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Volume 98, Issue 2

July 15 2001

In this Issue

INSIDE BLOOD
PLENARY PAPERS
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
ERRATA
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSPLANTATION
BRIEF REPORTS
CORRESPONDENCE

INSIDE BLOOD

Questions from Quebec

Douglas B. Cines

View Articletitled, Questions from Quebec

A severe illness associated with EBV infection of T and NK cells

Giovanna Tosato

View Articletitled, A severe illness associated with EBV infection of T and NK cells

RCAS1, physiologic or pathologic mediator of apoptosis

Mark J. Koury

View Articletitled, RCAS1, physiologic or pathologic mediator of apoptosis

PLENARY PAPERS

Platelets from patients with the Quebec platelet disorder contain and secrete abnormal amounts of urokinase-type plasminogen activator

Walter H. A. Kahr,Shilun Zheng,Prameet M. Sheth,Menaka Pai,Alison Cowie,Madeleine Bouchard,Thomas J. Podor,Georges E. Rivard,Catherine P. M. Hayward

View Articletitled, Platelets from patients with the Quebec platelet disorder contain and secrete abnormal amounts of urokinase-type plasminogen activator

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Sudden death among patients with acute promyelocytic leukemia treated with arsenic trioxide
Clinical Trials & Observations

Peter Westervelt,Randy A. Brown,Douglas R. Adkins,Hanna Khoury,Peter Curtin,David Hurd,Selina M. Luger,Margaret K. Ma,Timothy J. Ley,John F. DiPersio

View Articletitled, Sudden death among patients with acute promyelocytic leukemia treated with arsenic trioxide

Survival of transfused donor white blood cells in HIV-infected recipients
Clinical Trials & Observations

Margot S. Kruskall,Tzong-Hae Lee,Susan F. Assmann,Megan Laycock,Leslie A. Kalish,Michael M. Lederman,Michael P. Busch,for the Viral Activation Transfusion Study Group

View Articletitled, Survival of transfused donor white blood cells in HIV-infected recipients

Clinical and virologic characteristics of chronic active Epstein-Barr virus infection
Clinical Trials & Observations

Hiroshi Kimura,Yo Hoshino,Hirokazu Kanegane,Ikuya Tsuge,Takayuki Okamura,Keisei Kawa,Tsuneo Morishima

View Articletitled, Clinical and virologic characteristics of chronic active Epstein-Barr virus infection

ERRATA

Erratum for vol. 97, p. 2574

View Articletitled, Erratum for vol. 97, p. 2574

GENE THERAPY

Development of herpes simplex virus-1 amplicon–based immunotherapy for chronic lymphocytic leukemia

Khaled A. Tolba,William J. Bowers,Shannon P. Hilchey,Marc W. Halterman,Darlene F. Howard,Rita E. Giuliano,Howard J. Federoff,Joseph D. Rosenblatt

View Articletitled, Development of herpes simplex virus-1 amplicon–based immunotherapy for chronic lymphocytic leukemia

HEMATOPOIESIS

Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain

Emma C. Vaux,Eric Metzen,Kay M. Yeates,Peter J. Ratcliffe

View Articletitled, Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain

Correlation between nicotine-induced inhibition of hematopoiesis and decreased CD44 expression on bone marrow stromal cells

Sophia Khaldoyanidi,Lyudmila Sikora,Irina Orlovskaya,Vera Matrosova,Vladimir Kozlov,P. Sriramarao

View Articletitled, Correlation between nicotine-induced inhibition of hematopoiesis and decreased CD44 expression on bone marrow stromal cells

Receptor binding cancer antigen expressed on SiSo cells, a novel regulator of apoptosis of erythroid progenitor cells

Takamitsu Matsushima,Manabu Nakashima,Koichi Oshima,Yasunobu Abe,Junji Nishimura,Hajime Nawata,Takeshi Watanabe,Koichiro Muta

View Articletitled, Receptor binding cancer antigen expressed on SiSo cells, a novel regulator of apoptosis of erythroid progenitor cells

Hematopoietic responses to stress conditions in young dogs compared with elderly dogs

J. Maciej Zaucha,Cong Yu,George Mathioudakis,Kristy Seidel,George Georges,George Sale,Marie-Térèse Little,Beverly Torok-Storb,Rainer Storb

View Articletitled, Hematopoietic responses to stress conditions in young dogs compared with elderly dogs

Receptor specificity in the self-renewal and differentiation of primary multipotential hemopoietic cells

Hui Zeng,Masayoshi Masuko,Liqing Jin,Tobias Neff,Kevin G. Otto,C. Anthony Blau

View Articletitled, Receptor specificity in the self-renewal and differentiation of primary multipotential hemopoietic cells

Bone morphogenetic protein 4 induces efficient hematopoietic differentiation of rhesus monkey embryonic stem cells in vitro

Fei Li,Shijiang Lu,Loyda Vida,James A. Thomson,George R. Honig

View Articletitled, Bone morphogenetic protein 4 induces efficient hematopoietic differentiation of rhesus monkey embryonic stem cells in vitro

Lyn is required for normal stem cell factor–induced proliferation and chemotaxis of primary hematopoietic cells

Bridget O'Laughlin-Bunner,Nina Radosevic,Marcia L. Taylor,Shivakrupa,Candy DeBerry,Dean D. Metcalfe,Meijuan Zhou,Clifford Lowell,Diana Linnekin

View Articletitled, Lyn is required for normal stem cell factor–induced proliferation and chemotaxis of primary hematopoietic cells

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Fibrinogen Milano XII: a dysfunctional variant containing 2 amino acid substitutions, Aα R16C and γ G165R

Bettina Bolliger-Stucki,Susan T. Lord,Miha Furlan

View Articletitled, Fibrinogen Milano XII: a dysfunctional variant containing 2 amino acid substitutions, Aα R16C and γ G165R

Five novel mutations in the gene for human blood coagulation factor V associated with type I factor V deficiency

Richard van Wijk,Karel Nieuwenhuis,Marijke van den Berg,Eric G. Huizinga,Brenda B. van der Meijden,Rob J. Kraaijenhagen,Wouter W. van Solinge

View Articletitled, Five novel mutations in the gene for human blood coagulation factor V associated with type I factor V deficiency

Increased thrombogenesis and embolus formation in mice lacking glycoprotein V

Heyu Ni,Vanitha Ramakrishnan,Zaverio M. Ruggeri,Jessie M. Papalia,David R. Phillips,Denisa D. Wagner

View Articletitled, Increased thrombogenesis and embolus formation in mice lacking glycoprotein V

IMMUNOBIOLOGY

The functional interactions between CD98, β1-integrins, and CD147 in the induction of U937 homotypic aggregation

Jae Youl Cho,David A. Fox,Vaclav Horejsi,Kimitaka Sagawa,Keith M. Skubitz,David R. Katz,Benjamin Chain

View Articletitled, The functional interactions between CD98, β1-integrins, and CD147 in the induction of U937 homotypic aggregation

The HIV protease inhibitor Indinavir inhibits cell-cycle progression in vitro in lymphocytes of HIV-infected and uninfected individuals

Surendra Chavan,Sangeetha Kodoth,Rajendra Pahwa,Savita Pahwa

View Articletitled, The HIV protease inhibitor Indinavir inhibits cell-cycle progression in vitro in lymphocytes of HIV-infected and uninfected individuals

Major histocompatibility complex–mismatched allogeneic bone marrow transplantation using perforin and/or Fas ligand double-defective CD4⁺ donor T cells: involvement of cytotoxic function by donor lymphocytes prior to graft-versus-host disease pathogenesis

Zhe Jiang,Eckhard Podack,Robert B. Levy

View Articletitled, Major histocompatibility complex–mismatched allogeneic bone marrow transplantation using perforin and/or Fas ligand double-defective CD4+ donor T cells: involvement of cytotoxic function by donor lymphocytes prior to graft-versus-host disease pathogenesis

Impaired progenitor cell function in HIV-negative infants of HIV-positive mothers results in decreased thymic output and low CD4 counts

Susanne D. Nielsen,Dorthe L. Jeppesen,Lilian Kolte,Dawn R. Clark,Tine U. Sørensen,Anne-Mette Dreves,Annette K. Ersbøll,Lars P. Ryder,Niels H. Valerius,Jens O. Nielsen

View Articletitled, Impaired progenitor cell function in HIV-negative infants of HIV-positive mothers results in decreased thymic output and low CD4 counts

NEOPLASIA

Mitochondrial membrane sensitivity to depolarization in acute myeloblastic leukemia is associated with spontaneous in vitro apoptosis, wild-type TP53, and vicinal thiol/disulfide status

Monica Pallis,Martin Grundy,Julie Turzanski,Reinhard Kofler,Nigel Russell

View Articletitled, Mitochondrial membrane sensitivity to depolarization in acute myeloblastic leukemia is associated with spontaneous in vitro apoptosis, wild-type TP53, and vicinal thiol/disulfide status

Apaf-1 protein deficiency confers resistance to cytochromec–dependent apoptosis in human leukemic cells

Li Jia,Srinivasa M. Srinivasula,Feng-Ting Liu,Adrian C. Newland,Teresa Fernandes-Alnemri,Emad S. Alnemri,Stephen M. Kelsey

View Articletitled, Apaf-1 protein deficiency confers resistance to cytochromec–dependent apoptosis in human leukemic cells

Identification of myelodysplastic syndrome–specific genes by DNA microarray analysis with purified hematopoietic stem cell fraction

Akira Miyazato,Shuichi Ueno,Ken Ohmine,Masuzu Ueda,Koji Yoshida,Yoshihiro Yamashita,Takashi Kaneko,Masaki Mori,Keita Kirito,Masaki Toshima,Yuichi Nakamura,Kenji Saito,Yasuhiko Kano,Shinpei Furusawa,Keiya Ozawa,Hiroyuki Mano

View Articletitled, Identification of myelodysplastic syndrome–specific genes by DNA microarray analysis with purified hematopoietic stem cell fraction

Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration

Klaus Podar,Yu-Tzu Tai,Faith E. Davies,Suzanne Lentzsch,Martin Sattler,Teru Hideshima,Boris K. Lin,Deepak Gupta,Yoshihito Shima,Dharminder Chauhan,Constantine Mitsiades,Noopur Raje,Paul Richardson,Kenneth C. Anderson

View Articletitled, Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration

PHAGOCYTES

Improved superoxide-generating ability by interferon γ due to splicing pattern change of transcripts in neutrophils from patients with a splice site mutation inCYBB gene

Fuminari Ishibashi,Tomoyuki Mizukami,Shiro Kanegasaki,Lena Motoda,Ryota Kakinuma,Fumio Endo,Hiroyuki Nunoi

View Articletitled, Improved superoxide-generating ability by interferon γ due to splicing pattern change of transcripts in neutrophils from patients with a splice site mutation inCYBB gene

RED CELLS

Targeted deletion of the CD59 gene causes spontaneous intravascular hemolysis and hemoglobinuria

Dewi S. Holt,Marina Botto,Anne E. Bygrave,S. Melanie Hanna,Mark J. Walport,B. Paul Morgan

View Articletitled, Targeted deletion of the CD59 gene causes spontaneous intravascular hemolysis and hemoglobinuria

A comparison of the in vivo kinetics of Plasmodium falciparum ring–infected erythrocyte surface antigen–positive and –negative erythrocytes

Paul N. Newton,Kesinee Chotivanich,Wirongrong Chierakul,Ronatrai Ruangveerayuth,Pramote Teerapong,Kamolrat Silamut,Sornchai Looareesuwan,Nicholas J. White

View Articletitled, A comparison of the in vivo kinetics of Plasmodium falciparum ring–infected erythrocyte surface antigen–positive and –negative erythrocytes

Intercellular adhesion molecule-4 binds α₄β₁ and α_V-family integrins through novel integrin-binding mechanisms: Presented in part as abstracts at the 40th annual meeting of the American Society of Hematology, Miami, FL, December 1998 (Blood 1998;92:589a) and at the annual meeting of the British Blood Transfusion Society, Edinburgh, United Kingdom, September 1999 (Transfus Med 1999;9:[suppl 1]9).

Frances A. Spring,Stephen F. Parsons,Susan Ortlepp,Martin L. Olsson,Richard Sessions,R. Leo Brady,David J. Anstee

View Articletitled, Intercellular adhesion molecule-4 binds α4β1 and αV-family integrins through novel integrin-binding mechanisms: Presented in part as abstracts at the 40th annual meeting of the American Society of Hematology, Miami, FL, December 1998 (Blood 1998;92:589a) and at the annual meeting of the British Blood Transfusion Society, Edinburgh, United Kingdom, September 1999 (Transfus Med 1999;9:[suppl 1]9).

TRANSPLANTATION

Requirements for the promotion of allogeneic engraftment by anti-CD154 (anti-CD40L) monoclonal antibody under nonmyeloablative conditions

Patricia A. Taylor,Christopher J. Lees,Herman Waldmann,Randolph J. Noelle,Bruce R. Blazar

View Articletitled, Requirements for the promotion of allogeneic engraftment by anti-CD154 (anti-CD40L) monoclonal antibody under nonmyeloablative conditions

BRIEF REPORTS

The human erythropoietin receptor gene rescues erythropoiesis and developmental defects in the erythropoietin receptor null mouse
Brief Report

Xiaobing Yu,Chyuan-Sheng Lin,Frank Costantini,Constance Tom Noguchi

View Articletitled, The human erythropoietin receptor gene rescues erythropoiesis and developmental defects in the erythropoietin receptor null mouse

Molecular tracking of leukemogenesis in a triplet pregnancy
Brief Report

Ana Teresa Maia,Anthony M. Ford,G. Reza Jalali,Christine J. Harrison,G. Malcolm Taylor,Osborn B. Eden,Mel F. Greaves

View Articletitled, Molecular tracking of leukemogenesis in a triplet pregnancy

Acquired pure red cell aplasia associated with lymphoproliferative disease of granular T lymphocytes
Clinical Trials & Observations Brief Report

Ronald S. Go,Chin-Yang Li,Ayalew Tefferi,Robert L. Phyliky

View Articletitled, Acquired pure red cell aplasia associated with lymphoproliferative disease of granular T lymphocytes

Low frequency of BCL-2/J_H translocation in peripheral blood lymphocytes of healthy Japanese individuals
Brief Report

Masaki Yasukawa,Shiro Bando,Gottfried Dölken,Eiji Sada,Yoshihiro Yakushijin,Shigeru Fujita,Hideichi Makino

View Articletitled, Low frequency of BCL-2/JH translocation in peripheral blood lymphocytes of healthy Japanese individuals

Factors influencing B lymphopoiesis after allogeneic hematopoietic cell transplantation
Brief Report

Jan Storek,Denise Wells,Monja A. Dawson,Barry Storer,David G. Maloney

View Articletitled, Factors influencing B lymphopoiesis after allogeneic hematopoietic cell transplantation

Extended survival in advanced and refractory multiple myeloma after single-agent thalidomide: identification of prognostic factors in a phase 2 study of 169 patients
Brief Report

Bart Barlogie,Raman Desikan,Paul Eddlemon,Trey Spencer,Jerome Zeldis,Nikhil Munshi,Ashrof Badros,Maurizio Zangari,Elias Anaissie,Joshua Epstein,John Shaughnessy,Dan Ayers,Dan Spoon,Guido Tricot

View Articletitled, Extended survival in advanced and refractory multiple myeloma after single-agent thalidomide: identification of prognostic factors in a phase 2 study of 169 patients

Expression of p15^ink4b gene during megakaryocytic differentiation of normal and myelodysplastic hematopoietic progenitors
Brief Report

Luciana Teofili,Maurizio Martini,Antonella Di Mario,Sergio Rutella,Raffaella Urbano,Myriam Luongo,Giuseppe Leone,Luigi Maria Larocca

View Articletitled, Expression of p15ink4b gene during megakaryocytic differentiation of normal and myelodysplastic hematopoietic progenitors

CORRESPONDENCE

Deleterious consequences of allogeneic blood transfusion on postoperative infection: really a transfusion-related immunomodulation effect?

Arturo Pereira

View Articletitled, Deleterious consequences of allogeneic blood transfusion on postoperative infection: really a transfusion-related immunomodulation effect?

Relationship between HLA alleles and cytomegalovirus infection after allogeneic hematopoietic stem cell transplant

Yolande Chen,Vanderson Rocha,Henrique Bittencourt,Catherine Scieux,Pascale Loiseau,Hélène Espérou,Agnès Devergie,Philippe Guardiola,Gérard Socié,Sylvie Chevret,Dominique Charron,Eliane Gluckman,Patricia Ribaud

View Articletitled, Relationship between HLA alleles and cytomegalovirus infection after allogeneic hematopoietic stem cell transplant

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Issue Archive

Table of Contents

INSIDE BLOOD

PLENARY PAPERS

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Sudden death among patients with acute promyelocytic leukemia treated with arsenic trioxide Clinical Trials & Observations

Survival of transfused donor white blood cells in HIV-infected recipients Clinical Trials & Observations

Clinical and virologic characteristics of chronic active Epstein-Barr virus infection Clinical Trials & Observations

ERRATA

GENE THERAPY

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

IMMUNOBIOLOGY

NEOPLASIA

PHAGOCYTES

RED CELLS

TRANSPLANTATION

BRIEF REPORTS

The human erythropoietin receptor gene rescues erythropoiesis and developmental defects in the erythropoietin receptor null mouse Brief Report

Molecular tracking of leukemogenesis in a triplet pregnancy Brief Report

Acquired pure red cell aplasia associated with lymphoproliferative disease of granular T lymphocytes Clinical Trials & Observations Brief Report

Low frequency of BCL-2/JH translocation in peripheral blood lymphocytes of healthy Japanese individuals Brief Report

Factors influencing B lymphopoiesis after allogeneic hematopoietic cell transplantation Brief Report

Extended survival in advanced and refractory multiple myeloma after single-agent thalidomide: identification of prognostic factors in a phase 2 study of 169 patients Brief Report

Expression of p15ink4b gene during megakaryocytic differentiation of normal and myelodysplastic hematopoietic progenitors Brief Report