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Volume 97, Issue 12

June 15 2001

In this Issue

INSIDE BLOOD
PLENARY PAPERS
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
ERRATA
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
BRIEF REPORTS
CORRESPONDENCE

INSIDE BLOOD

Disorganized wound healing in fibrinogen-deficient mice

Charles W. Francis

View Articletitled, Disorganized wound healing in fibrinogen-deficient mice

Leukemic stem cells: where have they gone wrong?

Richard J. Jones

View Articletitled, Leukemic stem cells: where have they gone wrong?

Adverse effects of G-CSF in sickle cell syndromes

C. Anthony Blau

View Articletitled, Adverse effects of G-CSF in sickle cell syndromes

PLENARY PAPERS

Identification of a novel, human multilymphoid progenitor in cord blood

Qian-Lin Hao,Judy Zhu,Mary A. Price,Kimberly J. Payne,Lora W. Barsky,Gay M. Crooks

View Articletitled, Identification of a novel, human multilymphoid progenitor in cord blood

Wound-healing defects in mice lacking fibrinogen

Angela F. Drew,Hong Liu,Jeffrey M. Davidson,Cynthia C. Daugherty,Jay L. Degen

View Articletitled, Wound-healing defects in mice lacking fibrinogen

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Short-pulse B–non-Hodgkin lymphoma–type chemotherapy is efficacious treatment for pediatric anaplastic large cell lymphoma: a report of the Berlin-Frankfurt-Münster Group Trial NHL-BFM 90
Clinical Trials & Observations

Kathrin Seidemann,Markus Tiemann,Martin Schrappe,Elif Yakisan,Ingrid Simonitsch,Gritta Janka-Schaub,Wolfgang Dörffel,Martin Zimmermann,Georg Mann,Helmut Gadner,Reza Parwaresch,Hansjörg Riehm,Alfred Reiter

View Articletitled, Short-pulse B–non-Hodgkin lymphoma–type chemotherapy is efficacious treatment for pediatric anaplastic large cell lymphoma: a report of the Berlin-Frankfurt-Münster Group Trial NHL-BFM 90

Tumor necrosis factor α promoter polymorphisms influence the phenotypic expression of hereditary hemochromatosis
Clinical Trials & Observations

Silvia Fargion,Luca Valenti,Paola Dongiovanni,Anna Scaccabarozzi,Anna Ludovica Fracanzani,Emanuela Taioli,Michela Mattioli,Maurizio Sampietro,Gemino Fiorelli

View Articletitled, Tumor necrosis factor α promoter polymorphisms influence the phenotypic expression of hereditary hemochromatosis

The Burkitt-like lymphomas: a Southwest Oncology Group study delineating phenotypic, genotypic, and clinical features
Clinical Trials & Observations

Rita M. Braziel,Daniel A. Arber,Marilyn L. Slovak,Margaret L. Gulley,Catherine Spier,Carl Kjeldsberg,Joseph Unger,Thomas P. Miller,Raymond Tubbs,Catherine Leith,Richard I. Fisher,Thomas M. Grogan

View Articletitled, The Burkitt-like lymphomas: a Southwest Oncology Group study delineating phenotypic, genotypic, and clinical features

Regulation of monocyte procoagulant activity in acute myocardial infarction: role of tissue factor and tissue factor pathway inhibitor-1
Clinical Trials & Observations

Ilka Ott,Martin Andrassy,Dominik Zieglgänsberger,Stefanie Geith,Albert Schömig,Franz-Josef Neumann

View Articletitled, Regulation of monocyte procoagulant activity in acute myocardial infarction: role of tissue factor and tissue factor pathway inhibitor-1

Biology and outcome of childhood acute megakaryoblastic leukemia: a single institution's experience
Clinical Trials & Observations

Uma H. Athale,Bassem I. Razzouk,Susana C. Raimondi,Xin Tong,Frederick G. Behm,David R. Head,Deo K. Srivastava,Jeffrey E. Rubnitz,Laura Bowman,Ching-Hon Pui,Raul C. Ribeiro

View Articletitled, Biology and outcome of childhood acute megakaryoblastic leukemia: a single institution's experience

ERRATA

Erratum for vol. 97, p. 2667

View Articletitled, Erratum for vol. 97, p. 2667

Erratum for vol. 97, p. 2750

View Articletitled, Erratum for vol. 97, p. 2750

GENE THERAPY

Factors influencing the development of an anti–factor IX (FIX) immune response following administration of adeno-associated virus–FIX

Ying Ge,Sandra Powell,Melinda Van Roey,James G. McArthur

View Articletitled, Factors influencing the development of an anti–factor IX (FIX) immune response following administration of adeno-associated virus–FIX

Variable correction of host defense following gene transfer and bone marrow transplantation in murine X-linked chronic granulomatous disease

Mary C. Dinauer,Mary A. Gifford,Nancy Pech,Ling Lin Li,Patricia Emshwiller

View Articletitled, Variable correction of host defense following gene transfer and bone marrow transplantation in murine X-linked chronic granulomatous disease

Live attenuated measles virus induces regression of human lymphoma xenografts in immunodeficient mice

Deanna Grote,Stephen J. Russell,Tatjana I. Cornu,Roberto Cattaneo,Richard Vile,Gregory A. Poland,Adele K. Fielding

View Articletitled, Live attenuated measles virus induces regression of human lymphoma xenografts in immunodeficient mice

HEMATOPOIESIS

Development of human lymphohematopoietic stem and progenitor cells defined by expression of CD34 and CD81

Feng Ma,Mika Wada,Hiroshi Yoshino,Yasuhiro Ebihara,Takefumi Ishii,Atsushi Manabe,Ryuhei Tanaka,Taira Maekawa,Mamoru Ito,Hideo Mugishima,Shigetaka Asano,Tatsutoshi Nakahata,Kohichiro Tsuji

View Articletitled, Development of human lymphohematopoietic stem and progenitor cells defined by expression of CD34 and CD81

Expression of the neuronal cyclin-dependent kinase 5 activator p35Nck5a in human monocytic cells is associated with differentiation

Fei Chen,George P. Studzinski

View Articletitled, Expression of the neuronal cyclin-dependent kinase 5 activator p35Nck5a in human monocytic cells is associated with differentiation

The adapter protein CrkL associates with CD34

Donna M. Felschow,Megan L. McVeigh,Gerard T. Hoehn,Curt I. Civin,Mary Jo Fackler

View Articletitled, The adapter protein CrkL associates with CD34

Dimeric erythropoietin fusion protein with enhanced erythropoietic activity in vitro and in vivo

Bruno Dalle,Annie Henri,Philippe Rouyer-Fessard,Mickaël Bettan,Daniel Scherman,Yves Beuzard,Emmanuel Payen

View Articletitled, Dimeric erythropoietin fusion protein with enhanced erythropoietic activity in vitro and in vivo

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Autoantibody against prothrombin aberrantly alters the proenzyme to facilitate formation of a complex with its physiological inhibitor antithrombin III without thrombin conversion

Seiji Madoiwa,Yuichi Nakamura,Jun Mimuro,Shinpei Furusawa,Takatoshi Koyama,Teruko Sugo,Michio Matsuda,Yoichi Sakata

View Articletitled, Autoantibody against prothrombin aberrantly alters the proenzyme to facilitate formation of a complex with its physiological inhibitor antithrombin III without thrombin conversion

Activation of protease-activated receptors by gingipains fromPorphyromonas gingivalis leads to platelet aggregation: a new trait in microbial pathogenicity

Afrodite Lourbakos,YuPing Yuan,Alison L. Jenkins,James Travis,Patricia Andrade-Gordon,Rosemary Santulli,Jan Potempa,Robert N. Pike

View Articletitled, Activation of protease-activated receptors by gingipains fromPorphyromonas gingivalis leads to platelet aggregation: a new trait in microbial pathogenicity

Protein kinase C–catalyzed phosphorylation of an inhibitory phosphoprotein of myosin phosphatase is involved in human platelet secretion

Yasuyuki Watanabe,Masaaki Ito,Yoshiyuki Kataoka,Hideo Wada,Mutsumi Koyama,Jianhua Feng,Hiroshi Shiku,Masakatsu Nishikawa

View Articletitled, Protein kinase C–catalyzed phosphorylation of an inhibitory phosphoprotein of myosin phosphatase is involved in human platelet secretion

Differential requirements for the O-linked branching enzyme core 2 β1-6-N-glucosaminyltransferase in biosynthesis of ligands for E-selectin and P-selectin

Karen R. Snapp,Christine E. Heitzig,Lesley G. Ellies,Jamey D. Marth,Geoffrey S. Kansas

View Articletitled, Differential requirements for the O-linked branching enzyme core 2 β1-6-N-glucosaminyltransferase in biosynthesis of ligands for E-selectin and P-selectin

Severe impairment of leukocyte rolling in venules of core 2 glucosaminyltransferase–deficient mice

Markus Sperandio,Aravinda Thatte,Dan Foy,Lesley G. Ellies,Jamey D. Marth,Klaus Ley

View Articletitled, Severe impairment of leukocyte rolling in venules of core 2 glucosaminyltransferase–deficient mice

Supplemental data

The clonal analysis of anticardiolipin antibodies in a single patient with primary antiphospholipid syndrome reveals an extreme antibody heterogeneity

Patricia Lieby,Anne Soley,Honey Levallois,Benedicte Hugel,Jean-Marie Freyssinet,Martine Cerutti,Jean-Louis Pasquali,Thierry Martin

View Articletitled, The clonal analysis of anticardiolipin antibodies in a single patient with primary antiphospholipid syndrome reveals an extreme antibody heterogeneity

Evidence for cross-talk between glycoprotein VI and Gi-coupled receptors during collagen-induced platelet aggregation

Bernhard Nieswandt,Wolfgang Bergmeier,Anita Eckly,Valerie Schulte,Philippe Ohlmann,Jean-Pierre Cazenave,Hubert Zirngibl,Stefan Offermanns,Christian Gachet

View Articletitled, Evidence for cross-talk between glycoprotein VI and Gi-coupled receptors during collagen-induced platelet aggregation

Role of Fc receptor γ-chain in platelet glycoprotein Ib–mediated signaling

Yi Wu,Katsue Suzuki-Inoue,Kaneo Satoh,Naoki Asazuma,Yutaka Yatomi,Michael C. Berndt,Yukio Ozaki

View Articletitled, Role of Fc receptor γ-chain in platelet glycoprotein Ib–mediated signaling

Immune thrombocytopenia resulting from sensitivity to metabolites of naproxen and acetaminophen

Daniel Bougie,Richard Aster

View Articletitled, Immune thrombocytopenia resulting from sensitivity to metabolites of naproxen and acetaminophen

IMMUNOBIOLOGY

Generation and biochemical analysis of human effector CD4 T cells: alterations in tyrosine phosphorylation and loss of CD3ζ expression

Sandeep Krishnan,Vishal G. Warke,Madhusoodana P. Nambiar,Henry K. Wong,George C. Tsokos,Donna L. Farber

View Articletitled, Generation and biochemical analysis of human effector CD4 T cells: alterations in tyrosine phosphorylation and loss of CD3ζ expression

Specific down-regulation of interleukin-12 signaling through induction of phospho-STAT4 protein degradation

Kathy S. Wang,Emmanuel Zorn,Jerome Ritz

View Articletitled, Specific down-regulation of interleukin-12 signaling through induction of phospho-STAT4 protein degradation

Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP

Joan Sayós,Margarita Martı́n,Alice Chen,Marı́a Simarro,Duncan Howie,Massimo Morra,Pablo Engel,Cox Terhorst

View Articletitled, Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP

NEOPLASIA

Comparative genomic hybridization analysis in adult T-cell leukemia/lymphoma: correlation with clinical course

Kunihiro Tsukasaki,Johannes Krebs,Kazuhiro Nagai,Masao Tomonaga,H. Phillip Koeffler,Claus R. Bartram,Anna Jauch

View Articletitled, Comparative genomic hybridization analysis in adult T-cell leukemia/lymphoma: correlation with clinical course

Hoechst 33342 efflux identifies a subpopulation of cytogenetically normal CD34⁺CD38⁻ progenitor cells from patients with acute myeloid leukemia

Michaela Feuring-Buske,Donna E. Hogge

View Articletitled, Hoechst 33342 efflux identifies a subpopulation of cytogenetically normal CD34+CD38− progenitor cells from patients with acute myeloid leukemia

Epithelial membrane protein 2, a 4-transmembrane protein that suppresses B-cell lymphoma tumorigenicity

Chun-Xiang Wang,Madhuri Wadehra,Bernard C. Fisk,Lee Goodglick,Jonathan Braun

View Articletitled, Epithelial membrane protein 2, a 4-transmembrane protein that suppresses B-cell lymphoma tumorigenicity

Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma

Folkert J. van Kemenade,Frank M. Raaphorst,Tjasso Blokzijl,Elly Fieret,Karien M. Hamer,David P. E. Satijn,Arie P. Otte,Chris J. L. M. Meijer

View Articletitled, Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma

MCL1 transgenic mice exhibit a high incidence of B-cell lymphoma manifested as a spectrum of histologic subtypes

Ping Zhou,Norman B. Levy,Haiyi Xie,Liping Qian,Chi-Yu Gregory Lee,Randy D. Gascoyne,Ruth W. Craig

View Articletitled, MCL1 transgenic mice exhibit a high incidence of B-cell lymphoma manifested as a spectrum of histologic subtypes

H4(D10S170), a gene frequently rearranged in papillary thyroid carcinoma, is fused to the platelet-derived growth factor receptor β gene in atypical chronic myeloid leukemia with t(5;10)(q33;q22)

Juerg Schwaller,Ema Anastasiadou,Danielle Cain,Jeff Kutok,Sarah Wojiski,Ifor R. Williams,Roberta LaStarza,Barbara Crescenzi,David W. Sternberg,Patrick Andreasson,Roberta Schiavo,Salvatore Siena,Cristina Mecucci,D. Gary Gilliland

View Articletitled, H4(D10S170), a gene frequently rearranged in papillary thyroid carcinoma, is fused to the platelet-derived growth factor receptor β gene in atypical chronic myeloid leukemia with t(5;10)(q33;q22)

Angiogenesis in acute promyelocytic leukemia: induction by vascular endothelial growth factor and inhibition by all-trans retinoic acid: Presented in part at the American Society of Hematology meeting, New Orleans, LA, December 1999.

Ameet R. Kini,LoAnn C. Peterson,Martin S. Tallman,Mark W. Lingen

View Articletitled, Angiogenesis in acute promyelocytic leukemia: induction by vascular endothelial growth factor and inhibition by all-trans retinoic acid: Presented in part at the American Society of Hematology meeting, New Orleans, LA, December 1999.

Detection of leukemic cells in the CD34⁺CD38⁻ bone marrow progenitor population in children with acute lymphoblastic leukemia

Aswathi A. George,Janet Franklin,Keith Kerkof,Ami J. Shah,Mary Price,Eleanor Tsark,David Bockstoce,Dapeng Yao,Nancy Hart,Sherri Carcich,Robertson Parkman,Gay M. Crooks,Kenneth Weinberg

View Articletitled, Detection of leukemic cells in the CD34+CD38− bone marrow progenitor population in children with acute lymphoblastic leukemia

Mitochondria-targeting drugs arsenic trioxide and lonidamine bypass the resistance of TPA-differentiated leukemic cells to apoptosis

Olivier Sordet,Cédric Rébé,Ingrid Leroy,Jean-Marie Bruey,Carmen Garrido,Carole Miguet,Gérard Lizard,Stéphanie Plenchette,Laurent Corcos,Eric Solary

View Articletitled, Mitochondria-targeting drugs arsenic trioxide and lonidamine bypass the resistance of TPA-differentiated leukemic cells to apoptosis

PHAGOCYTES

Plasmin-induced expression of cytokines and tissue factor in human monocytes involves AP-1 and IKKβ-mediated NF-κB activation

Tatiana Syrovets,Marina Jendrach,Angela Rohwedder,Almut Schüle,Thomas Simmet

View Articletitled, Plasmin-induced expression of cytokines and tissue factor in human monocytes involves AP-1 and IKKβ-mediated NF-κB activation

Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3

Ole E. Sørensen,Per Follin,Anders H. Johnsen,Jero Calafat,G. Sandra Tjabringa,Pieter S. Hiemstra,Niels Borregaard

View Articletitled, Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3

RED CELLS

Effects of mixed hematopoietic chimerism in a mouse model of bone marrow transplantation for sickle cell anemia

Robert Iannone,Leo Luznik,Laura W. Engstrom,Sherrie L. Tennessee,Frederic B. Askin,James F. Casella,Thomas S. Kickler,Steven N. Goodman,Anita L. Hawkins,Constance A. Griffin,Lori Noffsinger,Ephraim J. Fuchs

View Articletitled, Effects of mixed hematopoietic chimerism in a mouse model of bone marrow transplantation for sickle cell anemia

Inhibition of Plasmodium yoelii blood-stage malaria by interferon α through the inhibition of the production of its target cell, the reticulocyte

Ana Margarida Vigário,Elodie Belnoue,Ana Cumano,Myriam Marussig,François Miltgen,Irene Landau,Dominique Mazier,Ion Gresser,Laurent Rénia

View Articletitled, Inhibition of Plasmodium yoelii blood-stage malaria by interferon α through the inhibition of the production of its target cell, the reticulocyte

Reduced incidence of thrombosis in mice with hereditary spherocytosis following neonatal treatment with normal hematopoietic cells

Nancy J. Wandersee,John C. Lee,Susan A. Deveau,Jane E. Barker

View Articletitled, Reduced incidence of thrombosis in mice with hereditary spherocytosis following neonatal treatment with normal hematopoietic cells

Dipyridamole inhibits sickling-induced cation fluxes in sickle red blood cells

Clinton H. Joiner,Maorong Jiang,William J. Claussen,Nancy J. Roszell,Zahida Yasin,Robert S. Franco

View Articletitled, Dipyridamole inhibits sickling-induced cation fluxes in sickle red blood cells

Unavailability of CD147 leads to selective erythrocyte trapping in the spleen

Isabelle Coste,Jean-François Gauchat,Anne Wilson,Shozo Izui,Pascale Jeannin,Yves Delneste,H. Robson MacDonald,Jean-Yves Bonnefoy,Toufic Renno

View Articletitled, Unavailability of CD147 leads to selective erythrocyte trapping in the spleen

BRIEF REPORTS

The snake venom toxin alboaggregin-A activates glycoprotein VI
Brief Report

Naoki Asazuma,Stuart J. Marshall,Oscar Berlanga,Daniel Snell,Alastair W. Poole,Michael C. Berndt,Robert K. Andrews,Steve P. Watson

View Articletitled, The snake venom toxin alboaggregin-A activates glycoprotein VI

Expression of macrophage inflammatory protein-3α, stromal cell–derived factor-1, and B-cell–attracting chemokine-1 identifies the tonsil crypt as an attractive site for B cells
Brief Report

Montserrat Casamayor-Pallejà,Paul Mondière,Ali Amara,Chantal Bella,Marie-Caroline Dieu-Nosjean,Christophe Caux,Thierry Defrance

View Articletitled, Expression of macrophage inflammatory protein-3α, stromal cell–derived factor-1, and B-cell–attracting chemokine-1 identifies the tonsil crypt as an attractive site for B cells

Anti-CD20 monoclonal antibody for the treatment of severe, immune-mediated, pure red cell aplasia and hemolytic anemia
Brief Report

Marco Zecca,Piero De Stefano,Bruno Nobili,Franco Locatelli

View Articletitled, Anti-CD20 monoclonal antibody for the treatment of severe, immune-mediated, pure red cell aplasia and hemolytic anemia

CORRESPONDENCE

Granulocyte colony-stimulating factor–induced sickle cell crisis and multiorgan dysfunction in a patient with compound heterozygous sickle cell/β⁺ thalassemia

Andrew Wei,Andrew Grigg

View Articletitled, Granulocyte colony-stimulating factor–induced sickle cell crisis and multiorgan dysfunction in a patient with compound heterozygous sickle cell/β+ thalassemia

Alloimmunization in Hong Kong southern Chinese transfusion-dependent thalassemia patients

Hok-Kung Ho,Shau-Yin Ha,Chun-Kit Lam,Godfrey C. F. Chan,Tsz-Leung Lee,Alan K. S. Chiang,Yu-Lung Lau

View Articletitled, Alloimmunization in Hong Kong southern Chinese transfusion-dependent thalassemia patients

X chromosome inactivation ratios in female carriers of X-linked sideroblastic anemia

Manuel Aivado,Norbert Gattermann,Sylvia Bottomley

View Articletitled, X chromosome inactivation ratios in female carriers of X-linked sideroblastic anemia

Prognostic value of p16^INK4a gene deletions in pediatric acute lymphoblastic leukemia

Hagen Graf Einsiedel,Tillmann Taube,Reinhard Hartmann,Cornelia Eckert,Georg Seifert,Sven Wellmann,Günter Henze,Karl Seeger

View Articletitled, Prognostic value of p16INK4a gene deletions in pediatric acute lymphoblastic leukemia

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Issue Archive

Table of Contents

INSIDE BLOOD

PLENARY PAPERS

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Short-pulse B–non-Hodgkin lymphoma–type chemotherapy is efficacious treatment for pediatric anaplastic large cell lymphoma: a report of the Berlin-Frankfurt-Münster Group Trial NHL-BFM 90 Clinical Trials & Observations

Tumor necrosis factor α promoter polymorphisms influence the phenotypic expression of hereditary hemochromatosis Clinical Trials & Observations

The Burkitt-like lymphomas: a Southwest Oncology Group study delineating phenotypic, genotypic, and clinical features Clinical Trials & Observations

Regulation of monocyte procoagulant activity in acute myocardial infarction: role of tissue factor and tissue factor pathway inhibitor-1 Clinical Trials & Observations

Biology and outcome of childhood acute megakaryoblastic leukemia: a single institution's experience Clinical Trials & Observations