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Volume 94, Issue 3

August 1 1999

In this Issue

PLENARY PAPERS
REVIEW ARTICLES
CHEMOKINES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
PHOTOGRAPH
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
TRANSPLANTATION
CORRESPONDENCE

PLENARY PAPERS

Serial Analysis of Gene Expression in Human Monocytes and Macrophages

Shin-ichi Hashimoto,Takuji Suzuki,Hong-Yan Dong,Nobuyuki Yamazaki,Kouji Matsushima

View Articletitled, Serial Analysis of Gene Expression in Human Monocytes and Macrophages

Serial Analysis of Gene Expression in Human Monocyte-Derived Dendritic Cells

Shin-ichi Hashimoto,Takuji Suzuki,Hong-Yan Dong,Shigenori Nagai,Nobuyuki Yamazaki,Kouji Matsushima

View Articletitled, Serial Analysis of Gene Expression in Human Monocyte-Derived Dendritic Cells

Requirement of Activation of JNK and p38 for Environmental Stress-Induced Erythroid Differentiation and Apoptosis and of Inhibition of ERK for Apoptosis

Yuka Nagata,Kazuo Todokoro

View Articletitled, Requirement of Activation of JNK and p38 for Environmental Stress-Induced Erythroid Differentiation and Apoptosis and of Inhibition of ERK for Apoptosis

REVIEW ARTICLES

Adeno-Associated Virus Vectors and Hematology

David W. Russell,Mark A. Kay

View Articletitled, Adeno-Associated Virus Vectors and Hematology

CHEMOKINES

Loss of CCR2 Expression and Functional Response to Monocyte Chemotactic Protein (MCP-1) During the Differentiation of Human Monocytes: Role of Secreted MCP-1 in the Regulation of the Chemotactic Response

Laura Fantuzzi,Paola Borghi,Veniero Ciolli,George Pavlakis,Filippo Belardelli,Sandra Gessani

View Articletitled, Loss of CCR2 Expression and Functional Response to Monocyte Chemotactic Protein (MCP-1) During the Differentiation of Human Monocytes: Role of Secreted MCP-1 in the Regulation of the Chemotactic Response

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Loss of Endothelial Surface Expression of E-Selectin in a Patient With Recurrent Infections

Horace M. DeLisser,Melpo Christofidou-Solomidou,Jing Sun,Marian T. Nakada,Kathleen E. Sullivan

View Articletitled, Loss of Endothelial Surface Expression of E-Selectin in a Patient With Recurrent Infections

Extensive Venous and Arterial Thrombosis Associated With an Inhibitor to Activated Protein C

Ariella Zivelin,Sanford Gitel,John H. Griffin,Xiao Xu,Jose A. Fernandez,Uri Martinowitz,Yael Cohen,Hillel Halkin,Uri Seligsohn,Aida Inbal

View Articletitled, Extensive Venous and Arterial Thrombosis Associated With an Inhibitor to Activated Protein C

Interleukin-12 Therapy of Cutaneous T-Cell Lymphoma Induces Lesion Regression and Cytotoxic T-Cell Responses

Alain H. Rook,Gary S. Wood,Elisa K. Yoo,Rosalie Elenitsas,David M.F. Kao,Matthew L. Sherman,William K. Witmer,Kenneth A. Rockwell,Ryan B. Shane,Stuart R. Lessin,Eric C. Vonderheid

View Articletitled, Interleukin-12 Therapy of Cutaneous T-Cell Lymphoma Induces Lesion Regression and Cytotoxic T-Cell Responses

The Incidence of Idiopathic Thrombocytopenic Purpura in Adults Increases With Age

Henrik Frederiksen,Kai Schmidt

View Articletitled, The Incidence of Idiopathic Thrombocytopenic Purpura in Adults Increases With Age

PHOTOGRAPH

Photograph

View Articletitled, Photograph

GENE THERAPY

Long-Term Correction of Phagocyte NADPH Oxidase Activity by Retroviral-Mediated Gene Transfer in Murine X-Linked Chronic Granulomatous Disease

Mary C. Dinauer,Ling Lin Li,Helga Björgvinsdóttir,Chunjin Ding,Nancy Pech

View Articletitled, Long-Term Correction of Phagocyte NADPH Oxidase Activity by Retroviral-Mediated Gene Transfer in Murine X-Linked Chronic Granulomatous Disease

HEMATOPOIESIS

The Soluble Interleukin-6 (IL-6) Receptor/IL-6 Fusion Protein Enhances In Vitro Maintenance and Proliferation of Human CD34⁺CD38^−/low Cells Capable of Repopulating Severe Combined Immunodeficiency Mice

Orit Kollet,Ronit Aviram,Judith Chebath,Herzl ben-Hur,Arnon Nagler,Leonard Shultz,Michel Revel,Tsvee Lapidot

View Articletitled, The Soluble Interleukin-6 (IL-6) Receptor/IL-6 Fusion Protein Enhances In Vitro Maintenance and Proliferation of Human CD34+CD38−/low Cells Capable of Repopulating Severe Combined Immunodeficiency Mice

Dysregulated Myelopoiesis in Mice Lacking Jak3

William J. Grossman,James W. Verbsky,Liping Yang,Leslie J. Berg,Larry E. Fields,David D. Chaplin,Lee Ratner

View Articletitled, Dysregulated Myelopoiesis in Mice Lacking Jak3

Hyaluronate-Enhanced Hematopoiesis: Two Different Receptors Trigger the Release of Interleukin-1β and Interleukin-6 From Bone Marrow Macrophages

Sophia Khaldoyanidi,Jürgen Moll,Svetlana Karakhanova,Peter Herrlich,Helmut Ponta

View Articletitled, Hyaluronate-Enhanced Hematopoiesis: Two Different Receptors Trigger the Release of Interleukin-1β and Interleukin-6 From Bone Marrow Macrophages

Differential Effects of Human Granulocyte Colony-Stimulating Factor (hG-CSF) and Thrombopoietin on Megakaryopoiesis and Platelet Function in hG-CSF Receptor-Transgenic Mice

Feng-Chun Yang,Kohichiro Tsuji,Atsushi Oda,Yasuhiro Ebihara,Ming-jiang Xu,Azusa Kaneko,Sachiyo Hanada,Tetsuo Mitsui,Akira Kikuchi,Atsushi Manabe,Sumiko Watanabe,Yasuo Ikeda,Tatsutoshi Nakahata

View Articletitled, Differential Effects of Human Granulocyte Colony-Stimulating Factor (hG-CSF) and Thrombopoietin on Megakaryopoiesis and Platelet Function in hG-CSF Receptor-Transgenic Mice

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Homocysteine-Induced Endoplasmic Reticulum Stress and Growth Arrest Leads to Specific Changes in Gene Expression in Human Vascular Endothelial Cells

P. Andrew Outinen,Sudesh K. Sood,Sabine I. Pfeifer,Sushmita Pamidi,Thomas J. Podor,Jun Li,Jeffrey I. Weitz,Richard C. Austin

View Articletitled, Homocysteine-Induced Endoplasmic Reticulum Stress and Growth Arrest Leads to Specific Changes in Gene Expression in Human Vascular Endothelial Cells

Real-Time Analysis of Mural Thrombus Formation in Various Platelet Aggregation Disorders: Distinct Shear-Dependent Roles of Platelet Receptors and Adhesive Proteins Under Flow

Shizuko Tsuji,Mitsuhiko Sugimoto,Shigeki Miyata,Mitsuhiro Kuwahara,Seiji Kinoshita,Akira Yoshioka

View Articletitled, Real-Time Analysis of Mural Thrombus Formation in Various Platelet Aggregation Disorders: Distinct Shear-Dependent Roles of Platelet Receptors and Adhesive Proteins Under Flow

Cyclophilin B Binding to Platelets Supports Calcium-Dependent Adhesion to Collagen

Fabrice Allain,Sandrine Durieux,Agnès Denys,Mathieu Carpentier,Geneviève Spik

View Articletitled, Cyclophilin B Binding to Platelets Supports Calcium-Dependent Adhesion to Collagen

Inhibition of In Vitro Angiogenesis by Platelet Factor-4–Derived Peptides and Mechanism of Action

Valérie Jouan,Xavier Canron,Monica Alemany,Jacques P. Caen,Gérard Quentin,Jean Plouet,Andreas Bikfalvi

View Articletitled, Inhibition of In Vitro Angiogenesis by Platelet Factor-4–Derived Peptides and Mechanism of Action

IMMUNOBIOLOGY

T-Cell Receptor-Independent Activation of Clonal Th2 Cells Associated With Chronic Hypereosinophilia

Florence Roufosse,Liliane Schandené,Catherine Sibille,Bernard Kennes,André Efira,Elie Cogan,Michel Goldman

View Articletitled, T-Cell Receptor-Independent Activation of Clonal Th2 Cells Associated With Chronic Hypereosinophilia

The Interleukin-12–Mediated Pathway of Immune Events Is Dysfunctional in Human Immunodeficiency Virus–Infected Individuals

Jason D. Marshall,Jihed Chehimi,Giorgia Gri,Jay R. Kostman,Luis J. Montaner,Giorgio Trinchieri

View Articletitled, The Interleukin-12–Mediated Pathway of Immune Events Is Dysfunctional in Human Immunodeficiency Virus–Infected Individuals

Surface Molecule Loss and Bleb Formation by Human Germinal Center B Cells Undergoing Apoptosis: Role of Apoptotic Blebs in Monocyte Chemotaxis

Carmen Segundo,Francisco Medina,Carmen Rodrı́guez,Rosalı́a Martı́nez-Palencia,Francisco Leyva-Cobián,José A. Brieva

View Articletitled, Surface Molecule Loss and Bleb Formation by Human Germinal Center B Cells Undergoing Apoptosis: Role of Apoptotic Blebs in Monocyte Chemotaxis

Human Immunodeficiency Virus Type 1 Protease Inhibitor Modulates Activation of Peripheral Blood CD4⁺ T Cells and Decreases Their Susceptibility to Apoptosis In Vitro and In Vivo

Elaine M. Sloand,Princy N. Kumar,Sonnie Kim,Aniruddho Chaudhuri,Frank F. Weichold,Neal S. Young

View Articletitled, Human Immunodeficiency Virus Type 1 Protease Inhibitor Modulates Activation of Peripheral Blood CD4+ T Cells and Decreases Their Susceptibility to Apoptosis In Vitro and In Vivo

Nitric Oxide Mediation of Active Immunosuppression Associated With Graft-Versus-Host Reaction

Pierre Bobé,Karim Benihoud,Danièle Grandjon,Paule Opolon,Linda Louise Pritchard,Roger Huchet

View Articletitled, Nitric Oxide Mediation of Active Immunosuppression Associated With Graft-Versus-Host Reaction

A BCR-ABL Oncoprotein p210b2a2 Fusion Region Sequence Is Recognized by HLA-DR2a Restricted Cytotoxic T Lymphocytes and Presented by HLA-DR Matched Cells Transfected With an Ii^b2a2 Construct

George J.A. ten Bosch,Jan H. Kessler,Antonia M. Joosten,Alexandra A. Bres-Vloemans,Annemieke Geluk,Barbara C. Godthelp,Jeroen van Bergen,Cornelis J.M. Melief,Onno C. Leeksma

View Articletitled, A BCR-ABL Oncoprotein p210b2a2 Fusion Region Sequence Is Recognized by HLA-DR2a Restricted Cytotoxic T Lymphocytes and Presented by HLA-DR Matched Cells Transfected With an Iib2a2 Construct

NEOPLASIA

Simultaneous Activity of MRP1 and Pgp Is Correlated With In Vitro Resistance to Daunorubicin and With In Vivo Resistance in Adult Acute Myeloid Leukemia

Ollivier Legrand,Ghislaine Simonin,Anne Beauchamp-Nicoud,Robert Zittoun,Jean-Pierre Marie

View Articletitled, Simultaneous Activity of MRP1 and Pgp Is Correlated With In Vitro Resistance to Daunorubicin and With In Vivo Resistance in Adult Acute Myeloid Leukemia

Protracted and Variable Latency of Acute Lymphoblastic Leukemia AfterTEL-AML1 Gene Fusion In Utero: Presented at the American Society of Hematology Meeting, held in Miami Beach, FL, December 4-8, 1998, and published as an abstract in Blood 92:68a, 1998 (suppl 1).

Joseph L. Wiemels,Anthony M. Ford,Elisabeth R. Van Wering,Aleida Postma,Mel Greaves

View Articletitled, Protracted and Variable Latency of Acute Lymphoblastic Leukemia AfterTEL-AML1 Gene Fusion In Utero: Presented at the American Society of Hematology Meeting, held in Miami Beach, FL, December 4-8, 1998, and published as an abstract in Blood 92:68a, 1998 (suppl 1).

Oligoclonal TCRBV Gene Usage in B-Cell Chronic Lymphocytic Leukemia: Major Perturbations Are Preferentially Seen Within the CD4 T-Cell Subset

Mohammad-Reza Rezvany,Mahmood Jeddi-Tehrani,Anders Österborg,Eva Kimby,Hans Wigzell,Håkan Mellstedt

View Articletitled, Oligoclonal TCRBV Gene Usage in B-Cell Chronic Lymphocytic Leukemia: Major Perturbations Are Preferentially Seen Within the CD4 T-Cell Subset

V_H Gene Analysis of IgM-Secreting Myeloma Indicates an Origin From a Memory Cell Undergoing Isotype Switch Events

Surinder S. Sahota,Richard Garand,Razeen Mahroof,Alastair Smith,Nadine Juge-Morineau,Freda K. Stevenson,Regis Bataille

View Articletitled, VH Gene Analysis of IgM-Secreting Myeloma Indicates an Origin From a Memory Cell Undergoing Isotype Switch Events

Basic Fibroblast Growth Factor Is Expressed by CD19/CD11c-Positive Cells in Hairy Cell Leukemia

Gerhard Gruber,Josef D. Schwarzmeier,Medhat Shehata,Martin Hilgarth,Rudolf Berger

View Articletitled, Basic Fibroblast Growth Factor Is Expressed by CD19/CD11c-Positive Cells in Hairy Cell Leukemia

Frequency and Clinical Significance of the Expression of the Multidrug Resistance Proteins MDR1/P-Glycoprotein, MRP1, and LRP in Acute Myeloid Leukemia. A Southwest Oncology Group Study

Catherine P. Leith,Kenneth J. Kopecky,I-Ming Chen,Lisette Eijdems,Marilyn L. Slovak,Thomas S. McConnell,David R. Head,James Weick,Michael R. Grever,Frederick R. Appelbaum,Cheryl L. Willman

View Articletitled, Frequency and Clinical Significance of the Expression of the Multidrug Resistance Proteins MDR1/P-Glycoprotein, MRP1, and LRP in Acute Myeloid Leukemia. A Southwest Oncology Group Study

Expression of the Death Gene Bik/Nbk Promotes Sensitivity to Drug-Induced Apoptosis in Corticosteroid-Resistant T-Cell Lymphoma and Prevents Tumor Growth in Severe Combined Immunodeficient Mice

Peter T. Daniel,Kwok-Tao Pun,Silke Ritschel,Isrid Sturm,Jutta Holler,Bernd Dörken,Robin Brown

View Articletitled, Expression of the Death Gene Bik/Nbk Promotes Sensitivity to Drug-Induced Apoptosis in Corticosteroid-Resistant T-Cell Lymphoma and Prevents Tumor Growth in Severe Combined Immunodeficient Mice

STAT5 Activation by BCR-Abl Contributes to Transformation of K562 Leukemia Cells

Rolf P. de Groot,Jan A.M. Raaijmakers,Jan-Willem J. Lammers,Richard Jove,Leo Koenderman

View Articletitled, STAT5 Activation by BCR-Abl Contributes to Transformation of K562 Leukemia Cells

Loss of p73 Gene Expression in Leukemias/Lymphomas Due to Hypermethylation

Seiji Kawano,Carl W. Miller,Adrian F. Gombart,Claus R. Bartram,Yoshinobu Matsuo,Hiroya Asou,Akiko Sakashita,Jonathan Said,Eiji Tatsumi,H. Phillip Koeffler

View Articletitled, Loss of p73 Gene Expression in Leukemias/Lymphomas Due to Hypermethylation

PHAGOCYTES

Regulation of p21rac Activation in Human Neutrophils

Niels Geijsen,Sanne van Delft,Jan A.M. Raaijmakers,Jan-Willem J. Lammers,John G. Collard,Leo Koenderman,Paul J. Coffer

View Articletitled, Regulation of p21rac Activation in Human Neutrophils

TRANSPLANTATION

Stable Mixed Hematopoietic Chimerism in Dog Leukocyte Antigen–Identical Littermate Dogs Given Lymph Node Irradiation Before and Pharmacologic Immunosuppression After Marrow Transplantation

Rainer Storb,Cong Yu,Todd Barnett,John L. Wagner,H. Joachim Deeg,Richard A. Nash,Hans-Peter Kiem,Peter McSweeney,Kristy Seidel,George Georges,J. Maciej Zaucha

View Articletitled, Stable Mixed Hematopoietic Chimerism in Dog Leukocyte Antigen–Identical Littermate Dogs Given Lymph Node Irradiation Before and Pharmacologic Immunosuppression After Marrow Transplantation

CORRESPONDENCE

The Juxtaposition of ABL With BCR and Risk for Fusion May Come at the Time of BCR Replication in Late S-Phase

John Anastasi,Rizwan Moinuddin,Christopher Daugherty

View Articletitled, The Juxtaposition of ABL With BCR and Risk for Fusion May Come at the Time of BCR Replication in Late S-Phase

Replication of Hepatitis C Virus in B Lymphocytes (CD19⁺)

Giulia Morsica,Giuseppe Tambussi,Giovanni Sitia,Roberto Novati,Adriano Lazzarin,Lucia Lopalco,Sylvain Mukenge

View Articletitled, Replication of Hepatitis C Virus in B Lymphocytes (CD19+)

Genetic Heterogeneity of Congenital Dyserythropoietic Anemia Type I

V.M. Hodges,G.Y. Molloy,S.N. Wickramasinghe

View Articletitled, Genetic Heterogeneity of Congenital Dyserythropoietic Anemia Type I

Prognostic Significance of c-ABL Methylation in Chronic Myelogenous Leukemia: Still an Open Question

Fotis A. Asimakopoulos,Pesach J. Shteper,Eitan Fibach,Eliezer Rachmilewitz,Yinon Ben-Neriah,Dina Ben-Yehuda

View Articletitled, Prognostic Significance of c-ABL Methylation in Chronic Myelogenous Leukemia: Still an Open Question

Inter-Strain Variation in Murine Models of Leukemia

Glenn S. Gerhard

View Articletitled, Inter-Strain Variation in Murine Models of Leukemia

Sequence of Bcl-X_L Antisense Oligonucleotides

Ana M. Tari

View Articletitled, Sequence of Bcl-XL Antisense Oligonucleotides

Expression of Laminin β2 Chain in Normal Human Bone Marrow

Wichard Vogel,Lothar Kanz,Wolfram Brugger,Alexander Berndt,Hartwig Kosmehl

View Articletitled, Expression of Laminin β2 Chain in Normal Human Bone Marrow

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