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Journal Articles

The role of CD8 + T-cell clones in immune thrombocytopenia

CME
Amna Malik, Anwar A. Sayed, Panpan Han, Michelle M. H. Tan, Eleanor Watt, Adela Constantinescu-Bercu, Alexander T. H. Cocker, Ahmad Khoder, Rocel C. Saputil, Emma Thorley, Ariam Teklemichael, Yunchuan Ding, Alice C. J. Hart, Haiyu Zhang, Wayne A. Mitchell, Nesrina Imami, James T. B. Crawley, Isabelle I. Salles-Crawley, James B. Bussel, James L. Zehnder, Stuart Adams, Bing M. Zhang, Nichola Cooper
Journal: Blood
Blood (2023) 141 (20): 2417–2429.
DOI: https://doi.org/10.1182/blood.2022018380
Published: 2023
Includes: Multimedia, Supplemental data
Journal Articles

RUNX1 isoform disequilibrium promotes the development of trisomy 21–associated myeloid leukemia

Sofia Gialesaki, Daniela Bräuer-Hartmann, Hasan Issa, Raj Bhayadia, Oriol Alejo-Valle, Lonneke Verboon, Anna-Lena Schmell, Stephanie Laszig, Enikő Regényi, Konstantin Schuschel, Maurice Labuhn, Michelle Ng, Robert Winkler, Christian Ihling, Andrea Sinz, Markus Glaß, Stefan Hüttelmaier, Sören Matzk, Lena Schmid, Farina Josepha Strüwe, Sofie-Katrin Kadel, Dirk Reinhardt, Marie-Laure Yaspo, Dirk Heckl, Jan-Henning Klusmann
Journal: Blood
Blood (2023) 141 (10): 1105–1118.
DOI: https://doi.org/10.1182/blood.2022017619
Published: 2023
Includes: Supplemental data
Journal Articles

A randomized, placebo-controlled phase 3 trial of the PI3Kδ inhibitor leniolisib for activated PI3Kδ syndrome

Clinical Trials & Observations
V. Koneti Rao, Sharon Webster, Anna Šedivá, Alessandro Plebani, Catharina Schuetz, Anna Shcherbina, Niall Conlon, Tanya Coulter, Virgil A. Dalm, Antonino Trizzino, Yulia Zharankova, Elaine Kulm, Julia Körholz, Vassilios Lougaris, Yulia Rodina, Kath Radford, Jason Bradt, Klaus Kucher, Anurag Relan, Steven M. Holland, Michael J. Lenardo, Gulbu Uzel
Journal: Blood
Blood (2023) 141 (9): 971–983.
DOI: https://doi.org/10.1182/blood.2022018546
Published: 2023
Includes: Supplemental data
Journal Articles

Hydroxyurea for secondary stroke prevention in children with sickle cell anemia in Nigeria: a randomized controlled trial

Clinical Trials & Observations
Shehu U. Abdullahi, Surayya Sunusi, Mohammed Sani Abba, Saifuddeen Sani, Hauwau Aminu Inuwa, Safiya Gambo, Awwal Gambo, Bilya Musa, Brittany V. Covert Greene, Adetola A. Kassim, Mark Rodeghier, Nafiu Hussaini, Mariana Ciobanu, Muktar H. Aliyu, Lori C. Jordan, Michael R. DeBaun
Journal: Blood
Blood (2023) 141 (8): 825–834.
DOI: https://doi.org/10.1182/blood.2022016620
Published: 2023
Includes: Supplemental data
Journal Articles

EVI1 drives leukemogenesis through aberrant ERG activation

Johannes Schmoellerl, Inês A.M. Barbosa, Martina Minnich, Florian Andersch, Leonie Smeenk, Marije Havermans, Thomas Eder, Tobias Neumann, Julian Jude, Michaela Fellner, Anja Ebert, Monika Steininger, Ruud Delwel, Florian Grebien, Johannes Zuber
Journal: Blood
Blood (2023) 141 (5): 453–466.
DOI: https://doi.org/10.1182/blood.2022016592
Published: 2023
Includes: Supplemental data
Journal Articles

Normalization of cerebral hemodynamics after hematopoietic stem cell transplant in children with sickle cell disease

Clinical Trials & Observations
Monica L. Hulbert, Melanie E. Fields, Kristin P. Guilliams, Priyesha Bijlani, Shalini Shenoy, Slim Fellah, Alison S. Towerman, Michael M. Binkley, Robert C. McKinstry, Joshua S. Shimony, Yasheng Chen, Cihat Eldeniz, Dustin K. Ragan, Katie Vo, Hongyu An, Jin-Moo Lee, Andria L. Ford
Journal: Blood
Blood (2023) 141 (4): 335–344.
DOI: https://doi.org/10.1182/blood.2022016618
Published: 2023
Includes: Supplemental data
Journal Articles

Missense mutations in PIEZO1, which encodes the Piezo1 mechanosensor protein, define Er red blood cell antigens

Vanja Karamatic Crew, Louise A. Tilley, Timothy J. Satchwell, Samah A. AlSubhi, Benjamin Jones, Frances A. Spring, Piers J. Walser, Catarina Martins Freire, Nicoletta Murciano, Maria Giustina Rotordam, Svenja J. Woestmann, Marwa Hamed, Reem Alradwan, Mouza AlKhrousey, Ian Skidmore, Sarah Lewis, Shimon Hussain, Jane Jackson, Tom Latham, Mark D. Kilby, William Lester, Nadine Becker, Markus Rapedius, Ashley M. Toye, Nicole M. Thornton
Journal: Blood
Blood (2023) 141 (2): 135–146.
DOI: https://doi.org/10.1182/blood.2022016504
Published: 2023
Includes: Supplemental data
Journal Articles

Immune thrombocytopenia and pregnancy: an exposed/nonexposed cohort study

Clinical Trials & Observations
Stéphanie Guillet, Valentine Loustau, Emmanuelle Boutin, Anissa Zarour, Thibault Comont, Odile Souchaud-Debouverie, Nathalie Costedoat Chalumeau, Brigitte Pan-Petesch, Delphine Gobert, Stéphane Cheze, Jean Francois Viallard, Anne-Sophie Morin, Gaetan Sauvetre, Manuel Cliquennois, Bruno Royer, Agathe Masseau, Louis Terriou, Claire Fieschi, Olivier Lambotte, Stéphane Girault, Bertrand Lioger, Sylvain Audia, Karim Sacre, Jean Christophe Lega, Vincent Langlois, Alexandra Benachi, Corentin Orvain, Alain Devidas, Sebastien Humbert, Nicolas Gambier, Marc Ruivard, Virginie Zarrouk, Mikael Ebbo, Lise Willems, Lauriane Segaux, Matthieu Mahevas, Bassam Haddad, Marc Michel, Florence Canoui-Poitrine, Bertrand Godeau
Journal: Blood
Blood (2023) 141 (1): 11–21.
DOI: https://doi.org/10.1182/blood.2022017277
Published: 2023
Includes: Supplemental data
Journal Articles

Germ line predisposition variants occur in myelodysplastic syndrome patients of all ages

Simone Feurstein, Amy M. Trottier, Noel Estrada-Merly, Matthew Pozsgai, Kelsey McNeely, Michael W. Drazer, Brian Ruhle, Katharine Sadera, Ashwin L. Koppayi, Bart L. Scott, Betul Oran, Taiga Nishihori, Vaibhav Agrawal, Ayman Saad, R. Coleman Lindsley, Ryotaro Nakamura, Soyoung Kim, Zhenhuan Hu, Ronald Sobecks, Stephen Spellman, Wael Saber, Lucy A. Godley
Journal: Blood
Blood (2022) 140 (24): 2533–2548.
DOI: https://doi.org/10.1182/blood.2022015790
Published: 2022
Includes: Supplemental data
Journal Articles

Lenalidomide promotes the development of TP53 -mutated therapy-related myeloid neoplasms

Clinical Trials & Observations
Adam S. Sperling, Veronica A. Guerra, James A. Kennedy, Yuanqing Yan, Joanne I. Hsu, Feng Wang, Andrew T. Nguyen, Peter G. Miller, Marie E. McConkey, Vanessa A. Quevedo Barrios, Ken Furudate, Linda Zhang, Rashmi Kanagal-Shamanna, Jianhua Zhang, Latasha Little, Curtis Gumbs, Naval Daver, Courtney D. DiNardo, Tapan Kadia, Farhad Ravandi, Hagop Kantarjian, Guillermo Garcia-Manero, P. Andrew Futreal, Benjamin L. Ebert, Koichi Takahashi
Journal: Blood
Blood (2022) 140 (16): 1753–1763.
DOI: https://doi.org/10.1182/blood.2021014956
Published: 2022
Includes: Supplemental data
Journal Articles

Race, rituximab, and relapse in TTP

Clinical Trials & Observations
Shruti Chaturvedi, Ana G. Antun, Andrew M. Farland, Ryan Woods, Ara Metjian, Yara A. Park, Gustaaf de Ridder, Briana Gibson, Raj S. Kasthuri, Darla K. Liles, Frank Akwaa, Todd Clover, Lisa Baumann Kreuziger, J. Evan Sadler, Meera Sridharan, Ronald S. Go, Keith R. McCrae, Harsh Vardhan Upreti, Angela Liu, Ming Y. Lim, Radhika Gangaraju, X. Long Zheng, Jay S. Raval, Camila Masias, Spero R. Cataland, Andrew Johnson, Elizabeth Davis, Michael D. Evans, Marshall A. Mazepa, for the United States Thrombotic Microangiopathies Consortium
Journal: Blood
Blood (2022) 140 (12): 1335–1344.
DOI: https://doi.org/10.1182/blood.2022016640
Published: 2022
Includes: Supplemental data
Journal Articles

Mechanosensation by endothelial PIEZO1 is required for leukocyte diapedesis

CME
ShengPeng Wang, Bianbian Wang, Yue Shi, Tanja Möller, Rebekka I. Stegmeyer, Boris Strilic, Ting Li, Zuyi Yuan, Changhe Wang, Nina Wettschureck, Dietmar Vestweber, Stefan Offermanns
Journal: Blood
Blood (2022) 140 (3): 171–183.
DOI: https://doi.org/10.1182/blood.2021014614
Published: 2022
Includes: Supplemental data
Journal Articles

Cryo-EM structure of the prothrombin-prothrombinase complex

Eliza A. Ruben, Brock Summers, Michael J. Rau, James A. J. Fitzpatrick, Enrico Di Cera
Journal: Blood
Blood (2022) 139 (24): 3463–3473.
DOI: https://doi.org/10.1182/blood.2022015807
Published: 2022
Includes: Supplemental data
Journal Articles

HEATR3 variants impair nuclear import of uL18 (RPL5) and drive Diamond-Blackfan anemia

Marie-Françoise O’Donohue, Lydie Da Costa, Marco Lezzerini, Sule Unal, Clément Joret, Marije Bartels, Eva Brilstra, Marijn Scheijde-Vermeulen, Ludivine Wacheul, Kim De Keersmaecker, Stijn Vereecke, Veerle Labarque, Manon Saby, Sophie D. Lefevre, Jessica Platon, Nathalie Montel-Lehry, Nathalie Laugero, Eric Lacazette, Koen van Gassen, Riekelt H. Houtkooper, Pelin Ozlem Simsek-Kiper, Thierry Leblanc, Nese Yarali, Arda Cetinkaya, Nurten A. Akarsu, Pierre-Emmanuel Gleizes, Denis L. J. Lafontaine, Alyson W. MacInnes
Journal: Blood
Blood (2022) 139 (21): 3111–3126.
DOI: https://doi.org/10.1182/blood.2021011846
Published: 2022
Includes: Supplemental data
Journal Articles

HLA-DQ heterodimers in hematopoietic cell transplantation

Effie W. Petersdorf, Mats Bengtsson, Mary Horowitz, Caroline McKallor, Stephen R. Spellman, Eric Spierings, Ted A. Gooley, Phil Stevenson, on behalf of the International Histocompatibility Working Group in Hematopoietic Cell Transplantation
Journal: Blood
Blood (2022) 139 (20): 3009–3017.
DOI: https://doi.org/10.1182/blood.2022015860
Published: 2022
Includes: Supplemental data
Journal Articles

Macrophage NOX2 NADPH oxidase maintains alveolar homeostasis in mice

Sourav Bhattacharya, Rachel A. Idol, Wei Yang, Jorge David Rojas Márquez, Yanan Li, Guangming Huang, Wandy L. Beatty, Jeffrey J. Atkinson, John H. Brumell, Juhi Bagaitkar, Jeffrey A. Magee, Mary C. Dinauer
Journal: Blood
Blood (2022) 139 (19): 2855–2870.
DOI: https://doi.org/10.1182/blood.2021015365
Published: 2022
Includes: Supplemental data
Journal Articles

Defects in mucosal immunity and nasopharyngeal dysbiosis in HSC-transplanted SCID patients with IL2RG/JAK3 deficiency

Pedro Goncalves, Jean-Marc Doisne, Toshiki Eri, Bruno Charbit, Vincent Bondet, Celine Posseme, Alba Llibre, Armanda Casrouge, Christelle Lenoir, Bénédicte Neven, Darragh Duffy, Alain Fischer, James P. Di Santo
Journal: Blood
Blood (2022) 139 (17): 2585–2600.
DOI: https://doi.org/10.1182/blood.2021014654
Published: 2022
Includes: Supplemental data
Journal Articles

Disrupting the adult globin promoter alleviates promoter competition and reactivates fetal globin gene expression

Sarah K. Topfer, Ruopeng Feng, Peng Huang, Lana C. Ly, Gabriella E. Martyn, Gerd A. Blobel, Mitchell J. Weiss, Kate G. R. Quinlan, Merlin Crossley
Journal: Blood
Blood (2022) 139 (14): 2107–2118.
DOI: https://doi.org/10.1182/blood.2021014205
Published: 2022
Includes: Supplemental data
Journal Articles

Systems medicine dissection of chr1q-amp reveals a novel PBX1-FOXM1 axis for targeted therapy in multiple myeloma

Nikolaos Trasanidis, Alexia Katsarou, Kanagaraju Ponnusamy, Yao-An Shen, Ioannis V. Kostopoulos, Bien Bergonia, Keren Keren, Paudel Reema, Xiaolin Xiao, Richard M. Szydlo, Pierangela M. R. Sabbattini, Irene A. G. Roberts, Holger W. Auner, Kikkeri N. Naresh, Aristeidis Chaidos, Tian-Li Wang, Luca Magnani, Valentina S. Caputo, Anastasios Karadimitris
Journal: Blood
Blood (2022) 139 (13): 1939–1953.
DOI: https://doi.org/10.1182/blood.2021014391
Published: 2022
Includes: Supplemental data
Journal Articles

Sirolimus plus prednisolone vs sirolimus monotherapy for kaposiform hemangioendothelioma: a randomized clinical trial

Clinical Trials & Observations
Yi Ji, Siyuan Chen, Jiangyuan Zhou, Kaiying Yang, Xuepeng Zhang, Bo Xiang, Tong Qiu, Xue Gong, Zixin Zhang, Yuru Lan, Fan Hu, Feiteng Kong, Qingxia Qiu, Yongbo Zhang
Journal: Blood
Blood (2022) 139 (11): 1619–1630.
DOI: https://doi.org/10.1182/blood.2021014027
Published: 2022
Includes: Supplemental data