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Volume 97, Issue 4

February 15 2001

In this Issue

PLENARY PAPERS
RETRACTIONS
CHEMOKINES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSPLANTATION
BRIEF REPORTS

When magic bullets miss their mark

Hyam I. Levitsky

View Articletitled, When magic bullets miss their mark

Receptor trees in chemokine forests

Robert Hromas

View Articletitled, Receptor trees in chemokine forests

Gene therapy to re-establish self-tolerance

Richard K. Burt

View Articletitled, Gene therapy to re-establish self-tolerance

PLENARY PAPERS

An Epstein-Barr virus deletion mutant associated with fatal lymphoproliferative disease unresponsive to therapy with virus-specific CTLs

Stephen Gottschalk,Catherine Y. C. Ng,Margot Perez,Colton A. Smith,Clare Sample,Malcolm K. Brenner,Helen E. Heslop,Cliona M. Rooney

View Articletitled, An Epstein-Barr virus deletion mutant associated with fatal lymphoproliferative disease unresponsive to therapy with virus-specific CTLs

Acquired activated protein C resistance is associated with lupus anticoagulants and thrombotic events in pediatric patients with systemic lupus erythematosus

Christoph Male,Lesley Mitchell,James Julian,Patricia Vegh,Penny Joshua,Margaret Adams,Michelle David,Maureen E. Andrew

View Articletitled, Acquired activated protein C resistance is associated with lupus anticoagulants and thrombotic events in pediatric patients with systemic lupus erythematosus

RETRACTIONS

Retraction

View Articletitled, Retraction

CHEMOKINES

Expression of CCR9 β-chemokine receptor is modulated in thymocyte differentiation and is selectively maintained in CD8⁺ T cells from secondary lymphoid organs

Laura Carramolino,Ángel Zaballos,Leonor Kremer,Ricardo Villares,Pilar Martı́n,Carlos Ardavı́n,Carlos Martı́nez-A,Gabriel Márquez

View Articletitled, Expression of CCR9 β-chemokine receptor is modulated in thymocyte differentiation and is selectively maintained in CD8+ T cells from secondary lymphoid organs

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Risk of recurrent venous thrombosis in children with combined prothrombotic risk factors
Clinical Trials & Observations

Ulrike Nowak-Göttl,Ralf Junker,Wolfhart Kreuz,Arnold von Eckardstein,Andrea Kosch,Natascha Nohe,Rosemarie Schobess,Silke Ehrenforth,for the Childhood Thrombophilia Study Group

View Articletitled, Risk of recurrent venous thrombosis in children with combined prothrombotic risk factors

Long-term use of anagrelide in young patients with essential thrombocythemia
Clinical Trials & Observations

Elizabeth C. Storen,Ayalew Tefferi

View Articletitled, Long-term use of anagrelide in young patients with essential thrombocythemia

Rising pp65 antigenemia during preemptive anticytomegalovirus therapy after allogeneic hematopoietic stem cell transplantation: risk factors, correlation with DNA load, and outcomes
Clinical Trials & Observations

W. Garrett Nichols,Lawrence Corey,Ted Gooley,W. Lawrence Drew,Richard Miner,Meei-Li Huang,Chris Davis,Michael Boeckh

View Articletitled, Rising pp65 antigenemia during preemptive anticytomegalovirus therapy after allogeneic hematopoietic stem cell transplantation: risk factors, correlation with DNA load, and outcomes

The Kozak sequence polymorphism of platelet glycoprotein Ibα and risk of nonfatal myocardial infarction and nonfatal stroke in young women
Clinical Trials & Observations

Michele B. Frank,Alexander P. Reiner,Stephen M. Schwartz,Prasanna N. Kumar,Rachel M. Pearce,Patrick G. Arbogast,W. T. Longstreth, Jr,Frits R. Rosendaal,Bruce M. Psaty,David S. Siscovick

View Articletitled, The Kozak sequence polymorphism of platelet glycoprotein Ibα and risk of nonfatal myocardial infarction and nonfatal stroke in young women

Human equivalent of the mouse Nude/SCID phenotype: long-term evaluation of immunologic reconstitution after bone marrow transplantation
Clinical Trials & Observations

Claudio Pignata,Lucia Gaetaniello,Anna Maria Masci,Jorge Frank,Angela Christiano,Eliana Matrecano,Luigi Racioppi

View Articletitled, Human equivalent of the mouse Nude/SCID phenotype: long-term evaluation of immunologic reconstitution after bone marrow transplantation

GENE THERAPY

A gene therapy approach for treating T-cell–mediated autoimmune diseases

Chiann-Chyi Chen,Amariliz Rivera,Naomi Ron,Joseph P. Dougherty,Yacov Ron

View Articletitled, A gene therapy approach for treating T-cell–mediated autoimmune diseases

HEMATOPOIESIS

Telomere length in leukocyte subpopulations of patients with aplastic anemia

Tim H. Brümmendorf,Jaroslaw P. Maciejewski,Jennifer Mak,Neal S. Young,Peter M. Lansdorp

View Articletitled, Telomere length in leukocyte subpopulations of patients with aplastic anemia

mDYRK3 kinase is expressed selectively in late erythroid progenitor cells and attenuates colony-forming unit–erythroid development

Justin N. Geiger,Geoffry T. Knudsen,Leigh Panek,Ajay K. Pandit,Michael D. Yoder,Kenneth A. Lord,Caretha L. Creasy,Brian M. Burns,Peter Gaines,Susan B. Dillon,Don M. Wojchowski

View Articletitled, mDYRK3 kinase is expressed selectively in late erythroid progenitor cells and attenuates colony-forming unit–erythroid development

Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development

Cheng-Kui Qu,Suzanne Nguyen,Jianzhu Chen,Gen-Sheng Feng

View Articletitled, Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development

New insights into the thrombopoietic status of patients on dialysis through the evaluation of megakaryocytopoiesis in bone marrow and of endogenous thrombopoietin levels
Clinical Trials & Observations

Minoru Ando,Yuhsuke Iwamoto,Akio Suda,Ken Tsuchiya,Hiroshi Nihei

View Articletitled, New insights into the thrombopoietic status of patients on dialysis through the evaluation of megakaryocytopoiesis in bone marrow and of endogenous thrombopoietin levels

Overlapping roles for granulocyte-macrophage colony-stimulating factor and interleukin-3 in eosinophil homeostasis and contact hypersensitivity

Silke Gillessen,Nicolas Mach,Clayton Small,Martin Mihm,Glenn Dranoff

View Articletitled, Overlapping roles for granulocyte-macrophage colony-stimulating factor and interleukin-3 in eosinophil homeostasis and contact hypersensitivity

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Alboaggregin A activates platelets by a mechanism involving glycoprotein VI as well as glycoprotein Ib

Dagmar Dörmann,Jeannine M. Clemetson,Alexei Navdaev,Beate E. Kehrel,Kenneth J. Clemetson

View Articletitled, Alboaggregin A activates platelets by a mechanism involving glycoprotein VI as well as glycoprotein Ib

Adenosine diphosphate strongly potentiates the ability of the chemokines MDC, TARC, and SDF-1 to stimulate platelet function

Adrian R. L. Gear,Sudawadee Suttitanamongkol,Delia Viisoreanu,Renata K. Polanowska-Grabowska,Sanghamitra Raha,David Camerini

View Articletitled, Adenosine diphosphate strongly potentiates the ability of the chemokines MDC, TARC, and SDF-1 to stimulate platelet function

Regulation of human coagulation factor X gene expression by GATA-4 and the Sp family of transcription factors

Hsiao-Ling Hung,Eleanor S. Pollak,Rama D. Kudaravalli,Valder Arruda,Kirk Chu,Katherine A. High

View Articletitled, Regulation of human coagulation factor X gene expression by GATA-4 and the Sp family of transcription factors

The arginine-552-cysteine (R1315C) mutation within the A1 loop of von Willebrand factor induces an abnormal folding with a loss of function resulting in type 2A–like phenotype of von Willebrand disease: study of 10 patients and mutated recombinant von Willebrand factor

Anne-Sophie Ribba,Lysiane Hilbert,Jean-Maurice Lavergne,Edith Fressinaud,Catherine Boyer-Neumann,Catherine Ternisien,Irène Juhan-Vague,Jenny Goudemand,Jean-Pierre Girma,Claudine Mazurier,Dominique Meyer

View Articletitled, The arginine-552-cysteine (R1315C) mutation within the A1 loop of von Willebrand factor induces an abnormal folding with a loss of function resulting in type 2A–like phenotype of von Willebrand disease: study of 10 patients and mutated recombinant von Willebrand factor

Abnormal secretion and function of recombinant human factor VII as the result of modification to a calcium binding site caused by a 15–base pair insertion in the F7 gene

Flora Peyvandi,Josephine A. Carew,David J. Perry,Mathilde Hunault,Uma Khanduri,Stephen J. Perkins,Pier M. Mannucci,Kenneth A. Bauer

View Articletitled, Abnormal secretion and function of recombinant human factor VII as the result of modification to a calcium binding site caused by a 15–base pair insertion in the F7 gene

Multiple VH genes are used to assemble human antibodies directed toward the A3-C1 domains of factor VIII

Edward N. van den Brink,Ellen A. M. Turenhout,Niels Bovenschen,Bram G. A. D. H. Heijnen,Koen Mertens,Marjolein Peters,Jan Voorberg

View Articletitled, Multiple VH genes are used to assemble human antibodies directed toward the A3-C1 domains of factor VIII

Aberrant fibrin formation and cross-linking of fibrinogen Nieuwegein, a variant with a shortened Aα-chain, alters endothelial capillary tube formation

Annemie Collen,Annemarie Maas,Teake Kooistra,Florea Lupu,Jos Grimbergen,Fred J. L. M. Haas,Douwe H. Biesma,Pieter Koolwijk,Jaap Koopman,Victor W. M. van Hinsbergh

View Articletitled, Aberrant fibrin formation and cross-linking of fibrinogen Nieuwegein, a variant with a shortened Aα-chain, alters endothelial capillary tube formation

Lipoprotein (a) up-regulates the expression of the plasminogen activator inhibitor 2 in human blood monocytes

Christa Buechler,Heidrun Ullrich,Mirko Ritter,Mustafa Porsch-Oezcueruemez,Karl J. Lackner,Stefan Barlage,Sven Olaf Friedrich,Gert M. Kostner,Gerd Schmitz

View Articletitled, Lipoprotein (a) up-regulates the expression of the plasminogen activator inhibitor 2 in human blood monocytes

IMMUNOBIOLOGY

Existence of escape mutant in HTLV-I tax during the development of adult T-cell leukemia

Yoshitaka Furukawa,Ryuji Kubota,Mitsutoshi Tara,Shuji Izumo,Mitsuhiro Osame

View Articletitled, Existence of escape mutant in HTLV-I tax during the development of adult T-cell leukemia

Induction of cytomegalovirus (CMV)–specific T-cell responses using dendritic cells pulsed with CMV antigen: a novel culture system free of live CMV virions

Karl Peggs,Stephanie Verfuerth,Stephen Mackinnon

View Articletitled, Induction of cytomegalovirus (CMV)–specific T-cell responses using dendritic cells pulsed with CMV antigen: a novel culture system free of live CMV virions

Ordered recombination of immunoglobulin light chain genes occurs at the IGK locus but seems less strict at theIGL locus

Mirjam van der Burg,Talip Tümkaya,Marjan Boerma,Sandra de Bruin-Versteeg,Anton W. Langerak,Jacques J. M. van Dongen

View Articletitled, Ordered recombination of immunoglobulin light chain genes occurs at the IGK locus but seems less strict at theIGL locus

Accumulation of HIF-1α under the influence of nitric oxide

Katrin Britta Sandau,Joachim Fandrey,Bernhard Brüne

View Articletitled, Accumulation of HIF-1α under the influence of nitric oxide

Selective down-regulation of high-affinity IgE receptor (FcεRI) α-chain messenger RNA among transcriptome in cord blood–derived versus adult peripheral blood–derived cultured human mast cells

Makoto Iida,Kenji Matsumoto,Hisashi Tomita,Toshiharu Nakajima,Akira Akasawa,Noriko Yuyama Ohtani,Ning Lu Yoshida,Keiko Matsui,Akiko Nakada,Yuji Sugita,Yuji Shimizu,Shunichi Wakahara,Toru Nakao,Yasuyuki Fujii,Chisei Ra,Hirohisa Saito

View Articletitled, Selective down-regulation of high-affinity IgE receptor (FcεRI) α-chain messenger RNA among transcriptome in cord blood–derived versus adult peripheral blood–derived cultured human mast cells

V_H1-69 gene is preferentially used by hepatitis C virus–associated B cell lymphomas and by normal B cells responding to the E2 viral antigen

Chunghuang Hubert Chan,Kenneth G. Hadlock,Steven K. H. Foung,Shoshana Levy

View Articletitled, VH1-69 gene is preferentially used by hepatitis C virus–associated B cell lymphomas and by normal B cells responding to the E2 viral antigen

Cell-surface trafficking and release of flt3 ligand from T lymphocytes is induced by common cytokine receptor γ-chain signaling and inhibited by cyclosporin A

Elena Chklovskaia,Catherine Nissen,Lukas Landmann,Christoph Rahner,Otmar Pfister,Aleksandra Wodnar-Filipowicz

View Articletitled, Cell-surface trafficking and release of flt3 ligand from T lymphocytes is induced by common cytokine receptor γ-chain signaling and inhibited by cyclosporin A

Interleukin 9 promotes influx and local maturation of eosinophils

Jamila Louahed,Yuhong Zhou,W. Lee Maloy,Pyapalli U. Rani,Christine Weiss,Yaniv Tomer,Anne Vink,Jean-Christophe Renauld,Jacques Van Snick,Nicholas C. Nicolaides,Roy C. Levitt,Angela Haczku

View Articletitled, Interleukin 9 promotes influx and local maturation of eosinophils

NEOPLASIA

Apoptosis of tumoral and nontumoral lymphoid cells is induced by both mdm2 and p53 antisense oligodeoxynucleotides

Corinne Capoulade,Lluis M. Mir,Karine Carlier,Yann Lécluse,Cécile Tétaud,Zohair Mishal,Joëlle Wiels

View Articletitled, Apoptosis of tumoral and nontumoral lymphoid cells is induced by both mdm2 and p53 antisense oligodeoxynucleotides

Constitutive kinase activation of the TEL-Syk fusion gene in myelodysplastic syndrome with t(9;12)(q22;p12)

Yoshie Kuno,Akihiro Abe,Nobuhiko Emi,Minako Iida,Toshiya Yokozawa,Masayuki Towatari,Mitsune Tanimoto,Hidehiko Saito

View Articletitled, Constitutive kinase activation of the TEL-Syk fusion gene in myelodysplastic syndrome with t(9;12)(q22;p12)

STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma

Christine Brender,Mette Nielsen,Keld Kaltoft,Gitte Mikkelsen,Qian Zhang,Mariusz Wasik,Nils Billestrup,Niels Ødum

View Articletitled, STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma

Expression of the c-met proto-oncogene and its ligand, hepatocyte growth factor, in Hodgkin disease

Luciana Teofili,Anna Laura Di Febo,Francesco Pierconti,Nicola Maggiano,Maurizio Bendandi,Sergio Rutella,Antonella Cingolani,Nicola Di Renzo,Pellegrino Musto,Stefano Pileri,Giuseppe Leone,Luigi Maria Larocca

View Articletitled, Expression of the c-met proto-oncogene and its ligand, hepatocyte growth factor, in Hodgkin disease

PHAGOCYTES

Regulation of plasminogen binding to neutrophils

Thomas Herren,Timothy A. Burke,Merce Jardi,Jordi Felez,Edward F. Plow

View Articletitled, Regulation of plasminogen binding to neutrophils

Cell-surface heparan sulfate proteoglycan–mediated regulation of human neutrophil migration by the serpin antithrombin III

Stefan Dunzendorfer,Nicole Kaneider,Andrea Rabensteiner,Christian Meierhofer,Christina Reinisch,Jürgen Römisch,Christian J. Wiedermann

View Articletitled, Cell-surface heparan sulfate proteoglycan–mediated regulation of human neutrophil migration by the serpin antithrombin III

Human peripheral blood eosinophils express stem cell factor

Mor-Li Hartman,Adrian M. Piliponsky,Vladislav Temkin,Francesca Levi-Schaffer

View Articletitled, Human peripheral blood eosinophils express stem cell factor

RED CELLS

Transcobalamin codon 259 polymorphism in HT-29 and Caco-2 cells and in Caucasians: relation to transcobalamin and homocysteine concentration in blood

Farès Namour,Jean-Luc Olivier,Idrissia Abdelmouttaleb,Charles Adjalla,Renée Debard,Colette Salvat,Jean-Louis Guéant

View Articletitled, Transcobalamin codon 259 polymorphism in HT-29 and Caco-2 cells and in Caucasians: relation to transcobalamin and homocysteine concentration in blood

Expression, purification, and characterization of human hemoglobins Gower-1 (ζ₂ε₂), Gower-2 (α₂ε₂), and Portland-2 (ζ₂β₂) assembled in complex transgenic–knockout mice

Zhenning He,J. Eric Russell

View Articletitled, Expression, purification, and characterization of human hemoglobins Gower-1 (ζ2ε2), Gower-2 (α2ε2), and Portland-2 (ζ2β2) assembled in complex transgenic–knockout mice

Seven new mutations in the nicotinamide adenine dinucleotide reduced–cytochrome b₅ reductase gene leading to methemoglobinemia type I

Jan Dekker,Michel H. M. Eppink,Rob van Zwieten,Thea de Rijk,Angel F. Remacha,Lap Kay Law,Albert M. Li,Kam Lau Cheung,Willem J. H. van Berkel,Dirk Roos

View Articletitled, Seven new mutations in the nicotinamide adenine dinucleotide reduced–cytochrome b5 reductase gene leading to methemoglobinemia type I

ICL670A: a new synthetic oral chelator: evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture

Chaim Hershko,Abraham M. Konijn,Hans Peter Nick,William Breuer,Zvi Ioav Cabantchik,Gabriela Link

View Articletitled, ICL670A: a new synthetic oral chelator: evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture

TRANSPLANTATION

Prevention of lethal acute graft-versus-host disease in mice by oral administration of T helper 1 inhibitor, TAK-603

Yue Lu,Sumio Sakamaki,Hiroyuki Kuroda,Toshiro Kusakabe,Yuichi Konuma,Takehide Akiyama,Akihito Fujimi,Naofumi Takemoto,Kyokusen Nishiie,Takuya Matsunaga,Yasuo Hirayama,Junji Kato,Shinichiro Kon,Katsuhisa Kogawa,Yoshiro Niitsu

View Articletitled, Prevention of lethal acute graft-versus-host disease in mice by oral administration of T helper 1 inhibitor, TAK-603

BRIEF REPORTS

Hemophagocytic lymphohistiocytosis due to germline mutations inSH2D1A, the X-linked lymphoproliferative disease gene
Brief Report

Maurizio Arico,Shinsaku Imashuku,Rita Clementi,Shigeyoshi Hibi,Tomoko Teramura,Cesare Danesino,Daniel A. Haber,Kim E. Nichols

View Articletitled, Hemophagocytic lymphohistiocytosis due to germline mutations inSH2D1A, the X-linked lymphoproliferative disease gene

CTLA-4 blockade of antigen-induced cell death
Brief Report

Silvy da Rocha Dias,Christopher E. Rudd

View Articletitled, CTLA-4 blockade of antigen-induced cell death

Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders
Brief Report

François Canonne-Hergaux,Joanne E. Levy,Mark D. Fleming,Lynne K. Montross,Nancy C. Andrews,Philippe Gros

View Articletitled, Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders

Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts
Brief Report

Ulrich Salzer,Rainer Prohaska

View Articletitled, Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts

Specialized roles of the chemokine receptors CCR1 and CCR5 in the recruitment of monocytes and T_H1-like/CD45RO⁺T cells
Brief Report

Christian Weber,Kim S. C. Weber,Christiane Klier,Songhai Gu,Rudolf Wank,Richard Horuk,Peter J. Nelson

View Articletitled, Specialized roles of the chemokine receptors CCR1 and CCR5 in the recruitment of monocytes and TH1-like/CD45RO+T cells

Mutations in the NMMHC-A gene cause autosomal dominant macrothrombocytopenia with leukocyte inclusions (May-Hegglin anomaly/Sebastian syndrome)
Brief Report

Shinji Kunishima,Tetsuhito Kojima,Tadashi Matsushita,Toshihiro Tanaka,Masahito Tsurusawa,Yoshio Furukawa,Yukitsugu Nakamura,Takashi Okamura,Norihiko Amemiya,Takayuki Nakayama,Tadashi Kamiya,Hidehiko Saito

View Articletitled, Mutations in the NMMHC-A gene cause autosomal dominant macrothrombocytopenia with leukocyte inclusions (May-Hegglin anomaly/Sebastian syndrome)

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Issue Archive

Table of Contents

PLENARY PAPERS

RETRACTIONS

CHEMOKINES

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Risk of recurrent venous thrombosis in children with combined prothrombotic risk factors Clinical Trials & Observations

Long-term use of anagrelide in young patients with essential thrombocythemia Clinical Trials & Observations

Rising pp65 antigenemia during preemptive anticytomegalovirus therapy after allogeneic hematopoietic stem cell transplantation: risk factors, correlation with DNA load, and outcomes Clinical Trials & Observations

The Kozak sequence polymorphism of platelet glycoprotein Ibα and risk of nonfatal myocardial infarction and nonfatal stroke in young women Clinical Trials & Observations

Human equivalent of the mouse Nude/SCID phenotype: long-term evaluation of immunologic reconstitution after bone marrow transplantation Clinical Trials & Observations

GENE THERAPY

HEMATOPOIESIS

New insights into the thrombopoietic status of patients on dialysis through the evaluation of megakaryocytopoiesis in bone marrow and of endogenous thrombopoietin levels Clinical Trials & Observations

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

IMMUNOBIOLOGY

NEOPLASIA

PHAGOCYTES

RED CELLS

TRANSPLANTATION

BRIEF REPORTS

Hemophagocytic lymphohistiocytosis due to germline mutations inSH2D1A, the X-linked lymphoproliferative disease gene Brief Report

CTLA-4 blockade of antigen-induced cell death Brief Report

Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders Brief Report

Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts Brief Report

Specialized roles of the chemokine receptors CCR1 and CCR5 in the recruitment of monocytes and TH1-like/CD45RO+T cells Brief Report

Mutations in the NMMHC-A gene cause autosomal dominant macrothrombocytopenia with leukocyte inclusions (May-Hegglin anomaly/Sebastian syndrome) Brief Report

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