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Journal Articles

Very long chain fatty acid metabolism is required in acute myeloid leukemia

Matthew Tcheng, Alessia Roma, Nawaz Ahmed, Richard William Smith, Dr, Preethi Jayanth, Mark D. Minden, Aaron D Schimmer, David A Hess, Kristin Hope, Tariq Akhtar, Eric Bohrnsen, Angelo D'Alessandro, Al-Walid Mohsen, Jerry Vockley, Paul A. Spagnuolo

Blood blood.2020008551.

DOI: https://doi.org/10.1182/blood.2020008551

Published: 2021

Includes: Supplemental data

Journal Articles

Nicotinamide Phosphoribosyltransferase Inhibitors Induce Apoptosis of AML Stem Cells through Dysregulation of Lipid Metabolism

Amit Subedi, PhD, Qiang Liu, PhD BSc, David Sharon, PhD, Severine Cathelin, PhD, Gary D Bader, Changjiang Xu, Veronique Voisin, PhD, Angelo D'Alessandro, PhD, Eric R Lechman, PhD, John E. Dick, PhD FRS, Mark D. Minden, Jean C.Y. Wang, MD, Steven M Chan, MD PhD

Blood (2020) 136 (Supplement 1): 25–26.

DOI: https://doi.org/10.1182/blood-2020-142404

Published: 2020

Journal Articles

Evolution of Gilteritinib Resistance from Residual Disease to Relapse

Blood (2020) 136 (Supplement 1): 4–5.

DOI: https://doi.org/10.1182/blood-2020-139084

Published: 2020

Journal Articles

Liver X Receptor (LXR) Is a Novel and Reversible Regulator of Trauma-Induced Coagulopathy

Blood (2020) 136 (Supplement 1): 2.

DOI: https://doi.org/10.1182/blood-2020-143292

Published: 2020

Journal Articles

In Situ Fate Mapping of Native and Stress Myelopoiesis Reveals a Unique Niche for Mono- and Dendritic Cell -Poiesis

Blood (2020) 136 (Supplement 1): 38–39.

DOI: https://doi.org/10.1182/blood-2020-143123

Published: 2020

Journal Articles

Linking Stored Red Blood Cell Metabolism to Transfusion Recipient Iron Homeostasis Pathophysiology in Critically-Ill Children

Ryan M. Fredericks, MD, Travis Nemkov, PhD, Camilla L'Acqua, MD, Steven L. Spitalnik, MD, Eldad A. Hod, MD, Angelo D'Alessandro, PhD

Blood (2019) 134 (Supplement_1): 1175.

DOI: https://doi.org/10.1182/blood-2019-125854

Published: 2019

Journal Articles

Differential Metabolomics and Lipidomics of Hypoxic/Hypocapnic Long-Term Stored Red Cells Associate with Improved 24-Hour Recovery after Transfusion

Tatsuro Yoshida, PhD, Angelo D'Alessandro, PhD, Xiaoyun Fu, PhD, Travis Nemkov, PhD, Davide Stefanoni, Michael Dioguardi, BS, Neeta Rugg, Shawnagay Nestheide, BS, William Iselin, BA, Andrew Dunham, PhD, James C. Zimring, MD PhD, Jose A Cancelas, MD

Blood (2019) 134 (Supplement_1): 4994.

DOI: https://doi.org/10.1182/blood-2019-125961

Published: 2019

Journal Articles

TNF-α–driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging

Blood (2019) 134 (9): 727–740.

DOI: https://doi.org/10.1182/blood.2019000200

Published: 2019

Includes: Multimedia, Supplemental data

Journal Articles

Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II

Brief Report

Courtney L. Jones, Brett M. Stevens, Angelo D’Alessandro, Rachel Culp-Hill, Julie A. Reisz, Shanshan Pei, Annika Gustafson, Nabilah Khan, James DeGregori, Daniel A. Pollyea, Craig T. Jordan

Blood (2019) 134 (4): 389–394.

DOI: https://doi.org/10.1182/blood.2019898114

Published: 2019

Includes: Supplemental data

Journal Articles

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells

Courtney L Jones, PhD, Brett M Stevens, PhD, Angelo D'Alessandro, PhD, Julia Reisz, PhD, Rachel Culp-Hill, BS, Travis Nemkov, Shanshan Pei, PhD, Nabilah Khan, Biniam Adane, PhD, Haobin Ye, PhD, Dominik Reinhold, Clayton Smith, MD, James DeGregori, PhD, Daniel A Pollyea, MD, Craig T Jordan, PhD

Blood (2018) 132 (Supplement 1): 1521.

DOI: https://doi.org/10.1182/blood-2018-99-111965

Published: 2018

Journal Articles

Relapsed Acute Myeloid Leukemia Is Less Sensitive to Venetoclax + Azacitidine Due to Leukemia Stem Cell Resistance Driven By Fatty Acid Metabolism and Can be Overcome By Pharmacologic Inhibition of CPT1

Daniel A Pollyea, MD, Courtney L Jones, PhD, Brett M Stevens, PhD, Shanshan Pei, PhD, Angelo D'Alessandro, PhD, Rachel Culp-Hill, BS, Diana Abbott, PhD, Andrew Hammes, MS, James Dugan, MD, Jonathan A Gutman, MD, Enkhtsetseg Purev, MD PhD, Clayton Smith, MD, Craig T Jordan, PhD

Blood (2018) 132 (Supplement 1): 432.

DOI: https://doi.org/10.1182/blood-2018-99-111507

Published: 2018

Journal Articles

Leukemia Stem Cells in Relapsed AML Patients Are Uniquely Dependent on Nicotinamide Metabolism

Courtney L Jones, PhD, Brett M Stevens, PhD, Rachel Culp-Hill, BS, Travis Nemkov, Angelo D'Alessandro, PhD, Shanshan Pei, PhD, Daniel A Pollyea, MD, Craig T Jordan, PhD

Blood (2018) 132 (Supplement 1): 429.

DOI: https://doi.org/10.1182/blood-2018-99-111366

Published: 2018

Journal Articles

Adenosine A2B Receptor Controls Erythroid Lineage Commitment in Stress Erythropoiesis By Promoting Metabolic Reprogramming

Hong Liu, MD, Rongrong Liu, Travis Nemkov, Jacob Couturier, PhD, Long Liang, Anren Song, PhD, Shushan Zhao, MD PhD, Kaiqi Sun, PhD, Morayo Adebiyi, PhD, Yuan Edward Wen, Alexander Wen, Jing Liu, PhD, Rodney Kellems, PhD, Angelo D'Alessandro, PhD, Michael Blackburn, PhD, Yang Xia, MD PhD

Blood (2018) 132 (Supplement 1): 845.

DOI: https://doi.org/10.1182/blood-2018-99-114075

Published: 2018

Journal Articles

Increased Methylation of Deamidated Asparagines and Aspartates in Stored Red Blood Cells from Glucose 6-Phosphate Dehydrogenase-Deficient Blood Donors

Blood (2018) 132 (Supplement 1): 2543.

DOI: https://doi.org/10.1182/blood-2018-99-119262

Published: 2018

Journal Articles

Elevated Circadian Period 2: A Missing Beneficial Factor in Sickle Cell Disease By Lowering Pulmonary Inflammation, Iron Overload and Mortality

Morayo Adebiyi, PhD, Zhaoyang Zhao, PhD, Jeanne Manalo, BS, Cheng Chi Lee, PhD, Wa Xian, PhD, Ye Youqiong, PhD, Frank McKeon, PhD, Rachel Culp-Hill, BS, Angelo D'Alessandro, PhD, Rodney Kellems, PhD, Seung-Hee Yoo, PhD, Leng Han, PhD, Yang Xia, MD PhD

Blood (2018) 132 (Supplement 1): 3644.

DOI: https://doi.org/10.1182/blood-2018-99-111211

Published: 2018

Journal Articles

Regulation of Mature Erythrocyte Proteasomal Machinery Under Hypoxia

Anren Song, PhD, Angelo D'Alessandro, PhD, Kaiqi Sun, PhD, Hong Liu, MD, Zhangzhe Peng, MD, Modupe Idowu, MD, Rodney Kellems, PhD, Harinder S. Juneja, MD, Yang Xia, MD PhD

Blood (2018) 132 (Supplement 1): 3616.

DOI: https://doi.org/10.1182/blood-2018-99-113050

Published: 2018

Journal Articles

Cysteine and Cystine Depletion Targets Leukemia Stem Cells

Courtney L Jones, PhD, Brett M Stevens, PhD, Angelo D'Alessandro, Rachel Culp-Hill, BS, Julie Reisz, PhD, Haobin Ye, PhD, Nabilah Khan, Mohd Minhajuddin, PhD, James DeGregori, PhD, Daniel A Pollyea, MD, Craig T Jordan, PhD

Blood (2018) 132 (Supplement 1): 431.

DOI: https://doi.org/10.1182/blood-2018-99-113181

Published: 2018

Journal Articles

Adenosine Signaling Regulates Erythroid Commitment Via Modulation of Metabolic Reprogramming in Stress Erythropoiesis

Blood (2017) 130 (Supplement 1): 1156.

DOI: https://doi.org/10.1182/blood.V130.Suppl_1.1156.1156

Published: 2017

Journal Articles

Mitochondrial Fission 1 Regulates GSK3 and AMPK Signaling to Sustain Leukemia Stem Cell Function in Acute Myelogenous Leukemia

Shanshan Pei, PhD, Mohammad Minhajuddin, PhD, Biniam Adane, BS, Brett M Stevens, PhD, Nabilah Khan, PhD, Angelo D'alessandro, PhD, Travis Nemkov, Kirk C Hansen, PhD, Daniel A Pollyea, MD, Craig T Jordan, PhD

Blood (2016) 128 (22): 1703.

DOI: https://doi.org/10.1182/blood.V128.22.1703.1703

Published: 2016

Journal Articles

Metabolic Abnormalities in G6PC3 Deficient Human Neutrophils Result in Severe Functional Defects

Christopher M. McKinney, MD, Michael A. Ellison, PhD, Natalie Briones, MS, Angelina Baroffio, MS, Julie A. Reisz, PhD, Angelo D'alessandro, PhD, Daniel R. Ambruso, MD

Blood (2016) 128 (22): 1024.

DOI: https://doi.org/10.1182/blood.V128.22.1024.1024

Published: 2016

NARROW

Very long chain fatty acid metabolism is required in acute myeloid leukemia

Nicotinamide Phosphoribosyltransferase Inhibitors Induce Apoptosis of AML Stem Cells through Dysregulation of Lipid Metabolism

Evolution of Gilteritinib Resistance from Residual Disease to Relapse

Liver X Receptor (LXR) Is a Novel and Reversible Regulator of Trauma-Induced Coagulopathy

In Situ Fate Mapping of Native and Stress Myelopoiesis Reveals a Unique Niche for Mono- and Dendritic Cell -Poiesis

Linking Stored Red Blood Cell Metabolism to Transfusion Recipient Iron Homeostasis Pathophysiology in Critically-Ill Children

Differential Metabolomics and Lipidomics of Hypoxic/Hypocapnic Long-Term Stored Red Cells Associate with Improved 24-Hour Recovery after Transfusion

TNF-α–driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging

Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells

Relapsed Acute Myeloid Leukemia Is Less Sensitive to Venetoclax + Azacitidine Due to Leukemia Stem Cell Resistance Driven By Fatty Acid Metabolism and Can be Overcome By Pharmacologic Inhibition of CPT1

Leukemia Stem Cells in Relapsed AML Patients Are Uniquely Dependent on Nicotinamide Metabolism

Adenosine A2B Receptor Controls Erythroid Lineage Commitment in Stress Erythropoiesis By Promoting Metabolic Reprogramming

Increased Methylation of Deamidated Asparagines and Aspartates in Stored Red Blood Cells from Glucose 6-Phosphate Dehydrogenase-Deficient Blood Donors

Elevated Circadian Period 2: A Missing Beneficial Factor in Sickle Cell Disease By Lowering Pulmonary Inflammation, Iron Overload and Mortality

Regulation of Mature Erythrocyte Proteasomal Machinery Under Hypoxia

Cysteine and Cystine Depletion Targets Leukemia Stem Cells

Adenosine Signaling Regulates Erythroid Commitment Via Modulation of Metabolic Reprogramming in Stress Erythropoiesis

Mitochondrial Fission 1 Regulates GSK3 and AMPK Signaling to Sustain Leukemia Stem Cell Function in Acute Myelogenous Leukemia

Metabolic Abnormalities in G6PC3 Deficient Human Neutrophils Result in Severe Functional Defects

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American Society of Hematology

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American Society of Hematology

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