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Ajay K. Nooka
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Journal Articles

Heme promotes venetoclax resistance in multiple myeloma through MEK-ERK signaling and purine biosynthesis

Remya Nair, An H. Vu, Abigail K. Freer, Karanpreet S. Bhatia, Dongxue Wang, Milan R. Savani, Shannon M. Matulis, Sagar Lonial, David L. Jaye, Lawrence H. Boise, Seung-Yong Seo, Timothy W. Corson, Ajay K. Nooka, Shruti Bhatt, Samuel K. McBrayer, Vikas A. Gupta, Xin Hu, Benjamin G. Barwick, Amit R. Reddi, Mala Shanmugam
Journal: Blood
Blood (2025) 145 (7): 732–747.
https://doi.org/10.1182/blood.2024025690
Published: 2025
Includes: Supplemental data
Journal Articles

Efficacy and safety of teclistamab in patients with relapsed/refractory multiple myeloma after BCMA-targeting therapies

Clinical Trials & Observations
Cyrille Touzeau, Amrita Y. Krishnan, Philippe Moreau, Aurore Perrot, Saad Z. Usmani, Salomon Manier, Michele Cavo, Carmen Martinez Chamorro, Ajay K. Nooka, Thomas G. Martin, Lionel Karlin, Xavier Leleu, Nizar J. Bahlis, Britta Besemer, Lixia Pei, Sarah Stein, Shun Xin Wang Lin, Danielle Trancucci, Raluca I. Verona, Suzette Girgis, Xin Miao, Clarissa M. Uhlar, Katherine Chastain, Alfred L. Garfall
Journal: Blood
Blood (2024) 144 (23): 2375–2388.
https://doi.org/10.1182/blood.2023023616
Published: 2024
Includes: Supplemental data
Journal Articles

Ide-cel vs standard regimens in triple-class–exposed relapsed and refractory multiple myeloma: updated KarMMa-3 analyses

Clinical Trials & Observations
Sikander Ailawadhi, Bertrand Arnulf, Krina Patel, Michele Cavo, Ajay K. Nooka, Salomon Manier, Natalie Callander, Luciano J. Costa, Ravi Vij, Nizar J. Bahlis, Philippe Moreau, Scott Solomon, Ingerid Weum Abrahamsen, Rachid Baz, Annemiek Broijl, Christine Chen, Sundar Jagannath, Noopur Raje, Christof Scheid, Michel Delforge, Reuben Benjamin, Thomas Pabst, Shinsuke Iida, Jesús Berdeja, Sergio Giralt, Anna Truppel-Hartmann, Yanping Chen, Xiaobo Zhong, Fan Wu, Julia Piasecki, Laurie Eliason, Devender Dhanda, Jasper Felten, Andrea Caia, Mark Cook, Mihaela Popa McKiver, Paula Rodríguez-Otero
Journal: Blood
Blood (2024) 144 (23): 2389–2401.
https://doi.org/10.1182/blood.2024024582
Published: 2024
Includes: Supplemental data
Journal Articles

Monumental-6: A Phase 3 Study of Talquetamab + Pomalidomide or Talquetamab + Teclistamab Vs Elotuzumab + Pomalidomide + Dexamethasone (EPd) or Pomalidomide + Bortezomib + Dexamethasone (PVd) in Patients with Relapsed/Refractory Multiple Myeloma Who Received 1-4 Prior Lines of Therapy, Including Lenalidomide and an Anti-CD38 Monoclonal Antibody

Ajay K. Nooka, Hira Mian, Cindy Lee, Paula Rodríguez-Otero, Shaji Kumar, Hermann Einsele, Deeksha Vishwamitra, Diego Vieyra, Colleen Kane, Michele Kosh, Tara J Masterson, Christoph Heuck, Ankit Kansagra, Philippe Moreau
Journal: Blood
Blood (2024) 144 (Supplement 1): 4757.1.
https://doi.org/10.1182/blood-2024-199752
Published: 2024
Journal Articles

Survival of Multiple Myeloma Patients in Epic Cosmos Confounded By Death Reporting

Craig C. Hofmeister, Mingyuan Zhang, Vikas A. Gupta, Nisha S. Joseph, Jonathan L. Kaufman, Ajay K. Nooka, Madhav V. Dhodapkar, Sagar Lonial, Douglas W. Sborov
Journal: Blood
Blood (2024) 144 (Supplement 1): 5152.
https://doi.org/10.1182/blood-2024-202100
Published: 2024
Journal Articles

Characterization of Newly Diagnosed Multiple Myeloma (NDMM) Patients with Early Progression Following Induction with Daratumumab, Lenalidomide, Bortezomib and Dexamethasone (D-RVd)

Lilly Gu, Nisha S. Joseph, Vikas A. Gupta, Craig C. Hofmeister, Madhav V. Dhodapkar, Sagar Lonial, Ajay K. Nooka, Jonathan L. Kaufman
Journal: Blood
Blood (2024) 144 (Supplement 1): 3780.
https://doi.org/10.1182/blood-2024-211474
Published: 2024
Journal Articles

Pooled Efficacy and Safety of Teclistamab in 217 Patients with Triple-Class Exposed Relapsed/Refractory Multiple Myeloma from 3 Registrational Clinical Studies

Thomas G Martin, María-Victoria Mateos, Niels W.C.J. van de Donk, Zhen Cai, Weijun Fu, Alfred L Garfall, Shinsuke Iida, Yoshiaki Kuroda, Ting Niu, Ajay K. Nooka, Surbhi Sidana, Katherine Chastain, Margaret Doyle, Kazuko Nishikawa, Yang Song, Hiroshi Yamazaki, Jianmin Zhuo, Yan Zhu, Juan Du, Tadao Ishida
Journal: Blood
Blood (2024) 144 (Supplement 1): 3331.
https://doi.org/10.1182/blood-2024-200354
Published: 2024
Journal Articles

Feasibility and Implementation of the ASH Research Collaborative's COVID-19 Outcomes in Myeloma and the Impact of Vaccines (COSMIC): A Decentralized, Real-World Evidence Study for Patients with Multiple Myeloma to Monitor Outcomes Related to COVID-19 Vaccines and Infections

William A. Wood, Emily A. Semmel, Shandra James, Donna S. Neuberg, Kathleen Hewitt, Kenneth C. Anderson, Shaji Kumar, Mark A. Schroeder, David J. Chung, Aaron S. Rosenberg, Jeffrey A. Zonder, Samuel M. Rubinstein, Anita D'Souza, Thomas Martin, Ajai Chari, Ravi Vij, Ajay K. Nooka, Brendan M. Weiss, Levi D. Pederson, Andriy Derkach, Susan M. Geyer, Saad Z. Usmani
Journal: Blood
Blood (2024) 144 (Supplement 1): 2393.
https://doi.org/10.1182/blood-2024-203892
Published: 2024
Journal Articles

The Effect of Elranatamab on Patient-Reported Outcomes in Patients with Relapsed/Refractory Multiple Myeloma Naïve and Exposed to B-Cell Maturation Antigen (BCMA)-Directed Therapies: Updated Follow-Up from the MagnetisMM-3 Study

Mohamad Mohty, Nizar J. Bahlis, Ajay K. Nooka, Marco DiBonaventura, Joseph C. Cappelleri, Umberto Conte
Journal: Blood
Blood (2024) 144 (Supplement 1): 1933.
https://doi.org/10.1182/blood-2024-203723
Published: 2024
Journal Articles

Enhanced Prognostic Value of the SKY92 Classifier over High-Risk Cytogenetic Aberrations in Multiple Myeloma: Results from the Prommis Real-World Study

Noa Biran, Binod Dhakal, Ruben Niesvizky, Suzanne Lentzsch, John T Mckay, David H. Vesole, Ajay K. Nooka, Barry Paul, Parameswaran N. Hari, Silvia D'Ambrosi, Rowan Kuiper, Martin H van Vliet, David S. Siegel, Saad Z. Usmani, Frits van Rhee
Journal: Blood
Blood (2024) 144 (Supplement 1): 1929.
https://doi.org/10.1182/blood-2024-209903
Published: 2024
Journal Articles

Risk of Infections in Multiple Myeloma Patients Treated with Bispecific Antibodies

Lorenzo Cani, Sara A. Scott, Nisha S. Joseph, Craig C. Hofmeister, Vikas A. Gupta, Madhav V. Dhodapkar, Sagar Lonial, Ajay K. Nooka, Jonathan L. Kaufman
Journal: Blood
Blood (2024) 144 (Supplement 1): 3311.
https://doi.org/10.1182/blood-2024-206155
Published: 2024
Journal Articles

Serum Free Light Chain Ratio Is Inversely Proportional to the Egfr, and Has Been Increasing over the Last Decade

Gabriel Najarro, Vikas A. Gupta, Nisha S. Joseph, Jonathan L. Kaufman, Ajay K. Nooka, Madhav V. Dhodapkar, Sagar Lonial, Craig C. Hofmeister
Journal: Blood
Blood (2024) 144 (Supplement 1): 5142.
https://doi.org/10.1182/blood-2024-202078
Published: 2024
Journal Articles

A Slow-Go Treatment in Newly Diagnosed AL Amyloidosis with Severe Cardiomyopathy

Craig C. Hofmeister, Vikas A. Gupta, Nisha S. Joseph, Sagar Lonial, Madhav V. Dhodapkar, Ajay K. Nooka, Jonathan L. Kaufman
Journal: Blood
Blood (2024) 144 (Supplement 1): 4672.
https://doi.org/10.1182/blood-2024-203485
Published: 2024
Journal Articles

Mitochondrial Priming Is Heterogenous in t(4;14) Multiple Myeloma and Can be Induced By Inhibition of NSD2

Shannon M Matulis, Robert M Chavez, Rebecca Owens, Arun P Wiita, Mala Shanmugam, Ricardo De Matos Simoes, Constantine S Mitsiades, Nisha S. Joseph, Craig C. Hofmeister, Jonathan L. Kaufman, Madhav V. Dhodapkar, Sagar Lonial, Ajay K. Nooka, Vikas A. Gupta, Jonathan D. Licht, Benjamin G. Barwick, Lawrence H. Boise
Journal: Blood
Blood (2024) 144 (Supplement 1): 4663.
https://doi.org/10.1182/blood-2024-210441
Published: 2024
Journal Articles

Real World Evidence of Outcomes of Patients Treated with Talquetamab in a Heavily Pretreated Population with Multiple Myeloma with High Exposure to Prior BCMA Therapies- a Report from the IMWG Consortium

Murali Janakiram, Carlyn Rose Tan, Rakesh Popat, Joaquín Martínez Lopez, Efstathios Kastritis, Chris Lau, Wee-Joo Chng, Prashant Kapoor, Hira Mian, Susan Bal, Ajay K. Nooka, Andre De Menezes Silva Corraes, Magdalena Corona, Arnab Chowdhury, Yi Lin, Thomas G Martin, Amrita Y Krishnan
Journal: Blood
Blood (2024) 144 (Supplement 1): 3368.
https://doi.org/10.1182/blood-2024-211167
Published: 2024
Journal Articles

Uncovering the Tumor Antigen Landscape in Patients Undergoing Dendritic Cell/Myeloma Fusion Vaccine with Lenalidomide Maintenance Treatment

Dimitra Karagkouni, Giulia Cheloni, Shivani Nanda, Yuling Ma, Shuoshuo Wang, Leda Xanthi Katopodi, Isabella Saldarriaga, Yered Pita-Juarez, David J. Chung, Nina Shah, Natalie Callander, Binod Dhakal, Thinle Chodon, Nikhil C. Munshi, Kenneth C. Anderson, Yvonne A. Efebera, Peiman Hematti, Hillard M. Lazarus, Ehsan Malek, Philip L. McCarthy, Ajay K. Nooka, Krina K. Patel, Aaron P. Rapoport, Robert J. Soiffer, Edmund K. Waller, Marcelo C. Pasquini, Jacalyn Rosenblatt, David Avigan, Ioannis S Vlachos
Journal: Blood
Blood (2024) 144 (Supplement 1): 3289.
https://doi.org/10.1182/blood-2024-211352
Published: 2024
Journal Articles

Feasibility and Target AUC Accuracy of Personalized High Dose Melphalan in Myeloma

Karen Sweiss, Kyeongmin Kim, Yizhen Guo, Kasey Hill, Nicole Abbott, Matias Eugenio Sanchez, Chukwuemeka Uzoka, Ana Maria Avila Rodriguez, John G Quigley, Nadim Mahmud, Damiano Rondelli, Douglas W Sborov, Donald Harvey, Ajay K. Nooka, Madhav V. Dhodapkar, Jonathan L. Kaufman, Nisha S. Joseph, Sagar Lonial, Pritesh Patel, Mitch A. Phelps, Craig C. Hofmeister
Journal: Blood
Blood (2024) 144 (Supplement 1): 1993.
https://doi.org/10.1182/blood-2024-205614
Published: 2024
Journal Articles

Iberdomide Alone or in Combination with Dexamethasone for the Treatment of Intermediate- or High-Risk Smoldering Multiple Myeloma (SMM)

Nisha S. Joseph, Jonathan L. Kaufman, Craig C. Hofmeister, Vikas A. Gupta, Bryan J Burton, Roseann M Pruitt, Ajay K. Nooka, Madhav V. Dhodapkar, Sagar Lonial
Journal: Blood
Blood (2024) 144 (Supplement 1): 1983.
https://doi.org/10.1182/blood-2024-210335
Published: 2024
Journal Articles

Talquetamab, a GPRC5D×CD3 Bispecific Antibody, in Combination with Daratumumab and Lenalidomide in Patients with Newly Diagnosed Multiple Myeloma: Safety and Efficacy Results from the Phase 1b Monumental-2 Study

Ajay K. Nooka, Tara Cochrane, Anita D'Souza, Jeffrey V Matous, Peter M. Voorhees, Karthik Ramasamy, Aurore Perrot, Andrew Spencer, Cyrille Hulin, Hang Quach, Deeksha Vishwamitra, Ashley Nguyen, Debopriya Ghosh, Elizabeth Shearin, Gary E Mason, Thomas Renaud, Gurdeep Parmar
Journal: Blood
Blood (2024) 144 (Supplement 1): 1975.
https://doi.org/10.1182/blood-2024-199773
Published: 2024
Journal Articles

Initial Results from the ASH Research Collaborative's COVID-19 Outcomes in Myeloma and the Impact of Vaccines (COSMIC): A Decentralized, Real-World Evidence Study for Patients with Multiple Myeloma to Monitor Outcomes Related to COVID-19 Vaccines and Infections

Saad Z. Usmani, Emily A. Semmel, Shandra James, William A. Wood, Mark A. Schroeder, David J. Chung, Aaron S. Rosenberg, Jeffrey A. Zonder, Samuel M. Rubinstein, Anita D'Souza, Thomas Martin, Ajai Chari, Ravi Vij, Ajay K. Nooka, Kenneth C. Anderson, Donna S. Neuberg, Kathleen Hewitt, Brendan M. Weiss, Levi D. Pederson, Andriy Derkach, Susan M. Geyer, Shaji Kumar
Journal: Blood
Blood (2024) 144 (Supplement 1): 1972.
https://doi.org/10.1182/blood-2024-210377
Published: 2024