Issue Archive

INSIDE BLOOD

Sugar in erythropoietin: clinical and forensic implications

H. Franklin Bunn

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“Special delivery” to cancer cells

Alexander Fefer

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Defining the genetic chaos in myeloma

Brian Van Ness

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CHEMOKINES

Frequent expression of CCR4 in adult T-cell leukemia and human T-cell leukemia virus type 1–transformed T cells

Osamu Yoshie,Ryuichi Fujisawa,Takashi Nakayama,Hitomi Harasawa,Hideaki Tago,Dai Izawa,Kunio Hieshima,Youichi Tatsumi,Kouji Matsushima,Hitoshi Hasegawa,Akihisa Kanamaru,Shimeru Kamihira,Yasuaki Yamada

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Inhibition of macrophage inflammatory protein–1α production by Epstein-Barr virus

Wolfram J. Jabs,Hans J. Wagner,Susanne Maurmann,Holger Hennig,Burkhard Kreft

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ERRATA

Erratum for vol. 98, p. 3505

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Erratum for vol. 98, p. 2326

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CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Idiotype-pulsed dendritic cell vaccination for B-cell lymphoma: clinical and immune responses in 35 patients

Clinical Trials & Observations

John M. Timmerman,Debra K. Czerwinski,Thomas A. Davis,Frank J. Hsu,Claudia Benike,Zheng Mei Hao,Behnaz Taidi,Ranjani Rajapaksa,Clemens B. Caspar,Craig Y. Okada,Adrienne van Beckhoven,Tina Marie Liles,Edgar G. Engleman,Ronald Levy

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A randomized study of interferon-α versus interferon-α and low-dose arabinosyl cytosine in chronic myeloid leukemia

Clinical Trials & Observations

Michele Baccarani,Gianantonio Rosti,Antonio de Vivo,Francesca Bonifazi,Domenico Russo,Giovanni Martinelli,Nicoletta Testoni,Marilina Amabile,Mauro Fiacchini,Enrico Montefusco,Giuseppe Saglio,Sante Tura,for the Italian Cooperative Study Group on Chronic Myeloid Leukemia

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Leading prognostic relevance of the BCR-ABL translocation in adult acute B-lineage lymphoblastic leukemia: a prospective study of the German Multicenter Trial Group and confirmed polymerase chain reaction analysis

Clinical Trials & Observations

Beate Gleißner,Nicola Gökbuget,Claus R. Bartram,Bart Janssen,Harald Rieder,Johannes W. G. Janssen,Christa Fonatsch,Axel Heyll,Dimitris Voliotis,Joachim Beck,Thomas Lipp,Gerd Munzert,Jürgen Maurer,Dieter Hoelzer,Eckhard Thiel,the German Multicenter Trials of Adult Acute Lymphoblastic Leukemia Study Group

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Severe deficiency of switched memory B cells (CD27⁺IgM⁻IgD⁻) in subgroups of patients with common variable immunodeficiency: a new approach to classify a heterogeneous disease

Clinical Trials & Observations

Klaus Warnatz,Axel Denz,Ruth Dräger,Moritz Braun,Christoph Groth,Guido Wolff-Vorbeck,Hermann Eibel,Michael Schlesier,Hans Hartmut Peter

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Effect of N-acetyl-cysteine on the hypoxic ventilatory response and erythropoietin production: linkage between plasma thiol redox state and O₂ chemosensitivity

Clinical Trials & Observations

Wulf Hildebrandt,Steve Alexander,Peter Bärtsch,Wulf Dröge

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Clinical and biologic features of CD4⁺CD56⁺ malignancies

Clinical Trials & Observations

Jean Feuillard,Marie-Christine Jacob,Françoise Valensi,Marc Maynadié,Rémy Gressin,Laurence Chaperot,Christine Arnoulet,Françoise Brignole-Baudouin,Bernard Drénou,Eliane Duchayne,Annie Falkenrodt,Richard Garand,Emanuelle Homolle,Bernard Husson,Emilienne Kuhlein,Geneviève Le Calvez,Danielle Sainty,Marie-France Sotto,Franck Trimoreau,Marie-Christine Béné

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Role of erythrocyte phosphatidylserine in sickle red cell–endothelial adhesion

Clinical Trials & Observations

B. N. Yamaja Setty,Surekha Kulkarni,Marie J. Stuart

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Effect of tolerance to noninherited maternal antigens on the occurrence of graft-versus-host disease after bone marrow transplantation from a parent or an HLA-haploidentical sibling

Clinical Trials & Observations

Jon J. van Rood,Fausto R. Loberiza, Jr,Mei-Jie Zhang,Machteld Oudshoorn,Frans Claas,Mitchell S. Cairo,Richard E. Champlin,Robert Peter Gale,Olle Ringdén,Jill M. Hows,Mary H. Horowitz

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Sustained response to recombinant human erythropoietin and intermittent all-trans retinoic acid in patients with myelodysplastic syndromes

Clinical Trials & Observations

Roberto Stasi,Maurizio Brunetti,Edmondo Terzoli,Sergio Amadori

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HEMATOPOIESIS

Homing efficiency, cell cycle kinetics, and survival of quiescent and cycling human CD34⁺ cells transplanted into conditioned NOD/SCID recipients

Anna Jetmore,P. Artur Plett,Xia Tong,Frances M. Wolber,Robert Breese,Rafat Abonour,Christie M. Orschell-Traycoff,Edward F. Srour

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In vitro proliferation and differentiation of erythroid progenitors from patients with myelodysplastic syndromes: evidence for Fas-dependent apoptosis

Yann-Erick Claessens,Didier Bouscary,Jean-Michel Dupont,Françoise Picard,Josiane Melle,Sylvie Gisselbrecht,Catherine Lacombe,François Dreyfus,Patrick Mayeux,Michaëla Fontenay-Roupie

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Effects of anagrelide on in vivo megakaryocyte proliferation and maturation in essential thrombocythemia

Aaron Tomer

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Bone marrow progenitor cell reserve and function and stromal cell function are defective in rheumatoid arthritis: evidence for a tumor necrosis factor alpha–mediated effect

Helen A. Papadaki,Heraklis D. Kritikos,Claudia Gemetzi,Helen Koutala,Judith C. W. Marsh,Dimitrios T. Boumpas,George D. Eliopoulos

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Adapted NOD/SCID model supports development of phenotypically and functionally mature T cells from human umbilical cord blood CD34⁺ cells

Tessa C. C. Kerre,Greet De Smet,Magda De Smedt,Alfred Zippelius,Mikaël J. Pittet,Anton W. Langerak,José De Bosscher,Fritz Offner,Bart Vandekerckhove,Jean Plum

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Differential expression and phosphorylation of distinct STAT3 proteins during granulocytic differentiation

Diane L. Hevehan,William M. Miller,Eleftherios T. Papoutsakis

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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Antithrombin prevents endotoxin-induced hypotension by inhibiting the induction of nitric oxide synthase in rats

Hirotaka Isobe,Kenji Okajima,Mitsuhiro Uchiba,Naoaki Harada,Hiroaki Okabe

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Thrombin induces increased expression and secretion of angiopoietin-2 from human umbilical vein endothelial cells

Yao-Qi Huang,Jian-Jun Li,Liang Hu,Merlin Lee,Simon Karpatkin

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The Hermansky-Pudlak syndrome 1 (HPS1) and HPS2 genes independently contribute to the production and function of platelet dense granules, melanosomes, and lysosomes

Lijun Feng,Edward K. Novak,Lisa M. Hartnell,Juan S. Bonifacino,Lucy M. Collinson,Richard T. Swank

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Enhancement of the antitumor properties of interleukin-2 by its targeted delivery to the tumor blood vessel extracellular matrix

Barbara Carnemolla,Laura Borsi,Enrica Balza,Patrizia Castellani,Raffaella Meazza,Alexander Berndt,Silvano Ferrini,Hartwig Kosmehl,Dario Neri,Luciano Zardi

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IMMUNOBIOLOGY

Increased sensitivity of T lymphocytes to tumor necrosis factor receptor 1 (TNFR1)– and TNFR2-mediated apoptosis in HIV infection: relation to expression of Bcl-2 and active caspase-8 and caspase-3

Luzia Maria de Oliveira Pinto,Sylvie Garcia,Hervé Lecoeur,Christophe Rapp,Marie-Lise Gougeon

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In vivo manipulation of dendritic cells to induce therapeutic immunity

Miriam Merad,Tomoharu Sugie,Edgar G. Engleman,Lawrence Fong

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Cell surface antigen CD109 is a novel member of the α₂ macroglobulin/C3, C4, C5 family of thioester-containing proteins

Martin Lin,D. Robert Sutherland,Wendy Horsfall,Nicholas Totty,Erik Yeo,Rakash Nayar,Xiang-Fu Wu,Andre C. Schuh

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A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens

Andre C. Schuh,Nick A. Watkins,Quang Nguyen,Nicholas J. Harmer,Martin Lin,Joseph Y. A. Prosper,Kate Campbell,D. Robert Sutherland,Paul Metcalfe,Wendy Horsfall,Willem H. Ouwehand

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Requirement for MD-1 in cell surface expression of RP105/CD180 and B-cell responsiveness to lipopolysaccharide

Yoshinori Nagai,Rintaro Shimazu,Hirotaka Ogata,Sachiko Akashi,Katsuko Sudo,Hidetoshi Yamasaki,Shin-Ichi Hayashi,Yoichiro Iwakura,Masao Kimoto,Kensuke Miyake

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Soluble HLA class I molecules induce natural killer cell apoptosis through the engagement of CD8: evidence for a negative regulation exerted by members of the inhibitory receptor superfamily

Grazia Maria Spaggiari,Paola Contini,Roberta Carosio,Marica Arvigo,Massimo Ghio,Daniela Oddone,Alessandra Dondero,Maria Raffaella Zocchi,Francesco Puppo,Francesco Indiveri,Alessandro Poggi

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Dendritic cells exposed to extracellular adenosine triphosphate acquire the migratory properties of mature cells and show a reduced capacity to attract type 1 T lymphocytes

Andrea la Sala,Silvia Sebastiani,Davide Ferrari,Francesco Di Virgilio,Marco Idzko,Johannes Norgauer,Giampiero Girolomoni

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Analysis of natural killer cells in TAP2-deficient patients: expression of functional triggering receptors and evidence for the existence of inhibitory receptor(s) that prevent lysis of normal autologous cells

Massimo Vitale,Jacques Zimmer,Roberta Castriconi,Daniel Hanau,Lionel Donato,Cristina Bottino,Lorenzo Moretta,Henri de la Salle,Alessandro Moretta

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Quantitation, selection, and functional characterization of Epstein-Barr virus–specific and alloreactive T cells detected by intracellular interferon-γ production and growth of cytotoxic precursors

Guenther Koehne,Katherine M. Smith,Teresa L. Ferguson,Roxanne Y. Williams,Glenn Heller,Eric G. Pamer,Bo Dupont,Richard J. O'Reilly

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NEOPLASIA

The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations

Yongsheng Ma,Shan Zeng,Dean D. Metcalfe,Cem Akin,Sasa Dimitrijevic,Joseph H. Butterfield,Gerald McMahon,B. Jack Longley

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Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undetermined significance, and normal bone marrow plasma cells

Fenghuang Zhan,Johanna Hardin,Bob Kordsmeier,Klaus Bumm,Mingzhong Zheng,Erming Tian,Ralph Sanderson,Yang Yang,Carla Wilson,Maurizio Zangari,Elias Anaissie,Christopher Morris,Firas Muwalla,Frits van Rhee,Athanasios Fassas,John Crowley,Guido Tricot,Bart Barlogie,John Shaughnessy, Jr

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TEL/platelet-derived growth factor receptor β activates phosphatidylinositol 3 (PI3) kinase and requires PI3 kinase to regulate the cell cycle

Jamil Dierov,Qing Xu,Raia Dierova,Martin Carroll

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Overexpression of SOCS-2 in advanced stages of chronic myeloid leukemia: possible inadequacy of a negative feedback mechanism

Beate Schultheis,Melina Carapeti-Marootian,Andreas Hochhaus,Andreas Weiβer,John M. Goldman,Junia V. Melo

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Evidence for position effects as a variantETV6-mediated leukemogenic mechanism in myeloid leukemias with a t(4;12)(q11-q12;p13) or t(5;12)(q31;p13)

Jan Cools,Nicole Mentens,Maria D. Odero,Pieter Peeters,Iwona Wlodarska,Michel Delforge,Anne Hagemeijer,Peter Marynen

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PHAGOCYTES

Secretion of heparin-binding protein from human neutrophils is determined by its localization in azurophilic granules and secretory vesicles

Hans Tapper,Anna Karlsson,Matthias Mörgelin,Hans Flodgaard,Heiko Herwald

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Macrophage functional maturation and cytokine production are impaired in C/EBPε-deficient mice

Sigal Tavor,Peter T. Vuong,Dorothy J. Park,Adrian F. Gombart,Arthur H. Cohen,H. Phillip Koeffler

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Defects in leukocyte-mediated initiation of lipid peroxidation in plasma as studied in myeloperoxidase-deficient subjects: systematic identification of multiple endogenous diffusible substrates for myeloperoxidase in plasma

Renliang Zhang,Zhongzhou Shen,William M. Nauseef,Stanley L. Hazen

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RED CELLS

Abnormally spliced β-globin mRNAs: a single point mutation generates transcripts sensitive and insensitive to nonsense-mediated mRNA decay

Sven Danckwardt,Gabriele Neu-Yilik,Rolf Thermann,Ute Frede,Matthias W. Hentze,Andreas E. Kulozik

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Failure of red blood cell maturation in mice with defects in the high-density lipoprotein receptor SR-BI

Teresa M. Holm,Anne Braun,Bernardo L. Trigatti,Carlo Brugnara,Masa Sakamoto,Monty Krieger,Nancy C. Andrews

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TRANSPLANTATION

Flt3 ligand therapy for recipients of allogeneic bone marrow transplants expands host CD8α⁺ dendritic cells and reduces experimental acute graft-versus-host disease

Takanori Teshima,Pavan Reddy,Kathleen P. Lowler,Mark A. KuKuruga,Chen Liu,Kenneth R. Cooke,James L. M. Ferrara

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HPA-1a phenotype–genotype discrepancy reveals a naturally occurring Arg93Gln substitution in the platelet β3 integrin that disrupts the HPA-1a epitope

Nicholas A. Watkins,Elisabeth Schaffner-Reckinger,David L. Allen,Graham J. Howkins,Nicolaas H. C. Brons,Graham A. Smith,Paul Metcalfe,Michael F. Murphy,Nelly Kieffer,Willem H. Ouwehand

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A cure for murine sickle cell disease through stable mixed chimerism and tolerance induction after nonmyeloablative conditioning and major histocompatibility complex–mismatched bone marrow transplantation

Leslie S. Kean,Megan M. Durham,Andrew B. Adams,Lewis L. Hsu,Jennifer R. Perry,Dirck Dillehay,Thomas C. Pearson,Edmund K. Waller,Christian P. Larsen,David R. Archer

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BRIEF REPORTS

Calpain is a signal transducer and activator of transcription (STAT) 3 and STAT5 protease

Brief Report

Atsushi Oda,Hiroshi Wakao,Hiroyoshi Fujita

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Immunophenotypic evaluation of the plasma cell compartment in multiple myeloma: a tool for comparing the efficacy of different treatment strategies and predicting outcome

Brief Report

Jesús F. San Miguel,Julia Almeida,Gema Mateo,Joan Bladé,Consuelo López-Berges,Dolores Caballero,José Hernández,Marı́a Jesús Moro,Javier Fernández-Calvo,Joaquı́n Dı́az-Mediavilla,Luis Palomera,Alberto Orfao

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Retrovirally mediated correction of bone marrow–derived mesenchymal stem cells from patients with mucopolysaccharidosis type I

Brief Report

Melissa A. Baxter,Robert F. Wynn,Jonathan A. Deakin,Ilaria Bellantuono,Kirsten G. Edington,Alan Cooper,Guy T. N. Besley,Heather J. Church,J. Ed Wraith,Trevor F. Carr,Leslie J. Fairbairn

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Ph⁺ acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation

Brief Report

Wolf-K. Hofmann,Letetia C. Jones,Nathan A. Lemp,Sven de Vos,Harald Gschaidmeier,Dieter Hoelzer,Oliver G. Ottmann,H. Phillip Koeffler

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Autocrine production of epithelial cell–derived neutrophil attractant-78 induced by granulocyte colony-stimulating factor in neutrophils

Brief Report

Sachiko Suzuki,Masanobu Kobayashi,Kouji Chiba,Iori Horiuchi,Jingxin Wang,Takeshi Kondoh,Satoshi Hashino,Junji Tanaka,Masuo Hosokawa,Masahiro Asaka

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Requirement of Gab2 for mast cell development and KitL/c-Kit signaling

Brief Report

Keigo Nishida,Lin Wang,Eiichi Morii,Sung Joo Park,Masahiro Narimatsu,Shousaku Itoh,Satoru Yamasaki,Masahiro Fujishima,Katsuhiko Ishihara,Masahiko Hibi,Yukihiko Kitamura,Toshio Hirano

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Allogenic fetal liver cells have a distinct competitive engraftment advantage over adult bone marrow cells when infused into fetal as compared with adult severe combined immunodeficient recipients

Brief Report

Patricia A. Taylor,Ronald T. McElmurry,Christopher J. Lees,David E. Harrison,Bruce R. Blazar

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CORRESPONDENCE

Different clinical value of minimal residual disease after autologous and allogeneic stem cell transplantation for chronic lymphocytic leukemia

Jordi Esteve,Neus Villamor,Dolors Colomer,Emili Montserrat

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Comprehensive cytogenetic and molecular genetic characterization of the TI-1 acute myeloid leukemia cell line reveals cross-contamination with K-562 cell line

Laura J. Rush,Kristiina Heinonen,Krzysztof Mrózek,Bryan J. Wolf,Mohamed Abdel-Rahman,Jadwiga Szymanska,Paivi Peltomäki,Fehmida Kapadia,Clara D. Bloomfield,Michael A. Caligiuri,Christoph Plass

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Why antiviral CD8 T lymphocytes fail to prevent progressive immunodeficiency in HIV-1 infection

Carlo Agostini,Gianpietro Semenzato

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Management of anticoagulation-associated toxicity during large-volume leukapheresis of peripheral blood stem cell donors

Charles D. Bolan,Susan F. Leitman

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Thr325Ile polymorphism of the TAFI gene does not influence the risk of myocardial infarction

Pierre E. Morange,Mireille Henry,Corinne Frere,Irène Juhan-Vague,on behalf of the HIFMECH study group

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