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Issue Archive

Volume 97, Issue 5
March 1 2001
Blood Cover Image for Volume 97, Issue 5

Table of Contents

INSIDE BLOOD

Multiple myeloma: multiple ways to defeat erythropoiesis
Kenneth Kaushansky
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Treating nonhematologic disorders with hematologic stem cells: can this work?
Charles L. Sawyers
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Viral load monitoring in transplant recipients
Lode J. Swinnen
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PLENARY PAPERS

Fas-L up-regulation by highly malignant myeloma plasma cells: role in the pathogenesis of anemia and disease progression
Franco Silvestris,Marco Tucci,Paola Cafforio,Franco Dammacco
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Frequent monitoring of Epstein-Barr virus DNA load in unfractionated whole blood is essential for early detection of posttransplant lymphoproliferative disease in high-risk patients
Clinical Trials & Observations
Servi J. C. Stevens,Erik A. M. Verschuuren,Inge Pronk,Wim van der Bij,Martin C. Harmsen,T. Hauw The,Chris J. L. M. Meijer,Adriaan J. C. van den Brule,Jaap M. Middeldorp
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Expression of DNA methyltransferases DNMT1,3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia
Shin-ichi Mizuno,Takahito Chijiwa,Takashi Okamura,Koichi Akashi,Yasuyuki Fukumaki,Yoshiyuki Niho,Hiroyuki Sasaki
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ERRATA

Erratum for vol. 97, p. 1
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REVIEW ARTICLES

Deleterious clinical effects of transfusion-associated immunomodulation: fact or fiction?
Clinical Trials & Observations
Eleftherios C. Vamvakas,Morris A. Blajchman
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HOW I TREAT

How I treat chronic graft-versus-host disease
Georgia B. Vogelsang
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CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Serum nm23-H1 protein as a prognostic factor in aggressive non-Hodgkin lymphoma
Clinical Trials & Observations
Nozomi Niitsu,Junko Okabe-Kado,Masataka Okamoto,Toshiyuki Takagi,Takashi Yoshida,Sadao Aoki,Masami Hirano,Yoshio Honma
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Improved outcome for children with acute lymphoblastic leukemia: results of Dana-Farber Consortium Protocol 91-01
Clinical Trials & Observations
Lewis B. Silverman,Richard D. Gelber,Virginia Kimball Dalton,Barbara L. Asselin,Ronald D. Barr,Luis A. Clavell,Craig A. Hurwitz,Albert Moghrabi,Yvan Samson,Marshall A. Schorin,Steven Arkin,Lieven Declerck,Harvey J. Cohen,Stephen E. Sallan
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Development of a prognostic model for grading chronic graft-versus-host disease
Clinical Trials & Observations
Görgün Akpek,Marianna L. Zahurak,Steven Piantadosi,Jeffrey Margolis,Jon Doherty,Robert Davidson,Georgia B. Vogelsang
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Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta
Clinical Trials & Observations
Edwin M. Horwitz,Darwin J. Prockop,Patricia L. Gordon,Winston W. K. Koo,Lorraine A. Fitzpatrick,Michael D. Neel,M. Elizabeth McCarville,Paul J. Orchard,Reed E. Pyeritz,Malcolm K. Brenner
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Direct visualization of cytomegalovirus-specific T-cell reconstitution after allogeneic stem cell transplantation
Clinical Trials & Observations
Kate Cwynarski,Jenni Ainsworth,Mark Cobbold,Simon Wagner,Prem Mahendra,Jane Apperley,John Goldman,Charles Craddock,Paul A. H. Moss
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Differentiation of Langerhans cells in Langerhans cell histiocytosis
Clinical Trials & Observations
Frederic Geissmann,Yves Lepelletier,Sylvie Fraitag,Jenny Valladeau,Christine Bodemer,Marianne Debré,Michelle Leborgne,Sem Saeland,Nicole Brousse
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GENE THERAPY

A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease
Daniel C. Thomis,Sarah Marktel,Chiara Bonini,Catia Traversari,Michael Gilman,Claudio Bordignon,Tim Clackson
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Factors influencing in vivo transduction by recombinant adeno-associated viral vectors expressing the human factor IX cDNA
Amit C. Nathwani,Andrew Davidoff,Hideki Hanawa,Jun-Fang Zhou,Elio F. Vanin,Arthur W. Nienhuis
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HEMATOPOIESIS

Initiation of polyoma virus origin-dependent DNA replication through STAT5 activation by human granulocyte-macrophage colony-stimulating factor
Sumiko Watanabe,Rong Zeng,Yutaka Aoki,Tohru Itoh,Ken-ichi Arai
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Assessment of mechanism of acquired skewed X inactivation by analysis of twins
Mark A. Vickers,Ewan McLeod,Timothy D. Spector,Ian J. Wilson
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Synergistic mobilization of hemopoietic progenitor cells using concurrent β1 and β2 integrin blockade or β2-deficient mice
Thalia Papayannopoulou,Gregory V. Priestley,Betty Nakamoto,Vivian Zafiropoulos,Linda M. Scott,John M. Harlan
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Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3–dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation
Chi-Wu Chiang,Gregory Harris,Cindy Ellig,Shane C. Masters,Romesh Subramanian,Shirish Shenolikar,Brian E. Wadzinski,Elizabeth Yang
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Early growth response gene 1 stimulates development of hematopoietic progenitor cells along the macrophage lineage at the expense of the granulocyte and erythroid lineages
Kandasamy Krishnaraju,Barbara Hoffman,Dan A. Liebermann
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Unique effects of zinc protoporphyrin on HO-1 induction and apoptosis
Guang Yang,Xuandai Nguyen,Judy Ou,Prasad Rekulapelli,David K. Stevenson,Phyllis A. Dennery
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Positive and negative regulation of granulopoiesis by endogenous RARα
Philippe Kastner,H. Jeffrey Lawrence,Caroline Waltzinger,Norbert B. Ghyselinck,Pierre Chambon,Susan Chan
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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

A permissive role for tumor necrosis factor in vascular endothelial growth factor–induced vascular permeability
Matthias Clauss,Cord Sunderkötter,Baldur Sveinbjörnsson,Stefan Hippenstiel,Antje Willuweit,Michael Marino,Elvira Haas,Rolf Seljelid,Peter Scheurich,Norbert Suttorp,Matthias Grell,Werner Risau
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Autosomal dominant macrothrombocytopenia in Italy is most frequently a type of heterozygous Bernard-Soulier syndrome
Anna Savoia,Carlo L. Balduini,Maria Savino,Patrizia Noris,Maria Del Vecchio,Silverio Perrotta,Simona Belletti,Vincenzo Poggi,Achille Iolascon
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IMMUNOBIOLOGY

Dissociation of thymic positive and negative selection in transgenic mice expressing major histocompatibility complex class I molecules exclusively on thymic cortical epithelial cells
Myriam Capone,Paola Romagnoli,Friedrich Beermann,H. Robson MacDonald,Joost P. M. van Meerwijk
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SHIP's C-terminus is essential for its hydrolysis of PIP3 and inhibition of mast cell degranulation
Jacqueline E. Damen,Mark D. Ware,Janet Kalesnikoff,Michael R. Hughes,Gerald Krystal
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SH2 domain–mediated targeting, but not localization, of Syk in the plasma membrane is critical for FcεRI signaling
Kiyonao Sada,Juan Zhang,Reuben P. Siraganian
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Thymic emigrants isolated by a new method possess unique phenotypic and functional properties
Chong-kil Lee,Kyungjae Kim,Lisbeth A. Welniak,William J. Murphy,Kathrin Muegge,Scott K. Durum
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NEOPLASIA

Idiotype-encoding recombinant adenoviruses provide protective immunity against murine B-cell lymphomas
John M. Timmerman,Clemens B. Caspar,Stacie L. Lambert,Athanasia D. Syrengelas,Ronald Levy
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Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3
Thomas Wieder,Frank Essmann,Aram Prokop,Karin Schmelz,Klaus Schulze-Osthoff,Rudi Beyaert,Bernd Dörken,Peter T. Daniel
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CD4+ cutaneous T-cell lymphoma cells express the p140–killer cell immunoglobulin-like receptor
Martine Bagot,Alessandro Moretta,Simona Sivori,Roberto Biassoni,Claudia Cantoni,Cristina Bottino,Laurence Boumsell,Armand Bensussan
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Homodimers but not monomers of Rituxan (chimeric anti-CD20) induce apoptosis in human B-lymphoma cells and synergize with a chemotherapeutic agent and an immunotoxin
Maria-Ana Ghetie,Helen Bright,Ellen S. Vitetta
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Treatment of Bcr/Abl-positive acute lymphoblastic leukemia in P190 transgenic mice with the farnesyl transferase inhibitor SCH66336
Anja Reichert,Nora Heisterkamp,George Q. Daley,John Groffen
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Activity of the farnesyl protein transferase inhibitor SCH66336 against BCR/ABL-induced murine leukemia and primary cells from patients with chronic myeloid leukemia
David G. Peters,Russell R. Hoover,Melissa J. Gerlach,Eugene Y. Koh,Haiyan Zhang,Kevin Choe,Paul Kirschmeier,W. Robert Bishop,George Q. Daley
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The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts
Beverly D. Smolich,Helene A. Yuen,Kristina A. West,Francis J. Giles,Maher Albitar,Julie M. Cherrington
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Low NAD(P)H:quinone oxidoreductase 1 activity is associated with increased risk of acute leukemia in adults
Martyn T. Smith,Yunxia Wang,Eleanor Kane,Sara Rollinson,Joseph L. Wiemels,Eve Roman,Philippa Roddam,Raymond Cartwright,Gareth Morgan
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Vascular endothelial cell growth factor is an autocrine promoter of abnormal localized immature myeloid precursors and leukemia progenitor formation in myelodysplastic syndromes
William T. Bellamy,Lynne Richter,Davuud Sirjani,Concepcion Roxas,Betty Glinsmann-Gibson,Yvette Frutiger,Thomas M. Grogan,Alan F. List
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Induction of myeloproliferative disease in mice by tyrosine kinase fusion oncogenes does not require granulocyte-macrophage colony-stimulating factor or interleukin-3
Michael H. Tomasson,Ifor R. Williams,Shaoguang Li,Jeffrey Kutok,Danielle Cain,Silke Gillessen,Glenn Dranoff,Richard A. Van Etten,D. Gary Gilliland
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Interleukin 3 and granulocyte-macrophage colony-stimulating factor are not required for induction of chronic myeloid leukemia-like myeloproliferative disease in mice by BCR/ABL
Shaoguang Li,Silke Gillessen,Michael H. Tomasson,Glenn Dranoff,D. Gary Gilliland,Richard A. Van Etten
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RED CELLS

Treatment with NS3623, a novel Cl-conductance blocker, ameliorates erythrocyte dehydration in transgenic SAD mice: a possible new therapeutic approach for sickle cell disease
Poul Bennekou,Lucia de Franceschi,Ove Pedersen,Lurong Lian,Toshio Asakura,Greg Evans,Carlo Brugnara,Palle Christophersen
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TRANSPLANTATION

Factors affecting thymic function after allogeneic hematopoietic stem cell transplantation
Kenneth Weinberg,Bruce R. Blazar,John E. Wagner,Edward Agura,Brenna J. Hill,Monika Smogorzewska,Richard A. Koup,Michael R. Betts,Robert H. Collins,Daniel C. Douek
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Posttransplantation lymphoproliferative disease in miniature swine after allogeneic hematopoietic cell transplantation: similarity to human PTLD and association with a porcine gammaherpesvirus
Christene A. Huang,Yasushi Fuchimoto,Zachary L. Gleit,Thomas Ericsson,Adam Griesemer,Rachel Scheier-Dolberg,Elizabeth Melendy,Hiroshi Kitamura,Jay A. Fishman,Judith A. Ferry,Nancy Lee Harris,Clive Patience,David H. Sachs
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In vitro tumor-pulsed or in vivo Flt3 ligand–generated dendritic cells provide protection against acute myelogenous leukemia in nontransplanted or syngeneic bone marrow–transplanted mice
Anna B. Pawlowska,Satoshi Hashino,Hilary McKenna,Brenda J. Weigel,Patricia A. Taylor,Bruce R. Blazar
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Defective antifungal T-helper 1 (TH1) immunity in a murine model of allogeneic T-cell–depleted bone marrow transplantation and its restoration by treatment with TH2 cytokine antagonists
Antonella Mencacci,Katia Perruccio,Angela Bacci,Elio Cenci,Roberta Benedetti,Massimo F. Martelli,Francesco Bistoni,Robert Coffman,Andrea Velardi,Luigina Romani
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IL-7 increases both thymic-dependent and thymic-independent T-cell regeneration after bone marrow transplantation
Crystal L. Mackall,Terry J. Fry,Cathy Bare,Paul Morgan,Anne Galbraith,Ronald E. Gress
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Nonablative neonatal marrow transplantation attenuates functional and physical defects of β-glucuronidase deficiency
Brian W. Soper,Mark D. Lessard,Carole A. Vogler,Beth Levy,Wesley G. Beamer,William S. Sly,Jane E. Barker
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BRIEF REPORTS

The interphase microtubule damage checkpoint defines an S-phase commitment point and does not requirep21waf-1
Brief Report
Charlie R. Mantel,Stephen E. Braun,Younghee Lee,Young-June Kim,Hal E. Broxmeyer
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Sperm protein 17 is a novel cancer-testis antigen in multiple myeloma
Brief Report
Seah H. Lim,Zhiqing Wang,Maurizio Chiriva-Internati,Yuying Xue
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The diversity of rearranged immunoglobulin heavy chain variable region genes in peripheral blood B cells of preterm infants is restricted by short third complementarity-determining regions but not by limited gene segment usage
Brief Report
Michael Zemlin,Karl Bauer,Michael Hummel,Sabine Pfeiffer,Simone Devers,Cosima Zemlin,Harald Stein,Hans T. Versmold
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Torsades de pointes in 3 patients with leukemia treated with arsenic trioxide
Brief Report
Dilip Unnikrishnan,Janice P. Dutcher,Nikita Varshneya,Richard Lucariello,Marietta Api,Susan Garl,Peter H. Wiernik,Salvatore Chiaramida
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CORRESPONDENCE

Recurrent ATM mutations in T-PLL on diverse haplotypes: no support for their germline origin
Tatjana Stankovic,A. Malcolm R. Taylor,Martin R. Yuille,Igor Vorechovsky
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Locus-specific regulation of HLA-A and HLA-B expression is not determined by nucleotide variation in the X2 box promoter element
Sam J. P. Gobin,Peter J. van den Elsen
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All Issues

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A phase 2 randomized study of modakafusp alfa as a single agent in patients with relapsed/refractory multiple myeloma
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