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Volume 96, Issue 5

September 1 2000

In this Issue

PLENARY PAPERS
ERRATA
REVIEW ARTICLES
HOW I TREAT
CHEMOKINES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSPLANTATION
BRIEF REPORTS
CORRESPONDENCE

PLENARY PAPERS

Carboxy terminal region of the Fanconi anemia protein, FANCG/XRCC9, is required for functional activity

Yanan Kuang,Irene Garcia-Higuera,Anna Moran,Michelle Mondoux,Martin Digweed,Alan D. D'Andrea

View Articletitled, Carboxy terminal region of the Fanconi anemia protein, FANCG/XRCC9, is required for functional activity

Langerhans cells develop from a lymphoid-committed precursor

Fabienne Anjuère,Gloria Martı́nez del Hoyo,Pilar Martı́n,Carlos Ardavı́n

View Articletitled, Langerhans cells develop from a lymphoid-committed precursor

Multiple nonfunctional alleles of CCR5 are frequent in various human populations

Cédric Blanpain,Benhur Lee,Marie Tackoen,Bridget Puffer,Alain Boom,Frédérick Libert,Mathew Sharron,Valérie Wittamer,Gilbert Vassart,Robert W. Doms,Marc Parmentier

View Articletitled, Multiple nonfunctional alleles of CCR5 are frequent in various human populations

Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency

David A. Williams,Wen Tao,Fengchun Yang,Chaekyun Kim,Yi Gu,Pamela Mansfield,John E. Levine,Bronia Petryniak,Caroline W. Derrow,Chad Harris,Baoqing Jia,Yi Zheng,Daniel R. Ambruso,John B. Lowe,Simon J. Atkinson,Mary C. Dinauer,Laurence Boxer

View Articletitled, Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency

ERRATA

Erratum in Hu et al. Regulation of drug sensitivity by ribosomal protein S3a. Blood. 2000;95:1047-1055.

View Articletitled, Erratum in Hu et al. Regulation of drug sensitivity by ribosomal protein S3a. Blood. 2000;95:1047-1055.

Erratum in Ledru et al. Alteration of tumor necrosis factor–α T-cell homeostasis following potent antiretroviral therapy: contribution to the development of human immunodeficiency virus–associated lipodystrophy syndrome. Blood. 2000;95:3191-3198.

View Articletitled, Erratum in Ledru et al. Alteration of tumor necrosis factor–α T-cell homeostasis following potent antiretroviral therapy: contribution to the development of human immunodeficiency virus–associated lipodystrophy syndrome. Blood. 2000;95:3191-3198.

Erratum in Pedersen-Bjergaard et al. Therapy-related acute myeloid leukemia and myelodysplasia after high-dose chemotherapy and autologous stem cell transplantation. Blood. 2000;95:3273-3279.

View Articletitled, Erratum in Pedersen-Bjergaard et al. Therapy-related acute myeloid leukemia and myelodysplasia after high-dose chemotherapy and autologous stem cell transplantation. Blood. 2000;95:3273-3279.

Erratum in El-Daher et al. Distinct localization and function of 1,4,5IP3 receptor subtypes and the 1,3,4,5IP4 receptor GAP1IP4BP in highly purified human platelet membranes. Blood. 2000;95:3412-3422.

View Articletitled, Erratum in El-Daher et al. Distinct localization and function of 1,4,5IP3 receptor subtypes and the 1,3,4,5IP4 receptor GAP1IP4BP in highly purified human platelet membranes. Blood. 2000;95:3412-3422.

REVIEW ARTICLES

Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies?

Christoph W. M. Reuter,Michael A. Morgan,Lothar Bergmann

View Articletitled, Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies?

HOW I TREAT

How I treat older patients with AML
Clinical Trials & Observations

Elihu H. Estey

View Articletitled, How I treat older patients with AML

CHEMOKINES

Cleavage by CD26/dipeptidyl peptidase IV converts the chemokine LD78β into a most efficient monocyte attractant and CCR1 agonist

Paul Proost,Patricia Menten,Sofie Struyf,Evemie Schutyser,Ingrid De Meester,Jo Van Damme

View Articletitled, Cleavage by CD26/dipeptidyl peptidase IV converts the chemokine LD78β into a most efficient monocyte attractant and CCR1 agonist

Exaggerated response to endotoxin in mice lacking the Duffy antigen/receptor for chemokines (DARC)

Tracey C. Dawson,Alex B. Lentsch,Zixuan Wang,John E. Cowhig,Antal Rot,Nobuyo Maeda,Stephen C. Peiper

View Articletitled, Exaggerated response to endotoxin in mice lacking the Duffy antigen/receptor for chemokines (DARC)

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Effect of active prenatal management on pregnancy outcome in sickle cell disease in an African setting
Clinical Trials & Observations

Mohamed C. Rahimy,Annick Gangbo,Roslyn Adjou,Chantal Deguenon,Stephanie Goussanou,Eusebe Alihonou

View Articletitled, Effect of active prenatal management on pregnancy outcome in sickle cell disease in an African setting

Cyclosporin A and short-term methotrexate versus cyclosporin A as graft versus host disease prophylaxis in patients with severe aplastic anemia given allogeneic bone marrow transplantation from an HLA-identical sibling: results of a GITMO/EBMT randomized trial
Clinical Trials & Observations

Franco Locatelli,Barbara Bruno,Marco Zecca,Maria Teresa Van-Lint,Shaun McCann,William Arcese,Sandro Dallorso,Paolo Di Bartolomeo,Franca Fagioli,Anna Locasciulli,Mark Lawler,Andrea Bacigalupo,on behalf of GITMO/EBMT

View Articletitled, Cyclosporin A and short-term methotrexate versus cyclosporin A as graft versus host disease prophylaxis in patients with severe aplastic anemia given allogeneic bone marrow transplantation from an HLA-identical sibling: results of a GITMO/EBMT randomized trial

Immune tolerance induction in hemophilia patients with inhibitors: costly can be cheaper
Clinical Trials & Observations

Alan B. Colowick,Rhonda L. Bohn,Jerry Avorn,Bruce M. Ewenstein

View Articletitled, Immune tolerance induction in hemophilia patients with inhibitors: costly can be cheaper

Impact of the patient population on the risk for heparin-induced thrombocytopenia
Clinical Trials & Observations

Theodore E. Warkentin,Jo-Ann I. Sheppard,Peter Horsewood,Patricia J. Simpson,Jane C. Moore,John G. Kelton

View Articletitled, Impact of the patient population on the risk for heparin-induced thrombocytopenia

Weekly polyethylene glycol conjugated L-asparaginase compared with biweekly dosing produces superior induction remission rates in childhood relapsed acute lymphoblastic leukemia: a pediatric oncology group study
Clinical Trials & Observations

Thomas C. Abshire,Brad H. Pollock,Amy L. Billett,Patricia Bradley,George R. Buchanan

View Articletitled, Weekly polyethylene glycol conjugated L-asparaginase compared with biweekly dosing produces superior induction remission rates in childhood relapsed acute lymphoblastic leukemia: a pediatric oncology group study

HEMATOPOIESIS

N^G-monomethyl-l-arginine inhibits erythropoietin gene expression by stimulating GATA-2

Takahisa Tarumoto,Shigehiko Imagawa,Ken Ohmine,Tadashi Nagai,Masato Higuchi,Nobuo Imai,Norio Suzuki,Masayuki Yamamoto,Keiya Ozawa

View Articletitled, NG-monomethyl-l-arginine inhibits erythropoietin gene expression by stimulating GATA-2

Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages

Takafumi Yokota,Kenji Oritani,Isao Takahashi,Jun Ishikawa,Akifumi Matsuyama,Noriyuki Ouchi,Shinji Kihara,Tohru Funahashi,Andrea J. Tenner,Yoshiaki Tomiyama,Yuji Matsuzawa

View Articletitled, Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages

Pyk2 and Syk participate in functional activation of granulocytic HL-60 cells in a different manner

Yasuo Miura,Yumi Tohyama,Terutoshi Hishita,Amitabha Lala,Ernesto De Nardin,Yataro Yoshida,Hirohei Yamamura,Takashi Uchiyama,Kaoru Tohyama

View Articletitled, Pyk2 and Syk participate in functional activation of granulocytic HL-60 cells in a different manner

Identification of novel circulating human embryonic blood stem cells

Lisa Gallacher,Barbara Murdoch,Dongmei Wu,Francis Karanu,Fraser Fellows,Mickie Bhatia

View Articletitled, Identification of novel circulating human embryonic blood stem cells

Interleukin-3 supports expansion of long-term multilineage repopulating activity after multiple stem cell divisions in vitro

David Bryder,Sten E. W. Jacobsen

View Articletitled, Interleukin-3 supports expansion of long-term multilineage repopulating activity after multiple stem cell divisions in vitro

Apoptosis is rapidly triggered by antisense depletion of MCL-1 in differentiating U937 cells

Dale A. Moulding,Richard V. Giles,David G. Spiller,Michael R. H. White,David M. Tidd,Steven W. Edwards

View Articletitled, Apoptosis is rapidly triggered by antisense depletion of MCL-1 in differentiating U937 cells

Mcl-1 is a common target of stem cell factor and interleukin-5 for apoptosis prevention activity via MEK/MAPK and PI-3K/Akt pathways

Huei-Mei Huang,Chang-Jen Huang,Jeffrey Jong-Young Yen

View Articletitled, Mcl-1 is a common target of stem cell factor and interleukin-5 for apoptosis prevention activity via MEK/MAPK and PI-3K/Akt pathways

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Egr-1 gene is induced by the systemic administration of the vascular endothelial growth factor and the epidermal growth factor

Lixin Liu,Jo C. Tsai,William C. Aird

View Articletitled, Egr-1 gene is induced by the systemic administration of the vascular endothelial growth factor and the epidermal growth factor

Molecular mechanisms of platelet exocytosis: role of SNAP-23 and syntaxin 2 and 4 in lysosome release

Dong Chen,Paula P. Lemons,Todd Schraw,Sidney W. Whiteheart

View Articletitled, Molecular mechanisms of platelet exocytosis: role of SNAP-23 and syntaxin 2 and 4 in lysosome release

Immobilized platelets support human colon carcinoma cell tethering, rolling, and firm adhesion under dynamic flow conditions

Owen J. T. McCarty,Shaker A. Mousa,Paul F. Bray,Konstantinos Konstantopoulos

View Articletitled, Immobilized platelets support human colon carcinoma cell tethering, rolling, and firm adhesion under dynamic flow conditions

Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily

Martine Jandrot-Perrus,Samantha Busfield,Anne-Helène Lagrue,Ximing Xiong,Najet Debili,Troy Chickering,Jean-Pierre Le Couedic,Andrew Goodearl,Barry Dussault,Christopher Fraser,William Vainchenker,Jean-Luc Villeval

View Articletitled, Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily

Von Willebrand factor storage and multimerization: 2 independent intracellular processes: Presented in abstract form at the 41st Annual Meeting of the American Society of Hematology, New Orleans, LA, December 3-7, 1999.

Sandra L. Haberichter,Scot A. Fahs,Robert R. Montgomery

View Articletitled, Von Willebrand factor storage and multimerization: 2 independent intracellular processes: Presented in abstract form at the 41st Annual Meeting of the American Society of Hematology, New Orleans, LA, December 3-7, 1999.

Influence of cytochrome P-450 CYP2C9 polymorphisms on warfarin sensitivity and risk of over-anticoagulation in patients on long-term treatment
Clinical Trials & Observations

Janis Taube,David Halsall,Trevor Baglin

View Articletitled, Influence of cytochrome P-450 CYP2C9 polymorphisms on warfarin sensitivity and risk of over-anticoagulation in patients on long-term treatment

Urokinase mediates fibrinolysis in the pulmonary microvasculature

Khalil Bdeir,Juan-Carlos Murciano,John Tomaszewski,Lauren Koniaris,Jose Martinez,Douglas B. Cines,Vladimir R. Muzykantov,Abd Al-Roof Higazi

View Articletitled, Urokinase mediates fibrinolysis in the pulmonary microvasculature

IMMUNOBIOLOGY

LSP1 modulates leukocyte populations in resting and inflamed peritoneum

Jenny Jongstra-Bilen,Virginia L. Misener,Chunjie Wang,Hedy Ginzberg,Anna Auerbach,Alexandra L. Joyner,Gregory P. Downey,Jan Jongstra

View Articletitled, LSP1 modulates leukocyte populations in resting and inflamed peritoneum

Activation of macrophage cytostatic effector mechanisms during acute graft-versus-host disease: release of intracellular iron and nitric oxide–mediated cytostasis

Frederick P. Nestel,Robert N. Greene,Krikor Kichian,Premysl Ponka,Wayne S. Lapp

View Articletitled, Activation of macrophage cytostatic effector mechanisms during acute graft-versus-host disease: release of intracellular iron and nitric oxide–mediated cytostasis

Importance of the MKK6/p38 pathway for interleukin-12–induced STAT4 serine phosphorylation and transcriptional activity

Roberta Visconti,Massimo Gadina,Mario Chiariello,Elbert H. Chen,Louis F. Stancato,J. Silvio Gutkind,John J. O'Shea

View Articletitled, Importance of the MKK6/p38 pathway for interleukin-12–induced STAT4 serine phosphorylation and transcriptional activity

Kinetics of CXCR4 and CCR5 up-regulation and human immunodeficiency virus expansion after antigenic stimulation of primary CD4⁺ T lymphocytes

Reinhard Maier,Marı́a Matilde Bartolomé-Rodrı́guez,Corinne Moulon,Hans Ulrich Weltzien,Andreas Meyerhans

View Articletitled, Kinetics of CXCR4 and CCR5 up-regulation and human immunodeficiency virus expansion after antigenic stimulation of primary CD4+ T lymphocytes

Mature dendritic cells pulsed with freeze–thaw cell lysates define an effective in vitro vaccine designed to elicit EBV-specific CD4⁺ and CD8⁺ T lymphocyte responses

Wolfgang Herr,Elena Ranieri,Walter Olson,Hassane Zarour,Loreto Gesualdo,Walter J. Storkus

View Articletitled, Mature dendritic cells pulsed with freeze–thaw cell lysates define an effective in vitro vaccine designed to elicit EBV-specific CD4+ and CD8+ T lymphocyte responses

Differentiation of myeloid dendritic cells into CD8α-positive dendritic cells in vivo

Miriam Merad,Lawrence Fong,Jakob Bogenberger,Edgar G. Engleman

View Articletitled, Differentiation of myeloid dendritic cells into CD8α-positive dendritic cells in vivo

Interleukin-7 stimulates osteoclast formation by up-regulating the T-cell production of soluble osteoclastogenic cytokines

M. Neale Weitzmann,Simone Cenci,Leonard Rifas,Christopher Brown,Roberto Pacifici

View Articletitled, Interleukin-7 stimulates osteoclast formation by up-regulating the T-cell production of soluble osteoclastogenic cytokines

Heparin and heparan sulfate bind interleukin-10 and modulate its activity

Shahram Salek-Ardakani,John R. Arrand,David Shaw,Mike Mackett

View Articletitled, Heparin and heparan sulfate bind interleukin-10 and modulate its activity

NEOPLASIA

European Task Force on Lymphoma project on lymphocyte predominance Hodgkin disease: histologic and immunohistologic analysis of submitted cases reveals 2 types of Hodgkin disease with a nodular growth pattern and abundant lymphocytes
Clinical Trials & Observations

Ioannis Anagnostopoulos,Martin-Leo Hansmann,Kaarle Franssila,Martin Harris,Nancy L. Harris,Elaine S. Jaffe,J. Han,J. M. van Krieken,Sibrand Poppema,Teresa Marafioti,Jeremy Franklin,Michael Sextro,Volker Diehl,Harald Stein,on behalf of the European Task Force on Lymphoma

View Articletitled, European Task Force on Lymphoma project on lymphocyte predominance Hodgkin disease: histologic and immunohistologic analysis of submitted cases reveals 2 types of Hodgkin disease with a nodular growth pattern and abundant lymphocytes

Effective targeting of tumor vasculature by the angiogenesis inhibitors vasostatin and interleukin-12

Lei Yao,Sandra E. Pike,Joyce Setsuda,Justin Parekh,Ghanshyam Gupta,Mark Raffeld,Elaine S. Jaffe,Giovanna Tosato

View Articletitled, Effective targeting of tumor vasculature by the angiogenesis inhibitors vasostatin and interleukin-12

A carboxy-terminal deletion mutant of Notch1accelerates lymphoid oncogenesis in E2A-PBX1transgenic mice

Brian J. Feldman,Tracy Hampton,Michael L. Cleary

View Articletitled, A carboxy-terminal deletion mutant of Notch1accelerates lymphoid oncogenesis in E2A-PBX1transgenic mice

Acute myeloblastic leukemic cells acquire cellular cytotoxicity under genotoxic stress: implication of granzyme B and perforin

Alain Pierre Bruno,Dominique Lautier,Aurélie de Thonel d'Orgeix,Guy Laurent,Anne Quillet-Mary

View Articletitled, Acute myeloblastic leukemic cells acquire cellular cytotoxicity under genotoxic stress: implication of granzyme B and perforin

Prognostic significance of survivin expression in diffuse large B-cell lymphomas

Colette Adida,Corinne Haioun,Philippe Gaulard,Eric Lepage,Pierre Morel,Josette Briere,Hervé Dombret,Felix Reyes,Jacques Diebold,Christian Gisselbrecht,Gilles Salles,Dario C. Altieri,Thierry J. Molina

View Articletitled, Prognostic significance of survivin expression in diffuse large B-cell lymphomas

Stromal cells regulate survival of B-lineage leukemic cells during chemotherapy

Ryan E. Mudry,James E. Fortney,Teresa York,Brett M. Hall,Laura F. Gibson

View Articletitled, Stromal cells regulate survival of B-lineage leukemic cells during chemotherapy

Bcr-Abl kinase down-regulates cyclin-dependent kinase inhibitor p27 in human and murine cell lines

Tarja Jonuleit,Heiko van der Kuip,Cornelius Miething,Heike Michels,Michael Hallek,Justus Duyster,Walter E. Aulitzky

View Articletitled, Bcr-Abl kinase down-regulates cyclin-dependent kinase inhibitor p27 in human and murine cell lines

Abnormal rearrangement within the α/δ T-cell receptor locus in lymphomas from Atm-deficient mice

Marek Liyanage,Zoë Weaver,Carrolee Barlow,Allen Coleman,Daniel G. Pankratz,Stacie Anderson,Anthony Wynshaw-Boris,Thomas Ried

View Articletitled, Abnormal rearrangement within the α/δ T-cell receptor locus in lymphomas from Atm-deficient mice

V(D)J recombinase-mediated transposition of the BCL2gene to the IGH locus in follicular lymphoma

Jan-Willem Vaandrager,Ed Schuuring,Katja Philippo,Philip M. Kluin

View Articletitled, V(D)J recombinase-mediated transposition of the BCL2gene to the IGH locus in follicular lymphoma

Cell–cell contact between marrow stromal cells and myeloma cells via VCAM-1 and α₄β₁-integrin enhances production of osteoclast-stimulating activity

Toshimi Michigami,Nobuaki Shimizu,Paul J. Williams,Maria Niewolna,Sarah L. Dallas,Gregory R. Mundy,Toshiyuki Yoneda

View Articletitled, Cell–cell contact between marrow stromal cells and myeloma cells via VCAM-1 and α4β1-integrin enhances production of osteoclast-stimulating activity

PHAGOCYTES

Natural killer cell dysfunction and apoptosis induced by chronic myelogenous leukemia cells: role of reactive oxygen species and regulation by histamine

Ulf-Henrik Mellqvist,Markus Hansson,Mats Brune,Claes Dahlgren,Svante Hermodsson,Kristoffer Hellstrand

View Articletitled, Natural killer cell dysfunction and apoptosis induced by chronic myelogenous leukemia cells: role of reactive oxygen species and regulation by histamine

Pathologic gene expression in Gaucher disease: up-regulation of cysteine proteinases including osteoclastic cathepsin K

Mary Teresa Moran,J. Paul Schofield,Alison R. Hayman,Guo-Ping Shi,Elisabeth Young,Timothy M. Cox

View Articletitled, Pathologic gene expression in Gaucher disease: up-regulation of cysteine proteinases including osteoclastic cathepsin K

Interleukin-15 enhances neutrophil functional activity in patients with human immunodeficiency virus infection

Claudio M. Mastroianni,Gabriella d'Ettorre,Gabriele Forcina,Miriam Lichtner,Fabio Mengoni,Claudia D'Agostino,Angela Corpolongo,Anna P. Massetti,Vincenzo Vullo

View Articletitled, Interleukin-15 enhances neutrophil functional activity in patients with human immunodeficiency virus infection

RED CELLS

Red cells from glutathione peroxidase-1–deficient mice have nearly normal defenses against exogenous peroxides

Robert M. Johnson,Gerard Goyette, Jr,Yaddanapudi Ravindranath,Ye-Shih Ho

View Articletitled, Red cells from glutathione peroxidase-1–deficient mice have nearly normal defenses against exogenous peroxides

TRANSPLANTATION

CD34 expression by murine hematopoietic stem cells mobilized by granulocyte colony-stimulating factor

Fumihito Tajima,Takashi Sato,Joseph H. Laver,Makio Ogawa

View Articletitled, CD34 expression by murine hematopoietic stem cells mobilized by granulocyte colony-stimulating factor

BRIEF REPORTS

Class I–unrestricted noncytotoxic anti–HTLV-I activity of CD8⁺ T cells
Brief Report

Masako Moriuchi,Hiroyuki Moriuchi

View Articletitled, Class I–unrestricted noncytotoxic anti–HTLV-I activity of CD8+ T cells

A gene-anchored map position of the rat warfarin-resistance locus, Rw, and its orthologs in mice and humans
Brief Report

Michael H. Kohn,Hans-Joachim Pelz

View Articletitled, A gene-anchored map position of the rat warfarin-resistance locus, Rw, and its orthologs in mice and humans

Chimeric Fv-ζ or Fv-ε receptors are not sufficient to induce activation or cytokine production in peripheral T cells
Brief Report

Thomas Brocker

View Articletitled, Chimeric Fv-ζ or Fv-ε receptors are not sufficient to induce activation or cytokine production in peripheral T cells

CORRESPONDENCE

Anticorresponding p15 promoter methylation and microsatellite instability in acute myeloblastic leukemia

Emma P. Das-Gupta,Nigel H. Russell

View Articletitled, Anticorresponding p15 promoter methylation and microsatellite instability in acute myeloblastic leukemia

The platelet glycoprotein Ia C807T polymorphism as risk factor for coronary catheter interventions

Christian Meisel,Ingolf Cascorbi,Antje Herrmann,Ivar Roots,Michael Laule,Verena Stangl,Karl Stangl

View Articletitled, The platelet glycoprotein Ia C807T polymorphism as risk factor for coronary catheter interventions

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Issue Archive

Table of Contents

PLENARY PAPERS

ERRATA

REVIEW ARTICLES

HOW I TREAT

How I treat older patients with AML Clinical Trials & Observations

CHEMOKINES

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Effect of active prenatal management on pregnancy outcome in sickle cell disease in an African setting Clinical Trials & Observations

Cyclosporin A and short-term methotrexate versus cyclosporin A as graft versus host disease prophylaxis in patients with severe aplastic anemia given allogeneic bone marrow transplantation from an HLA-identical sibling: results of a GITMO/EBMT randomized trial Clinical Trials & Observations

Immune tolerance induction in hemophilia patients with inhibitors: costly can be cheaper Clinical Trials & Observations

Impact of the patient population on the risk for heparin-induced thrombocytopenia Clinical Trials & Observations

Weekly polyethylene glycol conjugated L-asparaginase compared with biweekly dosing produces superior induction remission rates in childhood relapsed acute lymphoblastic leukemia: a pediatric oncology group study Clinical Trials & Observations