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Volume 94, Issue 4

August 15 1999

In this Issue

PLENARY PAPERS
REVIEW ARTICLES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSFUSION MEDICINE
TRANSPLANTATION
CORRESPONDENCE
ERRATA

PLENARY PAPERS

Cytosolic Calcium Changes in a Process of Platelet Adhesion and Cohesion on a von Willebrand Factor-Coated Surface Under Flow Conditions: Presented in part at the American Society of Hematology Meeting in Miami Beach, FL, December 4-8, 1998 (abstr no. 1423).

Mitsuhiro Kuwahara,Mitsuhiko Sugimoto,Shizuko Tsuji,Shigeki Miyata,Akira Yoshioka

View Articletitled, Cytosolic Calcium Changes in a Process of Platelet Adhesion and Cohesion on a von Willebrand Factor-Coated Surface Under Flow Conditions: Presented in part at the American Society of Hematology Meeting in Miami Beach, FL, December 4-8, 1998 (abstr no. 1423).

Genes Encoding Tumor-Specific Antigens Are Expressed in Human Myeloma Cells

Nicolas van Baren,Francis Brasseur,Danièle Godelaine,Gérald Hames,Augustin Ferrant,Frédéric Lehmann,Marc André,Christophe Ravoet,Chantal Doyen,Giulio C. Spagnoli,Marleen Bakkus,Kris Thielemans,Thierry Boon

View Articletitled, Genes Encoding Tumor-Specific Antigens Are Expressed in Human Myeloma Cells

A Synthetic Peptide Derived From Human Immunodeficiency Virus Type 1 gp120 Downregulates the Expression and Function of Chemokine Receptors CCR5 and CXCR4 in Monocytes by Activating the 7-Transmembrane G-Protein–Coupled Receptor FPRL1/LXA4R

Xiyun Deng,Hirotsugu Ueda,Shao Bo Su,Wanghua Gong,Nancy M. Dunlop,Ji-Liang Gao,Philip M. Murphy,Ji Ming Wang

View Articletitled, A Synthetic Peptide Derived From Human Immunodeficiency Virus Type 1 gp120 Downregulates the Expression and Function of Chemokine Receptors CCR5 and CXCR4 in Monocytes by Activating the 7-Transmembrane G-Protein–Coupled Receptor FPRL1/LXA4R

REVIEW ARTICLES

Benzene and Multiple Myeloma: Appraisal of the Scientific Evidence

Daniel E. Bergsagel,Otto Wong,P. Leif Bergsagel,Raymond Alexanian,Kenneth Anderson,Robert A. Kyle,Gerhard K. Raabe

View Articletitled, Benzene and Multiple Myeloma: Appraisal of the Scientific Evidence

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Low Levels of Hepatitis C Virus RNA in Serum, Plasma, and Peripheral Blood Mononuclear Cells of Injecting Drug Users During Long Antibody-Undetectable Periods Before Seroconversion

Marcel Beld,Maarten Penning,Marieke van Putten,Anneke van den Hoek,Marjolein Damen,Michèl R. Klein,Jaap Goudsmit

View Articletitled, Low Levels of Hepatitis C Virus RNA in Serum, Plasma, and Peripheral Blood Mononuclear Cells of Injecting Drug Users During Long Antibody-Undetectable Periods Before Seroconversion

A Randomized Comparison of All Transretinoic Acid (ATRA) Followed by Chemotherapy and ATRA Plus Chemotherapy and the Role of Maintenance Therapy in Newly Diagnosed Acute Promyelocytic Leukemia

Pierre Fenaux,Claude Chastang,Sylvie Chevret,Miguel Sanz,Hervé Dombret,Eric Archimbaud,Martin Fey,Consuelo Rayon,Françoise Huguet,Jean-Jacques Sotto,Claude Gardin,Pascale Cony Makhoul,Philippe Travade,Eric Solary,Nathalie Fegueux,Dominique Bordessoule,Jesus San Miguel,Harmut Link,Bernard Desablens,Aspasia Stamatoullas,E. Deconinck,Fréderic Maloisel,Sylvie Castaigne,Claude Preudhomme,Laurent Degos,for the European APL Group

View Articletitled, A Randomized Comparison of All Transretinoic Acid (ATRA) Followed by Chemotherapy and ATRA Plus Chemotherapy and the Role of Maintenance Therapy in Newly Diagnosed Acute Promyelocytic Leukemia

Complete Remission of Accelerated Phase Chronic Myeloid Leukemia by Treatment With Leukemia-Reactive Cytotoxic T Lymphocytes

J.H. Frederik Falkenburg,Amon R. Wafelman,Peter Joosten,Willem M. Smit,Cornelis A.M. van Bergen,Rian Bongaerts,Ellie Lurvink,Menno van der Hoorn,Petra Kluck,James E. Landegent,Hanneke C. Kluin-Nelemans,Willem E. Fibbe,Roel Willemze

View Articletitled, Complete Remission of Accelerated Phase Chronic Myeloid Leukemia by Treatment With Leukemia-Reactive Cytotoxic T Lymphocytes

Prednisone Response Is the Strongest Predictor of Treatment Outcome in Infant Acute Lymphoblastic Leukemia

Michael Dördelmann,Alfred Reiter,Arndt Borkhardt,Wolf-Dieter Ludwig,Nicolai Götz,Susanne Viehmann,Helmut Gadner,Hansjörg Riehm,Martin Schrappe,for the ALL-BFM Group

View Articletitled, Prednisone Response Is the Strongest Predictor of Treatment Outcome in Infant Acute Lymphoblastic Leukemia

Stem Cell Factor in Combination With Filgrastim After Chemotherapy Improves Peripheral Blood Progenitor Cell Yield and Reduces Apheresis Requirements in Multiple Myeloma Patients: A Randomized, Controlled Trial

Thierry Facon,Jean-Luc Harousseau,Frédéric Maloisel,Michel Attal,Jesus Odriozola,Adrian Alegre,Wilfried Schroyens,Cyrille Hulin,Rik Schots,Pedro Marin,François Guilhot,Albert Granena,Marc De Waele,Arnaud Pigneux,Valérie Méresse,Peter Clark,Josy Reiffers,the SCF-Multiple Myeloma Study Group

View Articletitled, Stem Cell Factor in Combination With Filgrastim After Chemotherapy Improves Peripheral Blood Progenitor Cell Yield and Reduces Apheresis Requirements in Multiple Myeloma Patients: A Randomized, Controlled Trial

Intensive Treatment of Children With Acute Lymphoblastic Leukemia According to ALL-BFM-86 Without Cranial Radiotherapy: Results of Dutch Childhood Leukemia Study Group Protocol ALL-7 (1988-1991)

W.A. Kamps,J.P.M. Bökkerink,K. Hählen,J. Hermans,H. Riehm,H. Gadner,M. Schrappe,R. Slater,E. van den Berg-de Ruiter,L.A. Smets,G.A.M. de Vaan,R.S. Weening,J.F. van Weerden,E.R. van Wering,A. van der Does-van den Berg

View Articletitled, Intensive Treatment of Children With Acute Lymphoblastic Leukemia According to ALL-BFM-86 Without Cranial Radiotherapy: Results of Dutch Childhood Leukemia Study Group Protocol ALL-7 (1988-1991)

Phase I Study of ¹³¹I-Anti-CD45 Antibody Plus Cyclophosphamide and Total Body Irradiation for Advanced Acute Leukemia and Myelodysplastic Syndrome

Dana C. Matthews,Frederick R. Appelbaum,Janet F. Eary,Darrell R. Fisher,Lawrence D. Durack,T. Edmond Hui,Paul J. Martin,David Mitchell,Oliver W. Press,Rainer Storb,Irwin D. Bernstein

View Articletitled, Phase I Study of 131I-Anti-CD45 Antibody Plus Cyclophosphamide and Total Body Irradiation for Advanced Acute Leukemia and Myelodysplastic Syndrome

Dose-Intensive Melphalan With Stem Cell Support (MEL100) Is Superior to Standard Treatment in Elderly Myeloma Patients

Antonio Palumbo,Sabrina Triolo,Chiara Argentino,Sara Bringhen,Alida Dominietto,Cecilia Rus,Paola Omedè,Corrado Tarella,Alessandro Pileri,Mario Boccadoro

View Articletitled, Dose-Intensive Melphalan With Stem Cell Support (MEL100) Is Superior to Standard Treatment in Elderly Myeloma Patients

HEMATOPOIESIS

Dyskeratosis Congenita Caused by a 3′ Deletion: Germline and Somatic Mosaicism in a Female Carrier

T.J. Vulliamy,S.W. Knight,N.S. Heiss,O.P. Smith,A. Poustka,I. Dokal,P.J. Mason

View Articletitled, Dyskeratosis Congenita Caused by a 3′ Deletion: Germline and Somatic Mosaicism in a Female Carrier

Primitive Myeloid Cells Express High Levels of Phospholipase A₂ Activity in the Absence of Leukotriene Release: Selective Regulation by Stem Cell Factor Involving the MAP Kinase Pathway

Pamela J. Roberts,Elahe Mollapour,Michael J. Watts,David C. Linch

View Articletitled, Primitive Myeloid Cells Express High Levels of Phospholipase A2 Activity in the Absence of Leukotriene Release: Selective Regulation by Stem Cell Factor Involving the MAP Kinase Pathway

Thrombopoietin-Induced Activation of the Mitogen-Activated Protein Kinase (MAPK) Pathway in Normal Megakaryocytes: Role in Endomitosis

Ponlapat Rojnuckarin,Jonathan G. Drachman,Kenneth Kaushansky

View Articletitled, Thrombopoietin-Induced Activation of the Mitogen-Activated Protein Kinase (MAPK) Pathway in Normal Megakaryocytes: Role in Endomitosis

A Critical Role for PU.1 in Homing and Long-Term Engraftment by Hematopoietic Stem Cells in the Bone Marrow

Robert C. Fisher,Joshua D. Lovelock,Edward W. Scott

View Articletitled, A Critical Role for PU.1 in Homing and Long-Term Engraftment by Hematopoietic Stem Cells in the Bone Marrow

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Endothelin-1–Induced Interleukin-8 Production in Human Brain-Derived Endothelial Cells Is Mediated by the Protein Kinase C and Protein Tyrosine Kinase Pathways

R. Zidovetzki,P. Chen,M. Chen,F.M. Hofman

View Articletitled, Endothelin-1–Induced Interleukin-8 Production in Human Brain-Derived Endothelial Cells Is Mediated by the Protein Kinase C and Protein Tyrosine Kinase Pathways

Synthesis and Ultrastructural Localization of Protein C Inhibitor in Human Platelets and Megakaryocytes: Presented at the 14th International Congress on Fibrinolysis and Thrombolysis, Ljubljana, Slovenia, June 22-26, 1998, and at the Xth International Vascular Biology Meeting in Cairns, Queensland, Australia, August 23-27, 1998.

Maria J. Prendes,Edith Bielek,Margareta Zechmeister-Machhart,Erika Vanyek-Zavadil,Veronica A. Carroll,Johannes Breuss,Bernd R. Binder,Margarethe Geiger

View Articletitled, Synthesis and Ultrastructural Localization of Protein C Inhibitor in Human Platelets and Megakaryocytes: Presented at the 14th International Congress on Fibrinolysis and Thrombolysis, Ljubljana, Slovenia, June 22-26, 1998, and at the Xth International Vascular Biology Meeting in Cairns, Queensland, Australia, August 23-27, 1998.

A Critical Role for N-ethylmaleimide–Sensitive Fusion Protein (NSF) in Platelet Granule Secretion: Presented in part in abstract form at the 1998 national meeting of the American Heart Association in Dallas, TX.

János Polgár,Guy L. Reed

View Articletitled, A Critical Role for N-ethylmaleimide–Sensitive Fusion Protein (NSF) in Platelet Granule Secretion: Presented in part in abstract form at the 1998 national meeting of the American Heart Association in Dallas, TX.

Ligation of CD31 (PECAM-1) on Endothelial Cells Increases Adhesive Function of vβ3 Integrin and Enhances β1 Integrin-Mediated Adhesion of Eosinophils to Endothelial Cells

Ryuichi Chiba,Noriaki Nakagawa,Kazuhiro Kurasawa,Yoshiya Tanaka,Yasushi Saito,Itsuo Iwamoto

View Articletitled, Ligation of CD31 (PECAM-1) on Endothelial Cells Increases Adhesive Function of vβ3 Integrin and Enhances β1 Integrin-Mediated Adhesion of Eosinophils to Endothelial Cells

Increased Clearance Explains Lower Plasma Levels of Tissue-Type Plasminogen Activator by Estradiol: Evidence for Potently Enhanced Mannose Receptor Expression in Mice

Mirian Lansink,Miek Jong,Martin Bijsterbosch,Marian Bekkers,Karin Toet,Louis Havekes,Jef Emeis,Teake Kooistra

View Articletitled, Increased Clearance Explains Lower Plasma Levels of Tissue-Type Plasminogen Activator by Estradiol: Evidence for Potently Enhanced Mannose Receptor Expression in Mice

Multimerin Processing by Cells With and Without Pathways for Regulated Protein Secretion

Catherine P.M. Hayward,Zhili Song,Shilun Zheng,Roxanna Fung,Menaka Pai,Jean-Marc Massé,Elisabeth M. Cramer

View Articletitled, Multimerin Processing by Cells With and Without Pathways for Regulated Protein Secretion

IMMUNOBIOLOGY

Retinoic Acid Prevents Phosphorylation of pRB in Normal Human B Lymphocytes: Regulation of Cyclin E, Cyclin A, and p21^Cip1

Soheil Naderi,Heidi Kiil Blomhoff

View Articletitled, Retinoic Acid Prevents Phosphorylation of pRB in Normal Human B Lymphocytes: Regulation of Cyclin E, Cyclin A, and p21Cip1

Calcium Ionophore-Treated Myeloid Cells Acquire Many Dendritic Cell Characteristics Independent of Prior Differentiation State, Transformation Status, or Sensitivity to Biologic Agents

Gary K. Koski,Gretchen N. Schwartz,David E. Weng,Ronald E. Gress,Friederike H.C. Engels,Maria Tsokos,Brian J. Czerniecki,Peter A. Cohen

View Articletitled, Calcium Ionophore-Treated Myeloid Cells Acquire Many Dendritic Cell Characteristics Independent of Prior Differentiation State, Transformation Status, or Sensitivity to Biologic Agents

Induction of Epstein-Barr Virus-Specific Cytotoxic T-Lymphocyte Responses Using Dendritic Cells Pulsed With EBNA-3A Peptides or UV-Inactivated, Recombinant EBNA-3A Vaccinia Virus

Marion Subklewe,Ann Chahroudi,Alan Schmaljohn,Michael G. Kurilla,Nina Bhardwaj,Ralph M. Steinman

View Articletitled, Induction of Epstein-Barr Virus-Specific Cytotoxic T-Lymphocyte Responses Using Dendritic Cells Pulsed With EBNA-3A Peptides or UV-Inactivated, Recombinant EBNA-3A Vaccinia Virus

CD22 Cross-Linking Generates B-Cell Antigen Receptor-Independent Signals That Activate the JNK/SAPK Signaling Cascade

Joseph M. Tuscano,Agostino Riva,Salvador N. Toscano,Thomas F. Tedder,John H. Kehrl

View Articletitled, CD22 Cross-Linking Generates B-Cell Antigen Receptor-Independent Signals That Activate the JNK/SAPK Signaling Cascade

NEOPLASIA

Expression of Chromosome 21-Localized Genes in Acute Myeloid Leukemia: Differences Between Down Syndrome and Non-Down Syndrome Blast Cells and Relationship to In Vitro Sensitivity to Cytosine Arabinoside and Daunorubicin

Jeffrey W. Taub,Xi Huang,Larry H. Matherly,Mark L. Stout,Steven A. Buck,Gita V. Massey,David L. Becton,Myron N. Chang,Howard J. Weinstein,Yaddanapudi Ravindranath

View Articletitled, Expression of Chromosome 21-Localized Genes in Acute Myeloid Leukemia: Differences Between Down Syndrome and Non-Down Syndrome Blast Cells and Relationship to In Vitro Sensitivity to Cytosine Arabinoside and Daunorubicin

Depsipeptide (FR901228): A Novel Therapeutic Agent With Selective, In Vitro Activity Against Human B-Cell Chronic Lymphocytic Leukemia Cells

John C. Byrd,Charlotte Shinn,Rajani Ravi,Carl R. Willis,Jamie K. Waselenko,Ian W. Flinn,Nancy A. Dawson,Michael R. Grever

View Articletitled, Depsipeptide (FR901228): A Novel Therapeutic Agent With Selective, In Vitro Activity Against Human B-Cell Chronic Lymphocytic Leukemia Cells

Demonstration of Frequent Occurrence of Clonal T Cells in the Peripheral Blood But Not in the Skin of Patients With Small Plaque Parapsoriasis

J. Marcus Muche,Ansgar Lukowsky,Jürgen Heim,Markus Friedrich,Heike Audring,Wolfram Sterry

View Articletitled, Demonstration of Frequent Occurrence of Clonal T Cells in the Peripheral Blood But Not in the Skin of Patients With Small Plaque Parapsoriasis

PHAGOCYTES

A Novel Serpin Expressed by Blood-Borne Microfilariae of the Parasitic Nematode Brugia malayi Inhibits Human Neutrophil Serine Proteinases

Xingxing Zang,Maria Yazdanbakhsh,Haobo Jiang,Michael R. Kanost,Rick M. Maizels

View Articletitled, A Novel Serpin Expressed by Blood-Borne Microfilariae of the Parasitic Nematode Brugia malayi Inhibits Human Neutrophil Serine Proteinases

C/EBPβ and GATA-1 Synergistically Regulate Activity of the Eosinophil Granule Major Basic Protein Promoter: Implication for C/EBPβ Activity in Eosinophil Gene Expression

Yuji Yamaguchi,Hitoshi Nishio,Kenji Kishi,Steven J. Ackerman,Toshio Suda

View Articletitled, C/EBPβ and GATA-1 Synergistically Regulate Activity of the Eosinophil Granule Major Basic Protein Promoter: Implication for C/EBPβ Activity in Eosinophil Gene Expression

RED CELLS

Proteolytic Processing of Big Endothelin-3 by the Kell Blood Group Protein: Presented in part in abstract form at the 40^th annual meeting of the American Society of Hematology, December, 1998.

Soohee Lee,Melissa Lin,Aldo Mele,Ying Cao,James Farmar,David Russo,Colvin Redman

View Articletitled, Proteolytic Processing of Big Endothelin-3 by the Kell Blood Group Protein: Presented in part in abstract form at the 40th annual meeting of the American Society of Hematology, December, 1998.

Altered Hematopoiesis in Murine Sickle Cell Disease

Marie-José Blouin,Monique E. De Paepe,Marie Trudel

View Articletitled, Altered Hematopoiesis in Murine Sickle Cell Disease

TRANSFUSION MEDICINE

The Significance of Hepatitis G Virus in Serum of Patients With Sporadic Fulminant and Subfulminant Hepatitis of Unknown Etiology

Santiago J. Muñoz,Harvey J. Alter,Yoshiyuki Nakatsuji,James W.-K. Shih,Rajender K. Reddy,Lennox Jeffers,Eugene R. Schiff,Andrea E. Reid,Aldo Marrone,Kenneth Rothstein,Cosme Manzarbeitia,T. Jake Liang

View Articletitled, The Significance of Hepatitis G Virus in Serum of Patients With Sporadic Fulminant and Subfulminant Hepatitis of Unknown Etiology

TRANSPLANTATION

Risk Factors for Acute Graft-Versus-Host Disease After Allogeneic Blood Stem Cell Transplantation

Donna Przepiorka,Terry L. Smith,Jody Folloder,Issa Khouri,Naoto T. Ueno,Rakesh Mehra,Martin Körbling,Yang O. Huh,Sergio Giralt,James Gajewski,Michele Donato,Karen Cleary,David Claxton,Ira Braunschweig,Koen van Besien,Borje S. Andersson,Paolo Anderlini,Richard Champlin

View Articletitled, Risk Factors for Acute Graft-Versus-Host Disease After Allogeneic Blood Stem Cell Transplantation

Nested Polymerase Chain Reaction With Sequence-Specific Primers Typing for HLA-A, -B, and -C Alleles: Detection of Microchimerism in DR-Matched Individuals

Anthony S. Carter,Lucia Cerundolo,Mike Bunce,Dicken D.H. Koo,Kenneth I. Welsh,Peter J. Morris,Susan V. Fuggle

View Articletitled, Nested Polymerase Chain Reaction With Sequence-Specific Primers Typing for HLA-A, -B, and -C Alleles: Detection of Microchimerism in DR-Matched Individuals

CORRESPONDENCE

Relationship Between Degradation of PML-RAR and Differentiation

Tomoki Naoe,Kunio Kitamura

View Articletitled, Relationship Between Degradation of PML-RAR and Differentiation

Successful Healing of Hydroxyurea-Related Leg Ulcers With Topical Granulocyte-Macrophage Colony-Stimulating Factor

Fabio Stagno,Patrizia Guglielmo,Ugo Consoli,Paolo Fiumara,Mario Russo,Rosario Giustolisi

View Articletitled, Successful Healing of Hydroxyurea-Related Leg Ulcers With Topical Granulocyte-Macrophage Colony-Stimulating Factor

A Single-Base Deletion in the Thrombopoietin (TPO) Gene Causes Familial Essential Thrombocythemia Through a Mechanism of More Efficient Translation of TPO mRNA

Nico Ghilardi,Radek C. Skoda

View Articletitled, A Single-Base Deletion in the Thrombopoietin (TPO) Gene Causes Familial Essential Thrombocythemia Through a Mechanism of More Efficient Translation of TPO mRNA

Circulating Apoptotic Endothelial Cells

Tihomir Štefanec

View Articletitled, Circulating Apoptotic Endothelial Cells

Fulminant Intravascular Disseminating Malignant Melanoma Mimicking Acute Leukemia

Uwe Trefzer,Christina Schlegel,Wolfram Sterry,Ernst Späth-Schwalbe,Kurt Possinger,Carsten Denkert

View Articletitled, Fulminant Intravascular Disseminating Malignant Melanoma Mimicking Acute Leukemia

Clinical Decision Making in Chronic Myeloid Leukemia Based on Polymerase Chain Reaction Analysis of Minimal Residual Disease

John M. Goldman,Jaspal S. Kaeda,Nicholas C.P. Cross,Andreas Hochhaus,Rüdiger Hehlmann

View Articletitled, Clinical Decision Making in Chronic Myeloid Leukemia Based on Polymerase Chain Reaction Analysis of Minimal Residual Disease

Monitoring of Residual Disease in Chronic Myelogenous Leukemia by Quantitative Polymerase Chain Reaction and Clinical Decision Making

Thomas Lion

View Articletitled, Monitoring of Residual Disease in Chronic Myelogenous Leukemia by Quantitative Polymerase Chain Reaction and Clinical Decision Making

The 782C → T (T254M) XHIM Mutation: Lack of a Tight Phenotype-Genotype Relationship

Esther de Vries,Jeroen G. Noordzij,E. Graham Davies,Nico Hartwig,Martÿn H. Breuning,Jacques J.M. van Dongen,Maarten J.D. van Tol

View Articletitled, The 782C → T (T254M) XHIM Mutation: Lack of a Tight Phenotype-Genotype Relationship

ERRATA

Erratum for vol. 93, p. 43

View Articletitled, Erratum for vol. 93, p. 43

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