HLA-DQ heterodimers and transplantation, the genomic landscape of LGL leukemia, and an updated classification of hemochromatosis

In this week’s episode we’ll feature new research demonstrating that certain HLA-DQ heterodimers can help predict clinical outcome following hematopoietic cell transplantation. Next, we’ll review a recent integrated and comprehensive genomic analysis that sheds new light on the molecular characteristics of large granular lymphocyte leukemia and its subtypes. Finally, we’ll review the work of a group that proposes a new and more accessible hemochromatosis classification system based on clinical characteristics and genetic features. 

Released May 19, 2022

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The articles highlighted in this episode are listed below:

• HLA-DQ heterodimers in hematopoietic cell transplantation

  Authors: Effie W. Petersdorf, Mats Bengtsson, Mary Horowitz, Caroline McKallor, Stephen R. Spellman, Eric Spierings, Ted A. Gooley, Phil Stevenson, on behalf of the International Histocompatibility Working Group in Hematopoietic Cell Transplantation

• HLA-DQ + CD4 help = graft-versus-tumor effect

  Authors : Alan Bidgoli, Sophie Paczesny

• Genomic landscape of TCRαβ and TCRγδ T-large granular lymphocyte leukemia

  Authors: HeeJin Cheon, Jeffrey C. Xing, Katharine B. Moosic, Johnson Ung, Vivian W. Chan, David S. Chung, Mariella F. Toro, Omar Elghawy, John S. Wang, Cait E. Hamele, Ross C. Hardison, Thomas L. Olson, Su-Fern Tan, David J. Feith, Aakrosh Ratan, Thomas P. Loughran, Jr

• Interrogating molecular genetics to refine LGLL classification

  Authors: Gianpietro Semenzato, Renato Zambello

• Hemochromatosis classification: update and recommendations by the BIOIRON Society

  Author: Domenico Girelli, Fabiana Busti, Pierre Brissot, Ioav Cabantchik, Martina U. Muckenthaler, Graça Porto on behalf of the Nomenclature Committee of the International Society for the Study of Iron in Biology and Medicine (BIOIRON Society)

• Hemochromatosis redefined

  Author: Chaim Hershko