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Alan S. Gamis
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Journal Articles

Clinical and Functional Implications of MYC Variants As a New Class of Pathogenic Variants in AML

Danielle C. Kirkey, Xiaoying Wu, Rhonda E. Ries, Tiffany A. Hylkema, Yanling Liu, Pandurang Kolekar, Quang Tran, Alan S. Gamis, Richard Aplenc, Anders E. Kolb, Todd A. Alonzo, Katherine Tarlock, Robert Eisenman, Soheil Meshinchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 3395–3396.
DOI: https://doi.org/10.1182/blood-2022-168469
Published: 2022
Journal Articles

Expanding the High-Risk Definition for Children with Newly Diagnosed Acute Myeloid Leukemia

Adam J. Lamble, Rhonda E. Ries, Todd A. Alonzo, Yi-Cheng Wang, Jason E Farrar, Benjamin J. Huang, Matthew A. Kutny, Jessica A. Pollard, Richard Aplenc, Alan S. Gamis, Edward A. Kolb, Todd M. Cooper, Soheil Meshinchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 3393–3394.
DOI: https://doi.org/10.1182/blood-2022-167680
Published: 2022
Journal Articles

Desensitization to Pegaspargase in Children with Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma Is Safe and Does Not Require Intensive Care - a Single Center Experience

Keith J August, Tristan Flatt, Joy M. Fulbright, Alan S. Gamis, Julia A. Hays, Maxine J Hetherington, Karen Lewing, Amanda August, Erin Guest
Journal: Blood
Blood (2022) 140 (Supplement 1): 6037–6038.
DOI: https://doi.org/10.1182/blood-2022-167549
Published: 2022
Journal Articles

Pathogenic TP53 mutations Are Associated with a Poor Prognosis in De Novo AML

Adam J. Lamble, Rhonda E. Ries, Alice Dang, Todd A. Alonzo, Karen Chisholm, Pandurang Kolekar, Yanling Liu, Quang Tran, Todd M. Cooper, Richard Aplenc, Alan S. Gamis, Edward A. Kolb, Xiaotu Ma, Soheil Meshinchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 6297–6298.
DOI: https://doi.org/10.1182/blood-2022-162832
Published: 2022
Journal Articles

Distinct Latent Trajectory Phenotypes of Left Ventricular Function Associated with Differential Survival Among Children Treated for Acute Myeloid Leukemia: A Report from the Children's Oncology Group

Kelly D. Getz, Robert B. Gerbing, Todd A. Alonzo, Yimei Li, Kasey J Leger, Jessica A. Pollard, Dava Szalda, Lillian Sung, Todd M. Cooper, Edward A. Kolb, Alan S. Gamis, Bonnie Ky, Richard Aplenc
Journal: Blood
Blood (2022) 140 (Supplement 1): 1014–1015.
DOI: https://doi.org/10.1182/blood-2022-170218
Published: 2022
Journal Articles

A Robust Long Non-Coding RNA Expression Classifier for Risk Stratification in Pediatric AML

Jason E Farrar, Jenny L. Smith, Megan Othus, Benjamin J. Huang, Yi-Cheng Wang, Rhonda E. Ries, Tiffany A. Hylkema, Era L Pogosova-Agadjanyan, Sneha Challa, Amanda R. Leonti, Timothy I. Shaw, Timothy Junius Triche, Jr., Alan S. Gamis, Richard Aplenc, Anders E. Kolb, Xiaotu Ma, Derek Stirewalt, Todd A. Alonzo, Soheil Meshinchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 9173–9174.
DOI: https://doi.org/10.1182/blood-2022-168296
Published: 2022
Journal Articles

Epigenetic Silencing of CD34 in AML and Association with Outcome in KMT2A Fusions

Rhonda E. Ries, Lisa Eidenschink Brodersen, Laura Pardo, Timothy Junius Triche, Jr., Amanda R. Leonti, Jenny L. Smith, Todd A. Alonzo, Jason E Farrar, Yi-Cheng Wang, Alice Dang, Alan S. Gamis, Richard Aplenc, E. Anders Kolb, Michael R. Loken, Soheil Meshinchi
Journal: Blood
Blood (2021) 138 (Supplement 1): 802.
DOI: https://doi.org/10.1182/blood-2021-149210
Published: 2021
Journal Articles

Valosin-Containing Protein (VCP/p97) Is Prognostically Unfavorable in Subtypes of Acute Leukemia, and Negatively Correlates with UPR-Proteins IRE1 and GRP78

Fieke W Hoff, Yihua Qiu, Brandon Brown, Robert B. Gerbing, Alan S. Gamis, Richard Aplenc, Edward A. Kolb, Todd A. Alonzo, Soheil Meshinchi, Gaye Jenkins, Terzah M. Horton, Steven M. Kornblau
Journal: Blood
Blood (2021) 138 (Supplement 1): 3447.
DOI: https://doi.org/10.1182/blood-2021-147066
Published: 2021
Journal Articles

A Polygenic DNA Damage Repair Pharmacogenomics (DDR_PGx8) Score Predicts GO Response in AML

Vivek M. Shastri, Lata Chauhan, Todd A. Alonzo, Yi-Cheng Wang, Richard Aplenc, Betsy A Hirsch, Alan S. Gamis, Soheil Meshinchi, Jatinder K. Lamba
Journal: Blood
Blood (2021) 138 (Supplement 1): 3456.
DOI: https://doi.org/10.1182/blood-2021-153181
Published: 2021
Journal Articles

ETS Family Transcription Factor Fusions in Childhood AML: Distinct Expression Networks and Clinical Implications

Jenny L. Smith, Rhonda E. Ries, Yi-Cheng Wang, Amanda R. Leonti, Todd A. Alonzo, Alan S. Gamis, Richard Aplenc, Anders E. Kolb, Benjamin J. Huang, Xiaotu Ma, Timothy I. Shaw, Soheil Meshinchi
Journal: Blood
Blood (2021) 138 (Supplement 1): 2356.
DOI: https://doi.org/10.1182/blood-2021-148894
Published: 2021
Journal Articles

Significant Improvements in Survival for Patients with t(6;9)(p23;q34)/ DEK-NUP214 in Contemporary Trials with Intensification of Therapy: A Report from the Children's Oncology Group

Katherine Tarlock, Todd A. Alonzo, Robert B. Gerbing, Yi-Cheng Wang, Rhonda E. Ries, Betsy A Hirsch, Beverly Lange, William G. Woods, Todd M. Cooper, Alan S. Gamis, Jessica A. Pollard, Richard Aplenc, Anders E. Kolb, Soheil Meshinchi
Journal: Blood
Blood (2021) 138 (Supplement 1): 519.
DOI: https://doi.org/10.1182/blood-2021-147576
Published: 2021
Journal Articles

CEBPA -bZip mutations are associated with favorable prognosis in de novo AML: a report from the Children’s Oncology Group

Clinical Trials & Observations
Katherine Tarlock, Adam J. Lamble, Yi-Cheng Wang, Robert B. Gerbing, Rhonda E. Ries, Michael R. Loken, Lisa Eidenschink Brodersen, Laura Pardo, Amanda Leonti, Jenny L. Smith, Tiffany A. Hylkema, William G. Woods, Todd M. Cooper, E. Anders Kolb, Alan S. Gamis, Richard Aplenc, Todd A. Alonzo, Soheil Meshinchi
Journal: Blood
Blood (2021) 138 (13): 1137–1147.
DOI: https://doi.org/10.1182/blood.2020009652
Published: 2021
Includes: Supplemental data
Journal Articles

Heat shock factor 1 (HSF1-pSer 326 ) predicts response to bortezomib-containing chemotherapy in pediatric AML: a COG report

Clinical Trials & Observations
Fieke W. Hoff, Anneke D. van Dijk, Yihua Qiu, Peter P. Ruvolo, Robert B. Gerbing, Amanda R. Leonti, Gaye N. Jenkins, Alan S. Gamis, Richard Aplenc, E. Anders Kolb, Todd A. Alonzo, Soheil Meshinchi, Eveline S. J. M. de Bont, Sophia W. M. Bruggeman, Steven M. Kornblau, Terzah M. Horton
Journal: Blood
Blood (2021) 137 (8): 1050–1060.
DOI: https://doi.org/10.1182/blood.2020005208
Published: 2021
Includes: Supplemental data
Journal Articles

Failures and Successes in Pediatric Patients with Acute Myeloid Leukemia with First Relapse: A Large International Report on Current Treatment Strategies and Outcome

Mareike Rasche, MD, Martin Zimmermann, Emma Steidel, Todd A. Alonzo, PhD, Richard Aplenc, MD PhD, Jean-Pierre Bourquin, MD PhD, Heidrun Boztug, Alan S. Gamis, MD MPH, Robert B. Gerbing, MA, Iveta Janotová, Thomas Lehrnbecher, Nora Muehlegger, Nils Von Neuhoff, PhD, Naghmeh Niktoreh, Lucie Sramkova, MD, Jan Stary, MD PhD, Christiane Walter, MSc, Ursula Creutzig, MD PhD, Michael Dworzak, MD PhD, Edward A. Kolb, MD, Dirk Reinhardt, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 6–7.
DOI: https://doi.org/10.1182/blood-2020-141774
Published: 2020
Journal Articles

Characteristics and Prognostic Effects of IDH Mutations across the Age Spectrum in AML: A Collaborative Analysis from COG, SWOG, and ECOG

Sara Zarnegar-Lumley, MD, Todd A. Alonzo, PhD, Megan Othus, PhD, Zhuoxin Sun, PhD, Rhonda E. Ries, MA, Yi-Cheng Wang, MS, Amanda R. Leonti, MS, Matthew A. Kutny, MD, Derek Stirewalt, MD, Jerald P. Radich, MD, Frederick R. Appelbaum, MD, Era L Pogosova-Agadjanyan, BS, Kristen Marie O'Dwyer, MD, Harry P. Erba, MD PhD, Omar Abdel-Wahab, MD, Martin S. Tallman, MD, Mark Litzow, MD, Ehab L. Atallah, MD, Selina M. Luger, MD FRCPC, Ross L. Levine, MD, Todd M. Cooper, DO, Alan S. Gamis, MD MPH, Richard Aplenc, MD PhD, Anders E. Kolb, MD, Soheil Meshinchi, MDPhD, Katherine Tarlock, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 31–32.
DOI: https://doi.org/10.1182/blood-2020-134211
Published: 2020
Journal Articles

The Molecular Characteristics and Clinical Relevance of NUP98 -Other Translocations in Pediatric Acute Myeloid Leukemia

Eline J.M. Bertrums, Jenny L. Smith, MSc, MD, Rhonda E. Ries, MA, Todd A. Alonzo, PhD, Fabiana Ostronoff, MD, Gertjan J.L. Kaspers, Prof. MD PhD, Henrik Hasle, PhD, Christian M. Zwaan, Betsy A Hirsch, PhD, Susana C. Raimondi, PhD, Todd M. Cooper, DO, Richard Aplenc, MD PhD, Alan S. Gamis, MD MPH, Edward A. Kolb, MD, Bianca F. Goemans, MD PhD, Soheil Meshinchi, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 36–37.
DOI: https://doi.org/10.1182/blood-2020-137537
Published: 2020
Journal Articles

Genome and Transcriptome Profiling of Monosomy 7 AML Defines Novel Risk and Therapeutic Cohorts

Rhonda E. Ries, MA, Timothy Junius Triche, Jr., PhD, Jenny L. Smith, MSc, MD, Amanda R. Leonti, MS, Todd A. Alonzo, PhD, Jason E. Farrar, MD, Xiaolong Chen, PhD, Yanling Liu, PhD, Timothy Shaw, PhD, Benjamin J. Huang, MD, Yi-Cheng Wang, MS, Robert B. Gerbing, MA, Betsy A Hirsch, PhD, Susana C. Raimondi, PhD, Alan S. Gamis, MD MPH, Richard Aplenc, MD PhD, Jinghui Zhang, PhD, E. Anders Kolb, MD, Xiaotu Ma, PhD, Soheil Meshinchi, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 20–21.
DOI: https://doi.org/10.1182/blood-2020-137244
Published: 2020
Journal Articles

Structural Variants Involving MLLT10/AF10 Are Associated with Adverse Outcome in AML Regardless of the Partner Gene - a COG/Tpaml Study

Rhonda E. Ries, MA, Amanda R. Leonti, MS, Timothy Junius Triche, Jr., PhD, Robert B. Gerbing, Betsy A Hirsch, PhD, Susana C. Raimondi, PhD, Jenny L. Smith, MSc, MD, Todd M Cooper, DO, Jason E. Farrar, MD, Aniruddha J. Deshpande, E. Anders Kolb, MD, Alan S Gamis, MD MPH, Richard Aplenc, MD PhD, Todd A. Alonzo, PhD, Soheil Meshinchi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 461.
DOI: https://doi.org/10.1182/blood-2019-125943
Published: 2019
Journal Articles

Occurrence and Resolution of Anthracycline Cardiotoxicity and Impact on Treatment Outcomes Among Children Treated on the AAML1031 Clinical Trial: A Report from the Children's Oncology Group

Kelly D Getz, Lillian Sung, MD PhD, Robert B. Gerbing, Todd A. Alonzo, PhD, Yimei Li, PhD, Yuan-Shung V. Huang, MS, Kasey J Leger, MD MSc, Jessica A. Pollard, MD, Todd M Cooper, DO, Edward Anders Kolb, MD, Alan S Gamis, MD MPH, Richard Aplenc, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 331.
DOI: https://doi.org/10.1182/blood-2019-131227
Published: 2019
Journal Articles

High-Dose Cytarabine Is Indispensable for the Survival of Children with Myeloid Leukemia of Down Syndrome Despite Negative Minimal Residual Disease Post-Induction

Johann K. Hitzler, MD, Jason Berman, MD, Robert B. Gerbing, Amy Beckman, Betsy A Hirsch, PhD, Susana C. Raimondi, PhD, Todd E Druley, MD PhD, Michael R. Loken, PhD, Lisa Eidenschink Brodersen, PhD, Karen Chisholm, Shelton A. Viola, MD, Jeffrey W. Taub, MD, Alan S Gamis, MD MPH, Todd A. Alonzo, PhD, E. Anders Kolb, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 118.
DOI: https://doi.org/10.1182/blood-2019-126723
Published: 2019