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Volume 97, Issue 11

June 1 2001

In this Issue

INSIDE BLOOD
PLENARY PAPERS
ERRATA
CHEMOKINES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSFUSION MEDICINE
BRIEF REPORTS
CORRESPONDENCE

INSIDE BLOOD

DNA-based diagnosis of red cell enzymopathies: how we threw out the baby with the bathwater

Ernest Beutler

View Articletitled, DNA-based diagnosis of red cell enzymopathies: how we threw out the baby with the bathwater

Parentage and heritage of dendritic cells

Ken Shortman,Li Wu

View Articletitled, Parentage and heritage of dendritic cells

PLENARY PAPERS

Genetic basis of hemolytic anemia caused by pyrimidine 5′ nucleotidase deficiency

Anthony M. Marinaki,Emilia Escuredo,John A. Duley,H. Anne Simmonds,Adolfo Amici,Valeria Naponelli,Giulio Magni,Martin Seip,Isaac Ben-Bassat,Eric H. Harley,Swee Lay Thein,David C. Rees

View Articletitled, Genetic basis of hemolytic anemia caused by pyrimidine 5′ nucleotidase deficiency

Dendritic cell potentials of early lymphoid and myeloid progenitors

Markus G. Manz,David Traver,Toshihiro Miyamoto,Irving L. Weissman,Koichi Akashi

View Articletitled, Dendritic cell potentials of early lymphoid and myeloid progenitors

ERRATA

Erratum for vol. 97, p. 1765

View Articletitled, Erratum for vol. 97, p. 1765

Erratum for vol. 97, p. 2130

View Articletitled, Erratum for vol. 97, p. 2130

CHEMOKINES

Janus kinase 2 is involved in stromal cell–derived factor-1α–induced tyrosine phosphorylation of focal adhesion proteins and migration of hematopoietic progenitor cells

Xue-Feng Zhang,Jian-Feng Wang,Ewa Matczak,JoAnn Proper,Jerome E. Groopman

View Articletitled, Janus kinase 2 is involved in stromal cell–derived factor-1α–induced tyrosine phosphorylation of focal adhesion proteins and migration of hematopoietic progenitor cells

Macrophage inflammatory protein-1α is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor κB ligand

Je-Ho Han,Sun Jin Choi,Noriyoshi Kurihara,Masanori Koide,Yasuo Oba,G. David Roodman

View Articletitled, Macrophage inflammatory protein-1α is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor κB ligand

Plasma elevation of stromal cell–derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells

Koichi Hattori,Beate Heissig,Kei Tashiro,Tasuku Honjo,Masatoshi Tateno,Jae-Hung Shieh,Neil R. Hackett,Mannix S. Quitoriano,Ronald G. Crystal,Shahin Rafii,Malcolm A. S. Moore

View Articletitled, Plasma elevation of stromal cell–derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial
Clinical Trials & Observations

Judith E. Karp,Jeffrey E. Lancet,Scott H. Kaufmann,David W. End,John J. Wright,Kees Bol,Ivan Horak,Michael L. Tidwell,Jane Liesveld,Timothy J. Kottke,Dawn Ange,Laxmi Buddharaju,Ivana Gojo,W. Edward Highsmith,Robert T. Belly,Raymond J. Hohl,Mary Ellen Rybak,Alain Thibault,Joseph Rosenblatt

View Articletitled, Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial

The Société Française d'Oncologie Pédiatrique LMB89 protocol: highly effective multiagent chemotherapy tailored to the tumor burden and initial response in 561 unselected children with B-cell lymphomas and L3 leukemia
Clinical Trials & Observations

Catherine Patte,Anne Auperin,Jean Michon,Henk Behrendt,Guy Leverger,Didier Frappaz,Patrick Lutz,Carole Coze,Yves Perel,Martine Raphaël,Marie-Josée Terrier-Lacombe,on behalf of the SociétéFrançaise d'Oncologie Pédiatrique

View Articletitled, The Société Française d'Oncologie Pédiatrique LMB89 protocol: highly effective multiagent chemotherapy tailored to the tumor burden and initial response in 561 unselected children with B-cell lymphomas and L3 leukemia

Immune reconstitution after allogeneic marrow transplantation compared with blood stem cell transplantation
Clinical Trials & Observations

Jan Storek,Monja A. Dawson,Barry Storer,Terry Stevens-Ayers,David G. Maloney,Kieren A. Marr,Robert P. Witherspoon,William Bensinger,Mary E. D. Flowers,Paul Martin,Rainer Storb,Frederick R. Appelbaum,Michael Boeckh

View Articletitled, Immune reconstitution after allogeneic marrow transplantation compared with blood stem cell transplantation

Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus-tumor effects
Clinical Trials & Observations

Peter A. McSweeney,Dietger Niederwieser,Judith A. Shizuru,Brenda M. Sandmaier,Arthur J. Molina,David G. Maloney,Thomas R. Chauncey,Theodore A. Gooley,Ute Hegenbart,Richard A. Nash,Jerald Radich,John L. Wagner,Steven Minor,Frederick R. Appelbaum,William I. Bensinger,Eileen Bryant,Mary E. D. Flowers,George E. Georges,F. Carl Grumet,Hans-Peter Kiem,Beverly Torok-Storb,Cong Yu,Karl G. Blume,Rainer F. Storb

View Articletitled, Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus-tumor effects

Correlation of abnormal intracranial vessel velocity, measured by transcranial Doppler ultrasonography, with abnormal conjunctival vessel velocity, measured by computer-assisted intravital microscopy, in sickle cell disease
Clinical Trials & Observations

Anthony T. W. Cheung,Paul Harmatz,Ted Wun,Peter C. Y. Chen,Edward C. Larkin,Robert J. Adams,Elliott P. Vichinsky

View Articletitled, Correlation of abnormal intracranial vessel velocity, measured by transcranial Doppler ultrasonography, with abnormal conjunctival vessel velocity, measured by computer-assisted intravital microscopy, in sickle cell disease

Controlled trial of filgrastim for acceleration of neutrophil recovery after allogeneic blood stem cell transplantation from human leukocyte antigen–matched related donors
Clinical Trials & Observations

Donna Przepiorka,Terry L. Smith,Jody Folloder,Paolo Anderlini,Ka-Wah Chan,Martin Körbling,Benjamin Lichtiger,Frank Norfleet,Richard Champlin

View Articletitled, Controlled trial of filgrastim for acceleration of neutrophil recovery after allogeneic blood stem cell transplantation from human leukocyte antigen–matched related donors

Cardiac involvement in thalassemia intermedia: a multicenter study
Clinical Trials & Observations

Athanasios Aessopos,Dimitrios Farmakis,Markisia Karagiorga,Ersi Voskaridou,Aphrodite Loutradi,Antonia Hatziliami,Jacqueline Joussef,John Rombos,Dimitris Loukopoulos

View Articletitled, Cardiac involvement in thalassemia intermedia: a multicenter study

GENE THERAPY

Induction of stable prenatal tolerance to β-galactosidase by in utero gene transfer into preimmune sheep fetuses

Nam D. Tran,Christopher D. Porada,Graça Almeida-Porada,Hudson A. Glimp,W. French Anderson,Esmail D. Zanjani

View Articletitled, Induction of stable prenatal tolerance to β-galactosidase by in utero gene transfer into preimmune sheep fetuses

HEMATOPOIESIS

Increased expression of the INK4a/ARF locus in polycythemia vera

Chunhua Dai,Sanford B. Krantz

View Articletitled, Increased expression of the INK4a/ARF locus in polycythemia vera

Chemotaxis and transendothelial migration of CD34⁺hematopoietic progenitor cells induced by the inflammatory mediator leukotriene D4 are mediated by the 7-transmembrane receptor CysLT1

Frank Bautz,Claudio Denzlinger,Lothar Kanz,Robert Möhle

View Articletitled, Chemotaxis and transendothelial migration of CD34+hematopoietic progenitor cells induced by the inflammatory mediator leukotriene D4 are mediated by the 7-transmembrane receptor CysLT1

Umbilical cord blood cells capable of engrafting in primary, secondary, and tertiary xenogeneic hosts are preserved after ex vivo culture in a noncontact system

Ian D. Lewis,Graca Almeida-Porada,Jingbo Du,Ihor R. Lemischka,Kateri A. Moore,Esmail D. Zanjani,Catherine M. Verfaillie

View Articletitled, Umbilical cord blood cells capable of engrafting in primary, secondary, and tertiary xenogeneic hosts are preserved after ex vivo culture in a noncontact system

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Differential regulation of the fibroblast growth factor (FGF) family by α₂-macroglobulin: evidence for selective modulation of FGF-2–induced angiogenesis

Iain R. Asplin,Sean M. Wu,Smitha Mathew,Gourab Bhattacharjee,Salvatore V. Pizzo

View Articletitled, Differential regulation of the fibroblast growth factor (FGF) family by α2-macroglobulin: evidence for selective modulation of FGF-2–induced angiogenesis

IMMUNOBIOLOGY

Allogeneic bone marrow cells that facilitate complete chimerism and eliminate tumor cells express both CD8 and T-cell antigen receptor–αβ

Fengshuo Lan,Defu Zeng,Philip Huie,John P. Higgins,Samuel Strober

View Articletitled, Allogeneic bone marrow cells that facilitate complete chimerism and eliminate tumor cells express both CD8 and T-cell antigen receptor–αβ

Prostaglandin E₂ is a selective inducer of interleukin-12 p40 (IL-12p40) production and an inhibitor of bioactive IL-12p70 heterodimer

Paweł Kaliński,Pedro L. Vieira,Joost H. N. Schuitemaker,Esther C. de Jong,Martien L. Kapsenberg

View Articletitled, Prostaglandin E2 is a selective inducer of interleukin-12 p40 (IL-12p40) production and an inhibitor of bioactive IL-12p70 heterodimer

Investigation of human spleen dendritic cell phenotype and distribution reveals evidence of in vivo activation in a subset of organ donors

Dorian McIlroy,Christelle Troadec,Fernanda Grassi,Assia Samri,Benoı̂t Barrou,Brigitte Autran,Patrice Debré,Jean Feuillard,Anne Hosmalin

View Articletitled, Investigation of human spleen dendritic cell phenotype and distribution reveals evidence of in vivo activation in a subset of organ donors

Cytokine-induced inside-out activation of FcαR (CD89) is mediated by a single serine residue (S263) in the intracellular domain of the receptor

Madelon Bracke,Jan-Willem J. Lammers,Paul J. Coffer,Leo Koenderman

View Articletitled, Cytokine-induced inside-out activation of FcαR (CD89) is mediated by a single serine residue (S263) in the intracellular domain of the receptor

Mast cells/basophils in the peripheral blood of allergic individuals who are HIV-1 susceptible due to their surface expression of CD4 and the chemokine receptors CCR3, CCR5, and CXCR4

Yong Li,Lixin Li,Robert Wadley,Stephen W. Reddel,Jian C. Qi,Con Archis,Andrew Collins,Elizabeth Clark,Margaret Cooley,Steven Kouts,Hassan M. Naif,Mohammed Alali,Anthony Cunningham,Guang W. Wong,Richard L. Stevens,Steven A. Krilis

View Articletitled, Mast cells/basophils in the peripheral blood of allergic individuals who are HIV-1 susceptible due to their surface expression of CD4 and the chemokine receptors CCR3, CCR5, and CXCR4

Expression of interferon consensus sequence binding protein induces potent immunity against BCR/ABL-induced leukemia

Ming Deng,George Q. Daley

View Articletitled, Expression of interferon consensus sequence binding protein induces potent immunity against BCR/ABL-induced leukemia

Functional soluble CD100/Sema4D released from activated lymphocytes: possible role in normal and pathologic immune responses

Xiaosong Wang,Atsushi Kumanogoh,Chie Watanabe,Wei Shi,Kanji Yoshida,Hitoshi Kikutani

View Articletitled, Functional soluble CD100/Sema4D released from activated lymphocytes: possible role in normal and pathologic immune responses

Stressed apoptotic tumor cells express heat shock proteins and elicit tumor-specific immunity

Hanping Feng,Yi Zeng,Luke Whitesell,Emmanuel Katsanis

View Articletitled, Stressed apoptotic tumor cells express heat shock proteins and elicit tumor-specific immunity

Molecular characterization and expression of a novel human leukocyte cell-surface marker homologous to mouse Ly-9

Miguel Angel de la Fuente,Victoria Tovar,Neus Villamor,Nuria Zapater,Pilar Pizcueta,Elias Campo,Jaime Bosch,Pablo Engel

View Articletitled, Molecular characterization and expression of a novel human leukocyte cell-surface marker homologous to mouse Ly-9

In vivo and in vitro apoptosis of human thymocytes are associated with nitrotyrosine formation

Nathalie Moulian,Frédérique Truffault,Yvette Morot Gaudry-Talarmain,Alain Serraf,Sonia Berrih-Aknin

View Articletitled, In vivo and in vitro apoptosis of human thymocytes are associated with nitrotyrosine formation

Activation of the formyl peptide receptor by the HIV-derived peptide T-20 suppresses interleukin-12 p70 production by human monocytes

Michael C. Braun,Ji Ming Wang,Edward Lahey,Ronald L. Rabin,Brian L. Kelsall

View Articletitled, Activation of the formyl peptide receptor by the HIV-derived peptide T-20 suppresses interleukin-12 p70 production by human monocytes

NEOPLASIA

Role of galactosylation in the renal pathogenicity of murine immunoglobulin G3 monoclonal cryoglobulins

Tsuguo Mizuochi,Yves Pastore,Kohdoh Shikata,Aki Kuroki,Shuichi Kikuchi,Thierry Fulpius,Munehiro Nakata,Liliane Fossati-Jimack,Luc Reininger,Misao Matsushita,Teizo Fujita,Shozo Izui

View Articletitled, Role of galactosylation in the renal pathogenicity of murine immunoglobulin G3 monoclonal cryoglobulins

Induction of mitochondrial changes in myeloma cells by imexon

Katerina Dvorakova,Caroline N. Waltmire,Claire M. Payne,Margaret E. Tome,Margaret M. Briehl,Robert T. Dorr

View Articletitled, Induction of mitochondrial changes in myeloma cells by imexon

p53 abnormalities in splenic lymphoma with villous lymphocytes

Alicja M. Gruszka-Westwood,Rifat A. Hamoudi,Estella Matutes,Esperanza Tuset,Daniel Catovsky

View Articletitled, p53 abnormalities in splenic lymphoma with villous lymphocytes

Signal transducer and activator of transcription 3 activation is required for Asp⁸¹⁶ mutant c-Kit–mediated cytokine-independent survival and proliferation in human leukemia cells

Zhi-Qiang Ning,Jin Li,Robert J. Arceci

View Articletitled, Signal transducer and activator of transcription 3 activation is required for Asp816 mutant c-Kit–mediated cytokine-independent survival and proliferation in human leukemia cells

Expression of interferon-α (IFN-α) receptor 2c at diagnosis is associated with cytogenetic response in IFN-α–treated chronic myeloid leukemia

Christophe Barthe,François-Xavier Mahon,Marie-José Gharbi,Carole Fabères,Chrystèle Bilhou-Nabéra,Andreas Hochhaus,Josy Reiffers,Gérald Marit

View Articletitled, Expression of interferon-α (IFN-α) receptor 2c at diagnosis is associated with cytogenetic response in IFN-α–treated chronic myeloid leukemia

High frequency of immunophenotype changes in acute myeloid leukemia at relapse: implications for residual disease detection (Cancer and Leukemia Group B Study 8361)

Maria R. Baer,Carleton C. Stewart,Richard K. Dodge,Gail Leget,Norbert Sulé,Krzysztof Mrózek,Charles A. Schiffer,Bayard L. Powell,Jonathan E. Kolitz,Joseph O. Moore,Richard M. Stone,Frederick R. Davey,Andrew J. Carroll,Richard A. Larson,Clara D. Bloomfield

View Articletitled, High frequency of immunophenotype changes in acute myeloid leukemia at relapse: implications for residual disease detection (Cancer and Leukemia Group B Study 8361)

Primary chromosomal rearrangements of leukemia are frequently accompanied by extensive submicroscopic deletions and may lead to altered prognosis

Elena Kolomietz,Jaudah Al-Maghrabi,Shawn Brennan,Jana Karaskova,Solomon Minkin,Jeffrey Lipton,Jeremy A. Squire

View Articletitled, Primary chromosomal rearrangements of leukemia are frequently accompanied by extensive submicroscopic deletions and may lead to altered prognosis

FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia

Derek L. Stirewalt,Kenneth J. Kopecky,Soheil Meshinchi,Frederick R. Appelbaum,Marilyn L. Slovak,Cheryl L. Willman,Jerald P. Radich

View Articletitled, FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia

CD99 expression is positively regulated by Sp1 and is negatively regulated by Epstein-Barr virus latent membrane protein 1 through nuclear factor-κB

Im-soon Lee,Min Kyung Kim,Eun Young Choi,Anja Mehl,Kyeong Cheon Jung,Min Chan Gil,Martin Rowe,Seong Hoe Park

View Articletitled, CD99 expression is positively regulated by Sp1 and is negatively regulated by Epstein-Barr virus latent membrane protein 1 through nuclear factor-κB

MDR1 gene–related clonal selection and P-glycoprotein function and expression in relapsed or refractory acute myeloid leukemia

Marry M. van den Heuvel-Eibrink,Erik A. C. Wiemer,Marjan J. de Boevere,Bronno van der Holt,Paula J. M. Vossebeld,Rob Pieters,Pieter Sonneveld

View Articletitled, MDR1 gene–related clonal selection and P-glycoprotein function and expression in relapsed or refractory acute myeloid leukemia

Cytogenetic analysis and clinical significance in adult T-cell leukemia/lymphoma: a study of 50 cases from the human T-cell leukemia virus type-1 endemic area, Nagasaki

Takahiro Itoyama,R. S. K. Chaganti,Yasuaki Yamada,Kunihiro Tsukasaki,Sunao Atogami,Hideo Nakamura,Masao Tomonaga,Koichi Ohshima,Masahiro Kikuchi,Naoki Sadamori

View Articletitled, Cytogenetic analysis and clinical significance in adult T-cell leukemia/lymphoma: a study of 50 cases from the human T-cell leukemia virus type-1 endemic area, Nagasaki

PHAGOCYTES

CD44 ligation on peripheral blood polymorphonuclear cells induces interleukin-6 production

Giuseppe Sconocchia,Laura Campagnano,Domenico Adorno,Angela Iacona,Nella Y. Cococcetta,Vittorio Boffo,Sergio Amadori,Carlo U. Casciani

View Articletitled, CD44 ligation on peripheral blood polymorphonuclear cells induces interleukin-6 production

RED CELLS

Five years of experience with hydroxyurea in children and young adults with sickle cell disease
Clinical Trials & Observations

Alina Ferster,Parvine Tahriri,Christiane Vermylen,Geneviève Sturbois,Francis Corazza,Pierre Fondu,Christine Devalck,Marie F. Dresse,Walter Feremans,Kathleen Hunninck,Michele Toppet,Pierre Philippet,Chris Van Geet,Eric Sariban

View Articletitled, Five years of experience with hydroxyurea in children and young adults with sickle cell disease

Loss of red cell A, B, and H antigens is frequent in myeloid malignancies

Tina Bianco,Belinda J. Farmer,Robert E. Sage,Alexander Dobrovic

View Articletitled, Loss of red cell A, B, and H antigens is frequent in myeloid malignancies

TRANSFUSION MEDICINE

The effect of leukocyte-reduction method on the amount of human cytomegalovirus in blood products: a comparison of apheresis and filtration methods

Larry J. Dumont,Janos Luka,Tania VandenBroeke,Pamella Whitley,Daniel R. Ambruso,M. Dean Elfath

View Articletitled, The effect of leukocyte-reduction method on the amount of human cytomegalovirus in blood products: a comparison of apheresis and filtration methods

BRIEF REPORTS

Expression of nuclear transcription factor interferon consensus sequence binding protein in chronic myeloid leukemia correlates with pretreatment risk features and cytogenetic response to interferon-α
Brief Report

Manuel Schmidt,Andreas Hochhaus,Andreas Nitsche,Rüdiger Hehlmann,Andreas Neubauer

View Articletitled, Expression of nuclear transcription factor interferon consensus sequence binding protein in chronic myeloid leukemia correlates with pretreatment risk features and cytogenetic response to interferon-α

A homologous naturally occurring mutation in Duffy and CCR5 leading to reduced receptor expression
Brief Report

Daniel Tamasauskas,Vivien Powell,Kalle Saksela,Karina Yazdanbakhsh

View Articletitled, A homologous naturally occurring mutation in Duffy and CCR5 leading to reduced receptor expression

Arrest of human dendritic cells at the CD34⁻/CD4⁺/HLA-DR⁺ stage in the bone marrow of NOD/SCID-human chimeric mice
Brief Report

Masaharu Nobuyoshi,Yoichiro Kusunoki,Toshio Seyama,Kazunori Kodama,Akiro Kimura,Seishi Kyoizumi

View Articletitled, Arrest of human dendritic cells at the CD34−/CD4+/HLA-DR+ stage in the bone marrow of NOD/SCID-human chimeric mice

Resting and activated endothelial cells are increased in the peripheral blood of cancer patients
Brief Report

Patrizia Mancuso,Alessandra Burlini,Giancarlo Pruneri,Aron Goldhirsch,Giovanni Martinelli,Francesco Bertolini

View Articletitled, Resting and activated endothelial cells are increased in the peripheral blood of cancer patients

Cell proliferation through forced engagement of c-Kit and Flt-3
Brief Report

Kevin G. Otto,Liqing Jin,David M. Spencer,C. Anthony Blau

View Articletitled, Cell proliferation through forced engagement of c-Kit and Flt-3

Clinical correlates of splenic histopathology and splenic karyotype in myelofibrosis with myeloid metaplasia
Brief Report

Ruben A. Mesa,Chin-Yang Li,Georgene Schroeder,Ayalew Tefferi

View Articletitled, Clinical correlates of splenic histopathology and splenic karyotype in myelofibrosis with myeloid metaplasia

CORRESPONDENCE

A novel BCR-ABL fusion transcript (e15a2) in 2 patients with atypical chronic myeloproliferative syndrome

Marı́a del Pilar Moreno,Marı́a Noel Cortinas,Rossana Bonomi,Adriana Cardeza,Marı́a del Rosario Uriarte

View Articletitled, A novel BCR-ABL fusion transcript (e15a2) in 2 patients with atypical chronic myeloproliferative syndrome

Long-term follow-up of a randomized trial comparing the combination of cyclophosphamide with total body irradiation or busulfan as conditioning regimen for patients receiving HLA-identical marrow grafts for acute myeloblastic leukemia in first complete remission

Didier Blaise,Dominique Maraninchi,Mauricette Michallet,Josy Reiffers,Jean Pierre Jouet,Noël Milpied,Agnes Devergie,Michel Attal,Jean Jacques Sotto,Mathieu Kuentz,Norbert Ifrah,Charles Dauriac,Pierre Bordigoni,Nicole Gratecos,François Guilhot,Denis Guyotat,Eliane Gluckman,Jean Paul Vernant

View Articletitled, Long-term follow-up of a randomized trial comparing the combination of cyclophosphamide with total body irradiation or busulfan as conditioning regimen for patients receiving HLA-identical marrow grafts for acute myeloblastic leukemia in first complete remission

Intensive chemotherapy versus bone marrow transplantation in pediatric acute myeloid leukemia: a matter of controversies

Ursula Creutzig,Dirk Reinhardt,Martin Zimmermann,Thomas Klingebiel,Helmut Gadner

View Articletitled, Intensive chemotherapy versus bone marrow transplantation in pediatric acute myeloid leukemia: a matter of controversies

Intensive chemotherapy and bone marrow transplantation for children with acute myeloid leukemia

John Horan,Dave Korones

View Articletitled, Intensive chemotherapy and bone marrow transplantation for children with acute myeloid leukemia

Treatment of children with acute myeloid leukemia

Donald Pinkel

View Articletitled, Treatment of children with acute myeloid leukemia

Screening for c-mpl mutations in patients with congenital amegakaryocytic thrombocytopenia identifies a polymorphism

Sonja van den Oudenrijn,Masja de Haas,Albert E. G. Kr. von dem Borne

View Articletitled, Screening for c-mpl mutations in patients with congenital amegakaryocytic thrombocytopenia identifies a polymorphism

Frequent detection of rising cytomegalovirus antigenemia after allogeneic stem cell transplantation following a regimen containing antithymocyte globulin

Yoshinobu Kanda,Shin Mineishi,Kunihisa Nakai,Takeshi Saito,Ryuji Tanosaki,Yoichi Takaue

View Articletitled, Frequent detection of rising cytomegalovirus antigenemia after allogeneic stem cell transplantation following a regimen containing antithymocyte globulin

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Issue Archive

Table of Contents

INSIDE BLOOD

PLENARY PAPERS

ERRATA

CHEMOKINES

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial Clinical Trials & Observations

The Société Française d'Oncologie Pédiatrique LMB89 protocol: highly effective multiagent chemotherapy tailored to the tumor burden and initial response in 561 unselected children with B-cell lymphomas and L3 leukemia Clinical Trials & Observations

Immune reconstitution after allogeneic marrow transplantation compared with blood stem cell transplantation Clinical Trials & Observations

Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus-tumor effects Clinical Trials & Observations

Correlation of abnormal intracranial vessel velocity, measured by transcranial Doppler ultrasonography, with abnormal conjunctival vessel velocity, measured by computer-assisted intravital microscopy, in sickle cell disease Clinical Trials & Observations

Controlled trial of filgrastim for acceleration of neutrophil recovery after allogeneic blood stem cell transplantation from human leukocyte antigen–matched related donors Clinical Trials & Observations

Cardiac involvement in thalassemia intermedia: a multicenter study Clinical Trials & Observations

GENE THERAPY

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

IMMUNOBIOLOGY

NEOPLASIA

PHAGOCYTES

RED CELLS

Five years of experience with hydroxyurea in children and young adults with sickle cell disease Clinical Trials & Observations

TRANSFUSION MEDICINE

BRIEF REPORTS

Expression of nuclear transcription factor interferon consensus sequence binding protein in chronic myeloid leukemia correlates with pretreatment risk features and cytogenetic response to interferon-α Brief Report

A homologous naturally occurring mutation in Duffy and CCR5 leading to reduced receptor expression Brief Report

Arrest of human dendritic cells at the CD34−/CD4+/HLA-DR+ stage in the bone marrow of NOD/SCID-human chimeric mice Brief Report

Resting and activated endothelial cells are increased in the peripheral blood of cancer patients Brief Report

Cell proliferation through forced engagement of c-Kit and Flt-3 Brief Report

Clinical correlates of splenic histopathology and splenic karyotype in myelofibrosis with myeloid metaplasia Brief Report