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Issue Archive

Volume 97, Issue 10
May 15 2001
Blood Cover Image for Volume 97, Issue 10

Table of Contents

INSIDE BLOOD

Young is better if enough
Claudio Anasetti
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Coagulation gene polymorphisms: the benefit?
David Lane
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Dx: leukemia; Rx: CD8+ NKT cell transplantation
Sebastian Joyce
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PLENARY PAPERS

Expansion of cytolytic CD8+ natural killer T cells with limited capacity for graft-versus-host disease induction due to interferon γ production
Jeanette Baker,Michael R. Verneris,Maki Ito,Judith A. Shizuru,Robert S. Negrin
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CHEMOKINES

Ligation of CD11b and CD11c β2 integrins by antibodies or soluble CD23 induces macrophage inflammatory protein 1α (MIP-1α) and MIP-1β production in primary human monocytes through a pathway dependent on nuclear factor–κB
Roger Rezzonico,Veronique Imbert,Rachel Chicheportiche,Jean-Michel Dayer
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The synthetic peptide WKYMVm attenuates the function of the chemokine receptors CCR5 and CXCR4 through activation of formyl peptide receptor-like 1
Bao-Qun Li,Michele A. Wetzel,Judy A. Mikovits,Earl E. Henderson,Thomas J. Rogers,Wanghua Gong,Yingying Le,Francis W. Ruscetti,Ji Ming Wang
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CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Larger numbers of CD4bright dendritic cells in donor bone marrow are associated with increased relapse after allogeneic bone marrow transplantation
Clinical Trials & Observations
Edmund K. Waller,Hilary Rosenthal,Terry W. Jones,Jennifer Peel,Sagar Lonial,Amelia Langston,Istvan Redei,Ingrid Jurickova,Michael W. Boyer
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Survival after transplantation of unrelated donor umbilical cord blood is comparable to that of human leukocyte antigen–matched unrelated donor bone marrow: results of a matched-pair analysis
Clinical Trials & Observations
Juliet N. Barker,Stella M. Davies,Todd DeFor,Norma K. C. Ramsay,Daniel J. Weisdorf,John E. Wagner
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Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia
Clinical Trials & Observations
Vanderson Rocha,Jacqueline Cornish,Eric L. Sievers,Alexandra Filipovich,Franco Locatelli,Cristina Peters,Mats Remberger,Gérard Michel,William Arcese,Sandro Dallorso,Karin Tiedemann,Alessandro Busca,Ka-Wah Chan,Shunichi Kato,Juan Ortega,Marcus Vowels,Axel Zander,Gérard Souillet,Anthony Oakill,Ann Woolfrey,Andrea L. Pay,Ann Green,Federico Garnier,Irina Ionescu,Peter Wernet,Girolamo Sirchia,Pablo Rubinstein,Sylvie Chevret,Eliane Gluckman
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Highly heterogeneous nature of δ-aminolevulinate dehydratase (ALAD) deficiencies in ALAD porphyria
Clinical Trials & Observations
Motoyoshi Maruno,Kazumichi Furuyama,Reiko Akagi,Yutaka Horie,Kuniaki Meguro,Luba Garbaczewski,Nicholas Chiorazzi,Manfred O. Doss,Alexandre Hassoun,Rudolf Mercelis,Luc Verstraeten,Pauline Harper,Ylva Floderus,Stig Thunell,Shigeru Sassa
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Polymorphisms of clotting factors modify the risk for primary intracranial hemorrhage
Clinical Trials & Observations
Javier Corral,Juan Antonio Iniesta,Rocio González-Conejero,Marino Villalón,Vicente Vicente
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A potential role for interleukin-7 in T-cell homeostasis
Clinical Trials & Observations
Terry J. Fry,Elizabeth Connick,Judith Falloon,Michael M. Lederman,David J. Liewehr,John Spritzler,Seth M. Steinberg,Lauren V. Wood,Robert Yarchoan,Judy Zuckerman,Alan Landay,Crystal L. Mackall
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Mitoxantrone is superior to doxorubicin in a multiagent weekly regimen for patients older than 60 with high-grade lymphoma: results of a BNLI randomized trial of PAdriaCEBO versus PMitCEBO
Clinical Trials & Observations
Paul N. Mainwaring,David Cunningham,Walter Gregory,Peter Hoskin,Barry Hancock,Andrew J. Norton,Ken MacLennan,Paul Smith,Gillian Vaughan Hudson,David Linch
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A randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis: Presented in part at the American Society of Hematology Conference in Miami Beach, FL, December 1998.
Clinical Trials & Observations
Stanton C. Goldman,John S. Holcenberg,Jerry Z. Finklestein,Raymond Hutchinson,Susan Kreissman,F. Leonard Johnson,Conrad Tou,Elizabeth Harvey,Erin Morris,Mitchell S. Cairo
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GENE THERAPY

Efficient retrovirus-mediated PIG-A gene transfer and stable restoration of GPI-anchored protein expression in cells with the PNH phenotype
Jun-ichi Nishimura,Ken L. Phillips,Russell E. Ware,Sharon Hall,Lee Wilson,Tracy L. Gentry,Thad A. Howard,Yoshiko Murakami,Masaru Shibano,Takashi Machii,Eli Gilboa,Yuzuru Kanakura,Junji Takeda,Taroh Kinoshita,Wendell F. Rosse,Clay A. Smith
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HEMATOPOIESIS

Shwachman-Diamond syndrome marrow cells show abnormally increased apoptosis mediated through the Fas pathway
Yigal Dror,Melvin H. Freedman
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Functional correction of FA-C cells withFANCC suppresses the expression of interferon γ–inducible genes
Sara R. Fagerlie,Jane Diaz,Tracy A. Christianson,Kelli McCartan,Winifred Keeble,Gregory R. Faulkner,Grover C. Bagby
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Mimicry between neurokinin-1 and fibronectin may explain the transport and stability of increased substance P immunoreactivity in patients with bone marrow fibrosis
Pranela Rameshwar,Deval D. Joshi,Prem Yadav,Jing Qian,Pedro Gascon,Victor T. Chang,Devashish Anjaria,Jonathan S. Harrison,Xiaosong Song
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Inhibitory effect of the mi transcription factor encoded by the mutant mi allele on GA binding protein–mediated transcript expression in mouse mast cells
Eiichi Morii,Hideki Ogihara,Keisuke Oboki,Chika Sawa,Takahiko Sakuma,Shintaro Nomura,Jeffrey D. Esko,Hiroshi Handa,Yukihiko Kitamura
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Accentuated response to phenylhydrazine and erythropoietin in mice genetically impaired for their GATA-1 expression (GATA-1low mice)
Alessandro Maria Vannucchi,Lucia Bianchi,Cristina Cellai,Francesco Paoletti,Valentina Carrai,Anna Calzolari,Lucia Centurione,Rodolfo Lorenzini,Claudio Carta,Elena Alfani,Massimo Sanchez,Giovanni Migliaccio,Anna Rita Migliaccio
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A novel regulator of G-protein signaling bearing GAP activity for Gαi and Gαq in megakaryocytes
Yuka Nagata,Masaaki Oda,Hiroko Nakata,Yuka Shozaki,Tohru Kozasa,Kazuo Todokoro
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The relative quiescence of hematopoietic stem cells in nonhuman primates
Nadim Mahmud,Steven M. Devine,Kevin P. Weller,Simrit Parmar,Cord Sturgeon,Mary C. Nelson,Terry Hewett,Ronald Hoffman
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Natural killer cell–dependent apoptosis of peripheral murine hematopoietic progenitor cells in response to Fas cross-linking: involvement of tumor necrosis factor-α
Géraldine Moreau,Maria Leite-de-Moraes,Sophie Ezine,James P. Di Santo,Michel Dy,Elke Schneider
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Numerous growth factors, cytokines, and chemokines are secreted by human CD34+ cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner: Presented at the 41st Annual Meeting of the American Society of Hematology, New Orleans, LA, December 3-7, 1999, and published in abstract form in Blood. 1999;94(suppl 1):465a.
Marcin Majka,Anna Janowska-Wieczorek,Janina Ratajczak,Karen Ehrenman,Zbigniew Pietrzkowski,M. Anna Kowalska,Alan M. Gewirtz,Stephen G. Emerson,Mariusz Z. Ratajczak
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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Depletion of circulating α2-antiplasmin by intravenous plasmin or immunoneutralization reduces focal cerebral ischemic injury in the absence of arterial recanalization
Nobus Nagai,Maria De Mol,Berthe Van Hoef,Maria Verstreken,Désiré Collen
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Effect of the PlA2 alloantigen on the function of β3-integrins in platelets
Joel S. Bennett,Francesca Catella-Lawson,Andrew R. Rut,Gaston Vilaire,Weiwei Qi,Shiv C. Kapoor,Scott Murphy,Garret A. FitzGerald
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Platelet activation by Shiga toxin and circulatory factors as a pathogenetic mechanism in the hemolytic uremic syndrome
Clinical Trials & Observations
Diana Karpman,Domniki Papadopoulou,Kajsa Nilsson,Ann-Christine Sjögren,Carl Mikaelsson,Stefan Lethagen
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Gene induction by coagulation factor Xa is mediated by activation of protease-activated receptor 1
Matthias Riewald,Vladimir V. Kravchenko,Ramona J. Petrovan,Peter J. O'Brien,Lawrence F. Brass,Richard J. Ulevitch,Wolfram Ruf
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Supplemental data
Model for a factor IX activation complex on blood platelets: dimeric conformation of factor XIa is essential
David Gailani,David Ho,Mao-Fu Sun,Qiufang Cheng,Peter N. Walsh
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Proteolysis of the urokinase-type plasminogen activator receptor by metalloproteinase-12: implication for angiogenesis in fibrin matrices
Pieter Koolwijk,Nicolai Sidenius,Erna Peters,Cornelis F. M. Sier,Roeland Hanemaaijer,Francesco Blasi,Victor W. M. van Hinsbergh
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IMMUNOBIOLOGY

Augmentation of antitumor effects by NK cell inhibitory receptor blockade in vitro and in vivo
Crystal Y. Koh,Bruce R. Blazar,Thaddeus George,Lisbeth A. Welniak,Christian M. Capitini,Arati Raziuddin,William J. Murphy,Michael Bennett
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Targeting of a B7-1 (CD80) immunoglobulin G fusion protein to acute myeloid leukemia blasts increases their costimulatory activity for autologous remission T cells
Michael Notter,Tim Willinger,Ulrike Erben,Eckhard Thiel
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Human natural killer cells: a unique innate immunoregulatory role for the CD56bright subset
Megan A. Cooper,Todd A. Fehniger,Sarah C. Turner,Kenneth S. Chen,Bobak A. Ghaheri,Tariq Ghayur,William E. Carson,Michael A. Caligiuri
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Red blood cells inhibit activation-induced cell death and oxidative stress in human peripheral blood T lymphocytes
Ana Mafalda Fonseca,Graça Porto,Koji Uchida,Fernando A. Arosa
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Increases in circulating and lymphoid tissue interleukin-10 in autoimmune lymphoproliferative syndrome are associated with disease expression
Uri Lopatin,Xu Yao,Richard K. Williams,Jack J. H. Bleesing,Janet K. Dale,David Wong,Julie Teruya-Feldstein,Scott Fritz,Matthew R. Morrow,Ivan Fuss,Michael C. Sneller,Mark Raffeld,Thomas A. Fleisher,Jennifer M. Puck,Warren Strober,Elaine S. Jaffe,Stephen E. Straus
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Impaired dendritic cell maturation in patients with chronic, but not resolved, hepatitis C virus infection
Susanne Auffermann-Gretzinger,Emmet B. Keeffe,Shoshana Levy
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Impaired production of naive T lymphocytes in human T-cell leukemia virus type I–infected individuals: its implications in the immunodeficient state
Jun-ichirou Yasunaga,Tatsunori Sakai,Kisato Nosaka,Ken-ichiro Etoh,Sadahiro Tamiya,Shin Koga,Shuji Mita,Makoto Uchino,Hiroaki Mitsuya,Masao Matsuoka
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Truncated thioredoxin (Trx80) induces production of interleukin-12 and enhances CD14 expression in human monocytes
Klas Pekkari,Javier Avila-Cariño,Åsa Bengtsson,Ramanathan Gurunath,Annika Scheynius,Arne Holmgren
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NEOPLASIA

Defective octamer-dependent transcription is responsible for silenced immunoglobulin transcription in Reed-Sternberg cells
Jan Theil,Helmut Laumen,Theresa Marafioti,Michael Hummel,Georg Lenz,Thomas Wirth,Harald Stein
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Targeting of the CD33-calicheamicin immunoconjugate Mylotarg (CMA-676) in acute myeloid leukemia: in vivo and in vitro saturation and internalization by leukemic and normal myeloid cells
Clinical Trials & Observations
Vincent H. J. van der Velden,Jeroen G. te Marvelde,Patricia G. Hoogeveen,Irwin D. Bernstein,Adriaan B. Houtsmuller,Mark S. Berger,Jacques J. M. van Dongen
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Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma
Keitaro Matsuo,Ritsuro Suzuki,Nobuyuki Hamajima,Michinori Ogura,Yoshitoyo Kagami,Hirofumi Taji,Eisei Kondoh,Satoko Maeda,Shoji Asakura,Sadayuki Kaba,Shigeo Nakamura,Masao Seto,Yasuo Morishima,Kazuo Tajima
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Identification of a leukemic counterpart of the plasmacytoid dendritic cells
Laurence Chaperot,Nathalie Bendriss,Olivier Manches,Rémy Gressin,Marc Maynadie,Franck Trimoreau,Hubert Orfeuvre,Bernadette Corront,Jean Feuillard,Jean-Jacques Sotto,Jean-Claude Bensa,Francine Brière,Joël Plumas,Marie-Christine Jacob
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Preconditioning with fetal cord blood facilitates engraftment of primary childhood T-cell acute lymphoblastic leukemia in immunodeficient mice
Deno P. Dialynas,Mi-Jeong Lee,Daniel P. Gold,Li-en Shao,Alice L. Yu,Michael J. Borowitz,John Yu
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Novel methylation targets in de novo acute myeloid leukemia with prevalence of chromosome 11 loci
Laura J. Rush,Zunyan Dai,Dominic J. Smiraglia,Xin Gao,Fred A. Wright,Michael Frühwald,Joseph F. Costello,William A. Held,Li Yu,Ralf Krahe,Jonathan E. Kolitz,Clara D. Bloomfield,Michael A. Caligiuri,Christoph Plass
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Tyrosine kinase inhibitor STI571 potentiates the pharmacologic activity of retinoic acid in acute promyelocytic leukemia cells: effects on the degradation of RARα and PML-RARα
Maurizio Gianni',Yesim Kalaç,Isabella Ponzanelli,Alessandro Rambaldi,Mineko Terao,Enrico Garattini
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Hypoxia induces lytic replication of Kaposi sarcoma–associated herpesvirus
David A. Davis,Andrea S. Rinderknecht,J. Paul Zoeteweij,Yoshiyasu Aoki,Elizabeth L. Read-Connole,Giovanna Tosato,Andrew Blauvelt,Robert Yarchoan
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PHAGOCYTES

Phosphoinositide 3-kinase modulation of β3-integrin represents an endogenous “braking” mechanism during neutrophil transmatrix migration
Walter J. Bruyninckx,Katrina M. Comerford,Donald W. Lawrence,Sean P. Colgan
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RED CELLS

Short-chain fatty acid derivatives stimulate cell proliferation and induce STAT-5 activation
Michael S. Boosalis,Ram Bandyopadhyay,Emery H. Bresnick,Betty S. Pace,Karyn Van DeMark,Baohua Zhang,Douglas V. Faller,Susan P. Perrine
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Modifications in the CD36 binding domain of the Plasmodium falciparum variant antigen are responsible for the inability of chondroitin sulfate A adherent parasites to bind CD36
Benoit Gamain,Joseph D. Smith,Louis H. Miller,Dror I. Baruch
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Functional requirements for phenotypic correction of murine β-thalassemia: implications for human gene therapy
Derek A. Persons,Esther R. Allay,Denise E. Sabatino,Patrick Kelly,David M. Bodine,Arthur W. Nienhuis
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TRANSPLANTATION

Rapid and efficient homing of human CD34+CD38−/lowCXCR4+stem and progenitor cells to the bone marrow and spleen of NOD/SCID and NOD/SCID/B2mnull mice
Orit Kollet,Asaf Spiegel,Amnon Peled,Isabelle Petit,Tamara Byk,Rami Hershkoviz,Esther Guetta,Gad Barkai,Arnon Nagler,Tsvee Lapidot
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Intra–bone marrow injection of allogeneic bone marrow cells: a powerful new strategy for treatment of intractable autoimmune diseases in MRL/lpr mice
Taketoshi Kushida,Muneo Inaba,Hiroko Hisha,Naoya Ichioka,Takashi Esumi,Ryokei Ogawa,Hirokazu Iida,Susumu Ikehara
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BRIEF REPORTS

Induction of monocyte tissue factor expression by antibodies to heparin–platelet factor 4 complexes developed in heparin-induced thrombocytopenia
Clinical Trials & Observations Brief Report
Claire Pouplard,Sophie Iochmann,Benoit Renard,Olivier Herault,Philippe Colombat,Jean Amiral,Yves Gruel
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The basophil activation marker defined by antibody 97A6 is identical to the ectonucleotide pyrophosphatase/phosphodiesterase 3
Brief Report
Hans-Jörg Bühring,Martina Seiffert,Christina Giesert,Anke Marxer,Lothar Kanz,Peter Valent,Kimihiko Sano
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Human polymorphism of P-selectin glycoprotein ligand 1 attributable to variable numbers of tandem decameric repeats in the mucinlike region
Brief Report
Vahid Afshar-Kharghan,Reyhan Diz-Küçükkaya,Erwin H. Ludwig,Ali J. Marian,José A. López
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Molecular genetic basis of porcine histo-blood group AO system
Brief Report
Fumiichiro Yamamoto,Miyako Yamamoto
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Induction of tolerance to human factor VIII in mice
Brief Report
Hengjun Chao,Christopher E. Walsh
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CORRESPONDENCE

Fatal sickle cell crisis after granulocyte colony-stimulating factor administration
Brian K. Adler,Donna E. Salzman,Matthew H. Carabasi,William P. Vaughan,Vishnu V. B. Reddy,Josef T. Prchal
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Acquired and inherited risk factors for splanchnic venous thrombosis
Valerio De Stefano,Luciana Teofili,Giuseppe Leone
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Cubilin and the hydrophobic intrinsic factor receptor are distinct molecules
Jean-Louis Guéant,Céline Chéry,Farès Namour
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Hepatitis C virus RNA dynamics during antiretroviral therapy
Raffaele Bruno,Paolo Sacchi,Gaetano Filice
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WA monoclonal rheumatoid factors and non-Hodgkin lymphoma
Glenn Knight,Vincent Agnello
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Clarifications to the standard neutrophil response criteria for clinical trials in myelodysplastic syndromes are needed
David P. Steensma,Louis Letendre,Ayalew Tefferi
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