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Journal Articles

HLA-Matched Treg/Tcon Allogeneic Hematopoietic Cell Transplantation Is Safe and Ensures Remarkable Chronic GvHD/Leukemia Free Survival in High-Risk Leukemia Patients

Blood (2022) 140 (Supplement 1): 2133–2134.

DOI: https://doi.org/10.1182/blood-2022-169351

Published: 2022

Journal Articles

Acute GvHD after HLA-Haploidentical Hematopoietic Cell Transplantation with Regulatory and Conventional T Cell Immunotherapy Does Not Adversely Affect Transplantation Outcomes

Blood (2021) 138 (Supplement 1): 2885.

DOI: https://doi.org/10.1182/blood-2021-152839

Published: 2021

Journal Articles

Regulatory T Cell Adoptive Immunotherapy Promotes B Cell Immunity after Haploidentical Transplantation

Sara Piccinelli, Antonella Mancusi, PhD, Eni Hoxha, Loredana Ruggeri, MD, Franca Falzetti, MD, Alessandra Carotti, MD, Adelmo Terenzi, MD, Samanta Bonato, MD, Matteo Paradiso, MD, Tiziana Zei, Roberta Iacucci Ostini, Barbara Bigerna, Brunangelo Falini, MD PhD, Mauro Di Ianni, MD PhD, Massimo Fabrizio Martelli, MD, Andrea Velardi, MD, Antonio Pierini, MD PhD

Blood (2019) 134 (Supplement_1): 1917.

DOI: https://doi.org/10.1182/blood-2019-125715

Published: 2019

Journal Articles

Adoptive Immunotherapy with Regulatory and Conventional T Cells in Haploidentical Transplantation Primes Dendritic Cells to Promote T Cell Alloreactivity in the Bone Marrow and Tolerance in the Periphery

Mauro Di Ianni, MD PhD, Raffaella Giancola, Stefano Baldoni, Francesca Ulbar, Beatrice Del Papa, Stella Santarone, Annalisa Natale, Paola Olioso, Paolo Di Bartolomeo, Tiziana Bonfini, Patrizia Accorsi, Paolo Sportoletti, Alessandra Carotti, MD, Antonio Pierini, MD PhD, Loredana Ruggeri, MD, Franca Falzetti, MD, Massimo Fabrizio Martelli, MD, Andrea Velardi, MD

Blood (2019) 134 (Supplement_1): 3224.

DOI: https://doi.org/10.1182/blood-2019-126061

Published: 2019

Journal Articles

Activation of Regulatory T Cells with IL-2 and TNF-α to Promote Homing to the Gut and to Improve Acute GvHD Prevention

Antonella Mancusi, PhD, Samanta Bonato, MD, Rachele Del Sordo, MD, Sara Piccinelli, Eni Hoxha, Tiziana Zei, Roberta Iacucci Ostini, Franca Falzetti, MD, Alessandra Carotti, MD, Loredana Ruggeri, MD, Michele Giansanti, MD, Robert S. Negrin, MD, Massimo Fabrizio Martelli, MD, Andrea Velardi, MD, Antonio Pierini, MD PhD

Blood (2019) 134 (Supplement_1): 4447.

DOI: https://doi.org/10.1182/blood-2019-123202

Published: 2019

Journal Articles

Haploidentical Transplantation with Regulatory and Conventional T Cells Improves Outcome of Patients Affected By Acute Myeloid Leukemia with Complex Karyotype and/or Monosomy 7/Del(7q)

Blood (2018) 132 (Supplement 1): 2183.

DOI: https://doi.org/10.1182/blood-2018-99-116638

Published: 2018

Journal Articles

How Adoptive Immunotherapy with Conventional T and Regulatory T Cells Exerts a Gvl Effect without GvHD, after Haploidentical Hematopoietic Transplantation

Blood (2018) 132 (Supplement 1): 3333.

DOI: https://doi.org/10.1182/blood-2018-99-112512

Published: 2018

Journal Articles

ANTI-CMV Immunoglobulins in Association with ANTI-CMV Drugs in Patients with Hematological Malignancies Submitted to Allogeneic STEM CELL Transplantation: A MULTI-Center Retrospective Experience

Blood (2018) 132 (Supplement 1): 3381.

DOI: https://doi.org/10.1182/blood-2018-99-110252

Published: 2018

Journal Articles

Low-Toxicity/High-Efficacy HLA Haploidentical Transplantation for Elderly/Unfit Patients with Acute Leukemia

Andrea Velardi, MD, Alessandra Carotti, MD, Franca Falzetti, MD, Adelmo Terenzi, MD, Loredana Ruggeri, MD PhD, Antonio Pierini, MD PhD, Sara Piccinelli, MD, Sara Tricarico, MD, Amico Lucia, MD, Genni Casarola, MD, Valentina Lancillotta, MD, Simonetta Saldi, MD, Mauro Di Ianni, MD PhD, Cynthia Aristei, MD PhD, Massimo Fabrizio Martelli, MD PhD

Blood (2017) 130 (Supplement 1): 4601.

DOI: https://doi.org/10.1182/blood.V130.Suppl_1.4601.4601

Published: 2017

Journal Articles

Chemotherapy-Based HLA Haploidentical Transplantation with Treg/Tcon Immunotherapy in Unfit/Elderly Leukemia Patients: Powerful Gvl Effect and Insights from Animal Models

Loredana Ruggeri, Alessandra Carotti, Franca Falzetti, MD, Mauro Diianni, Antonio Pierini, MD, Maria Speranza Massei, Lucia Amico, Sara Piccinelli, Elena Urbani, Massimo Fabrizio Martelli, Andrea Velardi

Blood (2016) 128 (22): 3483.

DOI: https://doi.org/10.1182/blood.V128.22.3483.3483

Published: 2016

Journal Articles

An Accelerated CD8+, but Not CD4+, T-Cell Reconstitution Associates with a More Favorable Outcome Following HLA-Haploidentical HSCT: Results from a Retrospective Study of the Cell Therapy and Immunobiology Working Party of the EBMT

Blood (2015) 126 (23): 1929.

DOI: https://doi.org/10.1182/blood.V126.23.1929.1929

Published: 2015

Journal Articles

Haploidentical hematopoietic transplantation from KIR ligand–mismatched donors with activating KIRs reduces nonrelapse mortality

Antonella Mancusi, Loredana Ruggeri, Elena Urbani, Antonio Pierini, Maria Speranza Massei, Alessandra Carotti, Adelmo Terenzi, Franca Falzetti, Antonella Tosti, Fabiana Topini, Silvia Bozza, Luigina Romani, Rita Tognellini, Martin Stern, Franco Aversa, Massimo F. Martelli, Andrea Velardi

Blood (2015) 125 (20): 3173–3182.

DOI: https://doi.org/10.1182/blood-2014-09-599993

Published: 2015

Includes: Supplemental data

Journal Articles

Tregs Suppress GvHD at the Periphery and Unleash the Gvl Effect in the Bone Marrow

Loredana Ruggeri, Mauro Di Ianni, Elena Urbani, Antonella Mancusi, Franca Falzetti, Alessandra Carotti, Adelmo Terenzi, Maria Speranza Massei, Lucia Amico, Tiziana Zei, Roberta Iacucci, Massimo Fabrizio Martelli, Andrea Velardi

Blood (2014) 124 (21): 842.

DOI: https://doi.org/10.1182/blood.V124.21.842.842

Published: 2014

Journal Articles

Mother Donors Confer Protection Against Infectious Mortality after Haploidentical T Cell-Depleted Hematopoietic Transplantation

Loredana Ruggeri, Antonella Tosti, Antonella Mancusi, Fabiana Topini, Elena Urbani, Alessandra Carotti, Massimo Fabrizio Martelli, Andrea Velardi

Blood (2014) 124 (21): 2485.

DOI: https://doi.org/10.1182/blood.V124.21.2485.2485

Published: 2014

Journal Articles

HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse

Massimo F. Martelli, Mauro Di Ianni, Loredana Ruggeri, Franca Falzetti, Alessandra Carotti, Adelmo Terenzi, Antonio Pierini, Maria Speranza Massei, Lucia Amico, Elena Urbani, Beatrice Del Papa, Tiziana Zei, Roberta Iacucci Ostini, Debora Cecchini, Rita Tognellini, Yair Reisner, Franco Aversa, Brunangelo Falini, Andrea Velardi

Blood (2014) 124 (4): 638–644.

DOI: https://doi.org/10.1182/blood-2014-03-564401

Published: 2014

Journal Articles

“Designed” grafts for HLA-haploidentical stem cell transplantation

Massimo F. Martelli, Mauro Di Ianni, Loredana Ruggeri, Antonio Pierini, Franca Falzetti, Alessandra Carotti, Adelmo Terenzi, Yair Reisner, Franco Aversa, Brunangelo Falini, Andrea Velardi

Blood (2014) 123 (7): 967–973.

DOI: https://doi.org/10.1182/blood-2013-10-531764

Published: 2014

Journal Articles

HLA-Haploidentical Stem Cell Transplantation with Treg and Tcon Adoptive Immunotherapy promotes a Strong Graft-Versus-Leukemia Effect

Mauro Di Ianni, Loredana Ruggeri, Franca Falzetti, Alessandra Carotti, Adelmo Terenzi, Maria Speranza Massei, Lucia Amico, Antonio Pierini, Andrea Velardi, Massimo Fabrizio Martelli

Blood (2013) 122 (21): 907.

DOI: https://doi.org/10.1182/blood.V122.21.907.907

Published: 2013

Journal Articles

Thymosin Alfa 1 Administration Improves Immune Reconstitution and Decreases Infection-Related Mortality After HLA-Matched Sibling T Cell-Depleted Stem Cell Transplantation

Katia Perruccio, Loredana Ruggeri, Silvia Moretti, Fabiana Topini, Antonella Tosti, Alessandra Carotti, Franco Aversa, Massimo F Martelli, Francesco Bistoni, Enrico Garaci, Luigina Romani, Andrea Velardi

Blood (2011) 118 (21): 1013.

DOI: https://doi.org/10.1182/blood.V118.21.1013.1013

Published: 2011

Journal Articles

Adoptive Immunotherapy with Tregs and Tcons Ensures Low TRM and a Low Incidence of Post Transplant Leukaemia Relapse After HLA Haploidentical Transplants for Acute Leukemia

Mauro Di Ianni, Franca Falzetti, Alessandra Carotti, Adelmo Terenzi, Loredana Ruggeri, Pierini Antonio, Vincenza de Fazio, Valentina Zoi, Maria Speranza Massei, Yair Reisner, Andrea Velardi, Franco Aversa, Massimo Fabrizio Martelli, MD

Blood (2011) 118 (21): 154.

DOI: https://doi.org/10.1182/blood.V118.21.154.154

Published: 2011

Journal Articles

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

Blood (2011) 117 (14): 3921–3928.

DOI: https://doi.org/10.1182/blood-2010-10-311894

Published: 2011

NARROW

HLA-Matched Treg/Tcon Allogeneic Hematopoietic Cell Transplantation Is Safe and Ensures Remarkable Chronic GvHD/Leukemia Free Survival in High-Risk Leukemia Patients

Acute GvHD after HLA-Haploidentical Hematopoietic Cell Transplantation with Regulatory and Conventional T Cell Immunotherapy Does Not Adversely Affect Transplantation Outcomes

Regulatory T Cell Adoptive Immunotherapy Promotes B Cell Immunity after Haploidentical Transplantation

Adoptive Immunotherapy with Regulatory and Conventional T Cells in Haploidentical Transplantation Primes Dendritic Cells to Promote T Cell Alloreactivity in the Bone Marrow and Tolerance in the Periphery

Activation of Regulatory T Cells with IL-2 and TNF-α to Promote Homing to the Gut and to Improve Acute GvHD Prevention

Haploidentical Transplantation with Regulatory and Conventional T Cells Improves Outcome of Patients Affected By Acute Myeloid Leukemia with Complex Karyotype and/or Monosomy 7/Del(7q)

How Adoptive Immunotherapy with Conventional T and Regulatory T Cells Exerts a Gvl Effect without GvHD, after Haploidentical Hematopoietic Transplantation

ANTI-CMV Immunoglobulins in Association with ANTI-CMV Drugs in Patients with Hematological Malignancies Submitted to Allogeneic STEM CELL Transplantation: A MULTI-Center Retrospective Experience

Low-Toxicity/High-Efficacy HLA Haploidentical Transplantation for Elderly/Unfit Patients with Acute Leukemia

Chemotherapy-Based HLA Haploidentical Transplantation with Treg/Tcon Immunotherapy in Unfit/Elderly Leukemia Patients: Powerful Gvl Effect and Insights from Animal Models

An Accelerated CD8+, but Not CD4+, T-Cell Reconstitution Associates with a More Favorable Outcome Following HLA-Haploidentical HSCT: Results from a Retrospective Study of the Cell Therapy and Immunobiology Working Party of the EBMT

Haploidentical hematopoietic transplantation from KIR ligand–mismatched donors with activating KIRs reduces nonrelapse mortality

Tregs Suppress GvHD at the Periphery and Unleash the Gvl Effect in the Bone Marrow

Mother Donors Confer Protection Against Infectious Mortality after Haploidentical T Cell-Depleted Hematopoietic Transplantation

HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse

“Designed” grafts for HLA-haploidentical stem cell transplantation

HLA-Haploidentical Stem Cell Transplantation with Treg and Tcon Adoptive Immunotherapy promotes a Strong Graft-Versus-Leukemia Effect

Thymosin Alfa 1 Administration Improves Immune Reconstitution and Decreases Infection-Related Mortality After HLA-Matched Sibling T Cell-Depleted Stem Cell Transplantation

Adoptive Immunotherapy with Tregs and Tcons Ensures Low TRM and a Low Incidence of Post Transplant Leukaemia Relapse After HLA Haploidentical Transplants for Acute Leukemia

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

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American Society of Hematology

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American Society of Hematology

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