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Adrian Alegre
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Journal Articles

Severity of Covid-19 Clinical Outcomes and Mortality in Multiple Myeloma Patients over Year 1 of the Pandemic

Joaquín Martínez-López, Maria-Victoria Mateos, Nieves López-Muñoz, Maria Alicia Senin Magan, Maria Dunia De Miguel, Ana López de la Guía, Anna Sureda, Cristina Encinas, Diego Conde Royo, Laura Rosinol, Lucía García Tomás, Jose Angel Hernandez-Rivas, Javier Alberto Rojas, Adrian Alegre, María Jesús Blanchard, Fernando Escalante Barrigón, Esther González Garcia, Belén Iñigo, Pilar Bravo Barahona, F. Javier Penalver, Javier De La Rubia, Noemi Fernandez-Escalada, Jose Maria Alonso Alonso, Joan Bladé, Juan Jose Lahuerta, Javier De La Cruz, Jesús F. San-Miguel
Journal: Blood
Blood (2021) 138 (Supplement 1): 2719.
DOI: https://doi.org/10.1182/blood-2021-149192
Published: 2021
Journal Articles

Compassionate Use of Belantamab Mafodotin for Treatment of Patients with Relapsed/Refractory Multiple Myeloma Heavily Treated. Spanish Experience

Adrian Alegre, Gonzalo Benzo Callejo, Rafael Alonso Fernández, Joaquin Martínez-López, Ana Jimenez-Ubieto, Clara Cuellar, Elham Askari, Elena Prieto, Concha Alaez, Beatriz Aguado, Alberto Velasco, Isabel Krsnik, Laura Llorente, Cristina Muñoz-Linares, Ana Morales, Eugenio Gimenez Mesa, Rebeca Iglesias, Carmen Martínez-Chamorro, Arancha Alonso, Carmen Jiménez-Montes, María Jesús Blanchard
Journal: Blood
Blood (2021) 138 (Supplement 1): 3775.
DOI: https://doi.org/10.1182/blood-2021-151267
Published: 2021
Journal Articles

Acute and Post-Acute COVID-19 Severity and Mortality in Patients with Hematologic Malignancies: A Population-Based Registry Study

Joaquin Martinez-Lopez, Javier De La Cruz, Rodrigo Gil-Manso, Angel Cedillo, Adrian Alegre, Maria Pilar Llamas Sillero, Rafael F. Duarte, Víctor Jiménez-Yuste, jose Angel Hernandez, Mi Kwon, Pedro Sanchez Godoy, Pilar Martinez-Barranco, Blanca Colás Lahuerta, Pilar Herrera Puente, Lauren Benito, Alberto Velasco, Arturo Matilla, Concha Alaez, Rafael Martos, Carmen Martínez-Chamorro, Keina Quiroz, Juan F del Campo, Adolfo De La Fuente, Maria Regina Herraez, Adriana Pascual, Elvira Gomez, Jaime Perez De Oteyza, Elena Ruiz, Jose Luis Diez Martin, Julio Garcia-Suarez
Journal: Blood
Blood (2021) 138 (Supplement 1): 186.
DOI: https://doi.org/10.1182/blood-2021-152539
Published: 2021
Journal Articles

Curative Strategy (GEM-CESAR) for High-Risk Smoldering Myeloma (SMM): Carfilzomib, Lenalidomide and Dexamethasone (KRd) As Induction Followed By HDT-ASCT, Consolidation with Krd and Maintenance with Rd

Maria-Victoria Mateos, Joaquin Martinez Lopez, Paula Rodríguez-Otero, Veronica Gonzalez-Calle, Marta Sonia Gonzalez, Albert Oriol, Norma C. Gutierrez, Rafael Rios, Laura Rosinol, Miguel Angel Alvarez, Joan Bargay, Ana Pilar Gonzalez, Adrian Alegre, Fernando Escalante, Belén Iñigo, Javier de la Rubia, Ana Isabel Teruel, Felipe De Arriba, Luis Palomera, Miguel-Teodoro Hernández, Javier Lopez Jimenez, Aránzazu García Mateo, Marta Reinoso Segura, Enrique Ocio, Bruno Paiva, Noemi Puig, María Teresa Cedena, Joan Bladé, Juan Jose Lahuerta, Jesús F. San-Miguel
Journal: Blood
Blood (2021) 138 (Supplement 1): 1829.
DOI: https://doi.org/10.1182/blood-2021-148423
Published: 2021
Journal Articles

HORIZON (OP-106): Melflufen Plus Dexamethasone (dex) in Patients (pts) with Relapsed/Refractory Multiple Myeloma (RRMM)-Analysis of Adverse Events Related to Hospitalizations

Omar Nadeem, MD, Paul G. Richardson, MD, María-Victoria Mateos, MD PhD, Albert Oriol, Alessandra Larocca, Joan Blade Creixenti, Paula Rodríguez-Otero, MD, Xavier Leleu, MD, Maxim Norkin, MD PhD, John W. Hiemenz, MD, Hani Hassoun, MD, Cyrille Touzeau, Adrián Alegre Amor, MD PhD, Agne Paner, MD, Christopher Maisel, MD, Amitabha Mazumder, MD, Anastasios Raptis, MD, Noemí Puig, MD PhD, Anna Sandberg, MmSc, Ivonne Pelaez, MD, Christian Jaques, MD, Marie Orre, PhD, Michele Cavo
Journal: Blood
Blood (2020) 136 (Supplement 1): 20–22.
DOI: https://doi.org/10.1182/blood-2020-136000
Published: 2020
Journal Articles

HORIZON (OP-106): Melflufen Plus Dexamethasone (dex) in Patients (pts) with Relapsed/Refractory Multiple Myeloma (RRMM) Exposed to Prior Alkylator Therapy-Subgroup Analysis

Paula Rodríguez-Otero, MD PhD, María-Victoria Mateos, MD PhD, Albert Oriol, Alessandra Larocca, Joan Blade Creixenti, Michele Cavo, Xavier Leleu, MD, Maxim Norkin, MD PhD, Omar Nadeem, MD, John W. Hiemenz, MD, Hani Hassoun, MD, Cyrille Touzeau, Adrián Alegre Amor, MD PhD, Agne Paner, MD, Christopher Maisel, MD, Amitabha Mazumder, MD, Anastasios Raptis, MD, Noemí Puig, MD PhD, Marcus Thuresson, PhD, Johan Harmenberg, MD PhD, Olof Harlin, VMD, PhD, Paul G. Richardson, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 22–23.
DOI: https://doi.org/10.1182/blood-2020-136466
Published: 2020
Journal Articles

HORIZON (OP-106): Melflufen Plus Dexamethasone in Patients with Relapsed/Refractory Multiple Myeloma-Age Subgroup Analysis of Elderly Patients

Alessandra Larocca, Paul G. Richardson, MD, Albert Oriol, Joan Blade Creixenti, Michele Cavo, Paula Rodríguez-Otero, MD PhD, Xavier Leleu, MD, Maxim Norkin, MD PhD, Omar Nadeem, MD, John W. Hiemenz, MD, Hani Hassoun, MD, Cyrille Touzeau, Adrián Alegre Amor, MD PhD, Agne Paner, MD, Christopher Maisel, MD, Amitabha Mazumder, MD, Anastasios Raptis, MD, Noemí Puig, MD PhD, Marcus Thuresson, PhD, Johan Harmenberg, MD PhD, Bengt Gustavsson, Dr MDSci, MSc Pharm, María-Victoria Mateos, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 44–46.
DOI: https://doi.org/10.1182/blood-2020-136856
Published: 2020
Journal Articles

Safety and Preliminary Efficacy Results from a Phase Ib/II Study of Cobimetinib As a Single Agent and in Combination with Venetoclax with or without Atezolizumab in Patients with Relapsed/Refractory Multiple Myeloma

Fredrik Schjesvold, Vincent Ribrag, MD, Paula Rodriguez-Otero, MD PhD, Pawel J. Robak, MDPhD, Markus Hansson, MD, Roman Hajek, Adrián Alegre Amor, MD PhD, Joaquin Martinez-López, Maika Onishi, Jorge D. Gallo, Aparna Raval, Sameer Deshpande, Vikram Malhi, Wan-Jen Hong, MD, Marc S. Raab, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 45–46.
DOI: https://doi.org/10.1182/blood-2020-135845
Published: 2020
Journal Articles

HORIZON (OP-106): Melflufen Plus Dexamethasone (dex) in Patients (pts) with Relapsed/Refractory Multiple Myeloma (RRMM) - Health-Related Quality of Life (HRQoL) Analysis

Albert Oriol, Paul G. Richardson, MD, María-Victoria Mateos, MD PhD, Alessandra Larocca, Joan Blade Creixenti, Michele Cavo, Paula Rodríguez-Otero, MD, Maxim Norkin, MD PhD, Omar Nadeem, MD, John W. Hiemenz, MD, Hani Hassoun, MD, Cyrille Touzeau, Adrián Alegre Amor, MD PhD, Agne Paner, MD, Christopher Maisel, MD, Amitabha Mazumder, MD, Anastasios Raptis, MD, Noemí Puig, MD PhD, Peter Strang, MD, Anna Sandberg, MmSc, Christian Jaques, MD, Marcus Thuresson, PhD, Marie Orre, PhD, Xavier Leleu, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 27–29.
DOI: https://doi.org/10.1182/blood-2020-135995
Published: 2020
Journal Articles

HORIZON (OP-106): Melflufen Plus Dexamethasone in Patients with Relapsed/Refractory Multiple Myeloma with High-Risk Cytogenetics-Subgroup Analysis

María-Victoria Mateos, MD PhD, Albert Oriol, Alessandra Larocca, Joan Blade Creixenti, Michele Cavo, Paula Rodríguez-Otero, MD, Xavier Leleu, MD, Maxim Norkin, MD PhD, Omar Nadeem, MD, John W. Hiemenz, MD, Hani Hassoun, MD, Cyrille Touzeau, Adrián Alegre Amor, MD PhD, Agne Paner, MD, Christopher Maisel, MD, Amitabha Mazumder, MD, Anastasios Raptis, MD, Noemí Puig, MD PhD, Johan Harmenberg, MD PhD, Bengt Gustavsson, Dr MDSci, MSc Pharm, Marcus Thuresson, PhD, Paul G. Richardson, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 41–43.
DOI: https://doi.org/10.1182/blood-2020-136002
Published: 2020
Journal Articles

HORIZON (OP-106): Melflufen Plus Dexamethasone (dex) in 55 Patients (pts) with Relapsed/Refractory Multiple Myeloma (RRMM) with Extramedullary Disease (EMD)-Subgroup Analysis

Paul G. Richardson, MD, María-Victoria Mateos, MD PhD, Albert Oriol, Alessandra Larocca, Michele Cavo, Paula Rodríguez-Otero, MD PhD, Xavier Leleu, MD, Maxim Norkin, MD PhD, Omar Nadeem, MD, John W. Hiemenz, MD, Hani Hassoun, MD, Cyrille Touzeau, Adrián Alegre Amor, MD PhD, Agne Paner, MD, Christopher Maisel, MD, Amitabha Mazumder, MD, Anastasios Raptis, MD, Noemí Puig, MD PhD, Elena Zamagni, Marcus Thuresson, PhD, Johan Harmenberg, MD PhD, Olof Harlin, VMD, PhD, Joan Blade Creixenti
Journal: Blood
Blood (2020) 136 (Supplement 1): 15–17.
DOI: https://doi.org/10.1182/blood-2020-137118
Published: 2020
Journal Articles

HORIZON (OP-106) Versus MAMMOTH: An Indirect Comparison of Efficacy Outcomes for Patients with Relapsed/Refractory Multiple Myeloma Refractory (RRMM) to Anti-CD38 Monoclonal Antibody Therapy Treated with Melflufen Plus Dexamethasone Versus Conventional Agents

Joan Blade Creixenti, María-Victoria Mateos, MD PhD, Albert Oriol, Alessandra Larocca, Michele Cavo, Paula Rodríguez-Otero, MD PhD, Xavier Leleu, MD, Maxim Norkin, MD PhD, Omar Nadeem, MD, John W. Hiemenz, MD, Hani Hassoun, MD, Cyrille Touzeau, Adrián Alegre Amor, MD PhD, Agne Paner, MD, Christopher Maisel, MD, Amitabha Mazumder, MD, Anastasios Raptis, MD, Noemí Puig, MD PhD, Stojan Zavisic, BSc, Marcus Thuresson, PhD, Johan Harmenberg, MD PhD, Paul G. Richardson, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 2–4.
DOI: https://doi.org/10.1182/blood-2020-137164
Published: 2020
Journal Articles

The Burden of Relapsed/Refractory Multiple Myeloma: An Indirect Comparison of Health-Related Quality of Life Burden across Different Types of Advanced Cancers at Baseline and after Treatment Based on HORIZON (OP-106) Study of Melflufen Plus Dexamethasone

Paul G. Richardson, MD, Alessandra Larocca, Xavier Leleu, MD PhD, Albert Oriol, MD, Agne Paner, MD, Paula Rodriguez Otero, Cyrille Touzeau, MD, Adrián Alegre Amor, MD, Christopher Maisel, MD, María-Victoria Mateos, MD PhD, Amitabha Mazumder, MD, Peter Strang, MD, Oskar Öhman, MSc, Johan Harmenberg, MD PhD, Stojan Zavisic, Joan Bladé, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3487.
DOI: https://doi.org/10.1182/blood-2019-124832
Published: 2019
Journal Articles

Impact of Modified Thalidomide Dosing in Bortezomib/Thalidomide/Dexamethasone for Patients with Newly Diagnosed Multiple Myeloma Who Are Transplant-Eligible: A Matching-Adjusted Indirect Comparison

Pieter Sonneveld, Maria-Victoria Mateos, MD PhD, Adrián Alegre, MD, Thierry Facon, MD, Cyrille Hulin, MD, Mahmoud Hashim, Talitha Vincken, Tobias Kampfenkel, MD, Sarah Cote, Philippe Moreau, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4739.
DOI: https://doi.org/10.1182/blood-2019-122775
Published: 2019
Journal Articles

Randomized Trial of Lenalidomide and Dexamethasone Versus Clarythromycin, Lenalidomide and Dexamethasone As First Line Treatment in Patients with Multiple Myeloma Not Candidates for Autologous Stem Cell Transplantation: Results of the GEM-Claridex Clinical Trial

Noemi Puig, MD PhD, Miguel T Hernández, Laura Rosinol Dachs, Esther González Garcia, MD, Felipe De Arriba, PhD, Albert Oriol, MD, Veronica Gonzalez-Calle, Fernando Escalante, MD, Javier De La Rubia, Mercedes Gironella Meda, Rafael Ríos Tamayo, Ricarda Belen Garcia Sanchez, José María Arguiñano Pérez, MD, Adrián Alegre Amor, MD, Jesús Martín, Norma C. Gutierrez, MD PhD, Maria Jose Calasanz, PhD BSc, Maria Luisa Martin-Ramos, María del Carmen Couto Caro, Maria Casanova, MD, Mario Arnao, MD, Ernesto Pérez Persona, Sebastián Garzón López, Marta Sonia Gonzalez, MD, Guillermo Martín Sánchez, MD, Adriana C. Rossi, MD MSc, Morton Coleman, MD, Cristina Encinas, Ana María Vale López, Ana Isabel Teruel, MDcal Doctor, Bruno Paiva, PhD, Maria Teresa Cedena Romero, MD PhD, Jesús San-Miguel, Juan Jose Lahuerta, MD PhD, Joan Bladé, MD, Ruben Niesvizky, MD, Maria-Victoria Mateos
Journal: Blood
Blood (2019) 134 (Supplement_1): 694.
DOI: https://doi.org/10.1182/blood-2019-123997
Published: 2019
Journal Articles

Qip-Mass Spectrometry in High Risk Smoldering Multiple Myeloma Patients Included in the GEM-CESAR Trial: Comparison with Conventional and Minimal Residual Disease IMWG Response Assessment

Noemi Puig, MD PhD, Maria-Victoria Mateos, Teresa Contreras, Bruno Paiva, PhD, María Teresa Cedena, José J Pérez, Irene Aires, Cristina Agullo, Joaquin Martinez-Lopez, MD PhD, Paula Rodriguez Otero, Veronica Gonzalez De La Calle, MD PhD, Marta Sonia Gonzalez, MD, Albert Oriol, Norma C. Gutierrez, MD PhD, Rafael Rios, MD PhD, Laura Rosiñol, Miguel Angel Alvarez, MD, Maria Jose Calasanz, PhD BSc, Joan Bargay, MD PhD, Ana Pilar Gonzalez, PhD, Adrián Alegre, MD, Fernando Escalante, MD, Rafael Martínez, Javier de la Rubia, MD PhD, Ana Isabel Teruel, MDcal Doctor, Felipe De Arriba, PhD, Luis Palomera, MD PhD, Miguel-Teodoro Hernández, Javier López, MD, Jesús Martín, Aránzazu García Mateo, PhD, Ramón García-Sanz, MD PhD, Enrique M. Ocio, Joan Bladé, MD PhD, Juan-José Lahuerta, MD PhD, Jesus F. San-Miguel, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 581.
DOI: https://doi.org/10.1182/blood-2019-127717
Published: 2019
Journal Articles

Curative Strategy (GEM-CESAR) for High-Risk Smoldering Myeloma (SMM): Carfilzomib, Lenalidomide and Dexamethasone (KRd) As Induction Followed By HDT-ASCT, Consolidation with Krd and Maintenance with Rd

Maria-Victoria Mateos, Joaquin Martinez-Lopez, MD PhD, Paula Rodriguez Otero, Veronica Gonzalez-Calle, Marta Sonia Gonzalez, MD, Albert Oriol, MD, Norma C. Gutierrez, MD PhD, Bruno Paiva, PhD, Rafael Ríos Tamayo, Laura Rosinol Dachs, Miguel Angel Alvarez, MD, Maria Jose Calasanz, PhD BSc, Joan Bargay, MD PhD, Ana Pilar Gonzalez, PhD, Adrián Alegre Amor, MD, Fernando Escalante, MD, Belén Iñigo, Noemi Puig, MD PhD, Javier De La Rubia, Ana Isabel Teruel, MDcal Doctor, Maria Teresa Cedena Romero, MD PhD, Felipe De Arriba, PhD, Luis Palomera, MD PhD, Miguel T Hernández, Javier Lopez Jimenez, MD, Jesús Martín, Aránzazu García Mateo, PhD, Enrique M. Ocio, Joan Bladé, MD, Juan Jose Lahuerta, MD PhD, Jesús San-Miguel
Journal: Blood
Blood (2019) 134 (Supplement_1): 781.
DOI: https://doi.org/10.1182/blood-2019-125204
Published: 2019
Journal Articles

Heavy and Light Chain Monitoring in High Risk Smoldering Multiple Myeloma Patients Included in the GEM-CESAR Trial: Comparison with Conventional and Minimal Residual Disease IMWG Response Assessment

Noemi Puig, MD PhD, Teresa Contreras, Bruno Paiva, PhD, María Teresa Cedena, José J Pérez, Irene Aires, Cristina Agullo, Joaquin Martinez-Lopez, MD PhD, Paula Rodriguez Otero, Veronica Gonzalez De La Calle, MD PhD, Marta Sonia Gonzalez, MD, Albert Oriol, Norma C. Gutierrez, MD PhD, Rafael Rios, MD PhD, Laura Rosiñol, Miguel Angel Alvarez, MD, Maria Jose Calasanz, PhD BSc, Joan Bargay, MD PhD, Ana Pilar Gonzalez, PhD, Adrián Alegre, MD, Fernando Escalante, MD, Rafael Martínez, Javier de la Rubia, MD PhD, Ana Isabel Teruel, MDcal Doctor, Felipe De Arriba, PhD, Luis Palomera, MD PhD, Miguel-Teodoro Hernández, Javier López, MD, Jesús Martín, Aránzazu García Mateo, PhD, Enrique M. Ocio, Ramón García-Sanz, MD PhD, Joan Bladé, MD PhD, Juan Jose Lahuerta, MD PhD, Jesus F. San-Miguel, MD, Maria-Victoria Mateos
Journal: Blood
Blood (2019) 134 (Supplement_1): 1852.
DOI: https://doi.org/10.1182/blood-2019-128655
Published: 2019
Journal Articles

Clinical Activity of Melflufen in Patients with Triple-Class Refractory Multiple Myeloma and Poor-Risk Features in an Updated Analysis of HORIZON (OP-106), a Phase 2 Study in Patients with Relapsed/Refractory Multiple Myeloma Refractory to Pomalidomide and/or Daratumumab

María-Victoria Mateos, MD PhD, Albert Oriol, MD, Alessandra Larocca, Paula Rodriguez Otero, Joan Bladé, MD, Michele Cavo, Hani Hassoun, MD, Xavier Leleu, MD PhD, Adrián Alegre Amor, MD, Christopher Maisel, MD, Agne Paner, MD, Johan Harmenberg, MD PhD, Catriona Byrne, RN, Sara Thuresson, MSc, Hanan Zubair, MSc, Paul G. Richardson, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1883.
DOI: https://doi.org/10.1182/blood-2019-124825
Published: 2019
Journal Articles

Efficacy of Isatuximab with Pomalidomide and Dexamethasone in Elderly Patients with Relapsed/Refractory Multiple Myeloma: Icaria-MM Subgroup Analysis

Fredrik H. Schjesvold, MD PhD, Paul G. Richardson, MD, Michel Attal, MD PhD, Thierry Facon, MD, Adrián Alegre, MD, Andrew Spencer, DM, Artur Jurczyszyn, MD, Kazutaka Sunami, MD PhD, Laurent Frenzel, MD PhD, Chang-Ki Min, MD PhD, Solenn Le-Guennec, Frank Campana, MD, Helgi van de Velde, MD PhD, Samira Bensfia, MD, Sara Bringhen
Journal: Blood
Blood (2019) 134 (Supplement_1): 1893.
DOI: https://doi.org/10.1182/blood-2019-128010
Published: 2019