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Volume 98, Issue 1

July 1 2001

In this Issue

INSIDE BLOOD
FOCUS ON HEMATOLOGY
PLENARY PAPERS
PERSPECTIVE
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
TRANSPLANTATION
BRIEF REPORTS
CORRESPONDENCE

INSIDE BLOOD

The fVIII inhibitor problem comes into focus

Pete Lollar

View Articletitled, The fVIII inhibitor problem comes into focus

FOCUS ON HEMATOLOGY

Introduction: spatial origin of murine hematopoietic stem cells

Mervin C. Yoder

View Articletitled, Introduction: spatial origin of murine hematopoietic stem cells

Generation of definitive hematopoietic stem cells from murine early yolk sac and paraaortic splanchnopleures by aorta-gonad-mesonephros region–derived stromal cells

Sahoko Matsuoka,Kohichiro Tsuji,Hiroaki Hisakawa,Ming-jiang Xu,Yasuhiro Ebihara,Takefumi Ishii,Daisuke Sugiyama,Atsushi Manabe,Ryuhei Tanaka,Yasuo Ikeda,Shigetaka Asano,Tatsutoshi Nakahata

View Articletitled, Generation of definitive hematopoietic stem cells from murine early yolk sac and paraaortic splanchnopleures by aorta-gonad-mesonephros region–derived stromal cells

PLENARY PAPERS

Structure of a factor VIII C2 domain–immunoglobulin G4κ Fab complex: identification of an inhibitory antibody epitope on the surface of factor VIII

Paul Clint Spiegel, Jr,Marc Jacquemin,Jean-Marie R. Saint-Remy,Barry L. Stoddard,Kathleen P. Pratt

View Articletitled, Structure of a factor VIII C2 domain–immunoglobulin G4κ Fab complex: identification of an inhibitory antibody epitope on the surface of factor VIII

PERSPECTIVE

Genetic hypercoagulability: screening should be an informed choice

David Green

View Articletitled, Genetic hypercoagulability: screening should be an informed choice

Genetic hypercoagulability: prevention suggests testing family members

Pier Mannuccio Mannucci

View Articletitled, Genetic hypercoagulability: prevention suggests testing family members

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Blood levels of immune cells predict survival in myeloma patients: results of an Eastern Cooperative Oncology Group phase 3 trial for newly diagnosed multiple myeloma patients
Clinical Trials & Observations

Neil E. Kay,Tracy L. Leong,Nancy Bone,David H. Vesole,Philip R. Greipp,Brian Van Ness,Martin M. Oken,Robert A. Kyle

View Articletitled, Blood levels of immune cells predict survival in myeloma patients: results of an Eastern Cooperative Oncology Group phase 3 trial for newly diagnosed multiple myeloma patients

Quantitation of minimal disease levels in chronic lymphocytic leukemia using a sensitive flow cytometric assay improves the prediction of outcome and can be used to optimize therapy
Clinical Trials & Observations

Andy C. Rawstron,Ben Kennedy,Paul A. S. Evans,Faith E. Davies,Stephen J. Richards,Andy P. Haynes,Nigel H. Russell,Geoff Hale,Gareth J. Morgan,Andrew S. Jack,Peter Hillmen

View Articletitled, Quantitation of minimal disease levels in chronic lymphocytic leukemia using a sensitive flow cytometric assay improves the prediction of outcome and can be used to optimize therapy

Platelet glycoprotein Ibα Kozak polymorphism is associated with an increased risk of ischemic stroke
Clinical Trials & Observations

Ross I. Baker,John Eikelboom,Elizabeth Lofthouse,Nicole Staples,Vahid Afshar-Kharghan,José A. López,Yang Shen,Michael C. Berndt,Graeme Hankey

View Articletitled, Platelet glycoprotein Ibα Kozak polymorphism is associated with an increased risk of ischemic stroke

Prognostic factors and response to fludarabine therapy in patients with Waldenström macroglobulinemia: results of United States intergroup trial (Southwest Oncology Group S9003)
Clinical Trials & Observations

Madhav V. Dhodapkar,Joth L. Jacobson,Morie A. Gertz,Saul E. Rivkin,G. David Roodman,Joseph M. Tuscano,Muhammad Shurafa,Robert A. Kyle,John J. Crowley,Bart Barlogie

View Articletitled, Prognostic factors and response to fludarabine therapy in patients with Waldenström macroglobulinemia: results of United States intergroup trial (Southwest Oncology Group S9003)

GENE THERAPY

Highly efficient gene delivery by mRNA electroporation in human hematopoietic cells: superiority to lipofection and passive pulsing of mRNA and to electroporation of plasmid cDNA for tumor antigen loading of dendritic cells

Viggo F. I. Van Tendeloo,Peter Ponsaerts,Filip Lardon,Griet Nijs,Marc Lenjou,Christine Van Broeckhoven,Dirk R. Van Bockstaele,Zwi N. Berneman

View Articletitled, Highly efficient gene delivery by mRNA electroporation in human hematopoietic cells: superiority to lipofection and passive pulsing of mRNA and to electroporation of plasmid cDNA for tumor antigen loading of dendritic cells

Genetically modified bone marrow continuously supplies anti-inflammatory cells and suppresses renal injury in mouse Goodpasture syndrome

Takashi Yokoo,Toya Ohashi,Yasunori Utsunomiya,Jin Song Shen,Yutaka Hisada,Yoshikatsu Eto,Tetsuya Kawamura,Tatsuo Hosoya

View Articletitled, Genetically modified bone marrow continuously supplies anti-inflammatory cells and suppresses renal injury in mouse Goodpasture syndrome

Lack of neighborhood effects from a transcriptionally active phosphoglycerate kinase–neo cassette located between the murine β-major and β-minor globin genes

Richard M. Kaufman,Zhi Hong Lu,Rajesh Behl,Jo M. Holt,Gary K. Ackers,Timothy J. Ley

View Articletitled, Lack of neighborhood effects from a transcriptionally active phosphoglycerate kinase–neo cassette located between the murine β-major and β-minor globin genes

HEMATOPOIESIS

Rescue of the colony-stimulating factor 1 (CSF-1)–nullizygous mouse (Csf1^op/Csf1^op) phenotype with a CSF-1 transgene and identification of sites of local CSF-1 synthesis

Gregory R. Ryan,Xu-Ming Dai,Melissa G. Dominguez,Wei Tong,Fenchi Chuan,Orin Chisholm,Robert G. Russell,Jeffrey W. Pollard,E. Richard Stanley

View Articletitled, Rescue of the colony-stimulating factor 1 (CSF-1)–nullizygous mouse (Csf1op/Csf1op) phenotype with a CSF-1 transgene and identification of sites of local CSF-1 synthesis

Platelet characteristics in patients with X-linked macrothrombocytopenia because of a novel GATA1mutation

Kathleen Freson,Koen Devriendt,Gert Matthijs,Achiel Van Hoof,Rita De Vos,Chantal Thys,Kristien Minner,Marc F. Hoylaerts,Jos Vermylen,Chris Van Geet

View Articletitled, Platelet characteristics in patients with X-linked macrothrombocytopenia because of a novel GATA1mutation

Highly abundant genes in the transcriptosome of human and baboon CD34 antigen-positive bone marrow cells

Ignatius Gomes,Tiffany T. Sharma,Nadim Mahmud,Jeffrey D. Kapp,Seby Edassery,Noreen Fulton,Jie Liang,Ronald Hoffman,Carol A. Westbrook

View Articletitled, Highly abundant genes in the transcriptosome of human and baboon CD34 antigen-positive bone marrow cells

Supplemental data

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Novel structurally altered P_2X1 receptor is preferentially activated by adenosine diphosphate in platelets and megakaryocytic cells

Nicholas J. Greco,Giovanni Tonon,Weidong Chen,Xunyi Luo,Rakhi Dalal,G. A. Jamieson

View Articletitled, Novel structurally altered P2X1 receptor is preferentially activated by adenosine diphosphate in platelets and megakaryocytic cells

Platelet/polymorphonuclear leukocyte adhesion: a new role for SRC kinases in Mac-1 adhesive function triggered by P-selectin: Presented in part at the 42nd Annual Meeting of the American Society of Hematology, December 1-5, 2000, San Francisco, CA.

Paola Piccardoni,Rita Sideri,Stefano Manarini,Antonio Piccoli,Nicola Martelli,Giovanni de Gaetano,Chiara Cerletti,Virgilio Evangelista

View Articletitled, Platelet/polymorphonuclear leukocyte adhesion: a new role for SRC kinases in Mac-1 adhesive function triggered by P-selectin: Presented in part at the 42nd Annual Meeting of the American Society of Hematology, December 1-5, 2000, San Francisco, CA.

Assembly of a fibronectin matrix by adherent platelets stimulated by lysophosphatidic acid and other agonists

Olufunke E. Olorundare,Olivier Peyruchaud,Ralph M. Albrecht,Deane F. Mosher

View Articletitled, Assembly of a fibronectin matrix by adherent platelets stimulated by lysophosphatidic acid and other agonists

Defective binding of factor XI–N248 to activated human platelets

Mao-Fu Sun,Frank A. Baglia,David Ho,Danko Martincic,Russell E. Ware,Peter N. Walsh,David Gailani

View Articletitled, Defective binding of factor XI–N248 to activated human platelets

Immunodominant epitopes on glycoprotein IIb-IIIa recognized by autoreactive T cells in patients with immune thrombocytopenic purpura

Masataka Kuwana,Junichi Kaburaki,Hidero Kitasato,Miyako Kato,Shinichi Kawai,Yutaka Kawakami,Yasuo Ikeda

View Articletitled, Immunodominant epitopes on glycoprotein IIb-IIIa recognized by autoreactive T cells in patients with immune thrombocytopenic purpura

IMMUNOBIOLOGY

Surgical and physical stress increases circulating blood dendritic cell counts independently of monocyte counts

Christopher S. K. Ho,Jose Alejandro López,Slavica Vuckovic,Christopher M. Pyke,Richard L. Hockey,Derek N. J. Hart

View Articletitled, Surgical and physical stress increases circulating blood dendritic cell counts independently of monocyte counts

Dysfunctional Epstein-Barr virus (EBV)–specific CD8⁺T lymphocytes and increased EBV load in HIV-1 infected individuals progressing to AIDS-related non-Hodgkin lymphoma

Debbie van Baarle,Egbert Hovenkamp,Margareth F. C. Callan,Katja C. Wolthers,Stefan Kostense,Linda C. Tan,Hubert G. M. Niesters,Albert D. M. E. Osterhaus,Andrew J. McMichael,Marinus H. J. van Oers,Frank Miedema

View Articletitled, Dysfunctional Epstein-Barr virus (EBV)–specific CD8+T lymphocytes and increased EBV load in HIV-1 infected individuals progressing to AIDS-related non-Hodgkin lymphoma

CD8 T cells specific for human immunodeficiency virus, Epstein-Barr virus, and cytomegalovirus lack molecules for homing to lymphoid sites of infection

Gang Chen,Premlata Shankar,Christoph Lange,Hernan Valdez,Paul R. Skolnik,Lijun Wu,N. Manjunath,Judy Lieberman

View Articletitled, CD8 T cells specific for human immunodeficiency virus, Epstein-Barr virus, and cytomegalovirus lack molecules for homing to lymphoid sites of infection

Molecular and flow cytometric analysis of the Vβ repertoire for clonality assessment in mature TCRαβ T-cell proliferations

Anton W. Langerak,René van den Beemd,Ingrid L. M. Wolvers-Tettero,Patrick P. C. Boor,Ellen G. van Lochem,Herbert Hooijkaas,Jacques J. M. van Dongen

View Articletitled, Molecular and flow cytometric analysis of the Vβ repertoire for clonality assessment in mature TCRαβ T-cell proliferations

Rapamycin induces apoptosis in monocyte- and CD34-derived dendritic cells but not in monocytes and macrophages

Andrea M. Woltman,Johan W. de Fijter,Sylvia W. A. Kamerling,Sandra W. van der Kooij,Leendert C. Paul,Mohamed R. Daha,Cees van Kooten

View Articletitled, Rapamycin induces apoptosis in monocyte- and CD34-derived dendritic cells but not in monocytes and macrophages

NEOPLASIA

CD38 expression as an important prognostic factor in B-cell chronic lymphocytic leukemia

Sherif Ibrahim,Michael Keating,Kim-Anh Do,Susan O'Brien,Yang O. Huh,Iman Jilani,Susan Lerner,Hagop M. Kantarjian,Maher Albitar

View Articletitled, CD38 expression as an important prognostic factor in B-cell chronic lymphocytic leukemia

Endogenous CD28 expressed on myeloma cells up-regulates interleukin-8 production: implications for multiple myeloma progression

Virginia Smith Shapiro,Marianne Newton Mollenauer,Arthur Weiss

View Articletitled, Endogenous CD28 expressed on myeloma cells up-regulates interleukin-8 production: implications for multiple myeloma progression

The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis

Stephen E. Straus,Elaine S. Jaffe,Jennifer M. Puck,Janet K. Dale,Keith B. Elkon,Angela Rösen-Wolff,Anke M. J. Peters,Michael C. Sneller,Claire W. Hallahan,Jin Wang,Roxanne E. Fischer,Christine M. Jackson,Albert Y. Lin,Caroline Bäumler,Elke Siegert,Alexander Marx,Akshay K. Vaishnaw,Tamara Grodzicky,Thomas A. Fleisher,Michael J. Lenardo

View Articletitled, The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis

EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein

Federico Simone,Paul E. Polak,Joseph J. Kaberlein,Roger T. Luo,Denise A. Levitan,Michael J. Thirman

View Articletitled, EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein

Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma

Faith E. Davies,Noopur Raje,Teru Hideshima,Suzanne Lentzsch,Gloria Young,Yu-Tzu Tai,Boris Lin,Klaus Podar,Deepak Gupta,Dharminder Chauhan,Steven P. Treon,Paul G. Richardson,Robert L. Schlossman,Gareth J. Morgan,George W. Muller,David I. Stirling,Kenneth C. Anderson

View Articletitled, Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma

Cyclin D3 at 6p21 is dysregulated by recurrent chromosomal translocations to immunoglobulin loci in multiple myeloma

John Shaughnessy, Jr,Ana Gabrea,Ying Qi,Leslie Brents,Fenghaung Zhan,Erming Tian,Jeffrey Sawyer,Bart Barlogie,P. Leif Bergsagel,Michael Kuehl

View Articletitled, Cyclin D3 at 6p21 is dysregulated by recurrent chromosomal translocations to immunoglobulin loci in multiple myeloma

TRANSPLANTATION

Intravenous injection of apoptotic leukocytes enhances bone marrow engraftment across major histocompatibility barriers

Marcelo de Carvalho Bittencourt,Sylvain Perruche,Emmanuel Contassot,Stéphanie Fresnay,Marie-Hélène Baron,Régis Angonin,François Aubin,Patrick Hervé,Pierre Tiberghien,Philippe Saas

View Articletitled, Intravenous injection of apoptotic leukocytes enhances bone marrow engraftment across major histocompatibility barriers

BRIEF REPORTS

Pharmacogenetics of methotrexate: toxicity among marrow transplantation patients varies with the methylenetetrahydrofolate reductase C677T polymorphism
Brief Report

Cornelia M. Ulrich,Yutaka Yasui,Rainer Storb,Mark M. Schubert,John L. Wagner,Jeannette Bigler,Kiley S. Ariail,Cassie L. Keener,Sue Li,Hao Liu,Federico M. Farin,John D. Potter

View Articletitled, Pharmacogenetics of methotrexate: toxicity among marrow transplantation patients varies with the methylenetetrahydrofolate reductase C677T polymorphism

Fas ligand–induced caspase-1–dependent accumulation of interleukin-18 in mice with acute graft-versus-host disease
Brief Report

Hisayuki Itoi,Yoshihiro Fujimori,Hiroko Tsutsui,Kiyoshi Matsui,Shizue Futatsugi,Haruki Okamura,Hiroshi Hara,Toshikazu Hada,Eizo Kakishita,Kenji Nakanishi

View Articletitled, Fas ligand–induced caspase-1–dependent accumulation of interleukin-18 in mice with acute graft-versus-host disease

Variable heavy-chain gene analysis of follicular lymphomas: subclone selection rather than clonal evolution over time
Brief Report

Wilhelmina M. Aarts,Richard J. Bende,Janneke G. Bossenbroek,Steven T. Pals,Carel J. M. van Noesel

View Articletitled, Variable heavy-chain gene analysis of follicular lymphomas: subclone selection rather than clonal evolution over time

Stable remission after administration of the receptor tyrosine kinase inhibitor SU5416 in a patient with refractory acute myeloid leukemia
Brief Report

Rolf M. Mesters,Teresa Padró,Ralf Bieker,Martin Steins,Michael Kreuter,Michael Göner,Stephen Kelsey,Paul Scigalla,Walter Fiedler,Thomas Büchner,Wolfgang E. Berdel

View Articletitled, Stable remission after administration of the receptor tyrosine kinase inhibitor SU5416 in a patient with refractory acute myeloid leukemia

p16^INK4a andp15^INK4b gene methylations in plasma cells from monoclonal gammopathy of undetermined significance
Brief Report

Gaëlle Guillerm,Emmanuel Gyan,Darius Wolowiec,Thierry Facon,Hervé Avet-Loiseau,Kazimierz Kuliczkowski,Francis Bauters,Pierre Fenaux,Bruno Quesnel

View Articletitled, p16INK4a andp15INK4b gene methylations in plasma cells from monoclonal gammopathy of undetermined significance

CORRESPONDENCE

T-cell clonality of undetermined significance

Edgar Dippel,Detlev Klemke,Michael Hummel,Harald Stein,Sergij Goerdt

View Articletitled, T-cell clonality of undetermined significance

Homozygous gene conversion in von Willebrand factor gene as a cause of type 3 von Willebrand disease and predisposition to inhibitor development

Gurcharan K. Surdhar,Mohammad S. Enayat,Sarah Lawson,Michael D. Williams,Frank G. H. Hill

View Articletitled, Homozygous gene conversion in von Willebrand factor gene as a cause of type 3 von Willebrand disease and predisposition to inhibitor development

A rapid and reliable 7-deletion multiplex polymerase chain reaction assay for α-thalassemia

Arnold S.-C. Tan,Thuan C. Quah,Poh S. Low,Samuel S. Chong

View Articletitled, A rapid and reliable 7-deletion multiplex polymerase chain reaction assay for α-thalassemia

Improve or abandon the standardized response criteria for myelodysplastic syndromes recommended by the International Working Group

Azra Raza

View Articletitled, Improve or abandon the standardized response criteria for myelodysplastic syndromes recommended by the International Working Group

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Issue Archive

Table of Contents

INSIDE BLOOD

FOCUS ON HEMATOLOGY

PLENARY PAPERS

PERSPECTIVE

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Blood levels of immune cells predict survival in myeloma patients: results of an Eastern Cooperative Oncology Group phase 3 trial for newly diagnosed multiple myeloma patients Clinical Trials & Observations

Quantitation of minimal disease levels in chronic lymphocytic leukemia using a sensitive flow cytometric assay improves the prediction of outcome and can be used to optimize therapy Clinical Trials & Observations

Platelet glycoprotein Ibα Kozak polymorphism is associated with an increased risk of ischemic stroke Clinical Trials & Observations

Prognostic factors and response to fludarabine therapy in patients with Waldenström macroglobulinemia: results of United States intergroup trial (Southwest Oncology Group S9003) Clinical Trials & Observations

GENE THERAPY

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

IMMUNOBIOLOGY

NEOPLASIA

TRANSPLANTATION

BRIEF REPORTS

Pharmacogenetics of methotrexate: toxicity among marrow transplantation patients varies with the methylenetetrahydrofolate reductase C677T polymorphism Brief Report

Fas ligand–induced caspase-1–dependent accumulation of interleukin-18 in mice with acute graft-versus-host disease Brief Report

Variable heavy-chain gene analysis of follicular lymphomas: subclone selection rather than clonal evolution over time Brief Report

Stable remission after administration of the receptor tyrosine kinase inhibitor SU5416 in a patient with refractory acute myeloid leukemia Brief Report

p16INK4a andp15INK4b gene methylations in plasma cells from monoclonal gammopathy of undetermined significance Brief Report