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Volume 94, Issue 12

December 15 1999

In this Issue

INTRODUCTION: FOCUS ON HEMATOLOGY
FOCUS ON HEMATOLOGY
OTHER PLENARY PAPERS
REVIEW ARTICLES
CHEMOKINES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSFUSION MEDICINE
TRANSPLANTATION
BRIEF REPORTS
CORRESPONDENCE

INTRODUCTION: FOCUS ON HEMATOLOGY

Gene Transfer by Adenovectors

Malcolm Brenner

View Articletitled, Gene Transfer by Adenovectors

FOCUS ON HEMATOLOGY

Adenovirus-Mediated Expression of Human Coagulation Factor IX in the Rhesus Macaque Is Associated With Dose-Limiting Toxicity: Presented in part at the 40th Annual Meeting of The American Society of Hematology, Miami Beach, FL.

Jay N. Lozier,Mark E. Metzger,Robert E. Donahue,Richard A. Morgan

View Articletitled, Adenovirus-Mediated Expression of Human Coagulation Factor IX in the Rhesus Macaque Is Associated With Dose-Limiting Toxicity: Presented in part at the 40th Annual Meeting of The American Society of Hematology, Miami Beach, FL.

OTHER PLENARY PAPERS

Correction of Leukocyte Adhesion Deficiency Type II With Oral Fucose

Thorsten Marquardt,Kerstin Lühn,Geetha Srikrishna,Hudson H. Freeze,Erik Harms,Dietmar Vestweber

View Articletitled, Correction of Leukocyte Adhesion Deficiency Type II With Oral Fucose

Molecular Configuration of Rh D Epitopes as Defined by Site-Directed Mutagenesis and Expression of Mutant Rh Constructs in K562 Erythroleukemia Cells

Wendy Liu,Neil D. Avent,Jeffrey W. Jones,Marion L. Scott,Douglas Voak

View Articletitled, Molecular Configuration of Rh D Epitopes as Defined by Site-Directed Mutagenesis and Expression of Mutant Rh Constructs in K562 Erythroleukemia Cells

REVIEW ARTICLES

Regulated Genomic Instability and Neoplasia in the Lymphoid Lineage

Gary J. Vanasse,Patrick Concannon,Dennis M. Willerford

View Articletitled, Regulated Genomic Instability and Neoplasia in the Lymphoid Lineage

CHEMOKINES

Stromal Derived Factor-1–Induced Chemokinesis of Cord Blood CD34⁺ Cells (Long-Term Culture-Initiating Cells) Through Endothelial Cells Is Mediated by E-Selectin

Afzal J. Naiyer,Deog-Yeon Jo,Jongcheol Ahn,Robert Mohle,Mario Peichev,George Lam,Roy L. Silverstein,Malcolm A.S. Moore,Shahin Rafii

View Articletitled, Stromal Derived Factor-1–Induced Chemokinesis of Cord Blood CD34+ Cells (Long-Term Culture-Initiating Cells) Through Endothelial Cells Is Mediated by E-Selectin

Platelet Factor 4-Induced Neutrophil-Endothelial Cell Interaction: Involvement of Mechanisms and Functional Consequences Different From Those Elicited by Interleukin-8

Frank Petersen,Lothar Bock,Hans-Dieter Flad,Ernst Brandt

View Articletitled, Platelet Factor 4-Induced Neutrophil-Endothelial Cell Interaction: Involvement of Mechanisms and Functional Consequences Different From Those Elicited by Interleukin-8

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Increased Incidence of Cytomegalovirus Disease After Autologous CD34-Selected Peripheral Blood Stem Cell Transplantation

Leona A. Holmberg,Michael Boeckh,Heather Hooper,Wendy Leisenring,Scott Rowley,Shelly Heimfeld,Oliver Press,David G. Maloney,Peter McSweeney,Lawrence Corey,Richard T. Maziarz,Frederick R. Appelbaum,William Bensinger

View Articletitled, Increased Incidence of Cytomegalovirus Disease After Autologous CD34-Selected Peripheral Blood Stem Cell Transplantation

Hypodiploidy With Less Than 45 Chromosomes Confers Adverse Risk in Childhood Acute Lymphoblastic Leukemia: A Report From the Children's Cancer Group

Nyla A. Heerema,James B. Nachman,Harland N. Sather,Martha G. Sensel,Mei K. Lee,Raymond Hutchinson,Beverly J. Lange,Peter G. Steinherz,Bruce Bostrom,Paul S. Gaynon,Fatih Uckun

View Articletitled, Hypodiploidy With Less Than 45 Chromosomes Confers Adverse Risk in Childhood Acute Lymphoblastic Leukemia: A Report From the Children's Cancer Group

Dual or Single Hepatitis B and C Virus Infections in Childhood Cancer Survivors: Long-Term Follow-Up and Effect of Interferon Treatment

Riccardo Utili,Rosa Zampino,Pasquale Bellopede,Marta Marracino,Enrico Ragone,Luigi Elio Adinolfi,Giuseppe Ruggiero,Maria Capasso,Paolo Indolfi,Fiorina Casale,Adele Martini,Maria Teresa Di Tullio

View Articletitled, Dual or Single Hepatitis B and C Virus Infections in Childhood Cancer Survivors: Long-Term Follow-Up and Effect of Interferon Treatment

HEMATOPOIESIS

Ex Vivo Generation of CD34⁺ Cells From CD34⁻ Hematopoietic Cells

Yoshihiko Nakamura,Kiyoshi Ando,Jamel Chargui,Hiroshi Kawada,Tadayuki Sato,Takashi Tsuji,Tomomitsu Hotta,Shunichi Kato

View Articletitled, Ex Vivo Generation of CD34+ Cells From CD34− Hematopoietic Cells

Amifostine Inhibits Hematopoietic Progenitor Cell Apoptosis by Activating NF-κB/Rel Transcription Factors

Maria Fiammetta Romano,Annalisa Lamberti,Rita Bisogni,Corrado Garbi,Antonio M. Pagnano,Pasquale Auletta,Pierfrancesco Tassone,Maria Caterina Turco,Salvatore Venuta

View Articletitled, Amifostine Inhibits Hematopoietic Progenitor Cell Apoptosis by Activating NF-κB/Rel Transcription Factors

Distinct Roles of JNKs/p38 MAP Kinase and ERKs in Apoptosis and Survival of HCD-57 Cells Induced by Withdrawal or Addition of Erythropoietin

Rujiao Shan,James O. Price,William A. Gaarde,Brett P. Monia,Sanford B. Krantz,Zhizhuang Joe Zhao

View Articletitled, Distinct Roles of JNKs/p38 MAP Kinase and ERKs in Apoptosis and Survival of HCD-57 Cells Induced by Withdrawal or Addition of Erythropoietin

Defective Proliferation of Primitive Myeloid Progenitor Cells in Patients With Severe Congenital Neutropenia

Nakao Konishi,Masao Kobayashi,Shin-ichiro Miyagawa,Takashi Sato,Osamu Katoh,Kazuhiro Ueda

View Articletitled, Defective Proliferation of Primitive Myeloid Progenitor Cells in Patients With Severe Congenital Neutropenia

Ex Vivo Cultured Megakaryocytes Express Functional Glycoprotein IIb-IIIa Receptors and Are Capable of Adenovirus-Mediated Transgene Expression

Nauder Faraday,Jeffrey J. Rade,David C. Johns,Gopal Khetawat,Stephen J. Noga,John F. DiPersio,Ying Jin,Janet L. Nichol,Jeff S. Haug,Paul F. Bray

View Articletitled, Ex Vivo Cultured Megakaryocytes Express Functional Glycoprotein IIb-IIIa Receptors and Are Capable of Adenovirus-Mediated Transgene Expression

Distinct Requirements for Optimal Growth and In Vitro Expansion of Human CD34⁺CD38⁻ Bone Marrow Long-Term Culture-Initiating Cells (LTC-IC), Extended LTC-IC, and Murine In Vivo Long-Term Reconstituting Stem Cells

Veslemøy Ramsfjell,David Bryder,Helga Björgvinsdóttir,Sten Kornfält,Lars Nilsson,Ole J. Borge,Sten E.W. Jacobsen

View Articletitled, Distinct Requirements for Optimal Growth and In Vitro Expansion of Human CD34+CD38− Bone Marrow Long-Term Culture-Initiating Cells (LTC-IC), Extended LTC-IC, and Murine In Vivo Long-Term Reconstituting Stem Cells

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

A Point Mutation Thr₇₉₉Met on the ₂ Integrin Leads to the Formation of New Human Platelet Alloantigen Sit^a and Affects Collagen-Induced Aggregation

Sentot Santoso,Julia Amrhein,Heiko A. Hofmann,Ulrich J.H. Sachs,Matthias M. Walka,Hartmut Kroll,Volker Kiefel

View Articletitled, A Point Mutation Thr799Met on the 2 Integrin Leads to the Formation of New Human Platelet Alloantigen Sita and Affects Collagen-Induced Aggregation

Glycoprotein V-Deficient Platelets Have Undiminished Thrombin Responsiveness and Do Not Exhibit a Bernard-Soulier Phenotype

Mark L. Kahn,Thomas G. Diacovo,Dorothy F. Bainton,Francois Lanza,JoAnn Trejo,Shaun R. Coughlin

View Articletitled, Glycoprotein V-Deficient Platelets Have Undiminished Thrombin Responsiveness and Do Not Exhibit a Bernard-Soulier Phenotype

Hypofibrinogenemia Associated With a Heterozygous Missense Mutation γ153Cys to Arg (Matsumoto IV): In Vitro Expression Demonstrates Defective Secretion of the Variant Fibrinogen

Fumiko Terasawa,Nobuo Okumura,Kiyoshi Kitano,Nobuaki Hayashida,Makoto Shimosaka,Mitsuo Okazaki,Susan T. Lord

View Articletitled, Hypofibrinogenemia Associated With a Heterozygous Missense Mutation γ153Cys to Arg (Matsumoto IV): In Vitro Expression Demonstrates Defective Secretion of the Variant Fibrinogen

Anti-Inflammatory Actions of Lipoxin A₄ Stable Analogs Are Demonstrable in Human Whole Blood: Modulation of Leukocyte Adhesion Molecules and Inhibition of Neutrophil-Endothelial Interactions

János G. Filep,Christine Zouki,Nicos A. Petasis,Mohamed Hachicha,Charles N. Serhan

View Articletitled, Anti-Inflammatory Actions of Lipoxin A4 Stable Analogs Are Demonstrable in Human Whole Blood: Modulation of Leukocyte Adhesion Molecules and Inhibition of Neutrophil-Endothelial Interactions

Antiangiogenesis Is Produced by Nontoxic Doses of Vinblastine

Angelo Vacca,Monica Iurlaro,Domenico Ribatti,Monica Minischetti,Beatrice Nico,Roberto Ria,Antonio Pellegrino,Franco Dammacco

View Articletitled, Antiangiogenesis Is Produced by Nontoxic Doses of Vinblastine

A Key Role of Adenosine Diphosphate in the Irreversible Platelet Aggregation Induced by the PAR1-Activating Peptide Through the Late Activation of Phosphoinositide 3-Kinase

Catherine Trumel,Bernard Payrastre,Monique Plantavid,Béatrice Hechler,Cécile Viala,Peter Presek,Elizabeth A. Martinson,Jean-Pierre Cazenave,Hugues Chap,Christian Gachet

View Articletitled, A Key Role of Adenosine Diphosphate in the Irreversible Platelet Aggregation Induced by the PAR1-Activating Peptide Through the Late Activation of Phosphoinositide 3-Kinase

Regulation and Function of WASp in Platelets by the Collagen Receptor, Glycoprotein VI

Barbara S. Gross,Jonathan I. Wilde,Lynn Quek,Helen Chapel,David L. Nelson,Steve P. Watson

View Articletitled, Regulation and Function of WASp in Platelets by the Collagen Receptor, Glycoprotein VI

Induction of the Plasminogen Activator Inhibitor-1 Gene Expression by Mild Hypoxia Via a Hypoxia Response Element Binding the Hypoxia-Inducible Factor-1 in Rat Hepatocytes

Thomas Kietzmann,Ulrike Roth,Kurt Jungermann

View Articletitled, Induction of the Plasminogen Activator Inhibitor-1 Gene Expression by Mild Hypoxia Via a Hypoxia Response Element Binding the Hypoxia-Inducible Factor-1 in Rat Hepatocytes

Modulation by Heparin of the Interaction of the A1 Domain of von Willebrand Factor With Glycoprotein Ib

Christelle Perrault,Nadine Ajzenberg,Paulette Legendre,Ghassem Rastegar-Lari,Dominique Meyer,Jose A. Lopez,Dominique Baruch

View Articletitled, Modulation by Heparin of the Interaction of the A1 Domain of von Willebrand Factor With Glycoprotein Ib

IMMUNOBIOLOGY

Differential In Situ Cytokine Profiles of Langerhans-Like Cells and T Cells in Langerhans Cell Histiocytosis: Abundant Expression of Cytokines Relevant to Disease and Treatment

R. Maarten Egeler,Blaise E. Favara,Marjan van Meurs,Jon D. Laman,Eric Claassen

View Articletitled, Differential In Situ Cytokine Profiles of Langerhans-Like Cells and T Cells in Langerhans Cell Histiocytosis: Abundant Expression of Cytokines Relevant to Disease and Treatment

Constitutive Activation of STATs Upon In Vivo Human Immunodeficiency Virus Infection

Chiara Bovolenta,Laura Camorali,Alessandro L. Lorini,Silvia Ghezzi,Elisa Vicenzi,Adriano Lazzarin,Guido Poli

View Articletitled, Constitutive Activation of STATs Upon In Vivo Human Immunodeficiency Virus Infection

Interleukin-15 as an Activator of Natural Killer Cell-Mediated Antiviral Response

Jean Gosselin,Andru TomoÏu,Robert C. Gallo,Louis Flamand

View Articletitled, Interleukin-15 as an Activator of Natural Killer Cell-Mediated Antiviral Response

Variant Genotypes of the Low-Affinity Fcγ Receptors in Two Control Populations and a Review of Low-Affinity Fcγ Receptor Polymorphisms in Control and Disease Populations

Thomas Lehrnbecher,Charles B. Foster,Shaoxian Zhu,Susan F. Leitman,Lynn R. Goldin,Konrad Huppi,Stephen J. Chanock

View Articletitled, Variant Genotypes of the Low-Affinity Fcγ Receptors in Two Control Populations and a Review of Low-Affinity Fcγ Receptor Polymorphisms in Control and Disease Populations

NEOPLASIA

The BCR/ABL Oncogene Alters the Chemotactic Response to Stromal-Derived Factor-1

Ravi Salgia,Elizabeth Quackenbush,Jeffrey Lin,Natalia Souchkova,Martin Sattler,Darren S. Ewaniuk,Kevin M. Klucher,George Q. Daley,Stine K. Kraeft,Robert Sackstein,Edwin P. Alyea, III,Ulrich H. von Andrian,Lan Bo Chen,Jose-Carlos Gutierrez-Ramos,Ann-Marie Pendergast,James D. Griffin

View Articletitled, The BCR/ABL Oncogene Alters the Chemotactic Response to Stromal-Derived Factor-1

Role of Vascular Endothelial Growth Factor/Vascular Permeability Factor in the Pathogenesis of Kaposi's Sarcoma-Associated Herpesvirus-Infected Primary Effusion Lymphomas: Presented in part at the 3rd National AIDS Malignancy Conference, May 27, 1999, in Bethesda, MD.

Yoshiyasu Aoki,Giovanna Tosato

View Articletitled, Role of Vascular Endothelial Growth Factor/Vascular Permeability Factor in the Pathogenesis of Kaposi's Sarcoma-Associated Herpesvirus-Infected Primary Effusion Lymphomas: Presented in part at the 3rd National AIDS Malignancy Conference, May 27, 1999, in Bethesda, MD.

c-myb Transactivates the Human Cyclin A1 Promoter and Induces Cyclin A1 Gene Expression

Carsten Müller,Rong Yang,Gregory Idos,Nicola Tidow,Sven Diederichs,Olaf M. Koch,Walter Verbeek,Timothy P. Bender,H. Phillip Koeffler

View Articletitled, c-myb Transactivates the Human Cyclin A1 Promoter and Induces Cyclin A1 Gene Expression

Vaccines With Interleukin-12–Transduced Acute Myeloid Leukemia Cells Elicit Very Potent Therapeutic and Long-Lasting Protective Immunity

Kyriaki Dunussi-Joannopoulos,Kathlene Runyon,Jamie Erickson,Robert G. Schaub,Robert G. Hawley,John P. Leonard

View Articletitled, Vaccines With Interleukin-12–Transduced Acute Myeloid Leukemia Cells Elicit Very Potent Therapeutic and Long-Lasting Protective Immunity

PHAGOCYTES

Interferon Consensus Sequence Binding Protein and Interferon Regulatory Factor-4/Pip Form a Complex That Represses the Expression of the Interferon-Stimulated Gene-15 in Macrophages

Frank Rosenbauer,Jeffrey F. Waring,John Foerster,Marcus Wietstruk,Dieter Philipp,Ivan Horak

View Articletitled, Interferon Consensus Sequence Binding Protein and Interferon Regulatory Factor-4/Pip Form a Complex That Represses the Expression of the Interferon-Stimulated Gene-15 in Macrophages

Normal Neutrophil Function in Cathepsin G-Deficient Mice

Debra M. MacIvor,Steven D. Shapiro,Christine T.N. Pham,Abderazzaq Belaaouaj,Soman N. Abraham,Timothy J. Ley

View Articletitled, Normal Neutrophil Function in Cathepsin G-Deficient Mice

RED CELLS

Mutations in Ribosomal Protein S19 Gene and Diamond Blackfan Anemia: Wide Variations in Phenotypic Expression

Thiébaut-Noël Willig,Natalia Draptchinskaia,Irma Dianzani,Sarah Ball,Charlotte Niemeyer,Ugo Ramenghi,Karen Orfali,Peter Gustavsson,Emanuela Garelli,Alfredo Brusco,Christian Tiemann,Jean Louis Pérignon,Christiane Bouchier,Lawrence Cicchiello,Niklas Dahl,Narla Mohandas,Gil Tchernia

View Articletitled, Mutations in Ribosomal Protein S19 Gene and Diamond Blackfan Anemia: Wide Variations in Phenotypic Expression

Formation of Dense Erythrocytes in SAD Mice Exposed to Chronic Hypoxia: Evaluation of Different Therapeutic Regimens and of a Combination of Oral Clotrimazole and Magnesium Therapies

Lucia De Franceschi,Carlo Brugnara,Philippe Rouyer-Fessard,Helene Jouault,Yves Beuzard

View Articletitled, Formation of Dense Erythrocytes in SAD Mice Exposed to Chronic Hypoxia: Evaluation of Different Therapeutic Regimens and of a Combination of Oral Clotrimazole and Magnesium Therapies

Ontogeny of Catecholamine and Adenosine Receptor-Mediated cAMP Signaling of Embryonic Red Blood Cells: Role of cGMP-Inhibited Phosphodiesterase 3 and Hemoglobin

Rosemarie Baumann,Christian Blass,Robert Götz,Stefanie Dragon

View Articletitled, Ontogeny of Catecholamine and Adenosine Receptor-Mediated cAMP Signaling of Embryonic Red Blood Cells: Role of cGMP-Inhibited Phosphodiesterase 3 and Hemoglobin

Impaired Ferritin mRNA Translation in Primary Erythroid Progenitors: Shift to Iron-Dependent Regulation by the v-ErbA Oncoprotein

Wolfgang Mikulits,Matthias Schranzhofer,Anton Bauer,Helmut Dolznig,Lioba Lobmayr,Anthony A. Infante,Hartmut Beug,Ernst W. Müllner

View Articletitled, Impaired Ferritin mRNA Translation in Primary Erythroid Progenitors: Shift to Iron-Dependent Regulation by the v-ErbA Oncoprotein

TRANSFUSION MEDICINE

TT Virus Is Present in a High Frequency of Italian Hemophilic Patients Transfused With Plasma-Derived Clotting Factor Concentrates

Benjamin P. Chen,Maria Grazia Rumi,Massimo Colombo,Yu-Huei Lin,Latha Ramaswamy,Jac Luna,Jen-Kuei Liu,Daniele Prati,Pier Mannuccio Mannucci

View Articletitled, TT Virus Is Present in a High Frequency of Italian Hemophilic Patients Transfused With Plasma-Derived Clotting Factor Concentrates

DAR, a New RhD Variant Involving Exons 4, 5, and 7, Often in Linkage With ceAR, a New Rhce Variant Frequently Found in African Blacks

M.B. Hemker,P.C. Ligthart,L. Berger,D.J. van Rhenen,C.E. van der Schoot,P.A. Maaskant-van Wijk

View Articletitled, DAR, a New RhD Variant Involving Exons 4, 5, and 7, Often in Linkage With ceAR, a New Rhce Variant Frequently Found in African Blacks

Inverse Association Between IgG–Anti-κ and Antierythrocyte Autoantibodies in Patients With Cold Agglutination

Peter Terness,Dan Navolan,Gerhard Opelz,Dieter Roelcke

View Articletitled, Inverse Association Between IgG–Anti-κ and Antierythrocyte Autoantibodies in Patients With Cold Agglutination

TRANSPLANTATION

Downregulation of Antigen-Presenting Cell Functions After Administration of Mitogenic Anti-CD3 Monoclonal Antibodies in Mice

Eric Muraille,Fabienne Andris,Bernard Pajak,K. Martin Wissing,Thibaut De Smedt,Fabrice Desalle,Michel Goldman,Maria-Luisa Alegre,Jacques Urbain,Muriel Moser,Oberdan Leo

View Articletitled, Downregulation of Antigen-Presenting Cell Functions After Administration of Mitogenic Anti-CD3 Monoclonal Antibodies in Mice

T-Cell Immune Reconstitution in Pediatric Leukemia Patients After Allogeneic Bone Marrow Transplantation With T-Cell–Depleted or Unmanipulated Grafts: Evaluation of Overall and Antigen-Specific T-Cell Repertoires

Barbara C. Godthelp,Maarten J.D. van Tol,Jaak M. Vossen,Peter J. van den Elsen

View Articletitled, T-Cell Immune Reconstitution in Pediatric Leukemia Patients After Allogeneic Bone Marrow Transplantation With T-Cell–Depleted or Unmanipulated Grafts: Evaluation of Overall and Antigen-Specific T-Cell Repertoires

BRIEF REPORTS

The Tyrosine Kinase Abl-Related Gene ARG Is Fused toETV6 in an AML-M4Eo Patient With a t(1;12)(q25;p13): Molecular Cloning of Both Reciprocal Transcripts

Giovanni Cazzaniga,Sabrina Tosi,Alessandra Aloisi,Giovanni Giudici,Maria Daniotti,Pietro Pioltelli,Lyndal Kearney,Andrea Biondi

View Articletitled, The Tyrosine Kinase Abl-Related Gene ARG Is Fused toETV6 in an AML-M4Eo Patient With a t(1;12)(q25;p13): Molecular Cloning of Both Reciprocal Transcripts

CORRESPONDENCE

Induction of Minor Histocompatibility Antigen HA-1–Specific Cytotoxic T Cells for the Treatment of Leukemia After Allogeneic Stem Cell Transplantation

Peter Brossart,Brigitte Spahlinger,Frank Grünebach,Gernot Stuhler,Volker L. Reichardt,Lothar Kanz,Wolfram Brugger

View Articletitled, Induction of Minor Histocompatibility Antigen HA-1–Specific Cytotoxic T Cells for the Treatment of Leukemia After Allogeneic Stem Cell Transplantation

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