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Issue Archive

Volume 95, Issue 1
January 1 2000
Blood Cover Image for Volume 95, Issue 1

Table of Contents

EDITORIAL

Blood: New designs for a new millennium
Kenneth Kaushansky, MD
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PLENARY PAPER

Impact on survival of high-dose therapy with autologous stem cell support in patients younger than 60 years with newly diagnosed multiple myeloma: a population-based study
Stig Lenhoff,Martin Hjorth,Erik Holmberg,Ingemar Turesson,Jan Westin,Johan Lanng Nielsen,Finn Wislöff,Lorentz Brinch,Kristina Carlson,Margaretha Carlsson,Inger-Marie Dahl,Peter Gimsing,Erik Hippe,Hans E. Johnsen,Jon Lamvik,Eva Löfvenberg,Ingerid Nesthus,Stig Rödjer,for the Nordic Myeloma Study Group
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The presence of an RHD pseudogene containing a 37 base pair duplication and a nonsense mutation in Africans with the Rh D-negative blood group phenotype
Belinda K. Singleton,Carole A. Green,Neil D. Avent,Peter G. Martin,Elizabeth Smart,Abigail Daka,Edwin G. Narter-Olaga,Linda M. Hawthorne,Geoff Daniels
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REVIEW ARTICLES

The Jak-Stat pathway in normal and perturbed hematopoiesis
Alister C. Ward,Ivo Touw,Akihiko Yoshimura
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CHEMOKINES

Increased chemokine receptor CCR7/EBI1 expression enhances the infiltration of lymphoid organs by adult T-cell leukemia cells
Hitoshi Hasegawa,Tetsuhiko Nomura,Masashi Kohno,Norihiko Tateishi,Yoji Suzuki,Nobuji Maeda,Ryuichi Fujisawa,Osamu Yoshie,Shigeru Fujita
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Activation of C-C β-chemokines in human peripheral blood γδ T cells by isopentenyl pyrophosphate and regulation by cytokines
Barbara Cipriani,Giovanna Borsellino,Fabrizio Poccia,Roberta Placido,Daniela Tramonti,Simona Bach,Luca Battistini,Celia F. Brosnan
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CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Changes in human immunodeficiency virus type 1 virus load during mobilization and harvesting of hemopoietic progenitor cells
Thomas B. Campbell,Anne Sevin,Robert W. Coombs,Gregory C. Peterson,Mary Rosandich,Daniel R. Kuritzkes,Jeannette Mladenovic,Alan Landay,Roberta Wong,Daniel Ambruso,Steve Miles,Roger J. Pomerantz,Robert T. Schooley,the Adult AIDS Clinical Trials Group 285 Study Team
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Improvement in Castleman's disease by humanized anti-interleukin-6 receptor antibody therapy
Norihiro Nishimoto,Mitsuko Sasai,Yoshihito Shima,Masashi Nakagawa,Tomoshige Matsumoto,Toshikazu Shirai,Tadamitsu Kishimoto,Kazuyuki Yoshizaki
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Molecular heterogeneity in complete cytogenetic responders after interferon-α therapy for chronic myelogenous leukemia: low levels of minimal residual disease are associated with continuing remission
Andreas Hochhaus,Andreas Reiter,Susanne Saußele, Anja Reichert,Michael Emig,Jaspal Kaeda,Beate Schultheis,Ute Berger,Patricia C. A. Shepherd,Norman C. Allan,Rüdiger Hehlmann,John M. Goldman,Nicholas C. P. Cross,for the German CML Study Group and the UK MRC CML Study Group
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Comparison of single-dose and escalating-dose regimens of donor lymphocyte infusion for relapse after allografting for chronic myeloid leukemia
F. Dazzi,R. M. Szydlo,C. Craddock,N. C. P. Cross,J. Kaeda,A. Chase,E. Olavarria,F. van Rhee,E. Kanfer,J. F. Apperley,J. M. Goldman
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Effect of time to complete remission on subsequent survival and disease-free survival time in AML, RAEB-t, and RAEB
Elihu H. Estey,Yu Shen,Peter F. Thall
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Outpatient penile aspiration and epinephrine irrigation for young patients with sickle cell anemia and prolonged priapism
Elpis Mantadakis,David H. Ewalt,Joe Don Cavender,Zora R. Rogers,George R. Buchanan
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Daclizumab, a humanized anti-interleukin-2 receptor alpha chain antibody, for treatment of acute graft-versus-host disease
D. Przepiorka,N. A. Kernan,C. Ippoliti,E. B. Papadopoulos,S. Giralt,I. Khouri,J.-G. Lu,J. Gajewski,A. Durett,K. Cleary,R. Champlin,B. S. Andersson,S. Light
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Clinical description of 44 patients with acute promyelocytic leukemia who developed the retinoic acid syndrome: Presented in part at the meeting of the American Society of Hematology, San Diego, CA, December 1997.
Martin S. Tallman,Janet W. Andersen,Charles A. Schiffer,Frederick R. Appelbaum,James H. Feusner,Angela Ogden,Lois Shepherd,Jacob M. Rowe,Christopher François,Richard S. Larson,Peter H. Wiernik
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A prospective study of residual-disease monitoring of theALL1/AF4 transcript in patients with t(4;11) acute lymphoblastic leukemia
Giuseppe Cimino,Loredana Elia,Maria Cristina Rapanotti,Teresa Sprovieri,Marco Mancini,Antonio Cuneo,Cristina Mecucci,Giuseppe Fioritoni,Mario Carotenuto,Enrica Morra,Vincenzo Liso,Luciana Annino,Giuseppe Saglio,Giulio De Rossi,Robin Foà,Franco Mandelli
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HEMATOPOIESIS

Expansion of human cord blood CD34+CD38−cells in ex vivo culture during retroviral transduction without a corresponding increase in SCID repopulating cell (SRC) frequency: dissociation of SRC phenotype and function
Craig Dorrell,Olga I. Gan,Daniel S. Pereira,Robert G. Hawley,John E. Dick
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DNA methylation represses the expression of the human erythropoietin gene by two different mechanisms
Hong Yin,K. L. Blanchard
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Novel murine myeloid cell lines that exhibit a differentiation switch in response to IL-3 or GM-CSF, or to different constitutively active mutants of the GM-CSF receptor β subunit
Matthew P. McCormack,Thomas J. Gonda
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Distinct signals control the hematopoiesis of lymphoid-related dendritic cells
Anne Galy,Indu Christopherson,Guido Ferlazzo,Guo Liu,Hergen Spits,Katia Georgopoulos
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Development of dendritic cells in vitro from murine fetal liver–derived lineage phenotype-negative c-kit+hematopoietic progenitor cells
Yanyun Zhang,Yi Zhang,Yong Wang,Masafumi Ogata,Shin-ichi Hashimoto,Nobuyuki Onai,Kouji Matsushima
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Human LTC-IC can be maintained for at least 5 weeks in vitro when interleukin-3 and a single chemokine are combined with O-sulfated heparan sulfates: requirement for optimal binding interactions of heparan sulfate with early-acting cytokines and matrix proteins
Pankaj Gupta,Theodore R. Oegema, Jr,Joseph J. Brazil,Arkaduisz Z. Dudek,Arne Slungaard,Catherine M. Verfaillie
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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

A human antibody directed to the factor VIII C1 domain inhibits factor VIII cofactor activity and binding to von Willebrand factor
Marc Jacquemin,Abdellah Benhida,Kathelijne Peerlinck,Benoı̂t Desqueper,Luc Vander Elst,Renaud Lavend'homme,Roseline d'Oiron,Rainer Schwaab,Marleen Bakkus,Kris Thielemans,Jean-Guy Gilles,Jos Vermylen,Jean-Marie Saint-Remy
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Structure and function of the von Willebrand factor A1 domain: analysis with monoclonal antibodies reveals distinct binding sites involved in recognition of the platelet membrane glycoprotein Ib-IX-V complex and ristocetin-dependent activation
Mariagrazia De Luca,David A. Facey,Emmanuel J. Favaloro,Mark S. Hertzberg,James C. Whisstock,Tracy McNally,Robert K. Andrews,Michael C. Berndt
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Protein S secretion differences of missense mutants account for phenotypic heterogeneity
Yolanda Espinosa-Parrilla,Tomio Yamazaki,Nùria Sala,Björn Dahlbäck,Pablo Garcı́a de Frutos
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A naturally occurring mutation near the amino terminus of αIIb defines a new region involved in ligand binding to αIIbβ3
Ramesh B. Basani,Deborah L. French,Gaston Vilaire,Deborah L. Brown,Fangping Chen,Barry S. Coller,Jerry M. Derrick,T. Kent Gartner,Joel S. Bennett,Mortimer Poncz
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Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide
Hideo Kimura,Alessandro Weisz,Yukiko Kurashima,Kouichi Hashimoto,Tsutomu Ogura,Fulvio D'Acquisto,Raffaelo Addeo,Masatoshi Makuuchi,Hiroyasu Esumi
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Fibrinogen is a component of a novel lipoprotein particle: Factor H–related protein (FHRP)–associated lipoprotein particle (FALP)
C. Thomas Park,Samuel D. Wright
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Threonine-145/Methionine-145 variants of baculovirus produced recombinant ligand binding domain of GPIbα express HPA-2 epitopes and show equal binding of von Willebrand factor
Chester Q. Li,Stephen F. Garner,Julian Davies,Peter A. Smethurst,Mark R. Wardell,Willem H. Ouwehand
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IMMUNOBIOLOGY

Nitric oxide-producing CD11b+Ly-6G(Gr-1)+CD31(ER-MP12)+cells in the spleen of cyclophosphamide–treated mice: implications for T-cell responses in immunosuppressed mice
Iñigo Angulo,Federico Gómez de las Heras,José F. Garcı́a-Bustos,Domingo Gargallo,M. Angeles Muñoz-Fernández,Manuel Fresno
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A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes
Hans-Christian Aasheim,Else Munthe,Steinar Funderud,Erlend B. Smeland,Klaus Beiske,Ton Logtenberg
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Human Tc1 and Tc2/Tc0 CD8 T-cell clones display distinct cell surface and functional phenotypes
Milica Vukmanovic-Stejic,Beejal Vyas,Patricia Gorak-Stolinska,Alistair Noble,David M. Kemeny
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Application of the ELISPOT assay to the characterization of CD8+ responses to Epstein-Barr virus antigens
Jie Yang,Victor M. Lemas,Ian W. Flinn,Chris Krone,Richard F. Ambinder
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T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART)
Mette D. Hazenberg,James W. T. Cohen Stuart,Sigrid A. Otto,Jan C. C. Borleffs,Charles A. B. Boucher,Rob J. de Boer,Frank Miedema,Dörte Hamann
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Nuclear factor-κB activation by the photochemotherapeutic agent verteporfin
D. J. Granville,C. M. Carthy,H. Jiang,J. G. Levy,B. M. McManus,J.-Y. Matroule,J. Piette,D. W. C. Hunt
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Inhibition of eosinophilic inflammation in allergen-challenged, IL-1 receptor type 1–deficient mice is associated with reduced eosinophil rolling and adhesion on vascular endothelium
David H. Broide,Keith Campbell,Tim Gifford,P. Sriramarao
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Human monocytes express functional receptors for granulocyte colony– stimulating factor that mediate suppression of monokines and interferon-γ
Eva-Maria Boneberg,Lars Hareng,Florian Gantner,Albrecht Wendel,Thomas Hartung
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Differential expression of Rel/NF-κB and octamer factors is a hallmark of the generation and maturation of dendritic cells
M. Neumann,H.-W. Fries,C. Scheicher,P. Keikavoussi,A. Kolb-Mäurer,E.-B. Bröcker,E. Serfling,E. Kämpgen
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HLA class I-restricted lysis of leukemia cells by a CD8+ cytotoxic T-lymphocyte clone specific for WT1 peptide
Hideki Ohminami,Masaki Yasukawa,Shigeru Fujita
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NEOPLASIA

Viral latent membrane protein 1 (LMP-1)–induced CD99 down-regulation in B cells leads to the generation of cells with Hodgkin's and Reed-Sternberg phenotype
Soon Ha Kim,Young Kee Shin,Im-soon Lee,Young Mee Bae,Hae Won Sohn,Young Ho Suh,Howe J. Ree,Martin Rowe,Seong Hoe Park
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Functional CD95 ligand and CD95 death-inducing signaling complex in activation-induced cell death and doxorubicin-induced apoptosis in leukemic T cells
Simone Fulda,Gudrun Strauss,Eric Meyer,Klaus-Michael Debatin
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Evidence of increased angiogenesis in patients with acute myeloid leukemia
Jerry W. Hussong,George M. Rodgers,Paul J. Shami
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Resistance of ICAM-1–deficient mice to metastasis overcome by increased aggressiveness of lymphoma cells
Maxime Lalancette,Fawzi Aoudjit,Edouard F. Potworowski,Yves St-Pierre
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PHAGOCYTES

Myelokathexis, a congenital disorder of severe neutropenia characterized by accelerated apoptosis and defective expression ofbcl-x in neutrophil precursors
Andrew A. G. Aprikyan,W. Conrad Liles,Julie R. Park,Mechthild Jonas,Emil Y. Chi,David C. Dale
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RED CELLS

Altered control of self-reactive IgG by autologous IgM in patients with warm autoimmune hemolytic anemia
Dorothea Stahl,Sébastien Lacroix-Desmazes,Didier Heudes,Luc Mouthon,Srini V. Kaveri,Michel D. Kazatchkine
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Surface expression of Rh-associated glycoprotein (RhAG) in nonerythroid COS-1 cells
Kimita Suyama,Hua Li,Alex Zhu
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Genetic influences on F cells and other hematologic variables: a twin heritability study
C. Garner,T. Tatu,J. E. Reittie,T. Littlewood,J. Darley,S. Cervino,M. Farrall,P. Kelly,T. D. Spector,S. L. Thein
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TRANSFUSION MEDICINE

Natural history of the TT virus infection through follow-up of TTV DNA–positive multiple-transfused patients
Jean-Jacques Lefrère,Françoise Roudot-Thoraval,François Lefrère,Alain Kanfer,Martine Mariotti,Joelle Lerable,Micheline Thauvin,Guillaume Lefèvre,Philippe Rouger,Robert Girot
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TRANSPLANTATION

Reconstitution of T-cell receptor repertoire diversity following T-cell depleted allogeneic bone marrow transplantation is related to hematopoietic chimerism
Catherine J. Wu,Antoinette Chillemi,Edwin P. Alyea,Enrica Orsini,Donna Neuberg,Robert J. Soiffer,Jerome Ritz
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BRIEF REPORTS

Single-tube multiplex-PCR screen for common deletional determinants of α-thalassemia
Brief Report
Samuel S. Chong,Corinne D. Boehm,Douglas R. Higgs,Garry R. Cutting
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