shinji Nakao, MD PhD, Eric Bachman, Lori Shafner, PhD, Andrew I. Damokosh, PhD, Stephan Ortiz, RPh, PhD, Alexander Röth, MD, Regis Peffault De Latour
Journal: Blood
Blood (2018) 132 (Supplement 1): 625.
https://doi.org/10.1182/blood-2018-99-119147
Published: 2018
Journal Articles

A Subcutaneously Administered Investigational RNAi Therapeutic (ALN-CC5) Targeting Complement C5 for Treatment of PNH and Complement-Mediated Diseases: Preliminary Phase 1/2 Study Results in Patients with PNH

Anita Hill, Anna Gaya Valls, Morag Griffin, Talha Munir, Anna Borodovsky, Nori Kawahata, Helen Mclean, Kelvin Shi, Angela M. Partisano, Jae Kim, Nader Najafian, Alvaro Urbano
Journal: Blood
Blood (2016) 128 (22): 3891.
https://doi.org/10.1182/blood.V128.22.3891.3891
Published: 2016
Journal Articles

Management of Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) - Data from the Spanish PNH Registry

Silvia De La Iglesia Iñigo, MD PhD, Cristina Notario McDonell, MD, Anna Gaya Valls, María Teresa Cedena Romero, MD PhD, María Isabel Gómez Roncero, MD, Beatriz Arrizabalaga Amunchastegui, MD PhD, Carmen Monteserin Monteserin, MD, Esperanza Lavilla Rubira, MD PhD, Ana María Villegas Martínez, Prof.
Journal: Blood
Blood (2016) 128 (22): 4811.
https://doi.org/10.1182/blood.V128.22.4811.4811
Published: 2016
Journal Articles

Relationship Between Myelodysplastic Syndrome and Paroxysmal Nocturnal Hemoglobinuria: Spanish Erythropathology Group and Spanish Paroxysmal Nocturnal Hemoglobinuria Working Group Experience

Montserrat Lopez Rubio, PhD, Anna Gaya, MD, Marta Morado, Vicente Carrasco, MD, Ataulfo Gonzalez Fernandez, Ph, Ana Villegas, Prof.
Journal: Blood
Blood (2015) 126 (23): 4546.
https://doi.org/10.1182/blood.V126.23.4546.4546
Published: 2015
Journal Articles

At-Home Management of Adult Patients Following Consolidation Chemotherapy for Acute Myeloid Leukemia

Anna Gaya, MD, Jordina Rovira, MD, Cristina Moreno, Cristina Gallego, Adelina Hernando, Susana Segura, Nacira Arab, Pilar Ayora, Montserrat Carreño, Núria Martínez-Cibrián, MD, Jordi Esteve, MD PhD, Francesc Fernández-Avilés, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3692.
https://doi.org/10.1182/blood.V124.21.3692.3692
Published: 2014
Journal Articles

Piwirna-651 Expression Influences Treatment Response and Impacts Survival in Classical Hodgkin Lymphoma Patients through Regulation of ABCC5

Alfons Navarro, PhD, Anna Cordeiro, Msc, Anna Gaya, MD, Blanca Gonzalez-Farre, MD, Marina Díaz-Beyá, MD PhD, Dolors Fuster, Carmen Martínez, MD, Jordi Esteve, MD PhD, Antonio Martinez, MD, Mariano Monzó, MD PhD
Journal: Blood
Blood (2014) 124 (21): 134.
https://doi.org/10.1182/blood.V124.21.134.134
Published: 2014
Journal Articles

Prognostic Significance Of a 4-Microrna Signature Targeting JAK2 In Classical Hodgkin Lymphoma

Alfons Navarro, PhD, Anna Gaya, MD, Anna Cordeiro, Msc, Blanca Gonzalez-Farre, MD, Marina Díaz-Beyá, MD, Dolors Fuster, Carmen Martinez, Jordi Esteve, MD, PhD, Antonio Martinez, MD, Mariano Monzó, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 629.
https://doi.org/10.1182/blood.V122.21.629.629
Published: 2013
Journal Articles

Mir-SNP Haplotype in the MicroRNA Maturation Pathway As a Marker of Clinical Outcome in Hodgkin Lymphoma (HL)

Alfons Navarro, PhD, Carmen Muñoz, PhD, Anna Gaya, MD, Antonio Martinez, MD, Marina Díaz Beyá, MD, Rut Tejero, Tania Díaz, PhD, Gerardo Ferrer, Msc, Alvaro Urbano-Ispizua, MD, Mariano Monzó, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 1561.
https://doi.org/10.1182/blood.V118.21.1561.1561
Published: 2011
Journal Articles

Lestaurtinib (CEP701) Inhibits Proliferation and Activates Apoptosis In Hodgkin Lymphoma Cells through Inhibition of the JAK/STAT Signaling Pathway

Alfons Navarro, PhD, Tania Díaz, Antonio Martinez, MD, PhD, Anna Gaya, MD, Mariano Monzó, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 3919.
https://doi.org/10.1182/blood.V116.21.3919.3919
Published: 2010