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Volume 94, Issue 11

December 1 1999

In this Issue

PLENARY PAPERS
PERSPECTIVE
CHEMOKINES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSFUSION MEDICINE
TRANSPLANTATION
BRIEF REPORTS
CORRESPONDENCE

PLENARY PAPERS

BSAP/Pax5A Expression Blocks Survival and Expansion of Early Myeloid Cells Implicating Its Involvement in Maintaining Commitment to the B-Lymphocyte Lineage

Mark Y. Chiang,John G. Monroe

View Articletitled, BSAP/Pax5A Expression Blocks Survival and Expansion of Early Myeloid Cells Implicating Its Involvement in Maintaining Commitment to the B-Lymphocyte Lineage

Human Signal-Regulatory Protein Is Expressed on Normal, But Not on Subsets of Leukemic Myeloid Cells and Mediates Cellular Adhesion Involving Its Counterreceptor CD47

Martina Seiffert,Charles Cant,Zhengjun Chen,Irene Rappold,Wolfram Brugger,Lothar Kanz,Eric J. Brown,Axel Ullrich,Hans-Jörg Bühring

View Articletitled, Human Signal-Regulatory Protein Is Expressed on Normal, But Not on Subsets of Leukemic Myeloid Cells and Mediates Cellular Adhesion Involving Its Counterreceptor CD47

Thymic Repopulation by CD34⁺ Human Cord Blood Cells After Expansion in Stroma-Free Culture

Bruno Verhasselt,Tessa Kerre,Evelien Naessens,Dominique Vanhecke,Magda De Smedt,Bart Vandekerckhove,Jean Plum

View Articletitled, Thymic Repopulation by CD34+ Human Cord Blood Cells After Expansion in Stroma-Free Culture

PERSPECTIVE

The Insulin-Like Growth Factor System in Normal and Malignant Hematopoietic Cells

Walter Zumkeller,Stefan Burdach

View Articletitled, The Insulin-Like Growth Factor System in Normal and Malignant Hematopoietic Cells

CHEMOKINES

Chronic Lymphocytic Leukemia B Cells Express Functional CXCR4 Chemokine Receptors That Mediate Spontaneous Migration Beneath Bone Marrow Stromal Cells

Jan A. Burger,Meike Burger,Thomas J. Kipps

View Articletitled, Chronic Lymphocytic Leukemia B Cells Express Functional CXCR4 Chemokine Receptors That Mediate Spontaneous Migration Beneath Bone Marrow Stromal Cells

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Interferon- Before Allogeneic Bone Marrow Transplantation in Chronic Myelogenous Leukemia Does Not Affect Outcome Adversely, Provided It Is Discontinued at Least 90 Days Before the Procedure

Rüdiger Hehlmann,Andreas Hochhaus,Hans-Jochem Kolb,Jörg Hasford,Alois Gratwohl,Hermann Heimpel,Wolfgang Siegert,Jürgen Finke,Gerhard Ehninger,Ernst Holler,Ute Berger,Markus Pfirrmann,Alexander Muth,Axel Zander,Axel A. Fauser,Axel Heyll,Christoph Nerl,Dieter K. Hossfeld,Helmut Löffler,Hans Pralle,Wolfgang Queißer, and Andreas Tobler,for the German CML-Study Group and the SAKK

View Articletitled, Interferon- Before Allogeneic Bone Marrow Transplantation in Chronic Myelogenous Leukemia Does Not Affect Outcome Adversely, Provided It Is Discontinued at Least 90 Days Before the Procedure

Lipoprotein (a) and Genetic Polymorphisms of Clotting Factor V, Prothrombin, and Methylenetetrahydrofolate Reductase Are Risk Factors of Spontaneous Ischemic Stroke in Childhood

Ulrike Nowak-Göttl,Ronald Sträter,Achim Heinecke,Ralf Junker,Hans-Georg Koch,Gerhard Schuierer,Arnold von Eckardstein,for the Childhood Stroke Study Group

View Articletitled, Lipoprotein (a) and Genetic Polymorphisms of Clotting Factor V, Prothrombin, and Methylenetetrahydrofolate Reductase Are Risk Factors of Spontaneous Ischemic Stroke in Childhood

Erythroblastic Synartesis: An Auto-immune Dyserythropoiesis

Elisabeth M. Cramer,Isabel Garcia,Jean-Marc Massé,Jean-Marc Zini,Patrick Lambin,Eric Oksenhendler,Fadila Souni,Mark Smith,Georges Flandrin,Janine Breton-Gorius,Gérard Tobelem,Nicole Casadevall

View Articletitled, Erythroblastic Synartesis: An Auto-immune Dyserythropoiesis

A Randomized, Double-Blind, Placebo-Controlled Study With Pegylated Recombinant Human Megakaryocyte Growth and Development Factor (PEG-rHuMGDF) as an Adjunct to Chemotherapy for Adults With De Novo Acute Myeloid Leukemia

Eric Archimbaud,Oliver G. Ottmann,John A. Liu Yin,Klaus Lechner,Herve Dombret,Miguel A. Sanz,Gerhard Heil,Pierre Fenaux,Wolfram Brugger,Alan Barge,Caroline O’Brien-Ewen,James Matcham,Dieter Hoelzer

View Articletitled, A Randomized, Double-Blind, Placebo-Controlled Study With Pegylated Recombinant Human Megakaryocyte Growth and Development Factor (PEG-rHuMGDF) as an Adjunct to Chemotherapy for Adults With De Novo Acute Myeloid Leukemia

The Incidence of Venous Thromboembolism in Asymptomatic Carriers of a Deficiency of Antithrombin, Protein C, or Protein S: A Prospective Cohort Study

Bernd-Jan Sanson,Paolo Simioni,Daniela Tormene,Marco Moia,Philip W. Friederich,Menno V. Huisman,Paolo Prandoni,Alessandra Bura,László Rejtő,Philip Wells,Pier M. Mannucci,Antonio Girolami,Harry R. Büller,Martin H. Prins

View Articletitled, The Incidence of Venous Thromboembolism in Asymptomatic Carriers of a Deficiency of Antithrombin, Protein C, or Protein S: A Prospective Cohort Study

Chromosomal Abnormalities in 478 Children With Acute Myeloid Leukemia: Clinical Characteristics and Treatment Outcome in a Cooperative Pediatric Oncology Group Study—POG 8821

Susana C. Raimondi,Myron N. Chang,Yaddanapudi Ravindranath,Frederick G. Behm,Mary V. Gresik,C. Philip Steuber,Howard J. Weinstein,Andrew J. Carroll,for the Pediatric Oncology Group

View Articletitled, Chromosomal Abnormalities in 478 Children With Acute Myeloid Leukemia: Clinical Characteristics and Treatment Outcome in a Cooperative Pediatric Oncology Group Study—POG 8821

Cellular Vascular Endothelial Growth Factor Is a Predictor of Outcome in Patients With Acute Myeloid Leukemia

Alvaro Aguayo,Elihu Estey,Hagop Kantarjian,Taghi Mansouri,Cristi Gidel,Michael Keating,Francis Giles,Zeev Estrov,Bart Barlogie,Maher Albitar

View Articletitled, Cellular Vascular Endothelial Growth Factor Is a Predictor of Outcome in Patients With Acute Myeloid Leukemia

HEMATOPOIESIS

Differentiation Stage–Specific Regulation of Primitive Human Hematopoietic Progenitor Cycling by Exogenous and Endogenous Inhibitors in an In Vivo Model

J.D. Cashman,I. Clark-Lewis,A.C. Eaves,C.J. Eaves

View Articletitled, Differentiation Stage–Specific Regulation of Primitive Human Hematopoietic Progenitor Cycling by Exogenous and Endogenous Inhibitors in an In Vivo Model

Changes in Chromatin Organization at the Neutrophil Elastase Locus Associated With Myeloid Cell Differentiation

Edmond T.L. Wong,Dieter E. Jenne,Michael Zimmer,Susan D. Porter,C. Blake Gilks

View Articletitled, Changes in Chromatin Organization at the Neutrophil Elastase Locus Associated With Myeloid Cell Differentiation

A Novel BTB/POZ Transcriptional Repressor Protein Interacts With the Fanconi Anemia Group C Protein and PLZF

Maureen E. Hoatlin,Yu Zhi,Helen Ball,Kirsten Silvey,Ari Melnick,Stacie Stone,Sally Arai,Nicola Hawe,Gareth Owen,Arthur Zelent,Jonathan D. Licht

View Articletitled, A Novel BTB/POZ Transcriptional Repressor Protein Interacts With the Fanconi Anemia Group C Protein and PLZF

Kinetic Resolution of Two Mechanisms for High-Affinity Granulocyte-Macrophage Colony-Stimulating Factor Binding to Its Receptor

Linghao Niu,David W. Golde,Juan Carlos Vera,Mark L. Heaney

View Articletitled, Kinetic Resolution of Two Mechanisms for High-Affinity Granulocyte-Macrophage Colony-Stimulating Factor Binding to Its Receptor

SCL Expression in the Mouse Embryo Detected With a Targeted lacZ Reporter Gene Demonstrates Its Localization to Hematopoietic, Vascular, and Neural Tissues

Andrew G. Elefanty,C. Glenn Begley,Lynne Hartley,Bette Papaevangeliou,Lorraine Robb

View Articletitled, SCL Expression in the Mouse Embryo Detected With a Targeted lacZ Reporter Gene Demonstrates Its Localization to Hematopoietic, Vascular, and Neural Tissues

Altered Development and Cytokine Responses of Myeloid Progenitors in the Absence of Transcription Factor, Interferon Consensus Sequence Binding Protein

Marina Scheller,John Foerster,Clare M. Heyworth,Jeffrey F. Waring,Jürgen Löhler,Gary L. Gilmore,Richard K. Shadduck,T. Mike Dexter,Ivan Horak

View Articletitled, Altered Development and Cytokine Responses of Myeloid Progenitors in the Absence of Transcription Factor, Interferon Consensus Sequence Binding Protein

A Nuclear Factor Y (NFY) Site Positively Regulates the Human CD34 Stem Cell Gene

Hanna S. Radomska,Anne B. Satterthwaite,Natalie Taranenko,Sailaja Narravula,Diane S. Krause,Daniel G. Tenen

View Articletitled, A Nuclear Factor Y (NFY) Site Positively Regulates the Human CD34 Stem Cell Gene

Lymphoid-Restricted Development From Multipotent Candidate Murine Stem Cells: Distinct and Complimentary Functions of the c-kit and flt3-Ligands

Ole Johan Borge,Jörgen Adolfsson,Annica Mårtensson, Inga-Lill Mårtensson, and Sten E.W. Jacobsen

View Articletitled, Lymphoid-Restricted Development From Multipotent Candidate Murine Stem Cells: Distinct and Complimentary Functions of the c-kit and flt3-Ligands

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Activated Platelets Release Two Types of Membrane Vesicles: Microvesicles by Surface Shedding and Exosomes Derived From Exocytosis of Multivesicular Bodies and -Granules

Harry F.G. Heijnen,Anja E. Schiel,Rob Fijnheer,Hans J. Geuze,Jan J. Sixma

View Articletitled, Activated Platelets Release Two Types of Membrane Vesicles: Microvesicles by Surface Shedding and Exosomes Derived From Exocytosis of Multivesicular Bodies and -Granules

Regulation of c-Jun-NH2 Terminal Kinase and Extracellular-Signal Regulated Kinase in Human Platelets

Franck Bugaud,Florence Nadal-Wollbold,Sylviane Lévy-Toledano,Jean-Philippe Rosa,Marijke Bryckaert

View Articletitled, Regulation of c-Jun-NH2 Terminal Kinase and Extracellular-Signal Regulated Kinase in Human Platelets

Fibrinogen Niigata With Impaired Fibrin Assembly: An Inherited Dysfibrinogen With a Bβ Asn-160 to Ser Substitution Associated With Extra Glycosylation at Bβ Asn-158

Teruko Sugo,Chizuko Nakamikawa,Hiroshi Takano,Jun Mimuro,Shu-ichi Yamaguchi,Michael W. Mosesson,David A. Meh,James P. DiOrio,Noriko Takahashi,Hoyu Takahashi,Koichi Nagai,Michio Matsuda

View Articletitled, Fibrinogen Niigata With Impaired Fibrin Assembly: An Inherited Dysfibrinogen With a Bβ Asn-160 to Ser Substitution Associated With Extra Glycosylation at Bβ Asn-158

Procoagulant Effect of Anti–β2-Glycoprotein I Antibodies With Lupus Anticoagulant Activity

V. Pengo,T. Brocco,A. Biasiolo,P. Rampazzo,P. Carraro,R. Zamarchi

View Articletitled, Procoagulant Effect of Anti–β2-Glycoprotein I Antibodies With Lupus Anticoagulant Activity

Divergent Inducible Expression of P-Selectin and E-Selectin in Mice and Primates

Longbiao Yao,Hendra Setiadi,Lijun Xia,Zoltan Laszik,Fletcher B. Taylor,Rodger P. McEver

View Articletitled, Divergent Inducible Expression of P-Selectin and E-Selectin in Mice and Primates

Fibrinogen Deposition at the Postischemic Vessel Wall Promotes Platelet Adhesion During Ischemia-Reperfusion In Vivo

Steffen Massberg,Georg Enders,Francine Cláudia de Melo Matos,Luciana Inês Domschke Tomic,Rosmarie Leiderer,Simone Eisenmenger,Konrad Messmer,Fritz Krombach

View Articletitled, Fibrinogen Deposition at the Postischemic Vessel Wall Promotes Platelet Adhesion During Ischemia-Reperfusion In Vivo

Inhibition of Activated Protein C Anticoagulant Activity by Prothrombin

Mikhail D. Smirnov,Omid Safa,Naomi L. Esmon,Charles T. Esmon

View Articletitled, Inhibition of Activated Protein C Anticoagulant Activity by Prothrombin

IMMUNOBIOLOGY

Inhibition of Caspase Cascade by HTLV-I Tax Through Induction of NF-κB Nuclear Translocation

Atsushi Kawakami,Tomoki Nakashima,Hideaki Sakai,Satoshi Urayama,Satoshi Yamasaki,Ayumi Hida,Masahiko Tsuboi,Hideki Nakamura,Hiroaki Ida,Kiyoshi Migita,Yojiro Kawabe,Katsumi Eguchi

View Articletitled, Inhibition of Caspase Cascade by HTLV-I Tax Through Induction of NF-κB Nuclear Translocation

Mast Cells Induce Autoantibody-Mediated Vasculitis Syndrome Through Tumor Necrosis Factor Production Upon Triggering Fcγ Receptors

Norihiko Watanabe,Bunshiro Akikusa,Seung Yong Park,Hiroshi Ohno,Liliane Fossati,Gianluca Vecchietti,J. Engelbert Gessner,Reinhold E. Schmidt,J. Sjef Verbeek,Bernhard Ryffel,Itsuo Iwamoto,Shozo Izui,Takashi Saito

View Articletitled, Mast Cells Induce Autoantibody-Mediated Vasculitis Syndrome Through Tumor Necrosis Factor Production Upon Triggering Fcγ Receptors

CD38 Triggers Cytotoxic Responses in Activated Human Natural Killer Cells

Giuseppe Sconocchia,Julie A. Titus,Alessandra Mazzoni,Alberto Visintin,Federica Pericle,Stuart W. Hicks,Fabio Malavasi,David M. Segal

View Articletitled, CD38 Triggers Cytotoxic Responses in Activated Human Natural Killer Cells

Spontaneous Apoptosis in Lymphocytes From Patients With Wiskott-Aldrich Syndrome: Correlation of Accelerated Cell Death and Attenuated Bcl-2 Expression

Stephen L. Rawlings,Gay M. Crooks,David Bockstoce,Lora W. Barsky,Robertson Parkman,Kenneth I. Weinberg

View Articletitled, Spontaneous Apoptosis in Lymphocytes From Patients With Wiskott-Aldrich Syndrome: Correlation of Accelerated Cell Death and Attenuated Bcl-2 Expression

NEOPLASIA

Hepatocyte Growth Factor (HGF) Induces Interleukin-11 Secretion From Osteoblasts: A Possible Role for HGF in Myeloma-Associated Osteolytic Bone Disease

Øyvind Hjertner,Maria Lyngaas Torgersen,Carina Seidel,Henrik Hjorth-Hansen,Anders Waage,Magne Børset,Anders Sundan

View Articletitled, Hepatocyte Growth Factor (HGF) Induces Interleukin-11 Secretion From Osteoblasts: A Possible Role for HGF in Myeloma-Associated Osteolytic Bone Disease

Immunophenotypic Analysis of Peripheral Blood and Bone Marrow in the Staging of B-Cell Malignant Lymphoma

Curtis A. Hanson,Paul J. Kurtin,Jerry A. Katzmann,James D. Hoyer,Chin-Yang Li,Janice M. Hodnefield,Cecelia H. Meyers,Thomas M. Habermann,Thomas E. Witzig

View Articletitled, Immunophenotypic Analysis of Peripheral Blood and Bone Marrow in the Staging of B-Cell Malignant Lymphoma

PHAGOCYTES

Granulocyte-Macrophage Colony-Stimulating Factor Upregulates Reduced 5-Lipoxygenase Metabolism in Peripheral Blood Monocytes and Neutrophils in Acquired Immunodeficiency Syndrome

Michael J. Coffey,Susan M. Phare,Sandro Cinti,Marc Peters-Golden,Powel H. Kazanjian

View Articletitled, Granulocyte-Macrophage Colony-Stimulating Factor Upregulates Reduced 5-Lipoxygenase Metabolism in Peripheral Blood Monocytes and Neutrophils in Acquired Immunodeficiency Syndrome

RED CELLS

Defective Recovery and Severe Renal Damage After Acute Hemolysis in Hemopexin-Deficient Mice

Emanuela Tolosano,Emilio Hirsch,Enrico Patrucco,Clara Camaschella,Roberto Navone,Lorenzo Silengo,Fiorella Altruda

View Articletitled, Defective Recovery and Severe Renal Damage After Acute Hemolysis in Hemopexin-Deficient Mice

HFE Downregulates Iron Uptake From Transferrin and Induces Iron-Regulatory Protein Activity in Stably Transfected Cells

H.D. Riedel,M.U. Muckenthaler,S.G. Gehrke,I. Mohr,K. Brennan,T. Herrmann,B.A. Fitscher,M.W. Hentze,W. Stremmel

View Articletitled, HFE Downregulates Iron Uptake From Transferrin and Induces Iron-Regulatory Protein Activity in Stably Transfected Cells

TRANSFUSION MEDICINE

Solvent/Detergent-Treated Plasma Has Decreased Antitrypsin Activity and Absent Antiplasmin Activity

Alan E. Mast,Jason E. Stadanlick,J. Marcus Lockett,Dennis J. Dietzen

View Articletitled, Solvent/Detergent-Treated Plasma Has Decreased Antitrypsin Activity and Absent Antiplasmin Activity

Human Cord Blood Progenitors Sustain Thymic T-Cell Development and a Novel Form of Angiogenesis

Laura Crisa,Vincenzo Cirulli,Kent A. Smith,Mark H. Ellisman,Bruce E. Torbett,Daniel R. Salomon

View Articletitled, Human Cord Blood Progenitors Sustain Thymic T-Cell Development and a Novel Form of Angiogenesis

TRANSPLANTATION

Recipient Tumor Necrosis Factor- and Interleukin-10 Gene Polymorphisms Associate With Early Mortality and Acute Graft-Versus-Host Disease Severity in HLA-Matched Sibling Bone Marrow Transplants

James Cavet,Peter G. Middleton,Miriam Segall,Harriet Noreen,Stella M. Davies,Anne M. Dickinson

View Articletitled, Recipient Tumor Necrosis Factor- and Interleukin-10 Gene Polymorphisms Associate With Early Mortality and Acute Graft-Versus-Host Disease Severity in HLA-Matched Sibling Bone Marrow Transplants

BRIEF REPORTS

Characterization of the Murine Platelet IIb Gene and Encoded cDNA

Michael A. Thornton,Mortimer Poncz

View Articletitled, Characterization of the Murine Platelet IIb Gene and Encoded cDNA

Recombinant Factor VIIa Is Effective for Bleeding and Surgery in Patients With Glanzmann Thrombasthenia

Man-Chiu Poon,Christine Demers,François Jobin,John W.Y. Wu

View Articletitled, Recombinant Factor VIIa Is Effective for Bleeding and Surgery in Patients With Glanzmann Thrombasthenia

CORRESPONDENCE

Tenupodia Formation by Blasts in Bone Marrow Aspirate Smears From a Patient With Acute Monoblastic Leukemia

Carlos Bueso-Ramos,L. Jeffrey Medeiros,Theodore Zipf,Cesar Nunez,David Tubergen

View Articletitled, Tenupodia Formation by Blasts in Bone Marrow Aspirate Smears From a Patient With Acute Monoblastic Leukemia

Loss of Endothelial Surface Expression of E-Selectin—A Third LAD Syndrome?

Amos Etzioni

View Articletitled, Loss of Endothelial Surface Expression of E-Selectin—A Third LAD Syndrome?

The C282Y Mutation of HFE Is Another Male-Specific Risk Factor for Childhood Acute Lymphoblastic Leukemia

M. Tevfik Dorak,Alan K. Burnett,Mark Worwood,Anne M. Sproul,Brenda E.S. Gibson

View Articletitled, The C282Y Mutation of HFE Is Another Male-Specific Risk Factor for Childhood Acute Lymphoblastic Leukemia

Data Requested From the Subgroups Studied in the APL93 Trial

Jeffrey A. Gordon

View Articletitled, Data Requested From the Subgroups Studied in the APL93 Trial

Prothrombotic Genetic Risk Factors and Myocardial Infarction at Young Age

Alberto Batalla,Julián R. Reguero,Gustavo I. Cubero,E. Coto

View Articletitled, Prothrombotic Genetic Risk Factors and Myocardial Infarction at Young Age

Homozygous Q100R Mutations in the Second EGF-Like Domain of Factor VII

Anita Kavlie,Hans Prydz

View Articletitled, Homozygous Q100R Mutations in the Second EGF-Like Domain of Factor VII

Long-Term Follow-up of a Randomized Study Comparing Cyclophosphamide and Total Body Irradiation With Busulfan and Cyclophosphamide for Patients Receiving Allogeneic Marrow Transplants During Chronic Phase of Chronic Myeloid Leukemia

R.A. Clift,J. Radich,F.R. Appelbaum,P. Martin,M.E.D. Flowers,H.J. Deeg,R. Storb,E.D. Thomas

View Articletitled, Long-Term Follow-up of a Randomized Study Comparing Cyclophosphamide and Total Body Irradiation With Busulfan and Cyclophosphamide for Patients Receiving Allogeneic Marrow Transplants During Chronic Phase of Chronic Myeloid Leukemia

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Human Herpesvirus-6 Reactivation and Disease Are Infrequent in Chimeric Antigen Receptor T-cell Therapy Recipients

Cost-effectiveness of prophylaxis with recombinant versus plasma-derived VWF in severe von Willebrand disease in the US

Deletion of mouse lysyl oxidase in megakaryocytes affects bone properties in a sex-dependent manner.

Standardized indolent systemic mastocytosis evaluations across a healthcare system: implications for screening accuracy

Real-World and Clinical Trial Outcomes in Large B-cell Lymphoma with Axicabtagene Ciloleucel Across Race and Ethnicity

Issue Archive

Table of Contents

PLENARY PAPERS

PERSPECTIVE

CHEMOKINES

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

IMMUNOBIOLOGY

NEOPLASIA

PHAGOCYTES

RED CELLS

TRANSFUSION MEDICINE

TRANSPLANTATION

BRIEF REPORTS

CORRESPONDENCE

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