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Volume 97, Issue 10

May 15 2001

In this Issue

INSIDE BLOOD
PLENARY PAPERS
CHEMOKINES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSPLANTATION
BRIEF REPORTS
CORRESPONDENCE

INSIDE BLOOD

Young is better if enough

Claudio Anasetti

View Articletitled, Young is better if enough

Coagulation gene polymorphisms: the benefit?

David Lane

View Articletitled, Coagulation gene polymorphisms: the benefit?

Dx: leukemia; Rx: CD8⁺ NKT cell transplantation

Sebastian Joyce

View Articletitled, Dx: leukemia; Rx: CD8+ NKT cell transplantation

PLENARY PAPERS

Expansion of cytolytic CD8⁺ natural killer T cells with limited capacity for graft-versus-host disease induction due to interferon γ production

Jeanette Baker,Michael R. Verneris,Maki Ito,Judith A. Shizuru,Robert S. Negrin

View Articletitled, Expansion of cytolytic CD8+ natural killer T cells with limited capacity for graft-versus-host disease induction due to interferon γ production

CHEMOKINES

Ligation of CD11b and CD11c β₂ integrins by antibodies or soluble CD23 induces macrophage inflammatory protein 1α (MIP-1α) and MIP-1β production in primary human monocytes through a pathway dependent on nuclear factor–κB

Roger Rezzonico,Veronique Imbert,Rachel Chicheportiche,Jean-Michel Dayer

View Articletitled, Ligation of CD11b and CD11c β2 integrins by antibodies or soluble CD23 induces macrophage inflammatory protein 1α (MIP-1α) and MIP-1β production in primary human monocytes through a pathway dependent on nuclear factor–κB

The synthetic peptide WKYMVm attenuates the function of the chemokine receptors CCR5 and CXCR4 through activation of formyl peptide receptor-like 1

Bao-Qun Li,Michele A. Wetzel,Judy A. Mikovits,Earl E. Henderson,Thomas J. Rogers,Wanghua Gong,Yingying Le,Francis W. Ruscetti,Ji Ming Wang

View Articletitled, The synthetic peptide WKYMVm attenuates the function of the chemokine receptors CCR5 and CXCR4 through activation of formyl peptide receptor-like 1

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Larger numbers of CD4^bright dendritic cells in donor bone marrow are associated with increased relapse after allogeneic bone marrow transplantation
Clinical Trials & Observations

Edmund K. Waller,Hilary Rosenthal,Terry W. Jones,Jennifer Peel,Sagar Lonial,Amelia Langston,Istvan Redei,Ingrid Jurickova,Michael W. Boyer

View Articletitled, Larger numbers of CD4bright dendritic cells in donor bone marrow are associated with increased relapse after allogeneic bone marrow transplantation

Survival after transplantation of unrelated donor umbilical cord blood is comparable to that of human leukocyte antigen–matched unrelated donor bone marrow: results of a matched-pair analysis
Clinical Trials & Observations

Juliet N. Barker,Stella M. Davies,Todd DeFor,Norma K. C. Ramsay,Daniel J. Weisdorf,John E. Wagner

View Articletitled, Survival after transplantation of unrelated donor umbilical cord blood is comparable to that of human leukocyte antigen–matched unrelated donor bone marrow: results of a matched-pair analysis

Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia
Clinical Trials & Observations

Vanderson Rocha,Jacqueline Cornish,Eric L. Sievers,Alexandra Filipovich,Franco Locatelli,Cristina Peters,Mats Remberger,Gérard Michel,William Arcese,Sandro Dallorso,Karin Tiedemann,Alessandro Busca,Ka-Wah Chan,Shunichi Kato,Juan Ortega,Marcus Vowels,Axel Zander,Gérard Souillet,Anthony Oakill,Ann Woolfrey,Andrea L. Pay,Ann Green,Federico Garnier,Irina Ionescu,Peter Wernet,Girolamo Sirchia,Pablo Rubinstein,Sylvie Chevret,Eliane Gluckman

View Articletitled, Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia

Highly heterogeneous nature of δ-aminolevulinate dehydratase (ALAD) deficiencies in ALAD porphyria
Clinical Trials & Observations

Motoyoshi Maruno,Kazumichi Furuyama,Reiko Akagi,Yutaka Horie,Kuniaki Meguro,Luba Garbaczewski,Nicholas Chiorazzi,Manfred O. Doss,Alexandre Hassoun,Rudolf Mercelis,Luc Verstraeten,Pauline Harper,Ylva Floderus,Stig Thunell,Shigeru Sassa

View Articletitled, Highly heterogeneous nature of δ-aminolevulinate dehydratase (ALAD) deficiencies in ALAD porphyria

Polymorphisms of clotting factors modify the risk for primary intracranial hemorrhage
Clinical Trials & Observations

Javier Corral,Juan Antonio Iniesta,Rocio González-Conejero,Marino Villalón,Vicente Vicente

View Articletitled, Polymorphisms of clotting factors modify the risk for primary intracranial hemorrhage

A potential role for interleukin-7 in T-cell homeostasis
Clinical Trials & Observations

Terry J. Fry,Elizabeth Connick,Judith Falloon,Michael M. Lederman,David J. Liewehr,John Spritzler,Seth M. Steinberg,Lauren V. Wood,Robert Yarchoan,Judy Zuckerman,Alan Landay,Crystal L. Mackall

View Articletitled, A potential role for interleukin-7 in T-cell homeostasis

Mitoxantrone is superior to doxorubicin in a multiagent weekly regimen for patients older than 60 with high-grade lymphoma: results of a BNLI randomized trial of PAdriaCEBO versus PMitCEBO
Clinical Trials & Observations

Paul N. Mainwaring,David Cunningham,Walter Gregory,Peter Hoskin,Barry Hancock,Andrew J. Norton,Ken MacLennan,Paul Smith,Gillian Vaughan Hudson,David Linch

View Articletitled, Mitoxantrone is superior to doxorubicin in a multiagent weekly regimen for patients older than 60 with high-grade lymphoma: results of a BNLI randomized trial of PAdriaCEBO versus PMitCEBO

A randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis: Presented in part at the American Society of Hematology Conference in Miami Beach, FL, December 1998.
Clinical Trials & Observations

Stanton C. Goldman,John S. Holcenberg,Jerry Z. Finklestein,Raymond Hutchinson,Susan Kreissman,F. Leonard Johnson,Conrad Tou,Elizabeth Harvey,Erin Morris,Mitchell S. Cairo

View Articletitled, A randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis: Presented in part at the American Society of Hematology Conference in Miami Beach, FL, December 1998.

GENE THERAPY

Efficient retrovirus-mediated PIG-A gene transfer and stable restoration of GPI-anchored protein expression in cells with the PNH phenotype

Jun-ichi Nishimura,Ken L. Phillips,Russell E. Ware,Sharon Hall,Lee Wilson,Tracy L. Gentry,Thad A. Howard,Yoshiko Murakami,Masaru Shibano,Takashi Machii,Eli Gilboa,Yuzuru Kanakura,Junji Takeda,Taroh Kinoshita,Wendell F. Rosse,Clay A. Smith

View Articletitled, Efficient retrovirus-mediated PIG-A gene transfer and stable restoration of GPI-anchored protein expression in cells with the PNH phenotype

HEMATOPOIESIS

Shwachman-Diamond syndrome marrow cells show abnormally increased apoptosis mediated through the Fas pathway

Yigal Dror,Melvin H. Freedman

View Articletitled, Shwachman-Diamond syndrome marrow cells show abnormally increased apoptosis mediated through the Fas pathway

Functional correction of FA-C cells withFANCC suppresses the expression of interferon γ–inducible genes

Sara R. Fagerlie,Jane Diaz,Tracy A. Christianson,Kelli McCartan,Winifred Keeble,Gregory R. Faulkner,Grover C. Bagby

View Articletitled, Functional correction of FA-C cells withFANCC suppresses the expression of interferon γ–inducible genes

Mimicry between neurokinin-1 and fibronectin may explain the transport and stability of increased substance P immunoreactivity in patients with bone marrow fibrosis

Pranela Rameshwar,Deval D. Joshi,Prem Yadav,Jing Qian,Pedro Gascon,Victor T. Chang,Devashish Anjaria,Jonathan S. Harrison,Xiaosong Song

View Articletitled, Mimicry between neurokinin-1 and fibronectin may explain the transport and stability of increased substance P immunoreactivity in patients with bone marrow fibrosis

Inhibitory effect of the mi transcription factor encoded by the mutant mi allele on GA binding protein–mediated transcript expression in mouse mast cells

Eiichi Morii,Hideki Ogihara,Keisuke Oboki,Chika Sawa,Takahiko Sakuma,Shintaro Nomura,Jeffrey D. Esko,Hiroshi Handa,Yukihiko Kitamura

View Articletitled, Inhibitory effect of the mi transcription factor encoded by the mutant mi allele on GA binding protein–mediated transcript expression in mouse mast cells

Accentuated response to phenylhydrazine and erythropoietin in mice genetically impaired for their GATA-1 expression (GATA-1^low mice)

Alessandro Maria Vannucchi,Lucia Bianchi,Cristina Cellai,Francesco Paoletti,Valentina Carrai,Anna Calzolari,Lucia Centurione,Rodolfo Lorenzini,Claudio Carta,Elena Alfani,Massimo Sanchez,Giovanni Migliaccio,Anna Rita Migliaccio

View Articletitled, Accentuated response to phenylhydrazine and erythropoietin in mice genetically impaired for their GATA-1 expression (GATA-1low mice)

A novel regulator of G-protein signaling bearing GAP activity for Gαi and Gαq in megakaryocytes

Yuka Nagata,Masaaki Oda,Hiroko Nakata,Yuka Shozaki,Tohru Kozasa,Kazuo Todokoro

View Articletitled, A novel regulator of G-protein signaling bearing GAP activity for Gαi and Gαq in megakaryocytes

The relative quiescence of hematopoietic stem cells in nonhuman primates

Nadim Mahmud,Steven M. Devine,Kevin P. Weller,Simrit Parmar,Cord Sturgeon,Mary C. Nelson,Terry Hewett,Ronald Hoffman

View Articletitled, The relative quiescence of hematopoietic stem cells in nonhuman primates

Natural killer cell–dependent apoptosis of peripheral murine hematopoietic progenitor cells in response to Fas cross-linking: involvement of tumor necrosis factor-α

Géraldine Moreau,Maria Leite-de-Moraes,Sophie Ezine,James P. Di Santo,Michel Dy,Elke Schneider

View Articletitled, Natural killer cell–dependent apoptosis of peripheral murine hematopoietic progenitor cells in response to Fas cross-linking: involvement of tumor necrosis factor-α

Numerous growth factors, cytokines, and chemokines are secreted by human CD34⁺ cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner: Presented at the 41st Annual Meeting of the American Society of Hematology, New Orleans, LA, December 3-7, 1999, and published in abstract form in Blood. 1999;94(suppl 1):465a.

Marcin Majka,Anna Janowska-Wieczorek,Janina Ratajczak,Karen Ehrenman,Zbigniew Pietrzkowski,M. Anna Kowalska,Alan M. Gewirtz,Stephen G. Emerson,Mariusz Z. Ratajczak

View Articletitled, Numerous growth factors, cytokines, and chemokines are secreted by human CD34+ cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner: Presented at the 41st Annual Meeting of the American Society of Hematology, New Orleans, LA, December 3-7, 1999, and published in abstract form in Blood. 1999;94(suppl 1):465a.

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Depletion of circulating α₂-antiplasmin by intravenous plasmin or immunoneutralization reduces focal cerebral ischemic injury in the absence of arterial recanalization

Nobus Nagai,Maria De Mol,Berthe Van Hoef,Maria Verstreken,Désiré Collen

View Articletitled, Depletion of circulating α2-antiplasmin by intravenous plasmin or immunoneutralization reduces focal cerebral ischemic injury in the absence of arterial recanalization

Effect of the Pl^A2 alloantigen on the function of β₃-integrins in platelets

Joel S. Bennett,Francesca Catella-Lawson,Andrew R. Rut,Gaston Vilaire,Weiwei Qi,Shiv C. Kapoor,Scott Murphy,Garret A. FitzGerald

View Articletitled, Effect of the PlA2 alloantigen on the function of β3-integrins in platelets

Platelet activation by Shiga toxin and circulatory factors as a pathogenetic mechanism in the hemolytic uremic syndrome
Clinical Trials & Observations

Diana Karpman,Domniki Papadopoulou,Kajsa Nilsson,Ann-Christine Sjögren,Carl Mikaelsson,Stefan Lethagen

View Articletitled, Platelet activation by Shiga toxin and circulatory factors as a pathogenetic mechanism in the hemolytic uremic syndrome

Gene induction by coagulation factor Xa is mediated by activation of protease-activated receptor 1

Matthias Riewald,Vladimir V. Kravchenko,Ramona J. Petrovan,Peter J. O'Brien,Lawrence F. Brass,Richard J. Ulevitch,Wolfram Ruf

View Articletitled, Gene induction by coagulation factor Xa is mediated by activation of protease-activated receptor 1

Supplemental data

Model for a factor IX activation complex on blood platelets: dimeric conformation of factor XIa is essential

David Gailani,David Ho,Mao-Fu Sun,Qiufang Cheng,Peter N. Walsh

View Articletitled, Model for a factor IX activation complex on blood platelets: dimeric conformation of factor XIa is essential

Proteolysis of the urokinase-type plasminogen activator receptor by metalloproteinase-12: implication for angiogenesis in fibrin matrices

Pieter Koolwijk,Nicolai Sidenius,Erna Peters,Cornelis F. M. Sier,Roeland Hanemaaijer,Francesco Blasi,Victor W. M. van Hinsbergh

View Articletitled, Proteolysis of the urokinase-type plasminogen activator receptor by metalloproteinase-12: implication for angiogenesis in fibrin matrices

IMMUNOBIOLOGY

Augmentation of antitumor effects by NK cell inhibitory receptor blockade in vitro and in vivo

Crystal Y. Koh,Bruce R. Blazar,Thaddeus George,Lisbeth A. Welniak,Christian M. Capitini,Arati Raziuddin,William J. Murphy,Michael Bennett

View Articletitled, Augmentation of antitumor effects by NK cell inhibitory receptor blockade in vitro and in vivo

Targeting of a B7-1 (CD80) immunoglobulin G fusion protein to acute myeloid leukemia blasts increases their costimulatory activity for autologous remission T cells

Michael Notter,Tim Willinger,Ulrike Erben,Eckhard Thiel

View Articletitled, Targeting of a B7-1 (CD80) immunoglobulin G fusion protein to acute myeloid leukemia blasts increases their costimulatory activity for autologous remission T cells

Human natural killer cells: a unique innate immunoregulatory role for the CD56^bright subset

Megan A. Cooper,Todd A. Fehniger,Sarah C. Turner,Kenneth S. Chen,Bobak A. Ghaheri,Tariq Ghayur,William E. Carson,Michael A. Caligiuri

View Articletitled, Human natural killer cells: a unique innate immunoregulatory role for the CD56bright subset

Red blood cells inhibit activation-induced cell death and oxidative stress in human peripheral blood T lymphocytes

Ana Mafalda Fonseca,Graça Porto,Koji Uchida,Fernando A. Arosa

View Articletitled, Red blood cells inhibit activation-induced cell death and oxidative stress in human peripheral blood T lymphocytes

Increases in circulating and lymphoid tissue interleukin-10 in autoimmune lymphoproliferative syndrome are associated with disease expression

Uri Lopatin,Xu Yao,Richard K. Williams,Jack J. H. Bleesing,Janet K. Dale,David Wong,Julie Teruya-Feldstein,Scott Fritz,Matthew R. Morrow,Ivan Fuss,Michael C. Sneller,Mark Raffeld,Thomas A. Fleisher,Jennifer M. Puck,Warren Strober,Elaine S. Jaffe,Stephen E. Straus

View Articletitled, Increases in circulating and lymphoid tissue interleukin-10 in autoimmune lymphoproliferative syndrome are associated with disease expression

Impaired dendritic cell maturation in patients with chronic, but not resolved, hepatitis C virus infection

Susanne Auffermann-Gretzinger,Emmet B. Keeffe,Shoshana Levy

View Articletitled, Impaired dendritic cell maturation in patients with chronic, but not resolved, hepatitis C virus infection

Impaired production of naive T lymphocytes in human T-cell leukemia virus type I–infected individuals: its implications in the immunodeficient state

Jun-ichirou Yasunaga,Tatsunori Sakai,Kisato Nosaka,Ken-ichiro Etoh,Sadahiro Tamiya,Shin Koga,Shuji Mita,Makoto Uchino,Hiroaki Mitsuya,Masao Matsuoka

View Articletitled, Impaired production of naive T lymphocytes in human T-cell leukemia virus type I–infected individuals: its implications in the immunodeficient state

Truncated thioredoxin (Trx80) induces production of interleukin-12 and enhances CD14 expression in human monocytes

Klas Pekkari,Javier Avila-Cariño,Åsa Bengtsson,Ramanathan Gurunath,Annika Scheynius,Arne Holmgren

View Articletitled, Truncated thioredoxin (Trx80) induces production of interleukin-12 and enhances CD14 expression in human monocytes

NEOPLASIA

Defective octamer-dependent transcription is responsible for silenced immunoglobulin transcription in Reed-Sternberg cells

Jan Theil,Helmut Laumen,Theresa Marafioti,Michael Hummel,Georg Lenz,Thomas Wirth,Harald Stein

View Articletitled, Defective octamer-dependent transcription is responsible for silenced immunoglobulin transcription in Reed-Sternberg cells

Targeting of the CD33-calicheamicin immunoconjugate Mylotarg (CMA-676) in acute myeloid leukemia: in vivo and in vitro saturation and internalization by leukemic and normal myeloid cells
Clinical Trials & Observations

Vincent H. J. van der Velden,Jeroen G. te Marvelde,Patricia G. Hoogeveen,Irwin D. Bernstein,Adriaan B. Houtsmuller,Mark S. Berger,Jacques J. M. van Dongen

View Articletitled, Targeting of the CD33-calicheamicin immunoconjugate Mylotarg (CMA-676) in acute myeloid leukemia: in vivo and in vitro saturation and internalization by leukemic and normal myeloid cells

Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma

Keitaro Matsuo,Ritsuro Suzuki,Nobuyuki Hamajima,Michinori Ogura,Yoshitoyo Kagami,Hirofumi Taji,Eisei Kondoh,Satoko Maeda,Shoji Asakura,Sadayuki Kaba,Shigeo Nakamura,Masao Seto,Yasuo Morishima,Kazuo Tajima

View Articletitled, Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma

Identification of a leukemic counterpart of the plasmacytoid dendritic cells

Laurence Chaperot,Nathalie Bendriss,Olivier Manches,Rémy Gressin,Marc Maynadie,Franck Trimoreau,Hubert Orfeuvre,Bernadette Corront,Jean Feuillard,Jean-Jacques Sotto,Jean-Claude Bensa,Francine Brière,Joël Plumas,Marie-Christine Jacob

View Articletitled, Identification of a leukemic counterpart of the plasmacytoid dendritic cells

Preconditioning with fetal cord blood facilitates engraftment of primary childhood T-cell acute lymphoblastic leukemia in immunodeficient mice

Deno P. Dialynas,Mi-Jeong Lee,Daniel P. Gold,Li-en Shao,Alice L. Yu,Michael J. Borowitz,John Yu

View Articletitled, Preconditioning with fetal cord blood facilitates engraftment of primary childhood T-cell acute lymphoblastic leukemia in immunodeficient mice

Novel methylation targets in de novo acute myeloid leukemia with prevalence of chromosome 11 loci

Laura J. Rush,Zunyan Dai,Dominic J. Smiraglia,Xin Gao,Fred A. Wright,Michael Frühwald,Joseph F. Costello,William A. Held,Li Yu,Ralf Krahe,Jonathan E. Kolitz,Clara D. Bloomfield,Michael A. Caligiuri,Christoph Plass

View Articletitled, Novel methylation targets in de novo acute myeloid leukemia with prevalence of chromosome 11 loci

Tyrosine kinase inhibitor STI571 potentiates the pharmacologic activity of retinoic acid in acute promyelocytic leukemia cells: effects on the degradation of RARα and PML-RARα

Maurizio Gianni',Yesim Kalaç,Isabella Ponzanelli,Alessandro Rambaldi,Mineko Terao,Enrico Garattini

View Articletitled, Tyrosine kinase inhibitor STI571 potentiates the pharmacologic activity of retinoic acid in acute promyelocytic leukemia cells: effects on the degradation of RARα and PML-RARα

Hypoxia induces lytic replication of Kaposi sarcoma–associated herpesvirus

David A. Davis,Andrea S. Rinderknecht,J. Paul Zoeteweij,Yoshiyasu Aoki,Elizabeth L. Read-Connole,Giovanna Tosato,Andrew Blauvelt,Robert Yarchoan

View Articletitled, Hypoxia induces lytic replication of Kaposi sarcoma–associated herpesvirus

PHAGOCYTES

Phosphoinositide 3-kinase modulation of β₃-integrin represents an endogenous “braking” mechanism during neutrophil transmatrix migration

Walter J. Bruyninckx,Katrina M. Comerford,Donald W. Lawrence,Sean P. Colgan

View Articletitled, Phosphoinositide 3-kinase modulation of β3-integrin represents an endogenous “braking” mechanism during neutrophil transmatrix migration

RED CELLS

Short-chain fatty acid derivatives stimulate cell proliferation and induce STAT-5 activation

Michael S. Boosalis,Ram Bandyopadhyay,Emery H. Bresnick,Betty S. Pace,Karyn Van DeMark,Baohua Zhang,Douglas V. Faller,Susan P. Perrine

View Articletitled, Short-chain fatty acid derivatives stimulate cell proliferation and induce STAT-5 activation

Modifications in the CD36 binding domain of the Plasmodium falciparum variant antigen are responsible for the inability of chondroitin sulfate A adherent parasites to bind CD36

Benoit Gamain,Joseph D. Smith,Louis H. Miller,Dror I. Baruch

View Articletitled, Modifications in the CD36 binding domain of the Plasmodium falciparum variant antigen are responsible for the inability of chondroitin sulfate A adherent parasites to bind CD36

Functional requirements for phenotypic correction of murine β-thalassemia: implications for human gene therapy

Derek A. Persons,Esther R. Allay,Denise E. Sabatino,Patrick Kelly,David M. Bodine,Arthur W. Nienhuis

View Articletitled, Functional requirements for phenotypic correction of murine β-thalassemia: implications for human gene therapy

TRANSPLANTATION

Rapid and efficient homing of human CD34⁺CD38^−/lowCXCR4⁺stem and progenitor cells to the bone marrow and spleen of NOD/SCID and NOD/SCID/B2m^null mice

Orit Kollet,Asaf Spiegel,Amnon Peled,Isabelle Petit,Tamara Byk,Rami Hershkoviz,Esther Guetta,Gad Barkai,Arnon Nagler,Tsvee Lapidot

View Articletitled, Rapid and efficient homing of human CD34+CD38−/lowCXCR4+stem and progenitor cells to the bone marrow and spleen of NOD/SCID and NOD/SCID/B2mnull mice

Intra–bone marrow injection of allogeneic bone marrow cells: a powerful new strategy for treatment of intractable autoimmune diseases in MRL/lpr mice

Taketoshi Kushida,Muneo Inaba,Hiroko Hisha,Naoya Ichioka,Takashi Esumi,Ryokei Ogawa,Hirokazu Iida,Susumu Ikehara

View Articletitled, Intra–bone marrow injection of allogeneic bone marrow cells: a powerful new strategy for treatment of intractable autoimmune diseases in MRL/lpr mice

BRIEF REPORTS

Induction of monocyte tissue factor expression by antibodies to heparin–platelet factor 4 complexes developed in heparin-induced thrombocytopenia
Clinical Trials & Observations Brief Report

Claire Pouplard,Sophie Iochmann,Benoit Renard,Olivier Herault,Philippe Colombat,Jean Amiral,Yves Gruel

View Articletitled, Induction of monocyte tissue factor expression by antibodies to heparin–platelet factor 4 complexes developed in heparin-induced thrombocytopenia

The basophil activation marker defined by antibody 97A6 is identical to the ectonucleotide pyrophosphatase/phosphodiesterase 3
Brief Report

Hans-Jörg Bühring,Martina Seiffert,Christina Giesert,Anke Marxer,Lothar Kanz,Peter Valent,Kimihiko Sano

View Articletitled, The basophil activation marker defined by antibody 97A6 is identical to the ectonucleotide pyrophosphatase/phosphodiesterase 3

Human polymorphism of P-selectin glycoprotein ligand 1 attributable to variable numbers of tandem decameric repeats in the mucinlike region
Brief Report

Vahid Afshar-Kharghan,Reyhan Diz-Küçükkaya,Erwin H. Ludwig,Ali J. Marian,José A. López

View Articletitled, Human polymorphism of P-selectin glycoprotein ligand 1 attributable to variable numbers of tandem decameric repeats in the mucinlike region

Molecular genetic basis of porcine histo-blood group AO system
Brief Report

Fumiichiro Yamamoto,Miyako Yamamoto

View Articletitled, Molecular genetic basis of porcine histo-blood group AO system

Induction of tolerance to human factor VIII in mice
Brief Report

Hengjun Chao,Christopher E. Walsh

View Articletitled, Induction of tolerance to human factor VIII in mice

CORRESPONDENCE

Fatal sickle cell crisis after granulocyte colony-stimulating factor administration

Brian K. Adler,Donna E. Salzman,Matthew H. Carabasi,William P. Vaughan,Vishnu V. B. Reddy,Josef T. Prchal

View Articletitled, Fatal sickle cell crisis after granulocyte colony-stimulating factor administration

Clarifications to the standard neutrophil response criteria for clinical trials in myelodysplastic syndromes are needed

David P. Steensma,Louis Letendre,Ayalew Tefferi

View Articletitled, Clarifications to the standard neutrophil response criteria for clinical trials in myelodysplastic syndromes are needed

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Cold exposure induces vaso-occlusion and pain in sickle mice that depend on complement activation

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Diagnosis and classification of myelodysplastic syndromes

FISH for EBV genome in a patient with diffuse large B-cell lymphoma harboring t(14;18)(q32;q21)

Balsas P, Veloza L, Clot G, et al. SOX11, CD70, and T_reg cells configure the tumor-immune microenvironment of aggressive mantle cell lymphoma. Blood. 2021;138(22):2202-2215.

Issue Archive

Table of Contents

INSIDE BLOOD

PLENARY PAPERS

CHEMOKINES

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Larger numbers of CD4bright dendritic cells in donor bone marrow are associated with increased relapse after allogeneic bone marrow transplantation Clinical Trials & Observations

Survival after transplantation of unrelated donor umbilical cord blood is comparable to that of human leukocyte antigen–matched unrelated donor bone marrow: results of a matched-pair analysis Clinical Trials & Observations

Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia Clinical Trials & Observations

Highly heterogeneous nature of δ-aminolevulinate dehydratase (ALAD) deficiencies in ALAD porphyria Clinical Trials & Observations

Polymorphisms of clotting factors modify the risk for primary intracranial hemorrhage Clinical Trials & Observations

A potential role for interleukin-7 in T-cell homeostasis Clinical Trials & Observations

Mitoxantrone is superior to doxorubicin in a multiagent weekly regimen for patients older than 60 with high-grade lymphoma: results of a BNLI randomized trial of PAdriaCEBO versus PMitCEBO Clinical Trials & Observations

A randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis: Presented in part at the American Society of Hematology Conference in Miami Beach, FL, December 1998. Clinical Trials & Observations

GENE THERAPY

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Platelet activation by Shiga toxin and circulatory factors as a pathogenetic mechanism in the hemolytic uremic syndrome Clinical Trials & Observations

IMMUNOBIOLOGY

NEOPLASIA

Targeting of the CD33-calicheamicin immunoconjugate Mylotarg (CMA-676) in acute myeloid leukemia: in vivo and in vitro saturation and internalization by leukemic and normal myeloid cells Clinical Trials & Observations

PHAGOCYTES

RED CELLS

TRANSPLANTATION

BRIEF REPORTS

Induction of monocyte tissue factor expression by antibodies to heparin–platelet factor 4 complexes developed in heparin-induced thrombocytopenia Clinical Trials & Observations Brief Report

The basophil activation marker defined by antibody 97A6 is identical to the ectonucleotide pyrophosphatase/phosphodiesterase 3 Brief Report

Human polymorphism of P-selectin glycoprotein ligand 1 attributable to variable numbers of tandem decameric repeats in the mucinlike region Brief Report

Molecular genetic basis of porcine histo-blood group AO system Brief Report

Induction of tolerance to human factor VIII in mice Brief Report

CORRESPONDENCE

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American Society of Hematology

This Feature Is Available To Subscribers Only

Larger numbers of CD4^bright dendritic cells in donor bone marrow are associated with increased relapse after allogeneic bone marrow transplantation
Clinical Trials & Observations

Survival after transplantation of unrelated donor umbilical cord blood is comparable to that of human leukocyte antigen–matched unrelated donor bone marrow: results of a matched-pair analysis
Clinical Trials & Observations

Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia
Clinical Trials & Observations

Highly heterogeneous nature of δ-aminolevulinate dehydratase (ALAD) deficiencies in ALAD porphyria
Clinical Trials & Observations

Polymorphisms of clotting factors modify the risk for primary intracranial hemorrhage
Clinical Trials & Observations

A potential role for interleukin-7 in T-cell homeostasis
Clinical Trials & Observations

Mitoxantrone is superior to doxorubicin in a multiagent weekly regimen for patients older than 60 with high-grade lymphoma: results of a BNLI randomized trial of PAdriaCEBO versus PMitCEBO
Clinical Trials & Observations

A randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis: Presented in part at the American Society of Hematology Conference in Miami Beach, FL, December 1998.
Clinical Trials & Observations

Platelet activation by Shiga toxin and circulatory factors as a pathogenetic mechanism in the hemolytic uremic syndrome
Clinical Trials & Observations

Targeting of the CD33-calicheamicin immunoconjugate Mylotarg (CMA-676) in acute myeloid leukemia: in vivo and in vitro saturation and internalization by leukemic and normal myeloid cells
Clinical Trials & Observations

Induction of monocyte tissue factor expression by antibodies to heparin–platelet factor 4 complexes developed in heparin-induced thrombocytopenia
Clinical Trials & Observations Brief Report

The basophil activation marker defined by antibody 97A6 is identical to the ectonucleotide pyrophosphatase/phosphodiesterase 3
Brief Report

Human polymorphism of P-selectin glycoprotein ligand 1 attributable to variable numbers of tandem decameric repeats in the mucinlike region
Brief Report

Molecular genetic basis of porcine histo-blood group AO system
Brief Report

Induction of tolerance to human factor VIII in mice
Brief Report