Season 1, Episode 4Today we’ll examine the role of heredity vs. environmental factors in the evolution of age-related clonal hematopoiesis, review the first systematic approach to uncover all possible activating point mutations within and around the transmembrane domain of the thrombopoietin receptor in myeloproliferative neoplasms, and discuss the role of complement activation and mutations in complement regulatory genes in patients with thrombotic or catastrophic antiphospholipid syndromes.
Published January 23, 2020
The articles highlighted in this episode are listed below:
Authors: Jakob Werner Hansen, Dorthe Almind Pedersen, Lisbeth Aagaard Larsen, Simon Husby, Signe Bedsted Clemmensen, Jacob Hjelmborg, Francesco Favero, Joachim Weischenfeldt, Kaare Christensen, Kirsten Grønbæk
Authors: Margarete A. Fabre, Thomas McKerrell, Maximillian Zwiebel, M. S. Vijayabaskar, Naomi Park, Philippa M. Wells, Roland Rad, Panagiotis Deloukas, Kerrin Small, Claire J. Steves, George S. Vassiliou
Authors: Shruti Chaturvedi, Evan M. Braunstein, Xuan Yuan, Jia Yu, Alice Alexander, Hang Chen, Eleni Gavriilaki, Ravi Alluri, Michael B. Streiff, Michelle Petri, Mark A. Crowther, Keith R. McCrae, Robert A. Brodsky
Authors: Jessica L. Bridgford, Su Min Lee, Christine M. M. Lee, Paola Guglielmelli, Elisa Rumi, Daniela Pietra, Stephen Wilcox, Yash Chhabra, Alan F. Rubin, Mario Cazzola, Alessandro M. Vannucchi, Andrew J. Brooks, Matthew E. Call, Melissa J. Call