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Volume 97, Issue 6

March 15 2001

In this Issue

INSIDE BLOOD
PLENARY PAPERS
ERRATA
CHEMOKINES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
BRIEF REPORTS
CORRESPONDENCE

INSIDE BLOOD

IL-7: success without a formal education

Michael A. Caligiuri

View Articletitled, IL-7: success without a formal education

Foiling IL-6 to treat B-lymphoproliferative disorder

Virginia C. Broudy

View Articletitled, Foiling IL-6 to treat B-lymphoproliferative disorder

Boosting a natural anticoagulant

J. Evan Sadler

View Articletitled, Boosting a natural anticoagulant

PLENARY PAPERS

Interleukin-7 restores immunity in athymic T-cell–depleted hosts

Terry J. Fry,Barbara L. Christensen,Kristin L. Komschlies,Ronald E. Gress,Crystal L. Mackall

View Articletitled, Interleukin-7 restores immunity in athymic T-cell–depleted hosts

ERRATA

CHEMOKINES

Rapid mobilization of murine hematopoietic stem cells with enhanced engraftment properties and evaluation of hematopoietic progenitor cell mobilization in rhesus monkeys by a single injection of SB-251353, a specific truncated form of the human CXC chemokine GROβ

Andrew G. King,Dan Horowitz,Susan B. Dillon,Robert Levin,Ann M. Farese,Thomas J. MacVittie,Louis M. Pelus

View Articletitled, Rapid mobilization of murine hematopoietic stem cells with enhanced engraftment properties and evaluation of hematopoietic progenitor cell mobilization in rhesus monkeys by a single injection of SB-251353, a specific truncated form of the human CXC chemokine GROβ

CC chemokines and the receptors CCR3 and CCR5 are differentially expressed in the nonneoplastic leukocytic infiltrates of Hodgkin disease

Caroline Buri,Meike Körner,Patrik Schärli,Daniel Cefai,Mariagrazia Uguccioni,Christoph Mueller,Jean A. Laissue,Luca Mazzucchelli

View Articletitled, CC chemokines and the receptors CCR3 and CCR5 are differentially expressed in the nonneoplastic leukocytic infiltrates of Hodgkin disease

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Characterization of a novel autosomal dominant bleeding disorder in a large kindred from east Texas
Clinical Trials & Observations

Shao-Qing Kuang,Sumera Hasham,Martin D. Phillips,David Wolf,Ying Wan,Perumal Thiagarajan,Dianna M. Milewicz

View Articletitled, Characterization of a novel autosomal dominant bleeding disorder in a large kindred from east Texas

The effect of antiviral therapy on t(14;18) translocation and immunoglobulin gene rearrangement in patients with chronic hepatitis C virus infection
Clinical Trials & Observations

Eli Zuckerman,Tsila Zuckerman,Dvora Sahar,Sara Streichman,Dina Attias,Edmond Sabo,Daniel Yeshurun,Jacob M. Rowe

View Articletitled, The effect of antiviral therapy on t(14;18) translocation and immunoglobulin gene rearrangement in patients with chronic hepatitis C virus infection

Early detection of BCR-ABL transcripts by quantitative reverse transcriptase–polymerase chain reaction predicts outcome after allogeneic stem cell transplantation for chronic myeloid leukemia
Clinical Trials & Observations

Eduardo Olavarria,Edward Kanfer,Richard Szydlo,Jaspal Kaeda,Katayoun Rezvani,Kate Cwynarski,Christopher Pocock,Francesco Dazzi,Charles Craddock,Jane F. Apperley,Nicholas C. P. Cross,John M. Goldman

View Articletitled, Early detection of BCR-ABL transcripts by quantitative reverse transcriptase–polymerase chain reaction predicts outcome after allogeneic stem cell transplantation for chronic myeloid leukemia

Chromosome 13 abnormalities identified by FISH analysis and serum β₂-microglobulin produce a powerful myeloma staging system for patients receiving high-dose therapy
Clinical Trials & Observations

Thierry Facon,Hervé Avet-Loiseau,Gaëlle Guillerm,Philippe Moreau,Franck Geneviève,Marc Zandecki,Jean-Luc Laı̈,Xavier Leleu,Jean-Pierre Jouet,Francis Bauters,Jean-Luc Harousseau,Régis Bataille,Jean-Yves Mary,on behalf of the Intergroupe Francophone du Myélome (IFM)

View Articletitled, Chromosome 13 abnormalities identified by FISH analysis and serum β2-microglobulin produce a powerful myeloma staging system for patients receiving high-dose therapy

Unrelated marrow transplantation for adult patients with poor-risk acute lymphoblastic leukemia: strong graft-versus-leukemia effect and risk factors determining outcome
Clinical Trials & Observations

Jan J. Cornelissen,Michael Carston,Craig Kollman,Roberta King,Adriaan W. Dekker,Bob Löwenberg,Claudio Anasetti

View Articletitled, Unrelated marrow transplantation for adult patients with poor-risk acute lymphoblastic leukemia: strong graft-versus-leukemia effect and risk factors determining outcome

Mechanisms of granulocytosis in the absence of CD18
Clinical Trials & Observations

Bruce H. Horwitz,Joseph P. Mizgerd,Martin L. Scott,Claire M. Doerschuk

View Articletitled, Mechanisms of granulocytosis in the absence of CD18

Endothelial dysfunction in patients with sickle cell disease is related to selective impairment of shear stress–mediated vasodilation
Clinical Trials & Observations

Laurent Belhassen,Gabriel Pelle,Saı̈d Sediame,Dora Bachir,Claudine Carville,Catherine Bucherer,Catherine Lacombe,Frederic Galacteros,Serge Adnot

View Articletitled, Endothelial dysfunction in patients with sickle cell disease is related to selective impairment of shear stress–mediated vasodilation

Treatment of B-lymphoproliferative disorder with a monoclonal anti–interleukin-6 antibody in 12 patients: a multicenter phase 1-2 clinical trial
Clinical Trials & Observations

Elie Haddad,Sophie Paczesny,Veronique Leblond,Jean-Marie Seigneurin,Marc Stern,Antoine Achkar,Marc Bauwens,Vincent Delwail,Dominique Debray,Christophe Duvoux,Philippe Hubert,Bruno Hurault de Ligny,John Wijdenes,Anne Durandy,Alain Fischer

View Articletitled, Treatment of B-lymphoproliferative disorder with a monoclonal anti–interleukin-6 antibody in 12 patients: a multicenter phase 1-2 clinical trial

Impact of donor type on outcome of bone marrow transplantation for Wiskott-Aldrich syndrome: collaborative study of the International Bone Marrow Transplant Registry and the National Marrow Donor Program
Clinical Trials & Observations

Alexandra H. Filipovich,Judy V. Stone,Sandra C. Tomany,Michele Ireland,Craig Kollman,Corey J. Pelz,James T. Casper,Morton J. Cowan,John R. Edwards,Anders Fasth,Robert Peter Gale,Anne Junker,Naynesh R. Kamani,Brett J. Loechelt,Daniel W. Pietryga,Olle Ringdén,Marcus Vowels,Janet Hegland,Aronica V. Williams,John P. Klein,Kathleen A. Sobocinski,Philip A. Rowlings,Mary M. Horowitz

View Articletitled, Impact of donor type on outcome of bone marrow transplantation for Wiskott-Aldrich syndrome: collaborative study of the International Bone Marrow Transplant Registry and the National Marrow Donor Program

Screening for circulating galactomannan as a noninvasive diagnostic tool for invasive aspergillosis in prolonged neutropenic patients and stem cell transplantation recipients: a prospective validation
Clinical Trials & Observations

Johan Maertens,Jan Verhaegen,Katrien Lagrou,Johan Van Eldere,Marc Boogaerts

View Articletitled, Screening for circulating galactomannan as a noninvasive diagnostic tool for invasive aspergillosis in prolonged neutropenic patients and stem cell transplantation recipients: a prospective validation

GENE THERAPY

Adenovirus-mediated expression of a mutant IκB kinase 2 inhibits the response of endothelial cells to inflammatory stimuli

Wolfgang Oitzinger,Renate Hofer-Warbinek,Johannes A. Schmid,Yuri Koshelnick,Bernd R. Binder,Rainer de Martin

View Articletitled, Adenovirus-mediated expression of a mutant IκB kinase 2 inhibits the response of endothelial cells to inflammatory stimuli

Lack of dominant-negative effects of a truncated γc on retroviral-mediated gene correction of immunodeficient mice

Makoto Otsu,Kazuo Sugamura,Fabio Candotti

View Articletitled, Lack of dominant-negative effects of a truncated γc on retroviral-mediated gene correction of immunodeficient mice

In utero transplantation of fetal liver cells in the mucopolysaccharidosis type VII mouse results in low-level chimerism, but overexpression of β-glucuronidase can delay onset of clinical signs

Margret L. Casal,John H. Wolfe

View Articletitled, In utero transplantation of fetal liver cells in the mucopolysaccharidosis type VII mouse results in low-level chimerism, but overexpression of β-glucuronidase can delay onset of clinical signs

HEMATOPOIESIS

Xenotransplantation of immunodeficient mice with mobilized human blood CD34⁺ cells provides an in vivo model for human megakaryocytopoiesis and platelet production

Lia E. Perez,Henry M. Rinder,Chao Wang,Jayne B. Tracey,Noel Maun,Diane S. Krause

View Articletitled, Xenotransplantation of immunodeficient mice with mobilized human blood CD34+ cells provides an in vivo model for human megakaryocytopoiesis and platelet production

Role of double-stranded RNA-dependent protein kinase in mediating hypersensitivity of Fanconi anemia complementation group C cells to interferon γ, tumor necrosis factor-α, and double-stranded RNA

Qishen Pang,Winifred Keeble,Jane Diaz,Tracy A. Christianson,Sara Fagerlie,Keaney Rathbun,Gregory R. Faulkner,Michael O'Dwyer,Grover C. Bagby, Jr

View Articletitled, Role of double-stranded RNA-dependent protein kinase in mediating hypersensitivity of Fanconi anemia complementation group C cells to interferon γ, tumor necrosis factor-α, and double-stranded RNA

Characterization of Mpl mutants using primary megakaryocyte-lineage cells from mpl^−/−mice: a new system for Mpl structure–function studies

Meenakshi Gaur,George J. Murphy,Frederic J. deSauvage,Andrew D. Leavitt

View Articletitled, Characterization of Mpl mutants using primary megakaryocyte-lineage cells from mpl−/−mice: a new system for Mpl structure–function studies

Distinct domains of the human granulocyte-macrophage colony-stimulating factor receptor α subunit mediate activation of Jak/Stat signaling and differentiation

Michael B. Lilly,Marina Zemskova,Arthur E. Frankel,Jonathan Salo,Andrew S. Kraft

View Articletitled, Distinct domains of the human granulocyte-macrophage colony-stimulating factor receptor α subunit mediate activation of Jak/Stat signaling and differentiation

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Exogenous clustered neuropilin 1 enhances vasculogenesis and angiogenesis

Yoshihiro Yamada,Nobuyuki Takakura,Hirofumi Yasue,Hisao Ogawa,Hajime Fujisawa,Toshio Suda

View Articletitled, Exogenous clustered neuropilin 1 enhances vasculogenesis and angiogenesis

Monoclonal antibodies directed to different regions of vascular endothelial cadherin extracellular domain affect adhesion and clustering of the protein and modulate endothelial permeability

Monica Corada,Fang Liao,Maria Lindgren,Maria Grazia Lampugnani,Ferruccio Breviario,Ronald Frank,William A. Muller,Daniel J. Hicklin,Peter Bohlen,Elisabetta Dejana

View Articletitled, Monoclonal antibodies directed to different regions of vascular endothelial cadherin extracellular domain affect adhesion and clustering of the protein and modulate endothelial permeability

Endothelial cell protein C receptor plays an important role in protein C activation in vivo

Fletcher B. Taylor, Jr,Glenn T. Peer,Marion S. Lockhart,Gary Ferrell,Charles T. Esmon

View Articletitled, Endothelial cell protein C receptor plays an important role in protein C activation in vivo

CD36 associates with CD9 and integrins on human blood platelets

Wei-Min Miao,Eliza Vasile,William S. Lane,Jack Lawler

View Articletitled, CD36 associates with CD9 and integrins on human blood platelets

Serotonin induces the expression of tissue factor and plasminogen activator inhibitor-1 in cultured rat aortic endothelial cells

Hidehiko Kawano,Hajime Tsuji,Hiromi Nishimura,Shinzo Kimura,Shingo Yano,Naoki Ukimura,Yasufumi Kunieda,Masami Yoshizumi,Tatsuya Sugano,Katsumi Nakagawa,Haruchika Masuda,Shohei Sawada,Masao Nakagawa

View Articletitled, Serotonin induces the expression of tissue factor and plasminogen activator inhibitor-1 in cultured rat aortic endothelial cells

Urokinase-dependent plasminogen activation is required for efficient skeletal muscle regeneration in vivo

Frederic Lluı́s,Josep Roma,Mònica Suelves,Maribel Parra,Gloria Aniorte,Eduard Gallardo,Isabel Illa,Luciano Rodrı́guez,Simon M. Hughes,Peter Carmeliet,Manuel Roig,Pura Muñoz-Cánoves

View Articletitled, Urokinase-dependent plasminogen activation is required for efficient skeletal muscle regeneration in vivo

Tissue factor–mediated endocytosis, recycling, and degradation of factor VIIa by a clathrin-independent mechanism not requiring the cytoplasmic domain of tissue factor

Carsten B. Hansen,Charles Pyke,Lars C. Petersen,L. Vijaya Mohan Rao

View Articletitled, Tissue factor–mediated endocytosis, recycling, and degradation of factor VIIa by a clathrin-independent mechanism not requiring the cytoplasmic domain of tissue factor

Allele-dependent transcriptional regulation of the human integrin α₂ gene

Beatrice Jacquelin,Michael D. Tarantino,Marcie Kritzik,Diana Rozenshteyn,James A. Koziol,Alan T. Nurden,Thomas J. Kunicki

View Articletitled, Allele-dependent transcriptional regulation of the human integrin α2 gene

Platelet endothelial cell adhesion molecule-1 serves as an inhibitory receptor that modulates platelet responses to collagen

Sonali Patil,Debra K. Newman,Peter J. Newman

View Articletitled, Platelet endothelial cell adhesion molecule-1 serves as an inhibitory receptor that modulates platelet responses to collagen

IMMUNOBIOLOGY

Human thymus contains 2 distinct dendritic cell populations

Stéphane Vandenabeele,Hubertus Hochrein,Nasim Mavaddat,Ken Winkel,Ken Shortman

View Articletitled, Human thymus contains 2 distinct dendritic cell populations

Selective inhibition of interleukin-4 gene expression in human T cells by aspirin

Antonella Cianferoni,John T. Schroeder,Jean Kim,John W. Schmidt,Lawrence M. Lichtenstein,Steve N. Georas,Vincenzo Casolaro

View Articletitled, Selective inhibition of interleukin-4 gene expression in human T cells by aspirin

Idiotype-specific cytotoxic T lymphocytes in multiple myeloma: evidence for their capacity to lyse autologous primary tumor cells

Yue-Jin Wen,Bart Barlogie,Qing Yi

View Articletitled, Idiotype-specific cytotoxic T lymphocytes in multiple myeloma: evidence for their capacity to lyse autologous primary tumor cells

Abnormal intracellular kinetics of cell-cycle–dependent proteins in lymphocytes from patients infected with human immunodeficiency virus: a novel biologic link between immune activation, accelerated T-cell turnover, and high levels of apoptosis

Giuseppe Cannavo',Mirco Paiardini,Domenico Galati,Barbara Cervasi,Maria Montroni,Gionata De Vico,Denise Guetard,Maria L. Bocchino,Isa Picerno,Mauro Magnani,Guido Silvestri,Giuseppe Piedimonte

View Articletitled, Abnormal intracellular kinetics of cell-cycle–dependent proteins in lymphocytes from patients infected with human immunodeficiency virus: a novel biologic link between immune activation, accelerated T-cell turnover, and high levels of apoptosis

Defective development of NK1.1⁺ T-cell antigen receptor αβ⁺ cells in zeta-associated protein 70 null mice with an accumulation of NK1.1⁺CD3⁻ NK-like cells in the thymus

Kazuya Iwabuchi,Chikako Iwabuchi,Saori Tone,Daisuke Itoh,Noriko Tosa,Izumi Negishi,Kazumasa Ogasawara,Toshimitsu Uede,Kazunori Onoé

View Articletitled, Defective development of NK1.1+ T-cell antigen receptor αβ+ cells in zeta-associated protein 70 null mice with an accumulation of NK1.1+CD3− NK-like cells in the thymus

Enhanced immune activity of cytotoxic T-lymphocyte epitope analogs derived from positional scanning synthetic combinatorial libraries

Corinna La Rosa,Radhika Krishnan,Susan Markel,Jonathan P. Schneck,Richard Houghten,Clemencia Pinilla,Don J. Diamond

View Articletitled, Enhanced immune activity of cytotoxic T-lymphocyte epitope analogs derived from positional scanning synthetic combinatorial libraries

Down-regulation of CD8⁺ T-cell expansions in patients with human immunodeficiency virus infection receiving highly active combination therapy

Guy Gorochov,Avidan U. Neumann,Christophe Parizot,Taisheng Li,Christine Katlama,Patrice Debré

View Articletitled, Down-regulation of CD8+ T-cell expansions in patients with human immunodeficiency virus infection receiving highly active combination therapy

Tissue inhibitor of metalloproteinases 1 regulation of interleukin-10 in B-cell differentiation and lymphomagenesis

Liliana Guedez,Adnan Mansoor,Bente Birkedal-Hansen,Megan S. Lim,Paula Fukushima,David Venzon,William G. Stetler-Stevenson,Maryalice Stetler-Stevenson

View Articletitled, Tissue inhibitor of metalloproteinases 1 regulation of interleukin-10 in B-cell differentiation and lymphomagenesis

UVB-induced apoptosis of human dendritic cells: contribution by caspase-dependent and caspase-independent pathways

Chiara Nicolò,Barbara Tomassini,Maria Rita Rippo,Roberto Testi

View Articletitled, UVB-induced apoptosis of human dendritic cells: contribution by caspase-dependent and caspase-independent pathways

B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function

Hideto Tamura,Haidong Dong,Gefeng Zhu,Gabriel L. Sica,Dallas B. Flies,Koji Tamada,Lieping Chen

View Articletitled, B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function

Interleukin-6 is a growth factor for nonmalignant human plasmablasts

Gaëtan Jego,Régis Bataille,Catherine Pellat-Deceunynck

View Articletitled, Interleukin-6 is a growth factor for nonmalignant human plasmablasts

NEOPLASIA

Cell-cycle–dependent activation of mitogen-activated protein kinase kinase (MEK-1/2) in myeloid leukemia cell lines and induction of growth inhibition and apoptosis by inhibitors of RAS signaling

Michael A. Morgan,Oliver Dolp,Christoph W. M. Reuter

View Articletitled, Cell-cycle–dependent activation of mitogen-activated protein kinase kinase (MEK-1/2) in myeloid leukemia cell lines and induction of growth inhibition and apoptosis by inhibitors of RAS signaling

Involvement of caspase-2 long isoform in Fas-mediated cell death of human leukemic cells

Nathalie Droin,Florence Bichat,Cedric Rébé,Anne Wotawa,Olivier Sordet,Arlette Hammann,Richard Bertrand,Eric Solary

View Articletitled, Involvement of caspase-2 long isoform in Fas-mediated cell death of human leukemic cells

Lymphocyte predominance Hodgkin disease is characterized by recurrent genomic imbalances

Sabine Franke,Iwona Wlodarska,Brigitte Maes,Peter Vandenberghe,Jan Delabie,Anne Hagemeijer,Chris De Wolf-Peeters

View Articletitled, Lymphocyte predominance Hodgkin disease is characterized by recurrent genomic imbalances

PHAGOCYTES

Platelet-endothelial cell adhesion molecule-1 (PECAM-1)–deficient mice demonstrate a transient and cytokine-specific role for PECAM-1 in leukocyte migration through the perivascular basement membrane

Richard D. Thompson,Karen E. Noble,Karen Y. Larbi,Ann Dewar,Gordon S. Duncan,Tak W. Mak,Sussan Nourshargh

View Articletitled, Platelet-endothelial cell adhesion molecule-1 (PECAM-1)–deficient mice demonstrate a transient and cytokine-specific role for PECAM-1 in leukocyte migration through the perivascular basement membrane

RED CELLS

Erythroid Kruppel-like factor (EKLF) coordinates erythroid cell proliferation and hemoglobinization in cell lines derived from EKLF null mice

Elise Coghill,Sarah Eccleston,Vanessa Fox,Loretta Cerruti,Clark Brown,John Cunningham,Stephen Jane,Andrew Perkins

View Articletitled, Erythroid Kruppel-like factor (EKLF) coordinates erythroid cell proliferation and hemoglobinization in cell lines derived from EKLF null mice

Membrane instability in late-stage erythropoiesis

Richard E. Waugh,Athanassios Mantalaris,Richard G. Bauserman,William C. Hwang,J. H. David Wu

View Articletitled, Membrane instability in late-stage erythropoiesis

BRIEF REPORTS

Replicative stress after allogeneic bone marrow transplantation: changes in cycling of CD34⁺CD90⁺ and CD34⁺CD90⁻ hematopoietic progenitors
Brief Report

Ian Thornley,D. Robert Sutherland,Rakash Nayar,Lillian Sung,Melvin H. Freedman,Hans A. Messner

View Articletitled, Replicative stress after allogeneic bone marrow transplantation: changes in cycling of CD34+CD90+ and CD34+CD90− hematopoietic progenitors

Activation of multiple cryptic donor splice sites by the common congenital afibrinogenemia mutation, FGA IVS4 + 1 G→T
Brief Report

Catia Attanasio,Philippe de Moerloose,Stylianos E. Antonarakis,Michael A. Morris,Marguerite Neerman-Arbez

View Articletitled, Activation of multiple cryptic donor splice sites by the common congenital afibrinogenemia mutation, FGA IVS4 + 1 G→T

Time course of increasing numbers of mutations in the granulocyte colony-stimulating factor receptor gene in a patient with congenital neutropenia who developed leukemia
Brief Report

Christoph A. Tschan,Christina Pilz,Cornelia Zeidler,Karl Welte,Manuela Germeshausen

View Articletitled, Time course of increasing numbers of mutations in the granulocyte colony-stimulating factor receptor gene in a patient with congenital neutropenia who developed leukemia

Acquired factor X deficiency in patients with amyloid light-chain amyloidosis: incidence, bleeding manifestations, and response to high-dose chemotherapy
Clinical Trials & Observations Brief Report

Elie B. Choufani,Vaishali Sanchorawala,Timothy Ernst,Karen Quillen,Martha Skinner,Daniel G. Wright,David C. Seldin

View Articletitled, Acquired factor X deficiency in patients with amyloid light-chain amyloidosis: incidence, bleeding manifestations, and response to high-dose chemotherapy

The effect of multidrug-resistance 1 gene versus neotransduction on ex vivo and in vivo expansion of rhesus macaque hematopoietic repopulating cells
Brief Report

Stephanie E. Sellers,John F. Tisdale,Brian A. Agricola,Mark E. Metzger,Robert E. Donahue,Cynthia E. Dunbar,Brian P. Sorrentino

View Articletitled, The effect of multidrug-resistance 1 gene versus neotransduction on ex vivo and in vivo expansion of rhesus macaque hematopoietic repopulating cells

CORRESPONDENCE

CD38 expression is a poor predictor for V_H gene mutational status and prognosis in chronic lymphocytic leukemia

Ulf Thunberg,Anna Johnson,Göran Roos,Ingrid Thörn,Gerard Tobin,Jan Sällström,Christer Sundström,Richard Rosenquist

View Articletitled, CD38 expression is a poor predictor for VH gene mutational status and prognosis in chronic lymphocytic leukemia

Factor XIIIV34L is not an additional genetic risk factor for venous thrombosis in Factor V Leiden carriers

Pierre E. Morange,Mireille Henry,Dominique Brunet,Marie-Françoise Aillaud,Irène Juhan-Vague

View Articletitled, Factor XIIIV34L is not an additional genetic risk factor for venous thrombosis in Factor V Leiden carriers

Clinical and bone marrow effects of interferon alfa therapy in myelofibrosis with myeloid metaplasia

Ayalew Tefferi,Michelle A. Elliott,Soo-Young Yoon,Chin-Yang Li,Ruben A. Mesa,Timothy G. Call,Angela Dispenzieri

View Articletitled, Clinical and bone marrow effects of interferon alfa therapy in myelofibrosis with myeloid metaplasia

Radiation-induced leukemia

Stuart C. Finch

View Articletitled, Radiation-induced leukemia

Criteria for the diagnosis of acute megakaryocytic leukemia

James A. Strauchen

View Articletitled, Criteria for the diagnosis of acute megakaryocytic leukemia

T-cell apoptosis in HIV-1–infected individuals receiving highly active antiretroviral therapy

Thomas Böhler,Klaus-Michael Debatin,Uwe Wintergerst

View Articletitled, T-cell apoptosis in HIV-1–infected individuals receiving highly active antiretroviral therapy

ALK is not expressed in Hodgkin disease

Sophie Camilleri-Broët,Josée Audouin,Christophe Fermé,Josette Brière,Karen Pulford,Philippe Gaulard,Marine Diviné,Elizabeth Macintyre,Georges Delsol,Françoise Berger

View Articletitled, ALK is not expressed in Hodgkin disease

CD38 expression and Ig V_H gene mutation in B-cell chronic lymphocytic leukemia

Zoltan Matrai,Ke Lin,Michael Dennis,Paul Sherrington,Mirko Zuzel,Andrew R Pettitt,John C. Cawley

View Articletitled, CD38 expression and Ig VH gene mutation in B-cell chronic lymphocytic leukemia

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Issue Archive

Table of Contents

INSIDE BLOOD

PLENARY PAPERS

ERRATA

CHEMOKINES

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Characterization of a novel autosomal dominant bleeding disorder in a large kindred from east Texas Clinical Trials & Observations

The effect of antiviral therapy on t(14;18) translocation and immunoglobulin gene rearrangement in patients with chronic hepatitis C virus infection Clinical Trials & Observations

Early detection of BCR-ABL transcripts by quantitative reverse transcriptase–polymerase chain reaction predicts outcome after allogeneic stem cell transplantation for chronic myeloid leukemia Clinical Trials & Observations

Chromosome 13 abnormalities identified by FISH analysis and serum β2-microglobulin produce a powerful myeloma staging system for patients receiving high-dose therapy Clinical Trials & Observations

Unrelated marrow transplantation for adult patients with poor-risk acute lymphoblastic leukemia: strong graft-versus-leukemia effect and risk factors determining outcome Clinical Trials & Observations

Mechanisms of granulocytosis in the absence of CD18 Clinical Trials & Observations

Endothelial dysfunction in patients with sickle cell disease is related to selective impairment of shear stress–mediated vasodilation Clinical Trials & Observations

Treatment of B-lymphoproliferative disorder with a monoclonal anti–interleukin-6 antibody in 12 patients: a multicenter phase 1-2 clinical trial Clinical Trials & Observations

Impact of donor type on outcome of bone marrow transplantation for Wiskott-Aldrich syndrome: collaborative study of the International Bone Marrow Transplant Registry and the National Marrow Donor Program Clinical Trials & Observations

Screening for circulating galactomannan as a noninvasive diagnostic tool for invasive aspergillosis in prolonged neutropenic patients and stem cell transplantation recipients: a prospective validation Clinical Trials & Observations