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Volume 98, Issue 12

December 1 2001

In this Issue

INSIDE BLOOD
PLENARY PAPERS
REVIEW ARTICLES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSPLANTATION
BRIEF REPORTS
CORRESPONDENCE

INSIDE BLOOD

“Affenmensch” defect defined

Shigeru Sassa

View Articletitled, “Affenmensch” defect defined

In search of the ideal allogeneic inoculum

Karl G. Blume

View Articletitled, In search of the ideal allogeneic inoculum

Pumped on steroids

Robert Hromas

View Articletitled, Pumped on steroids

Regulation of granulopoiesis: lessons from leukocyte adhesion deficiency

Daniel C. Link

View Articletitled, Regulation of granulopoiesis: lessons from leukocyte adhesion deficiency

PLENARY PAPERS

Functional consequences of naturally occurring mutations in human uroporphyrinogen decarboxylase

John D. Phillips,Tiffany L. Parker,Heidi L. Schubert,Frank G. Whitby,Christopher P. Hill,James P. Kushner

View Articletitled, Functional consequences of naturally occurring mutations in human uroporphyrinogen decarboxylase

Granulocyte–colony-stimulating factor (G-CSF)–primed allogeneic bone marrow: significantly less graft-versus-host disease and comparable engraftment to G-CSF–mobilized peripheral blood stem cells

James Morton,Cheryl Hutchins,Simon Durrant

View Articletitled, Granulocyte–colony-stimulating factor (G-CSF)–primed allogeneic bone marrow: significantly less graft-versus-host disease and comparable engraftment to G-CSF–mobilized peripheral blood stem cells

REVIEW ARTICLES

The history and future of T-cell depletion as graft-versus-host disease prophylaxis for allogeneic hematopoietic stem cell transplantation
Clinical Trials & Observations

Vincent T. Ho,Robert J. Soiffer

View Articletitled, The history and future of T-cell depletion as graft-versus-host disease prophylaxis for allogeneic hematopoietic stem cell transplantation

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

The effect of pretransplant interferon therapy on the outcome of unrelated donor hematopoietic stem cell transplantation for patients with chronic myelogenous leukemia in first chronic phase
Clinical Trials & Observations

Stephanie J. Lee,John P. Klein,Claudio Anasetti,Joseph H. Antin,Fausto R. Loberiza,Brian J. Bolwell,Charles F. LeMaistre,Mark R. Litzow,David Marks,Edmund K. Waller,Marie Matlack,Sergio Giralt,Mary M. Horowitz

View Articletitled, The effect of pretransplant interferon therapy on the outcome of unrelated donor hematopoietic stem cell transplantation for patients with chronic myelogenous leukemia in first chronic phase

Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group study
Clinical Trials & Observations

Alan F. List,Kenneth J. Kopecky,Cheryl L. Willman,David R. Head,Diane L. Persons,Marilyn L. Slovak,Robert Dorr,Chatchada Karanes,Harry E. Hynes,James H. Doroshow,Muhammad Shurafa,Frederick R. Appelbaum

View Articletitled, Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group study

CD34 cell dose in granulocyte colony-stimulating factor–mobilized peripheral blood mononuclear cell grafts affects engraftment kinetics and development of extensive chronic graft-versus-host disease after human leukocyte antigen–identical sibling transplantation
Clinical Trials & Observations

J. Maciej Zaucha,Theodore Gooley,William I. Bensinger,Shelly Heimfeld,Thomas R. Chauncey,Renata Zaucha,Paul J. Martin,Mary E. D. Flowers,Jan Storek,George Georges,Rainer Storb,Beverly Torok-Storb

View Articletitled, CD34 cell dose in granulocyte colony-stimulating factor–mobilized peripheral blood mononuclear cell grafts affects engraftment kinetics and development of extensive chronic graft-versus-host disease after human leukocyte antigen–identical sibling transplantation

Thrombophilia in sickle cell disease: the red cell connection
Clinical Trials & Observations

B. N. Yamaja Setty,A. Koneti Rao,Marie J. Stuart

View Articletitled, Thrombophilia in sickle cell disease: the red cell connection

Identification of poor prognostic features among patients requiring mechanical ventilation after hematopoietic stem cell transplantation
Clinical Trials & Observations

Peter B. Bach,Deborah Schrag,David M. Nierman,David Horak,Peter White, Jr,James W. Young,Jeffrey S. Groeger

View Articletitled, Identification of poor prognostic features among patients requiring mechanical ventilation after hematopoietic stem cell transplantation

Thrombocytopenia caused by the development of antibodies to thrombopoietin
Clinical Trials & Observations

Junzhi Li,Chun Yang,Yuping Xia,Amy Bertino,John Glaspy,Michael Roberts,David J. Kuter

View Articletitled, Thrombocytopenia caused by the development of antibodies to thrombopoietin

Diagnostic and clinical relevance of the number of circulating CD34⁺ cells in myelofibrosis with myeloid metaplasia
Clinical Trials & Observations

Giovanni Barosi,Gianluca Viarengo,Alessandro Pecci,Vittorio Rosti,Giovanna Piaggio,Monia Marchetti,Francesco Frassoni,on behalf of the Investigators of the Italian Registry of Myelofibrosis with Myeloid Metaplasia

View Articletitled, Diagnostic and clinical relevance of the number of circulating CD34+ cells in myelofibrosis with myeloid metaplasia

Genetic variation in glycoprotein IIb/IIIa (GPIIb/IIIa) as a determinant of the responses to an oral GPIIb/IIIa antagonist in patients with unstable coronary syndromes
Clinical Trials & Observations

Fiona F. O'Connor,Denis C. Shields,Anthony Fitzgerald,Christopher P. Cannon,Eugene Braunwald,Desmond J. Fitzgerald

View Articletitled, Genetic variation in glycoprotein IIb/IIIa (GPIIb/IIIa) as a determinant of the responses to an oral GPIIb/IIIa antagonist in patients with unstable coronary syndromes

HEMATOPOIESIS

Ineffective erythropoiesis in Stat5a^−/−5b^−/− mice due to decreased survival of early erythroblasts

Merav Socolovsky,Hyung-song Nam,Mark D. Fleming,Volker H. Haase,Carlo Brugnara,Harvey F. Lodish

View Articletitled, Ineffective erythropoiesis in Stat5a−/−5b−/− mice due to decreased survival of early erythroblasts

Role of p21^Cip1/Waf1 in cell-cycle exit of endomitotic megakaryocytes

Véronique Baccini,Lydia Roy,Natacha Vitrat,Hédia Chagraoui,Siham Sabri,Jean-Pierre Le Couedic,Najet Debili,Françoise Wendling,William Vainchenker

View Articletitled, Role of p21Cip1/Waf1 in cell-cycle exit of endomitotic megakaryocytes

Notch1 inhibits differentiation of hematopoietic cells by sustaining GATA-2 expression

Keiki Kumano,Shigeru Chiba,Kiyoshi Shimizu,Tetsuya Yamagata,Noriko Hosoya,Toshiki Saito,Tokiharu Takahashi,Yoshio Hamada,Hisamaru Hirai

View Articletitled, Notch1 inhibits differentiation of hematopoietic cells by sustaining GATA-2 expression

The acute promyelocytic leukemia–associated protein, promyelocytic leukemia zinc finger, regulates 1,25-dihydroxyvitamin D₃–induced monocytic differentiation of U937 cells through a physical interaction with vitamin D₃receptor

Jeremy O. Ward,Melanie J. McConnell,Graeme W. Carlile,Pier Paolo Pandolfi,Jonathan D. Licht,Leonard P. Freedman

View Articletitled, The acute promyelocytic leukemia–associated protein, promyelocytic leukemia zinc finger, regulates 1,25-dihydroxyvitamin D3–induced monocytic differentiation of U937 cells through a physical interaction with vitamin D3receptor

Proliferation of primitive myeloid progenitors can be reversibly induced by HOXA10

Jon Mar Björnsson,Elisabet Andersson,Patrik Lundström,Nina Larsson,Xiufeng Xu,Ewa Repetowska,R. Keith Humphries,Stefan Karlsson

View Articletitled, Proliferation of primitive myeloid progenitors can be reversibly induced by HOXA10

Increased granulopoiesis through interleukin-17 and granulocyte colony-stimulating factor in leukocyte adhesion molecule–deficient mice

S. Bradley Forlow,Jill R. Schurr,Jay K. Kolls,Gregory J. Bagby,Paul O. Schwarzenberger,Klaus Ley

View Articletitled, Increased granulopoiesis through interleukin-17 and granulocyte colony-stimulating factor in leukocyte adhesion molecule–deficient mice

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Redox cycling of diaspirin cross-linked hemoglobin induces G2/M arrest and apoptosis in cultured endothelial cells

Felice D'Agnillo,Abdu I. Alayash

View Articletitled, Redox cycling of diaspirin cross-linked hemoglobin induces G2/M arrest and apoptosis in cultured endothelial cells

Response to hypoxia involves transforming growth factor-β2 and Smad proteins in human endothelial cells

Hasan O. Akman,Hong Zhang,M. A. Q. Siddiqui,William Solomon,Eric L. P. Smith,Olcay A. Batuman

View Articletitled, Response to hypoxia involves transforming growth factor-β2 and Smad proteins in human endothelial cells

Combined genomic and antisense analysis reveals that the transcription factor Erg is implicated in endothelial cell differentiation

Fiona McLaughlin,Valerie J. Ludbrook,Joanne Cox,Ira von Carlowitz,Suzy Brown,Anna M. Randi

View Articletitled, Combined genomic and antisense analysis reveals that the transcription factor Erg is implicated in endothelial cell differentiation

Blockade of adenosine diphosphate receptors P2Y₁₂ and P2Y₁ is required to inhibit platelet aggregation in whole blood under flow

Nancy A. Turner,Joel L. Moake,Larry V. McIntire

View Articletitled, Blockade of adenosine diphosphate receptors P2Y12 and P2Y1 is required to inhibit platelet aggregation in whole blood under flow

C-terminal peptide of thrombospondin-1 induces platelet aggregation through the Fc receptor γ-chain–associated signaling pathway and by agglutination

David Tulasne,Barbi A. Judd,Mette Johansen,Naoki Asazuma,Denise Best,Eric J. Brown,Mark Kahn,Gary A. Koretzky,Steve P. Watson

View Articletitled, C-terminal peptide of thrombospondin-1 induces platelet aggregation through the Fc receptor γ-chain–associated signaling pathway and by agglutination

Regulation of tissue factor gene expression in obesity

Fahumiya Samad,Manjula Pandey,David J. Loskutoff

View Articletitled, Regulation of tissue factor gene expression in obesity

IMMUNOBIOLOGY

Ex vivo priming for long-term maintenance of antileukemia human cytotoxic T cells suggests a general procedure for adoptive immunotherapy

Daniela Montagna,Rita Maccario,Franco Locatelli,Vittorio Rosti,Young Yang,Peggy Farness,Antonia Moretta,Patrizia Comoli,Enrica Montini,Antonella Vitiello

View Articletitled, Ex vivo priming for long-term maintenance of antileukemia human cytotoxic T cells suggests a general procedure for adoptive immunotherapy

Selective T-cell subset ablation demonstrates a role for T1 and T2 cells in ongoing acute graft-versus-host disease: a model system for the reversal of disease

Jinli Liu,Britt E. Anderson,Marie E. Robert,Jennifer M. McNiff,Stephen G. Emerson,Warren D. Shlomchik,Mark J. Shlomchik

View Articletitled, Selective T-cell subset ablation demonstrates a role for T1 and T2 cells in ongoing acute graft-versus-host disease: a model system for the reversal of disease

Development of thymic and splenic dendritic cell populations from different hemopoietic precursors

Li Wu,Angela D'Amico,Hubertus Hochrein,Meredith O'Keeffe,Ken Shortman,Karen Lucas

View Articletitled, Development of thymic and splenic dendritic cell populations from different hemopoietic precursors

NEOPLASIA

CD20 levels determine the in vitro susceptibility to rituximab and complement of B-cell chronic lymphocytic leukemia: further regulation by CD55 and CD59

Josée Golay,Manuela Lazzari,Valeria Facchinetti,Sergio Bernasconi,Gianmaria Borleri,Tiziano Barbui,Alessandro Rambaldi,Martino Introna

View Articletitled, CD20 levels determine the in vitro susceptibility to rituximab and complement of B-cell chronic lymphocytic leukemia: further regulation by CD55 and CD59

The TEL/PDGFβR fusion in chronic myelomonocytic leukemia signals through STAT5-dependent and STAT5-independent pathways

David W. Sternberg,Michael H. Tomasson,Martin Carroll,David P. Curley,George Barker,Michael Caprio,Alyson Wilbanks,Andrius Kazlauskas,D. Gary Gilliland

View Articletitled, The TEL/PDGFβR fusion in chronic myelomonocytic leukemia signals through STAT5-dependent and STAT5-independent pathways

Pro-B-cell to pre-B-cell development in B-lineage acute lymphoblastic leukemia expressing the MLL/AF4 fusion protein

Fred E. Bertrand,Christine Vogtenhuber,Nisha Shah,Tucker W. LeBien

View Articletitled, Pro-B-cell to pre-B-cell development in B-lineage acute lymphoblastic leukemia expressing the MLL/AF4 fusion protein

Non-Hodgkin lymphoma in HIV-infected patients in the era of highly active antiretroviral therapy

Ole Kirk,Court Pedersen,Alessandro Cozzi-Lepri,Francisco Antunes,Veronica Miller,Jose M. Gatell,Christine Katlama,Adriano Lazzarin,Peter Skinhøj,Simon E. Barton,for the EuroSIDA Study Group

View Articletitled, Non-Hodgkin lymphoma in HIV-infected patients in the era of highly active antiretroviral therapy

The BCL11 gene family: involvement of BCL11A in lymphoid malignancies

Ed Satterwhite,Takashi Sonoki,Tony G. Willis,Lana Harder,Rachael Nowak,Emma L. Arriola,Hui Liu,Helen P. Price,Stefan Gesk,Doris Steinemann,Brigitte Schlegelberger,David G. Oscier,Reiner Siebert,Philip W. Tucker,Martin J. S. Dyer

View Articletitled, The BCL11 gene family: involvement of BCL11A in lymphoid malignancies

PHAGOCYTES

Functional coupling of FcγRI to nicotinamide adenine dinucleotide phosphate (reduced form) oxidative burst and immune complex trafficking requires the activation of phospholipase D1

Alirio J. Melendez,Luce Bruetschy,R. Andres Floto,Margaret M. Harnett,Janet M. Allen

View Articletitled, Functional coupling of FcγRI to nicotinamide adenine dinucleotide phosphate (reduced form) oxidative burst and immune complex trafficking requires the activation of phospholipase D1

The cytoplasmic domain of FcγRIIA (CD32) participates in phagolysosome formation

Randall G. Worth,Laura Mayo-Bond,Moo-Kyung Kim,Jan G. J. van de Winkel,Robert F. Todd, III,Howard R. Petty,Alan D. Schreiber

View Articletitled, The cytoplasmic domain of FcγRIIA (CD32) participates in phagolysosome formation

RED CELLS

Targeted disruption of the murine Fanconi anemia gene,Fancg/Xrcc9

Yi Yang,Yanan Kuang,Rocio Montes De Oca,Tobias Hays,Lisa Moreau,Naifang Lu,Brian Seed,Alan D. D'Andrea

View Articletitled, Targeted disruption of the murine Fanconi anemia gene,Fancg/Xrcc9

De novo methylation of an embryonic globin gene during normal development is strand specific and spreads from the proximal transcribed region

Rakesh Singal,Jane M. vanWert

View Articletitled, De novo methylation of an embryonic globin gene during normal development is strand specific and spreads from the proximal transcribed region

TRANSPLANTATION

Engraftment of DLA-haploidentical marrow with ex vivo expanded, retrovirally transduced cytotoxic T lymphocytes

George E. Georges,Rainer Storb,Benedetto Bruno,Scott J. Brodie,Jennifer D. Thompson,Anna G. Taranova,J. Maciej Zaucha,Marie-Térèse Little,Eustacia Zellmer,Peter F. Moore,Theodore Gooley,George Sale,Hans-Peter Kiem,Brenda M. Sandmaier,Russette M. Lyons,Richard A. Nash

View Articletitled, Engraftment of DLA-haploidentical marrow with ex vivo expanded, retrovirally transduced cytotoxic T lymphocytes

Durable engraftment of major histocompatibility complex–incompatible cells after nonmyeloablative conditioning with fludarabine, low-dose total body irradiation, and posttransplantation cyclophosphamide

Leo Luznik,Sanju Jalla,Laura W. Engstrom,Robert Iannone,Ephraim J. Fuchs

View Articletitled, Durable engraftment of major histocompatibility complex–incompatible cells after nonmyeloablative conditioning with fludarabine, low-dose total body irradiation, and posttransplantation cyclophosphamide

Immunosuppressive properties of CD95L-transduced “killer” hybrids created by fusing donor- and recipient-derived dendritic cells

Hiroyuki Matsue,Keiko Matsue,Masahiro Kusuhara,Tadashi Kumamoto,Ko Okumura,Hideo Yagita,Akira Takashima

View Articletitled, Immunosuppressive properties of CD95L-transduced “killer” hybrids created by fusing donor- and recipient-derived dendritic cells

BRIEF REPORTS

Long-term remission of Kaposi sarcoma–associated herpesvirus-related multicentric Castleman disease with anti-CD20 monoclonal antibody therapy
Clinical Trials & Observations Brief Report

Mario Corbellino,Giovanna Bestetti,Chiara Scalamogna,Sara Calattini,Morena Galazzi,Luca Meroni,Daniele Manganaro,Marco Fasan,Mauro Moroni,Massimo Galli,Carlo Parravicini

View Articletitled, Long-term remission of Kaposi sarcoma–associated herpesvirus-related multicentric Castleman disease with anti-CD20 monoclonal antibody therapy

Macrophage inflammatory protein-1α uses a novel receptor for primitive hemopoietic cell inhibition
Brief Report

Katrin Ottersbach,Donald N. Cook,William A. Kuziel,Alison Humbles,Bao Lu,Craig Gerard,Amanda E. I. Proudfoot,Gerard J. Graham

View Articletitled, Macrophage inflammatory protein-1α uses a novel receptor for primitive hemopoietic cell inhibition

Loss of a novel tumor suppressor gene locus at chromosome 8p is associated with leukemic mantle cell lymphoma
Brief Report

Jose A. Martinez-Climent,Esperanza Vizcarra,Dolors Sanchez,David Blesa,Isabel Marugan,Isabel Benet,Françesc Sole,Francisca Rubio-Moscardo,Maria J. Terol,Joan Climent,Elena Sarsotti,Mar Tormo,Enrique Andreu,Marta Salido,Maria A. Ruiz,Felipe Prosper,Reiner Siebert,Martin J. S. Dyer,Javier Garcı́a-Conde

View Articletitled, Loss of a novel tumor suppressor gene locus at chromosome 8p is associated with leukemic mantle cell lymphoma

Increased frequencies of glutathione S-transferase(GSTM1 and GSTT1) gene deletions in Korean patients with acquired aplastic anemia
Brief Report

Kyung A. Lee,Sun Hee Kim,Hee Yeon Woo,Young Joon Hong,Hyoun Chan Cho

View Articletitled, Increased frequencies of glutathione S-transferase(GSTM1 and GSTT1) gene deletions in Korean patients with acquired aplastic anemia

Successful allogeneic engraftment of mismatched unrelated cord blood following a nonmyeloablative preparative regimen
Brief Report

David A. Rizzieri,Gwynn D. Long,James J. Vredenburgh,Christina Gasparetto,Ashley Morris,Timothy T. Stenzel,Patti Davis,Nelson J. Chao

View Articletitled, Successful allogeneic engraftment of mismatched unrelated cord blood following a nonmyeloablative preparative regimen

The association of the glycophorin C exon 3 deletion with ovalocytosis and malaria susceptibility in the Wosera, Papua New Guinea
Brief Report

Sheral S. Patel,Rajeev K. Mehlotra,William Kastens,Charles S. Mgone,James W. Kazura,Peter A. Zimmerman

View Articletitled, The association of the glycophorin C exon 3 deletion with ovalocytosis and malaria susceptibility in the Wosera, Papua New Guinea

Erythropoietin-dependent transformation of myelodysplastic syndrome to acute monoblastic leukemia
Clinical Trials & Observations Brief Report

Udomsak Bunworasate,Hilal Arnouk,Hans Minderman,Kieran L. O'Loughlin,Sheila N. J. Sait,Maurice Barcos,Carleton C. Stewart,Maria R. Baer

View Articletitled, Erythropoietin-dependent transformation of myelodysplastic syndrome to acute monoblastic leukemia

CORRESPONDENCE

Cross-contamination: HS-Sultan is not a myeloma but a Burkitt lymphoma cell line

Hans G. Drexler,Roderick A. F. MacLeod,Willy G. Dirks

View Articletitled, Cross-contamination: HS-Sultan is not a myeloma but a Burkitt lymphoma cell line

Traumatic lumbar puncture at diagnosis and outcome in childhood acute lymphoblastic leukemia

Christian Kebelmann-Betzing,Karlheinz Seeger,Renate Wolf,Günter Henze

View Articletitled, Traumatic lumbar puncture at diagnosis and outcome in childhood acute lymphoblastic leukemia

Transcobalamin polymorphism and homocysteine

Andrew McCaddon,Kaj Blennow,Peter Hudson,Björn Regland,Diane Hill

View Articletitled, Transcobalamin polymorphism and homocysteine

Dependence of age-specific incidence of acute myeloid leukemia on karyotype

Claudia Schoch,Wolfgang Kern,Peter Krawitz,Martin Dugas,Susanne Schnittger,Torsten Haferlach,Wolfgang Hiddemann

View Articletitled, Dependence of age-specific incidence of acute myeloid leukemia on karyotype

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Issue Archive

Table of Contents

INSIDE BLOOD

PLENARY PAPERS

REVIEW ARTICLES

The history and future of T-cell depletion as graft-versus-host disease prophylaxis for allogeneic hematopoietic stem cell transplantation Clinical Trials & Observations

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

The effect of pretransplant interferon therapy on the outcome of unrelated donor hematopoietic stem cell transplantation for patients with chronic myelogenous leukemia in first chronic phase Clinical Trials & Observations

Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group study Clinical Trials & Observations

CD34 cell dose in granulocyte colony-stimulating factor–mobilized peripheral blood mononuclear cell grafts affects engraftment kinetics and development of extensive chronic graft-versus-host disease after human leukocyte antigen–identical sibling transplantation Clinical Trials & Observations

Thrombophilia in sickle cell disease: the red cell connection Clinical Trials & Observations

Identification of poor prognostic features among patients requiring mechanical ventilation after hematopoietic stem cell transplantation Clinical Trials & Observations

Thrombocytopenia caused by the development of antibodies to thrombopoietin Clinical Trials & Observations

Diagnostic and clinical relevance of the number of circulating CD34+ cells in myelofibrosis with myeloid metaplasia Clinical Trials & Observations

Genetic variation in glycoprotein IIb/IIIa (GPIIb/IIIa) as a determinant of the responses to an oral GPIIb/IIIa antagonist in patients with unstable coronary syndromes Clinical Trials & Observations