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Volume 98, Issue 13

December 15 2001

In this Issue

INSIDE BLOOD
PLENARY PAPERS
REVIEW ARTICLES
CHEMOKINES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
BRIEF REPORTS
CORRESPONDENCE

INSIDE BLOOD

Long-term immune reconstitution after marrow transplantation

Gérard Socié

View Articletitled, Long-term immune reconstitution after marrow transplantation

Plasmacytoid dendritic cells: ready to be tested in vivo

Markus G. Manz

View Articletitled, Plasmacytoid dendritic cells: ready to be tested in vivo

Finally, how myeloma lyses bone

Geraldine P. Schechter

View Articletitled, Finally, how myeloma lyses bone

Some signals are more equal than others

Radek C. Skoda

View Articletitled, Some signals are more equal than others

PLENARY PAPERS

Immunity of patients surviving 20 to 30 years after allogeneic or syngeneic bone marrow transplantation
Clinical Trials & Observations

Jan Storek,Ansamma Joseph,German Espino,Monja A. Dawson,Daniel C. Douek,Keith M. Sullivan,Mary E. D. Flowers,Paul Martin,George Mathioudakis,Richard A. Nash,Rainer Storb,Frederick R. Appelbaum,David G. Maloney

View Articletitled, Immunity of patients surviving 20 to 30 years after allogeneic or syngeneic bone marrow transplantation

Increased frequency of HLA-DR2 in patients with paroxysmal nocturnal hemoglobinuria and the PNH/aplastic anemia syndrome

Jaroslaw P. Maciejewski,Dean Follmann,Ryotaro Nakamura,Yogen Saunthararajah,Candido E. Rivera,Toni Simonis,Kevin E. Brown,John A. Barrett,Neal S. Young

View Articletitled, Increased frequency of HLA-DR2 in patients with paroxysmal nocturnal hemoglobinuria and the PNH/aplastic anemia syndrome

Isolation and characterization of plasmacytoid dendritic cells from Flt3 ligand and granulocyte-macrophage colony-stimulating factor–treated mice

Pia Björck

View Articletitled, Isolation and characterization of plasmacytoid dendritic cells from Flt3 ligand and granulocyte-macrophage colony-stimulating factor–treated mice

Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment

Nicola Giuliani,Régis Bataille,Cristina Mancini,Mirca Lazzaretti,Sophie Barillé

View Articletitled, Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment

Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma

Peter I. Croucher,Claire M. Shipman,Jennifer Lippitt,Mark Perry,Kewal Asosingh,Anja Hijzen,Alex C. Brabbs,Edwin J. R. van Beek,Ingunn Holen,Timothy M. Skerry,Colin R. Dunstan,Graham R. Russell,Ben Van Camp,Karin Vanderkerken

View Articletitled, Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma

REVIEW ARTICLES

Receptor- and mitochondrial-mediated apoptosis in acute leukemia: a translational view

Aaron D. Schimmer,David W. Hedley,Linda Z. Penn,Mark D. Minden

View Articletitled, Receptor- and mitochondrial-mediated apoptosis in acute leukemia: a translational view

CHEMOKINES

Amino-terminal truncation of CXCR3 agonists impairs receptor signaling and lymphocyte chemotaxis, while preserving antiangiogenic properties

Paul Proost,Evemie Schutyser,Patricia Menten,Sofie Struyf,Anja Wuyts,Ghislain Opdenakker,Michel Detheux,Marc Parmentier,Christine Durinx,Anne-Marie Lambeir,Johan Neyts,Sandra Liekens,Prabhat C. Maudgal,Alfons Billiau,Jo Van Damme

View Articletitled, Amino-terminal truncation of CXCR3 agonists impairs receptor signaling and lymphocyte chemotaxis, while preserving antiangiogenic properties

Transgenic overexpression of the CC chemokine CCL21 disrupts T-cell migration

Kent W. Christopherson, II,James J. Campbell,Robert A. Hromas

View Articletitled, Transgenic overexpression of the CC chemokine CCL21 disrupts T-cell migration

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Busulfan plus cyclophosphamide compared with total-body irradiation plus cyclophosphamide before marrow transplantation for myeloid leukemia: long-term follow-up of 4 randomized studies
Clinical Trials & Observations

Gérard Socié,Reginald A. Clift,Didier Blaise,Agnès Devergie,Olle Ringden,Paul J. Martin,Mats Remberger,H. Joachim Deeg,Tapani Ruutu,Mauricette Michallet,Keith M. Sullivan,Sylvie Chevret

View Articletitled, Busulfan plus cyclophosphamide compared with total-body irradiation plus cyclophosphamide before marrow transplantation for myeloid leukemia: long-term follow-up of 4 randomized studies

Comparison of idarubicin + ara-C–, fludarabine + ara-C–, and topotecan + ara-C–based regimens in treatment of newly diagnosed acute myeloid leukemia, refractory anemia with excess blasts in transformation, or refractory anemia with excess blasts
Clinical Trials & Observations

Elihu H. Estey,Peter F. Thall,Jorge E. Cortes,Francis J. Giles,Susan O'Brien,Sherry A. Pierce,Xuemei Wang,Hagop M. Kantarjian,Miloslav Beran

View Articletitled, Comparison of idarubicin + ara-C–, fludarabine + ara-C–, and topotecan + ara-C–based regimens in treatment of newly diagnosed acute myeloid leukemia, refractory anemia with excess blasts in transformation, or refractory anemia with excess blasts

Decreased transfusion requirements for patients receiving nonmyeloablative compared with conventional peripheral blood stem cell transplants from HLA-identical siblings
Clinical Trials & Observations

Florian Weissinger,Brenda M. Sandmaier,David G. Maloney,William I. Bensinger,Ted Gooley,Rainer Storb

View Articletitled, Decreased transfusion requirements for patients receiving nonmyeloablative compared with conventional peripheral blood stem cell transplants from HLA-identical siblings

Superior outcome of infant acute myeloid leukemia with intensive chemotherapy: results of the Japan Infant Leukemia Study Group
Clinical Trials & Observations

Hajime Kawasaki,Keiichi Isoyama,Mariko Eguchi,Shigeyoshi Hibi,Naoko Kinukawa,Yoshiyuki Kosaka,Takanori Oda,Megumi Oda,Shin-ichiro Nishimura,Masue Imaizumi,Takayuki Okamura,Teruaki Hongo,Hiroji Okawa,Shuki Mizutani,Yasuhide Hayashi,Ichiro Tsukimoto,Nanao Kamada,Eiichi Ishii

View Articletitled, Superior outcome of infant acute myeloid leukemia with intensive chemotherapy: results of the Japan Infant Leukemia Study Group

Nonablative allogeneic hematopoietic transplantation as adoptive immunotherapy for indolent lymphoma: low incidence of toxicity, acute graft-versus-host disease, and treatment-related mortality
Clinical Trials & Observations

Issa F. Khouri,Rima M. Saliba,Sergio A. Giralt,Ming-Sheng Lee,Grace-Julia Okoroji,Fredrick B. Hagemeister,Martin Korbling,Anas Younes,Cindy Ippoliti,James L. Gajewski,Peter McLaughlin,Paolo Anderlini,Michele L. Donato,Fernando F. Cabanillas,Richard E. Champlin

View Articletitled, Nonablative allogeneic hematopoietic transplantation as adoptive immunotherapy for indolent lymphoma: low incidence of toxicity, acute graft-versus-host disease, and treatment-related mortality

Human recombinant factor IX: safety and efficacy studies in hemophilia B patients previously treated with plasma-derived factor IX concentrates
Clinical Trials & Observations

David A. Roth,Craig M. Kessler,K. John Pasi,Bonita Rup,Suzanne G. Courter,Karen L. Tubridy,for the Recombinant Factor IX Study Group

View Articletitled, Human recombinant factor IX: safety and efficacy studies in hemophilia B patients previously treated with plasma-derived factor IX concentrates

GENE THERAPY

Effects of CD2 locus control region sequences on gene expression by retroviral and lentiviral vectors

Stefano Indraccolo,Sonia Minuzzo,Francesca Roccaforte,Rita Zamarchi,Walter Habeler,Laura Stievano,Valeria Tosello,Dieter Klein,Walter H. Günzburg,Giuseppe Basso,Luigi Chieco-Bianchi,Alberto Amadori

View Articletitled, Effects of CD2 locus control region sequences on gene expression by retroviral and lentiviral vectors

HEMATOPOIESIS

Human granulocyte-macrophage colony-stimulating factor (hGM-CSF) stimulates primitive and definitive erythropoiesis in mouse embryos expressing hGM-CSF receptors but not erythropoietin receptors

Hiroaki Hisakawa,Daisuke Sugiyama,Ichiko Nishijima,Ming-jiang Xu,Hong Wu,Kazuki Nakao,Sumiko Watanabe,Motoya Katsuki,Shigetaka Asano,Ken-ichi Arai,Tatsutoshi Nakahata,Kohichiro Tsuji

View Articletitled, Human granulocyte-macrophage colony-stimulating factor (hGM-CSF) stimulates primitive and definitive erythropoiesis in mouse embryos expressing hGM-CSF receptors but not erythropoietin receptors

Sugar profiling proves that human serum erythropoietin differs from recombinant human erythropoietin

Venke Skibeli,Gro Nissen-Lie,Peter Torjesen

View Articletitled, Sugar profiling proves that human serum erythropoietin differs from recombinant human erythropoietin

Expression and function of CD105 during the onset of hematopoiesis from Flk1⁺ precursors

Sarah K. Cho,Annie Bourdeau,Michelle Letarte,Juan Carlos Zúñiga-Pflücker

View Articletitled, Expression and function of CD105 during the onset of hematopoiesis from Flk1+ precursors

Transforming growth factor β1 mediates cell-cycle arrest of primitive hematopoietic cells independent of p21^Cip1/Waf1or p27^Kip1

Tao Cheng,Hongmei Shen,Neil Rodrigues,Sebastian Stier,David T. Scadden

View Articletitled, Transforming growth factor β1 mediates cell-cycle arrest of primitive hematopoietic cells independent of p21Cip1/Waf1or p27Kip1

A cytoplasmic serine protein kinase binds and may regulate the Fanconi anemia protein FANCA

Hiroshi Yagasaki,Daiki Adachi,Tsukasa Oda,Irene Garcia-Higuera,Nii Tetteh,Alan D. D'Andrea,Makoto Futaki,Shigetaka Asano,Takayuki Yamashita

View Articletitled, A cytoplasmic serine protein kinase binds and may regulate the Fanconi anemia protein FANCA

Lymphoid apoptosis and myeloid hyperplasia in CCAAT displacement protein mutant mice

Angus M. Sinclair,Jamie A. Lee,Adrian Goldstein,Dongxia Xing,Shengxi Liu,Ruzeng Ju,Philip W. Tucker,Ellis J. Neufeld,Richard H. Scheuermann

View Articletitled, Lymphoid apoptosis and myeloid hyperplasia in CCAAT displacement protein mutant mice

The leucine zipper region of Myb oncoprotein regulates the commitment of hematopoietic progenitors

Vı́t Karafiát,Marta Dvořáková,Petr Pajer,Jarmila Králová,Zuzana Hořejšı́,Vladimı́r Čermák,Petr Bartůněk,Martin Zenke,Michal Dvořák

View Articletitled, The leucine zipper region of Myb oncoprotein regulates the commitment of hematopoietic progenitors

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Identification of CD146 as a component of the endothelial junction involved in the control of cell-cell cohesion

Nathalie Bardin,Francine Anfosso,Jean-Marc Massé,Elisabeth Cramer,Florence Sabatier,André Le Bivic,José Sampol,Françoise Dignat-George

View Articletitled, Identification of CD146 as a component of the endothelial junction involved in the control of cell-cell cohesion

Congenital afibrinogenemia: mutations leading to premature termination codons in fibrinogen Aα-chain gene are not associated with the decay of the mutant mRNAs

Rosanna Asselta,Stefano Duga,Silvia Spena,Elena Santagostino,Flora Peyvandi,Gavino Piseddu,Roberto Targhetta,Massimo Malcovati,Pier Mannuccio Mannucci,Maria Luisa Tenchini

View Articletitled, Congenital afibrinogenemia: mutations leading to premature termination codons in fibrinogen Aα-chain gene are not associated with the decay of the mutant mRNAs

Structure-function analysis of the antioxidant properties of haptoglobin

Meira Melamed-Frank,Orit Lache,Benjamin I. Enav,Tal Szafranek,Nina S. Levy,Rebecca M. Ricklis,Andrew P. Levy

View Articletitled, Structure-function analysis of the antioxidant properties of haptoglobin

Heterogeneity of endothelial junctions is reflected by differential expression and specific subcellular localization of the three JAM family members

Michel Aurrand-Lions,Caroline Johnson-Leger,Cindy Wong,Louis Du Pasquier,Beat A. Imhof

View Articletitled, Heterogeneity of endothelial junctions is reflected by differential expression and specific subcellular localization of the three JAM family members

Rac, a small guanosine triphosphate–binding protein, and p21-activated kinase are activated during platelet spreading on collagen-coated surfaces: roles of integrin α₂β₁

Katsue Suzuki-Inoue,Yutaka Yatomi,Naoki Asazuma,Mie Kainoh,Toshiaki Tanaka,Kaneo Satoh,Yukio Ozaki

View Articletitled, Rac, a small guanosine triphosphate–binding protein, and p21-activated kinase are activated during platelet spreading on collagen-coated surfaces: roles of integrin α2β1

Regulatory role of tetraspanin CD9 in tumor–endothelial cell interaction during transendothelial invasion of melanoma cells

Natividad Longo,Marı́a Yáñez-Mó,Marı́a Mittelbrunn,Gonzalo de la Rosa,Marı́a-Luisa Muñoz,Francisco Sánchez-Madrid,Paloma Sánchez-Mateos

View Articletitled, Regulatory role of tetraspanin CD9 in tumor–endothelial cell interaction during transendothelial invasion of melanoma cells

Supplemental data

IMMUNOBIOLOGY

A rheostatic mechanism for T-cell inhibition based on elevation of activation thresholds

Jacob Rachmilewitz,Gregory J. Riely,Jui-Han Huang,Aoshuang Chen,Mark L. Tykocinski

View Articletitled, A rheostatic mechanism for T-cell inhibition based on elevation of activation thresholds

The normal cellular prion protein is strongly expressed by myeloid dendritic cells

John Burthem,Britta Urban,Arnab Pain,David J. Roberts

View Articletitled, The normal cellular prion protein is strongly expressed by myeloid dendritic cells

Asymptomatic primary Epstein-Barr virus infection occurs in the absence of blood T-cell repertoire perturbations despite high levels of systemic viral load

Sharon L. Silins,Martina A. Sherritt,Jodie M. Silleri,Simone M. Cross,Suzanne L. Elliott,Mandvi Bharadwaj,Thuy T. T. Le,Leanne E. Morrison,Rajiv Khanna,Denis J. Moss,Andreas Suhrbier,Ihor S. Misko

View Articletitled, Asymptomatic primary Epstein-Barr virus infection occurs in the absence of blood T-cell repertoire perturbations despite high levels of systemic viral load

The B-cell receptor of a hepatitis C virus (HCV)–associated non-Hodgkin lymphoma binds the viral E2 envelope protein, implicating HCV in lymphomagenesis

Elizabeth R. Quinn,Chunghuang Hubert Chan,Kenneth G. Hadlock,Steven K. H. Foung,Mike Flint,Shoshana Levy

View Articletitled, The B-cell receptor of a hepatitis C virus (HCV)–associated non-Hodgkin lymphoma binds the viral E2 envelope protein, implicating HCV in lymphomagenesis

Circulating blood dendritic cells from myeloid leukemia patients display quantitative and cytogenetic abnormalities as well as functional impairment

Mohamad Mohty,David Jarrossay,Marina Lafage-Pochitaloff,Christine Zandotti,Francine Brière,Xavier-Nicolas de Lamballeri,Daniel Isnardon,Danielle Sainty,Daniel Olive,Béatrice Gaugler

View Articletitled, Circulating blood dendritic cells from myeloid leukemia patients display quantitative and cytogenetic abnormalities as well as functional impairment

Simian immunodeficiency virus (SIV)–specific cytotoxic T lymphocytes in gastrointestinal tissues of chronically SIV-infected rhesus monkeys

Jörn E. Schmitz,Ronald S. Veazey,Marcelo J. Kuroda,Daniel B. Levy,Aruna Seth,Keith G. Mansfield,Christine E. Nickerson,Michelle A. Lifton,Xavier Alvarez,Andrew A. Lackner,Norman L. Letvin

View Articletitled, Simian immunodeficiency virus (SIV)–specific cytotoxic T lymphocytes in gastrointestinal tissues of chronically SIV-infected rhesus monkeys

NEOPLASIA

Arsenic trioxide induces apoptosis in human T-cell leukemia virus type 1– and type 2–infected cells by a caspase-3–dependent mechanism involving Bcl-2 cleavage

Renaud Mahieux,Cynthia Pise-Masison,Antoine Gessain,John. N. Brady,René Olivier,Emmanuelle Perret,Tom Misteli,Christophe Nicot

View Articletitled, Arsenic trioxide induces apoptosis in human T-cell leukemia virus type 1– and type 2–infected cells by a caspase-3–dependent mechanism involving Bcl-2 cleavage

Role of protein kinase C ζ isoform in Fas resistance of immature myeloid KG1a leukemic cells

Aurélie de Thonel,Ali Bettaı̈eb,Christine Jean,Guy Laurent,Anne Quillet-Mary

View Articletitled, Role of protein kinase C ζ isoform in Fas resistance of immature myeloid KG1a leukemic cells

The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins

Asuman Demiroglu,E. Joanna Steer,Carol Heath,Kerry Taylor,Mark Bentley,Steven L. Allen,Prasad Koduru,Judith P. Brody,Geoffrey Hawson,Robyn Rodwell,Mary-Lou Doody,Fernando Carnicero,Andreas Reiter,John M. Goldman,Junia V. Melo,Nicholas C. P. Cross

View Articletitled, The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins

Expression, epitope analysis, and functional role of the LFA-2 antigen detectable on neoplastic mast cells

Gerit-Holger Schernthaner,John-Hendrik Jordan,Minoo Ghannadan,Hermine Agis,Dorian Bevec,Rosa Nuñez,Luis Escribano,Otto Majdic,Martin Willheim,Christof Worda,Dieter Printz,Gerhard Fritsch,Klaus Lechner,Peter Valent

View Articletitled, Expression, epitope analysis, and functional role of the LFA-2 antigen detectable on neoplastic mast cells

A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when overexpressed in mice by retroviral-mediated gene transfer

Xiao-Qiang Yan,Ulla Sarmiento,Yu Sun,Guo Huang,Jane Guo,Todd Juan,Gwyneth Van,Mei-Ying Qi,Sheila Scully,Giorgio Senaldi,Frederick A. Fletcher

View Articletitled, A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when overexpressed in mice by retroviral-mediated gene transfer

PHAGOCYTES

High concentrations of lipopolysaccharide-binding protein in serum of patients with severe sepsis or septic shock inhibit the lipopolysaccharide response in human monocytes

Janine Zweigner,Hans-Joachim Gramm,Oliver C. Singer,Karl Wegscheider,Ralf R. Schumann

View Articletitled, High concentrations of lipopolysaccharide-binding protein in serum of patients with severe sepsis or septic shock inhibit the lipopolysaccharide response in human monocytes

RED CELLS

Multiple cis elements regulate an alternative splicing event at 4.1R pre-mRNA during erythroid differentiation

Mireille Deguillien,Shu-Ching Huang,Madeleine Morinière,Natacha Dreumont,Edward J. Benz, Jr,Faouzi Baklouti

View Articletitled, Multiple cis elements regulate an alternative splicing event at 4.1R pre-mRNA during erythroid differentiation

Correction of cross-linker sensitivity of Fanconi anemia group F cells by CD33-mediated protein transfer

Rebecca K. Holmes,Karine Harutyunyan,Maulik Shah,Hans Joenje,Hagop Youssoufian

View Articletitled, Correction of cross-linker sensitivity of Fanconi anemia group F cells by CD33-mediated protein transfer

Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mkmice

François Canonne-Hergaux,An-Sheng Zhang,Prem Ponka,Philippe Gros

View Articletitled, Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mkmice

Cellular zinc content is a major determinant of iron chelator–induced apoptosis of thymocytes

Kirsteen H. Maclean,John L. Cleveland,John B. Porter

View Articletitled, Cellular zinc content is a major determinant of iron chelator–induced apoptosis of thymocytes

Molecular basis of the adult i phenotype and the gene responsible for the expression of the human blood group I antigen

Lung-Chih Yu,Yuh-Ching Twu,Ching-Yi Chang,Marie Lin

View Articletitled, Molecular basis of the adult i phenotype and the gene responsible for the expression of the human blood group I antigen

BRIEF REPORTS

Salvage therapy for multiple myeloma with thalidomide and CED chemotherapy
Clinical Trials & Observations Brief Report

Thomas M. Moehler,Kai Neben,Axel Benner,Gerlinde Egerer,Fatime Krasniqi,Anthony D. Ho,Hartmut Goldschmidt

View Articletitled, Salvage therapy for multiple myeloma with thalidomide and CED chemotherapy

Identification of LIL-STAT in monocytic leukemia cells and monocytes after stimulation with interleukin-6 or interferon γ
Brief Report

Henny H. Lemmink,Leonore Tuyt,Gerlinde Knol,Ellen Krikke,Edo Vellenga

View Articletitled, Identification of LIL-STAT in monocytic leukemia cells and monocytes after stimulation with interleukin-6 or interferon γ

Identification and characterization of cis elements in the STAT3 gene regulating STAT3α and STAT3β messenger RNA splicing
Brief Report

Huang Shao,Andres J. Quintero,David J. Tweardy

View Articletitled, Identification and characterization of cis elements in the STAT3 gene regulating STAT3α and STAT3β messenger RNA splicing

Autologous stem cell transplantation for HIV-associated lymphoma
Clinical Trials & Observations Brief Report

Amrita Krishnan,Arturo Molina,John Zaia,Auayporn Nademanee,Neil Kogut,Joseph Rosenthal,Doni Woo,Stephen J. Forman

View Articletitled, Autologous stem cell transplantation for HIV-associated lymphoma

The antitumor ether lipid ET-18-OCH₃ induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells
Brief Report

Consuelo Gajate,Faustino Mollinedo

View Articletitled, The antitumor ether lipid ET-18-OCH3 induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells

Restoration of sensitivity to STI571 in STI571-resistant chronic myeloid leukemia cells
Brief Report

Alex J. Tipping,François X. Mahon,Valerie Lagarde,John M. Goldman,Junia V. Melo

View Articletitled, Restoration of sensitivity to STI571 in STI571-resistant chronic myeloid leukemia cells

Administration of cyclosporine for 24 months compared with 6 months for prevention of chronic graft-versus-host disease: a prospective randomized clinical trial
Clinical Trials & Observations Brief Report

Emin Kansu,Ted Gooley,Mary E. D. Flowers,Claudio Anasetti,H. Joachim Deeg,Richard A. Nash,Jean E. Sanders,Robert P. Witherspoon,Frederick R. Appelbaum,Rainer Storb,Paul J. Martin

View Articletitled, Administration of cyclosporine for 24 months compared with 6 months for prevention of chronic graft-versus-host disease: a prospective randomized clinical trial

Neonatal-onset hereditary coproporphyria with male pseudohermaphrodism
Clinical Trials & Observations Brief Report

Harue Takeuchi,Masao Kondo,Makoto Daimon,Shinji Susa,Katsuhiko Ueoka,Osamu Uemura,Hajime Togari

View Articletitled, Neonatal-onset hereditary coproporphyria with male pseudohermaphrodism

CORRESPONDENCE

Reduced risk for chronic myelogenous leukemia in individuals with the cytochrome P-450 gene polymorphism CYP1A12A*

Harald Löffler,Jörg Bergmann,Andreas Hochhaus,Rüdiger Hehlmann,Alwin Krämer,the German CML Study Group

View Articletitled, Reduced risk for chronic myelogenous leukemia in individuals with the cytochrome P-450 gene polymorphism CYP1A1*2A

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Issue Archive

Table of Contents

INSIDE BLOOD

PLENARY PAPERS

Immunity of patients surviving 20 to 30 years after allogeneic or syngeneic bone marrow transplantation Clinical Trials & Observations

REVIEW ARTICLES

CHEMOKINES

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Busulfan plus cyclophosphamide compared with total-body irradiation plus cyclophosphamide before marrow transplantation for myeloid leukemia: long-term follow-up of 4 randomized studies Clinical Trials & Observations

Comparison of idarubicin + ara-C–, fludarabine + ara-C–, and topotecan + ara-C–based regimens in treatment of newly diagnosed acute myeloid leukemia, refractory anemia with excess blasts in transformation, or refractory anemia with excess blasts Clinical Trials & Observations

Decreased transfusion requirements for patients receiving nonmyeloablative compared with conventional peripheral blood stem cell transplants from HLA-identical siblings Clinical Trials & Observations

Superior outcome of infant acute myeloid leukemia with intensive chemotherapy: results of the Japan Infant Leukemia Study Group Clinical Trials & Observations

Nonablative allogeneic hematopoietic transplantation as adoptive immunotherapy for indolent lymphoma: low incidence of toxicity, acute graft-versus-host disease, and treatment-related mortality Clinical Trials & Observations

Human recombinant factor IX: safety and efficacy studies in hemophilia B patients previously treated with plasma-derived factor IX concentrates Clinical Trials & Observations

GENE THERAPY

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

IMMUNOBIOLOGY

NEOPLASIA

PHAGOCYTES

RED CELLS

BRIEF REPORTS

Salvage therapy for multiple myeloma with thalidomide and CED chemotherapy Clinical Trials & Observations Brief Report

Identification of LIL-STAT in monocytic leukemia cells and monocytes after stimulation with interleukin-6 or interferon γ Brief Report

Identification and characterization of cis elements in the STAT3 gene regulating STAT3α and STAT3β messenger RNA splicing Brief Report

Autologous stem cell transplantation for HIV-associated lymphoma Clinical Trials & Observations Brief Report

The antitumor ether lipid ET-18-OCH3 induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells Brief Report

Restoration of sensitivity to STI571 in STI571-resistant chronic myeloid leukemia cells Brief Report

Administration of cyclosporine for 24 months compared with 6 months for prevention of chronic graft-versus-host disease: a prospective randomized clinical trial Clinical Trials & Observations Brief Report

Neonatal-onset hereditary coproporphyria with male pseudohermaphrodism Clinical Trials & Observations Brief Report