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Issue Archive

Volume 95, Issue 4
February 15 2000
Blood Cover Image for Volume 95, Issue 4

Table of Contents

FOCUS ON HEMATOLOGY

Introduction: are natural anticoagulants candidates for modulating the inflammatory response to endotoxin?
Charles T. Esmon
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Recombinant human antithrombin III improves survival and attenuates inflammatory responses in baboons lethally challenged with Escherichia coli
M. C. Minnema,A. C. K. Chang,P. M. Jansen,Y. T. P. Lubbers,B. M. Pratt,B. G. Whittaker,F. B. Taylor,C. E. Hack,B. Friedman
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Tissue factor pathway inhibitor dose-dependently inhibits coagulation activation without influencing the fibrinolytic and cytokine response during human endotoxemia
Evert de Jonge,Pascale E. P. Dekkers,Abla A. Creasey,C. Erik Hack,Susan K. Paulson,Aziz Karim,Jozef Kesecioglu,Marcel Levi,Sander J. H. van Deventer,Tom van der Poll
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PLENARY PAPER

Sickle cell anemia day hospital: an approach for the management of uncomplicated painful crises
Lennette J. Benjamin,Gwendolyn I. Swinson,Ronald L. Nagel
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Simple PCR detection of haptoglobin gene deletion in anhaptoglobinemic patients with antihaptoglobin antibody that causes anaphylactic transfusion reactions
Yoshiro Koda,Yoshihisa Watanabe,Mikiko Soejima,Eiko Shimada,Motoko Nishimura,Kaichiro Morishita,Susumu Moriya,Shigeki Mitsunaga,Kenji Tadokoro,Hiroshi Kimura
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Acquired loss of p53 induces blastic transformation in p210bcr/abl-expressing hematopoietic cells: a transgenic study for blast crisis of human CML
Hiroaki Honda,Toshikazu Ushijima,Kuniko Wakazono,Hideaki Oda,Yuji Tanaka,Shin-ichi Aizawa,Takatoshi Ishikawa,Yoshio Yazaki,Hisamaru Hirai
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ERRATA

Erratum for vol. 94, p. 434
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Erratum for vol. 95, p. 111
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CHEMOKINES

KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells
Johnny T. Stine,Christi Wood,Mark Hill,Angela Epp,Carol J. Raport,Vicki L. Schweickart,Yoshio Endo,Takuma Sasaki,Graham Simmons,Chris Boshoff,Paul Clapham,Yuan Chang,Patrick Moore,Patrick W. Gray,David Chantry
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The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages
Barbara Scheuerer,Martin Ernst,Iris Dürrbaum-Landmann,Jens Fleischer,Evelin Grage-Griebenow,Ernst Brandt,Hans-Dieter Flad,Frank Petersen
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Limited expression of R5-tropic HIV-1 in CCR5-positive type 1–polarized T cells explained by their ability to produce RANTES, MIP-1α, and MIP-1β
Francesco Annunziato,Grazia Galli,Filomena Nappi,Lorenzo Cosmi,Roberto Manetti,Enrico Maggi,Barbara Ensoli,Sergio Romagnani
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CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Effect of recombinant human erythropoietin combined with granulocyte/ macrophage colony-stimulating factor in the treatment of patients with myelodysplastic syndrome
John A. Thompson,D. Gary Gilliland,Josef T. Prchal,John M. Bennett,Kay Larholt,Richard A. Nelson,Esther H. Rose,Margaret H. Dugan,the GM/EPO MDS Study Group
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Genetic aberrations common in gastric high-grade large B-cell lymphoma
Petr Starostik,Axel Greiner,Anja Schultz,Andreas Zettl,Katharina Peters,Andreas Rosenwald,Mariele Kolve,Hans Konrad Müller-Hermelink
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Allogeneic and syngeneic marrow transplantation for myelodysplastic syndrome in patients 55 to 66 years of age
H. J. Deeg,H. M. Shulman,J. E. Anderson,E. M. Bryant,T. A. Gooley,J. T. Slattery,C. Anasetti,A. Fefer,R. Storb,F. R. Appelbaum
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Stem cell transplantation in patients with severe congenital neutropenia without evidence of leukemic transformation
C. Zeidler,K. Welte,Y. Barak,F. Barriga,A. A. Bolyard,L. Boxer,G. Cornu,M. J. Cowan,D. C. Dale,T. Flood,M. Freedman,H. Gadner,H. Mandel,R. J. O'Reilly,U. Ramenghi,A. Reiter,R. Skinner,C. Vermylen,J. E. Levine
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Apoptosis or plasma cell differentiation of CD38-positive B-chronic lymphocytic leukemia cells induced by cross-linking of surface IgM or IgD
Simona Zupo,Rosanna Massara,Mariella Dono,Edoardo Rossi,Fabio Malavasi,M. Elisabetta Cosulich,Manlio Ferrarini
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Tissue eosinophilia correlates strongly with poor prognosis in nodular sclerosing Hodgkin's disease, allowing for known prognostic factors
R. von Wasielewski,S. Seth,J. Franklin,R. Fischer,K. Hübner,M. L. Hansmann,V. Diehl,A. Georgii
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Treatment of relapsed leukemia after unrelated donor marrow transplantation with unrelated donor leukocyte infusions
David L. Porter,Robert H. Collins, Jr,Christine Hardy,Nancy A. Kernan,William R. Drobyski,Sergio Giralt,Mary E.D. Flowers,James Casper,Ann Leahey,Pablo Parker,Rosemarie Mick,Bev Bate-Boyle,Roberta King,Joseph H. Antin
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Polymorphisms within glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia: a case-control study
Martin Stanulla,Martin Schrappe,Annette Müller Brechlin,Martin Zimmermann,Karl Welte
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Long-term outcome of continuous 24-hour deferoxamine infusion via indwelling intravenous catheters in high-risk β-thalassemia
Bernard A. Davis,John B. Porter
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GENE THERAPY

Quantitative assessment of retroviral transfer of the human multidrug resistance 1 gene to human mobilized peripheral blood progenitor cells engrafted in nonobese diabetic/severe combined immunodeficient mice
B. Schiedlmeier,K. Kühlcke,H. G. Eckert,C. Baum,W. J. Zeller,S. Fruehauf
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Targeted disruption of Stat6 DNA binding activity by an oligonucleotide decoy blocks IL-4–driven TH2 cell response
Li Hua Wang,Xiao Yi Yang,Robert A. Kirken,James H. Resau,William L. Farrar
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An oral CD40 ligand gene therapy against lymphoma using attenuated Salmonella typhimurium
Mitsuyoshi Urashima,Hideaki Suzuki,Youki Yuza,Masaharu Akiyama,Noriko Ohno,Yoshikatsu Eto
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HEMATOPOIESIS

GATA-1 blocks IL-6-induced macrophage differentiation and apoptosis through the sustained expression of cyclin D1 and Bcl-2 in a murine myeloid cell line M1
Hirokazu Tanaka,Itaru Matsumura,Koichi Nakajima,Hanako Daino,Junko Sonoyama,Hitoshi Yoshida,Kenji Oritani,Takashi Machii,Masayuki Yamamoto,Toshio Hirano,Yuzuru Kanakura
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Hemopoietic lineage commitment decisions: in vivo evidence from a transgenic mouse model harboring μLCR-βpro-LacZ as a transgene
Thalia Papayannopoulou,Gregory V. Priestley,Alex Rohde,Kenneth R. Peterson,Betty Nakamoto
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Actin cytoskeletal function is spared, but apoptosis is increased, in WAS patient hematopoietic cells
Ramesh Rengan,Hans D. Ochs,Leonard I. Sweet,Michael L. Keil,William T. Gunning,Neil A. Lachant,Laurence A. Boxer,Geneva M. Omann
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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Adherence of phosphatidylserine-exposing erythrocytes to endothelial matrix thrombospondin
Annamaria B. Manodori,Gilda A. Barabino,Bertram H. Lubin,Frans A. Kuypers
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Streptokinase-induced platelet activation involves antistreptokinase antibodies and cleavage of protease-activated receptor-1
James P. McRedmond,Patrick Harriott,Brian Walker,Desmond J. Fitzgerald
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Transcriptional activation of urokinase by the Krüppel-like factor Zf9/COPEB activates latent TGF-β1 in vascular endothelial cells
Soichi Kojima,Shinichi Hayashi,Kentaro Shimokado,Yasuhiro Suzuki,Jun Shimada,Massimo P. Crippa,Scott L. Friedman
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Leukocyte-leukocyte interactions mediated by platelet microparticles under flow
Stephen B. Forlow,Rodger P. McEver,Matthias U. Nollert
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Prevention and treatment of factor VIII inhibitors in murine hemophilia A
Jiahua Qian,Mary Collins,Arlene H. Sharpe,Leon W. Hoyer
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Inhibition of thrombin generation by the zymogen factor VII: implications for the treatment of hemophilia A by factor VIIa
Cornelis van 't Veer,Neal J. Golden,Kenneth G. Mann
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Missense mutations in the human β fibrinogen gene cause congenital afibrinogenemia by impairing fibrinogen secretion
Stefano Duga,Rosanna Asselta,Elena Santagostino,Sirous Zeinali,Tatjana Simonic,Massimo Malcovati,Pier Mannuccio Mannucci,Maria Luisa Tenchini
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IMMUNOBIOLOGY

Stimulation of cytotoxic T cells against idiotype immunoglobulin of malignant lymphoma with protein-pulsed or idiotype-transduced dendritic cells
Frank Osterroth,Annette Garbe,Paul Fisch,Hendrik Veelken
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Circulating forms of intercellular adhesion molecule (ICAM)-1 in mice lacking membranous ICAM-1
Natasja K. van den Engel,Edmund Heidenthal,Antje Vinke,Hubert Kolb,Stephan Martin
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Thymocyte development past the CD4+CD8+stage requires an active p38 mitogen-activated protein kinase
Edgar Fernández
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Migration of activated CD8+ T lymphocytes to sites of viral infection does not require endothelial selectins
Christina Bartholdy,Ole Marker,Allan Randrup Thomsen
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Both Stat5a and Stat5b are required for antigen-induced eosinophil and T-cell recruitment into the tissue
Shin-ichiro Kagami,Hiroshi Nakajima,Kotaro Kumano,Kotaro Suzuki,Akira Suto,Kazunori Imada,Helen W. Davey,Yasushi Saito,Kiyoshi Takatsu,Warren J. Leonard,Itsuo Iwamoto
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Gene expressions of lipopolysaccharide receptors, toll-like receptors 2 and 4, are differently regulated in mouse T lymphocytes
Tetsuya Matsuguchi,Kensuke Takagi,Tipayaratn Musikacharoen,Yasunobu Yoshikai
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Abundant Tax protein expression in CD4+ T cells infected with human T-cell lymphotropic virus type I (HTLV-I) is prevented by cytotoxic T lymphocytes
Emmanuel Hanon,Sarah Hall,Graham P. Taylor,Mineki Saito,Ricardo Davis,Yuetsu Tanaka,Koichiro Usuku,Mitsuhiro Osame,Jonathan N. Weber,Charles R. M. Bangham
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Evidence that immunoglobulin specificities of AIDS-related lymphoma are not directed to HIV-related antigens
Gina Cunto-Amesty,Grzegorz Przybylski,Marek Honczarenko,John G. Monroe,Leslie E. Silberstein
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NEOPLASIA

Mutation analysis of the 5′ noncoding regulatory region of the BCL-6 gene in non-Hodgkin lymphoma: evidence for recurrent mutations and intraclonal heterogeneity
Izidore S. Lossos,Ronald Levy
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HHV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HHV-8–positive plasmablastic lymphoma
Nicolas Dupin,Tim L. Diss,Paul Kellam,Micheline Tulliez,Ming-Qing Du,Didier Sicard,Robin A. Weiss,Peter G. Isaacson,Chris Boshoff
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Analysis of expressed immunoglobulin heavy chain genes in familial B-CLL
Akira Sakai,Gerald E. Marti,Neil Caporaso,Stefania Pittaluga,Jeffrey W. Touchman,Falko Fend,Mark Raffeld
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Thioredoxin prolongs survival of B-type chronic lymphocytic leukemia cells
Joacim Nilsson,Ola Söderberg,Kenneth Nilsson,Anders Rosén
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Apoptosis of leukemic cells accompanies reduction in intracellular pH after targeted inhibition of the Na+/H+exchanger
Ivan N. Rich,Diana Worthington-White,Oliver A. Garden,Philip Musk
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Three differentially expressed survivin cDNA variants encode proteins with distinct antiapoptotic functions
Edward M. Conway,Saskia Pollefeyt,Jan Cornelissen,Inky DeBaere,Marta Steiner-Mosonyi,Kelly Ong,Mathijs Baens,Désiré Collen,Andre C. Schuh
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Hodgkin and Reed-Sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription
Theresa Marafioti,Michael Hummel,Hans-Dieter Foss,Helmut Laumen,Petra Korbjuhn,Ioannis Anagnostopoulos,Hetty Lammert,Gudrun Demel,Jan Theil,Thomas Wirth,Harald Stein
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PHAGOCYTES

Hematopoietic-specific expression of MEFV, the gene mutated in familial Mediterranean fever, and subcellular localization of its corresponding protein, pyrin
Nicola Tidow,Xiaoguang Chen,Carsten Müller,Seiji Kawano,Adrian F. Gombart,Nathan Fischel-Ghodsian,H. Phillip Koeffler
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Aberrant expression of active leukotriene C4 synthase in CD16+ neutrophils from patients with chronic myeloid leukemia
Mikael Sjölinder,Leif Stenke,Barbro Näsman-Glaser,Susanne Widell,Johanne Doucet,Per-Johan Jakobsson,Jan Åke Lindgren
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Extracellular granzyme A, complexed to proteoglycans, is protected against inactivation by protease inhibitors
Elisabeth H. A. Spaeny-Dekking,Angela M. Kamp,Christopher J. Froelich,C. Erik Hack
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RED CELLS

Tropomyosin isoform 5b is expressed in human erythrocytes: implications of tropomodulin-TM5 or tropomodulin-TM5b complexes in the protofilament and hexagonal organization of membrane skeletons
Lanping Amy Sung,Ke-Ming Gao,Leland J. Yee,Constance J. Temm-Grove,David M. Helfman,Jim J.-C. Lin,Majid Mehrpouryan
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Red cell surface changes and erythrophagocytosis in children with severe Plasmodium falciparum anemia
John N. Waitumbi,Malachi O. Opollo,Richard O. Muga,Ambrose O. Misore,José A. Stoute
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Single-tube multiplex PCR-SSCP analysis distinguishes 7 common ABO alleles and readily identifies new alleles
Shea Ping Yip
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The IVS4 + 4 A to T mutation of the Fanconi anemia geneFANCC is not associated with a severe phenotype in Japanese patients
Makoto Futaki,Takayuki Yamashita,Hiroshi Yagasaki,Tatsushi Toda,Miharu Yabe,Shunichi Kato,Shigetaka Asano,Tatsutoshi Nakahata
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BRIEF REPORTS

Glucose-6-phosphate dehydrogenase Aveiro: a de novo mutation associated with chronic nonspherocytic hemolytic anemia
Brief Report
Elı́sio Costa,José Manuel Cabeda,Emilia Vieira,Rui Pinto,Susana Aires Pereira,Leonor Ferraz,Rosário Santos,José Barbot
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CD20 monoclonal antibody (rituximab) for therapy of Epstein-Barr virus lymphoma after hemopoietic stem-cell transplantation
Brief Report
Ingrid Kuehnle,M. Helen Huls,Zhensheng Liu,Micah Semmelmann,Robert A. Krance,Malcolm K. Brenner,Cliona M. Rooney,Helen E. Heslop
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The Exodus subfamily of CC chemokines inhibits the proliferation of chronic myelogenous leukemia progenitors
Brief Report
Robert Hromas,Larry Cripe,Giao Hangoc,Scott Cooper,Hal E. Broxmeyer
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Mutations of the E2F4 gene in hematological malignancies having microsatellite instability
Brief Report
Naoki Komatsu,Seisho Takeuchi,Takayuki Ikezoe,Taizo Tasaka,Yoshihiro Hatta,Hisanori Machida,Ian K. Williamson,Claus R. Bartram,H. Phillip Koeffler,Hirokuni Taguchi
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CORRESPONDENCE

MAP kinase localizes to the platelet-yielding demarcation membrane system in megakaryocytes
Shishinn Sun,Carl W. Jackson,Katya Ravid
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The causal relation between benzene exposure and multiple myeloma
Bernard D. Goldstein Stuart L. Shalat
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All Issues

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