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Volume 98, Issue 9

November 1 2001

In this Issue

INSIDE BLOOD
PERSPECTIVE
REVIEW ARTICLES
PLENARY PAPERS
CHEMOKINES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
BRIEF REPORTS
CORRESPONDENCE

INSIDE BLOOD

Multipotent human cells expand indefinitely

Diane S. Krause

View Articletitled, Multipotent human cells expand indefinitely

Globin vectors: control without the locus

David Russell

View Articletitled, Globin vectors: control without the locus

PERSPECTIVE

Discrepancies between genotype and phenotype in hematology: an important frontier

Ernest Beutler

View Articletitled, Discrepancies between genotype and phenotype in hematology: an important frontier

REVIEW ARTICLES

Cellular stress response and apoptosis in cancer therapy

Ingrid Herr,Klaus-Michael Debatin

View Articletitled, Cellular stress response and apoptosis in cancer therapy

PLENARY PAPERS

Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells

Morayma Reyes,Troy Lund,Todd Lenvik,Dean Aguiar,Lisa Koodie,Catherine M. Verfaillie

View Articletitled, Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells

CHEMOKINES

Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor γδ⁺ gut intraepithelial lymphocytes

Marc-André Wurbel,Marie Malissen,Delphine Guy-Grand,Eric Meffre,Michel C. Nussenzweig,Mireille Richelme,Alice Carrier,Bernard Malissen

View Articletitled, Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor γδ+ gut intraepithelial lymphocytes

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Clinical significance of CD38 expression in chronic lymphocytic leukemia
Clinical Trials & Observations

Giovanni Del Poeta,Luca Maurillo,Adriano Venditti,Francesco Buccisano,Anna Maria Epiceno,Giovanni Capelli,Anna Tamburini,Giovanna Suppo,Alessandra Battaglia,Maria Ilaria Del Principe,Beatrice Del Moro,Mario Masi,Sergio Amadori

View Articletitled, Clinical significance of CD38 expression in chronic lymphocytic leukemia

Multicenter, randomized comparative trial of fludarabine and the combination of cyclophosphamide-doxorubicin-prednisone in 92 patients with Waldenström macroglobulinemia in first relapse or with primary refractory disease
Clinical Trials & Observations

Véronique Leblond,Vincent Lévy,Frédéric Maloisel,Bruno Cazin,Jean-Paul Fermand,Jean-Luc Harousseau,Liliane Remenieras,Raphaël Porcher,Martine Gardembas,Gérald Marit,Eric Deconinck,Bernard Desablens,François Guilhot,Guilaine Philippe,Aspasia Stamatoullas,Odile Guibon,for the French Cooperative Group on Chronic Lymphocytic Leukemia and Macroglobulinemia

View Articletitled, Multicenter, randomized comparative trial of fludarabine and the combination of cyclophosphamide-doxorubicin-prednisone in 92 patients with Waldenström macroglobulinemia in first relapse or with primary refractory disease

Mutations in the ELA2 gene encoding neutrophil elastase are present in most patients with sporadic severe congenital neutropenia but only in some patients with the familial form of the disease
Clinical Trials & Observations

Phil J. Ancliff,Rosemary E. Gale,Ri Liesner,Ian M. Hann,David C. Linch

View Articletitled, Mutations in the ELA2 gene encoding neutrophil elastase are present in most patients with sporadic severe congenital neutropenia but only in some patients with the familial form of the disease

Prognostic significance of minimal residual disease detection and PML/RAR-α isoform type: long-term follow-up in acute promyelocytic leukemia
Clinical Trials & Observations

Joseph G. Jurcic,Stephen D. Nimer,David A. Scheinberg,Tony DeBlasio,Raymond P. Warrell, Jr,Wilson H. Miller, Jr

View Articletitled, Prognostic significance of minimal residual disease detection and PML/RAR-α isoform type: long-term follow-up in acute promyelocytic leukemia

A 385 insertion in the hypervariable region 1 of hepatitis C virus E2 envelope protein is found in some patients with mixed cryoglobulinemia type 2
Clinical Trials & Observations

Martina Gerotto,Francesca Dal Pero,Stefano Loffreda,Francesco B. Bianchi,Alfredo Alberti,Marco Lenzi

View Articletitled, A 385 insertion in the hypervariable region 1 of hepatitis C virus E2 envelope protein is found in some patients with mixed cryoglobulinemia type 2

GENE THERAPY

High-level erythroid-specific gene expression in primary human and murine hematopoietic cells with self-inactivating lentiviral vectors

Francois Moreau-Gaudry,Ping Xia,Gang Jiang,Natalya P. Perelman,Gerhard Bauer,James Ellis,Katherine H. Surinya,Fulvio Mavilio,Che-Kun Shen,Punam Malik

View Articletitled, High-level erythroid-specific gene expression in primary human and murine hematopoietic cells with self-inactivating lentiviral vectors

HEMATOPOIESIS

Forced expression of the Ikaros 6 isoform in human placental blood CD34⁺ cells impairs their ability to differentiate toward the B-lymphoid lineage

Cécile Tonnelle,Florence Bardin,Christine Maroc,Anne-Marie Imbert,Fanny Campa,Ali Dalloul,Christian Schmitt,Christian Chabannon

View Articletitled, Forced expression of the Ikaros 6 isoform in human placental blood CD34+ cells impairs their ability to differentiate toward the B-lymphoid lineage

X-linked thrombocytopenia caused by a novel mutation ofGATA-1

Michele G. Mehaffey,Anthea L. Newton,Manish J. Gandhi,Merlin Crossley,Jonathan G. Drachman

View Articletitled, X-linked thrombocytopenia caused by a novel mutation ofGATA-1

Inhibition of granulocyte-macrophage colony-stimulating factor receptor function by a splice variant of the common β-receptor subunit

Katharina Wagner,Sabine Kafert-Kasting,Gerhard Heil,Arnold Ganser,Matthias Eder

View Articletitled, Inhibition of granulocyte-macrophage colony-stimulating factor receptor function by a splice variant of the common β-receptor subunit

Negative feedback on the effects of stem cell factor on hematopoiesis is partly mediated through neutral endopeptidase activity on substance P: a combined functional and proteomic study

Deval D. Joshi,Anju Dang,Prem Yadav,Jing Qian,Persis S. Bandari,Kunhua Chen,Robert Donnelly,Tammy Castro,Pedro Gascon,Ali Haider,Pranela Rameshwar

View Articletitled, Negative feedback on the effects of stem cell factor on hematopoiesis is partly mediated through neutral endopeptidase activity on substance P: a combined functional and proteomic study

FLT3 ligand can substitute for macrophage colony-stimulating factor in support of osteoclast differentiation and function

Jeny Maree Lean,Karen Fuller,Timothy John Chambers

View Articletitled, FLT3 ligand can substitute for macrophage colony-stimulating factor in support of osteoclast differentiation and function

Expression of transferrin receptor 2 in normal and neoplastic hematopoietic cells

Hiroshi Kawabata,Tsuyoshi Nakamaki,Pranvera Ikonomi,Reginald D. Smith,Rasha S. Germain,H. Phillip Koeffler

View Articletitled, Expression of transferrin receptor 2 in normal and neoplastic hematopoietic cells

Interleukin-6 stimulates thrombopoiesis through thrombopoietin: role in inflammatory thrombocytosis

Arthur Kaser,Gerald Brandacher,Wolfgang Steurer,Susanne Kaser,Felix A. Offner,Heinz Zoller,Igor Theurl,Walter Widder,Clemens Molnar,Othmar Ludwiczek,Michael B. Atkins,James W. Mier,Herbert Tilg

View Articletitled, Interleukin-6 stimulates thrombopoiesis through thrombopoietin: role in inflammatory thrombocytosis

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Thrombogenic potential of human coronary atherosclerotic plaques

Diego Ardissino,Piera Angelica Merlini,Kenneth A. Bauer,Ezio Bramucci,Maurizio Ferrario,Raffaella Coppola,Raffaela Fetiveau,Stefano Lucreziotti,Robert D. Rosenberg,Pier Mannuccio Mannucci

View Articletitled, Thrombogenic potential of human coronary atherosclerotic plaques

Changes in health and disease of the metalloprotease that cleaves von Willebrand factor

Pier Mannuccio Mannucci,Maria Teresa Canciani,Ileana Forza,Federico Lussana,Antonella Lattuada,Edoardo Rossi

View Articletitled, Changes in health and disease of the metalloprotease that cleaves von Willebrand factor

IMMUNOBIOLOGY

Human CD4⁺CD25⁺ cells: a naturally occurring population of regulatory T cells

Wan Fai Ng,Phillip J. Duggan,Frederique Ponchel,Giuseppe Matarese,Giovanna Lombardi,A. David Edwards,John D. Isaacs,Robert I. Lechler

View Articletitled, Human CD4+CD25+ cells: a naturally occurring population of regulatory T cells

Slow, programmed maturation of the immunoglobulin HCDR3 repertoire during the third trimester of fetal life

Harry W. Schroeder, Jr,Liming Zhang,Joseph B. Philips, III

View Articletitled, Slow, programmed maturation of the immunoglobulin HCDR3 repertoire during the third trimester of fetal life

HIV-1 Nef activates STAT1 in human monocytes/macrophages through the release of soluble factors

Maurizio Federico,Zulema Percario,Eleonora Olivetta,Gianna Fiorucci,Claudia Muratori,Alessandro Micheli,Giovanna Romeo,Elisabetta Affabris

View Articletitled, HIV-1 Nef activates STAT1 in human monocytes/macrophages through the release of soluble factors

NEOPLASIA

Isotype-switched immunoglobulin genes with a high load of somatic hypermutation and lack of ongoing mutational activity are prevalent in mediastinal B-cell lymphoma

Frank Leithäuser,Martin Bäuerle,Minh Quang Huynh,Peter Möller

View Articletitled, Isotype-switched immunoglobulin genes with a high load of somatic hypermutation and lack of ongoing mutational activity are prevalent in mediastinal B-cell lymphoma

Complement-mediated cell death induced by rituximab in B-cell lymphoproliferative disorders is mediated in vitro by a caspase-independent mechanism involving the generation of reactive oxygen species

Beatriz Bellosillo,Neus Villamor,Armando López-Guillermo,Silvia Marcé,Jordi Esteve,Elias Campo,Dolors Colomer,Emili Montserrat

View Articletitled, Complement-mediated cell death induced by rituximab in B-cell lymphoproliferative disorders is mediated in vitro by a caspase-independent mechanism involving the generation of reactive oxygen species

Interleukin-7 and interleukin-15 regulate the expression of thebcl-2 and c-myb genes in cutaneous T-cell lymphoma cells

Jian-Zhong Qin,Chun-Lei Zhang,Jivko Kamarashev,Reinhard Dummer,Günter Burg,Udo Döbbeling

View Articletitled, Interleukin-7 and interleukin-15 regulate the expression of thebcl-2 and c-myb genes in cutaneous T-cell lymphoma cells

Functional expression of receptor activator of nuclear factor κB in Hodgkin disease cell lines

Paolo Fiumara,Virginia Snell,Yang Li,Asok Mukhopadhyay,Mamoun Younes,Ann Marie Gillenwater,Fernando Cabanillas,Bharat B. Aggarwal,Anas Younes

View Articletitled, Functional expression of receptor activator of nuclear factor κB in Hodgkin disease cell lines

Persistent preswitch clonotypic myeloma cells correlate with decreased survival: evidence for isotype switching within the myeloma clone

Tony Reiman,Karen Seeberger,Brian J. Taylor,Agnieszka J. Szczepek,John Hanson,Michael J. Mant,Robert W. Coupland,Andrew R. Belch,Linda M. Pilarski

View Articletitled, Persistent preswitch clonotypic myeloma cells correlate with decreased survival: evidence for isotype switching within the myeloma clone

Caspase 8 activation independent of Fas (CD95/APO-1) signaling may mediate killing of B-chronic lymphocytic leukemia cells by cytotoxic drugs or γ radiation

Dylan T. Jones,Kanagasabai Ganeshaguru,Andres E. Virchis,Najeem I. Folarin,Mark W. Lowdell,Atul B. Mehta,H. Grant Prentice,A. Victor Hoffbrand,R. Gitendra Wickremasinghe

View Articletitled, Caspase 8 activation independent of Fas (CD95/APO-1) signaling may mediate killing of B-chronic lymphocytic leukemia cells by cytotoxic drugs or γ radiation

Establishment of a murine model for therapy-treated chronic myelogenous leukemia using the tyrosine kinase inhibitor STI571

Nicholas C. Wolff,Robert L. Ilaria, Jr

View Articletitled, Establishment of a murine model for therapy-treated chronic myelogenous leukemia using the tyrosine kinase inhibitor STI571

Clonal cytotoxic T cells are expanded in myeloma and reside in the CD8⁺CD57⁺CD28⁻ compartment

Daniel M.-Y. Sze,Gillian Giesajtis,Ross D. Brown,Maria Raitakari,John Gibson,Joy Ho,Alan G. Baxter,Barbara Fazekas de St Groth,Antony Basten,Douglas E. Joshua

View Articletitled, Clonal cytotoxic T cells are expanded in myeloma and reside in the CD8+CD57+CD28− compartment

Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria

Olivier Cuvillier,Thierry Levade

View Articletitled, Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria

Cyclin D3 is a target gene of t(6;14)(p21.1;q32.3) of mature B-cell malignancies

Takashi Sonoki,Lana Harder,Doug E. Horsman,Loraine Karran,Izumi Taniguchi,Tony G. Willis,Stefan Gesk,Doris Steinemann,Emanuele Zucca,Brigitte Schlegelberger,Francesc Solé,Andrew J. Mungall,Randy D. Gascoyne,Reiner Siebert,Martin J. S. Dyer

View Articletitled, Cyclin D3 is a target gene of t(6;14)(p21.1;q32.3) of mature B-cell malignancies

PHAGOCYTES

Alveolar macrophage deficiency in osteopetrotic mice deficient in macrophage colony-stimulating factor is spontaneously corrected with age and associated with matrix metalloproteinase expression and emphysema

Yoko Shibata,Zsuzsanna Zsengeller,Kazuhisa Otake,Nades Palaniyar,Bruce C. Trapnell

View Articletitled, Alveolar macrophage deficiency in osteopetrotic mice deficient in macrophage colony-stimulating factor is spontaneously corrected with age and associated with matrix metalloproteinase expression and emphysema

BRIEF REPORTS

The AKT kinase is activated in multiple myeloma tumor cells
Brief Report

Jung-hsin Hsu,Yijiang Shi,Stanislaw Krajewski,Stephen Renner,Myrna Fisher,John C. Reed,Thomas F. Franke,Alan Lichtenstein

View Articletitled, The AKT kinase is activated in multiple myeloma tumor cells

A novel CBFA2 single-nucleotide mutation in familial platelet disorder with propensity to develop myeloid malignancies
Brief Report

Arjan Buijs,Pino Poddighe,Richard van Wijk,Wouter van Solinge,Eric Borst,Leo Verdonck,Anton Hagenbeek,Peter Pearson,Henk Lokhorst

View Articletitled, A novel CBFA2 single-nucleotide mutation in familial platelet disorder with propensity to develop myeloid malignancies

Peripheral blood dendritic cells in children with acute Plasmodium falciparum malaria
Clinical Trials & Observations Brief Report

Britta C. Urban,Tabitha Mwangi,Amanda Ross,Samson Kinyanjui,Moses Mosobo,Oscar Kai,Brett Lowe,Kevin Marsh,David J. Roberts

View Articletitled, Peripheral blood dendritic cells in children with acute Plasmodium falciparum malaria

In vitro all-trans retinoic acid sensitivity of acute promyelocytic leukemia blasts: a novel indicator of poor patient outcome
Clinical Trials & Observations Brief Report

Bruno Cassinat,Sylvie Chevret,Fabien Zassadowski,Nicole Balitrand,Isabelle Guillemot,Marie-Laurence Menot,Laurent Degos,Pierre Fenaux,Christine Chomienne,for the European APL Group

View Articletitled, In vitro all-trans retinoic acid sensitivity of acute promyelocytic leukemia blasts: a novel indicator of poor patient outcome

Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report
Brief Report

Richard L. Piekarz,Rob Robey,Victor Sandor,Susan Bakke,Wyndham H. Wilson,Laila Dahmoush,Douglas M. Kingma,Maria L. Turner,Rosemary Altemus,Susan E. Bates

View Articletitled, Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report

Syk expression in endothelial cells and their morphologic defects in embryonic Syk-deficient mice
Brief Report

Shigeru Yanagi,Ryoko Inatome,Junyi Ding,Hironori Kitaguchi,Victor L. J. Tybulewicz,Hirohei Yamamura

View Articletitled, Syk expression in endothelial cells and their morphologic defects in embryonic Syk-deficient mice

Erythropoietin expression in primary rat Sertoli and peritubular myoid cells
Brief Report

Massimo Magnanti,Orietta Gandini,Laura Giuliani,Paola Gazzaniga,Hugo H. Marti,Angela Gradilone,Luigi Frati,Anna Maria Aglianò,Max Gassmann

View Articletitled, Erythropoietin expression in primary rat Sertoli and peritubular myoid cells

CORRESPONDENCE

Factor V Leiden and intracranial hemorrhage

J. Nathan Hagstrom

View Articletitled, Factor V Leiden and intracranial hemorrhage

Short-course corticosteroid–induced pulmonary and apparent cerebral aspergillosis in a patient with idiopathic thrombocytopenic purpura

John Apostolidis,Marina Tsandekidi,Demitris Kousiafes,Maria Pagoni,Chrisanthi Mitsouli,Themis Karmiris,Maria Bakiri,Demitris Karakasis,Nikolaos Harhalakis,Emmanuel Nikiforakis

View Articletitled, Short-course corticosteroid–induced pulmonary and apparent cerebral aspergillosis in a patient with idiopathic thrombocytopenic purpura

Interleukin-13 levels in serum from patients with Hodgkin disease and healthy volunteers

Paolo Fiumara,Fernando Cabanillas,Anas Younes

View Articletitled, Interleukin-13 levels in serum from patients with Hodgkin disease and healthy volunteers

Is hydroxyurea leukemogenic in children with sickle cell disease?

Mariane de Montalembert,Sally C. Davies

View Articletitled, Is hydroxyurea leukemogenic in children with sickle cell disease?

ABL-BCR expression does not correlate with deletions on the derivative chromosome 9 or survival in chronic myeloid leukemia

Josu de la Fuente,Kirsten Merx,E. Joanna Steer,Martin Müller,Richard M. Szydlo,Ole Maywald,Ute Berger,Rüdiger Hehlmann,John M. Goldman,Nicholas C. P. Cross,Junia V. Melo,Andreas Hochhaus,the German CML Study Group

View Articletitled, ABL-BCR expression does not correlate with deletions on the derivative chromosome 9 or survival in chronic myeloid leukemia

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Issue Archive

Table of Contents

INSIDE BLOOD

PERSPECTIVE

REVIEW ARTICLES

PLENARY PAPERS

CHEMOKINES

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Clinical significance of CD38 expression in chronic lymphocytic leukemia Clinical Trials & Observations

Multicenter, randomized comparative trial of fludarabine and the combination of cyclophosphamide-doxorubicin-prednisone in 92 patients with Waldenström macroglobulinemia in first relapse or with primary refractory disease Clinical Trials & Observations

Mutations in the ELA2 gene encoding neutrophil elastase are present in most patients with sporadic severe congenital neutropenia but only in some patients with the familial form of the disease Clinical Trials & Observations

Prognostic significance of minimal residual disease detection and PML/RAR-α isoform type: long-term follow-up in acute promyelocytic leukemia Clinical Trials & Observations

A 385 insertion in the hypervariable region 1 of hepatitis C virus E2 envelope protein is found in some patients with mixed cryoglobulinemia type 2 Clinical Trials & Observations

GENE THERAPY

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

IMMUNOBIOLOGY

NEOPLASIA

PHAGOCYTES

BRIEF REPORTS

The AKT kinase is activated in multiple myeloma tumor cells Brief Report

A novel CBFA2 single-nucleotide mutation in familial platelet disorder with propensity to develop myeloid malignancies Brief Report

Peripheral blood dendritic cells in children with acute Plasmodium falciparum malaria Clinical Trials & Observations Brief Report

In vitro all-trans retinoic acid sensitivity of acute promyelocytic leukemia blasts: a novel indicator of poor patient outcome Clinical Trials & Observations Brief Report

Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report Brief Report

Syk expression in endothelial cells and their morphologic defects in embryonic Syk-deficient mice Brief Report

Erythropoietin expression in primary rat Sertoli and peritubular myoid cells Brief Report