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Volume 93, Issue 6

March 15 1999

In this Issue

INTRODUCTION: FOCUS ON HEMATOLOGY
FOCUS ON HEMATOLOGY
REVIEW ARTICLES
RAPID COMMUNICATIONS
CHEMOKINES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
PHOTOGRAPH
NEOPLASIA
PHAGOCYTES
RED CELLS
CORRESPONDENCE
ERRATA

INTRODUCTION: FOCUS ON HEMATOLOGY

Induction of Fetal Hemoglobin in Sickle Cell Disease

H. Franklin Bunn

View Articletitled, Induction of Fetal Hemoglobin in Sickle Cell Disease

FOCUS ON HEMATOLOGY

Sustained Induction of Fetal Hemoglobin by Pulse Butyrate Therapy in Sickle Cell Disease

George F. Atweh,Millicent Sutton,Imad Nassif,Vassiliki Boosalis,George J. Dover,Sylvan Wallenstein,Elizabeth Wright,Lillian McMahon,George Stamatoyannopoulos,Douglas V. Faller,Susan P. Perrine

View Articletitled, Sustained Induction of Fetal Hemoglobin by Pulse Butyrate Therapy in Sickle Cell Disease

REVIEW ARTICLES

Vitamin K-Dependent Biosynthesis of γ-Carboxyglutamic Acid

Bruce Furie,Beth A. Bouchard,Barbara C. Furie

View Articletitled, Vitamin K-Dependent Biosynthesis of γ-Carboxyglutamic Acid

RAPID COMMUNICATIONS

Gab-Family Adapter Proteins Act Downstream of Cytokine and Growth Factor Receptors and T- and B-Cell Antigen Receptors

Keigo Nishida,Yuichi Yoshida,Motoyuki Itoh,Toshiyuki Fukada,Takuya Ohtani,Takahiro Shirogane,Toru Atsumi,Mariko Takahashi-Tezuka,Katsuhiko Ishihara,Masahiko Hibi,Toshio Hirano

View Articletitled, Gab-Family Adapter Proteins Act Downstream of Cytokine and Growth Factor Receptors and T- and B-Cell Antigen Receptors

Biallelic and Heterozygous Point Mutations in the Runt Domain of theAML1/PEBP2B Gene Associated With Myeloblastic Leukemias

Motomi Osato,Norio Asou,Essam Abdalla,Koyu Hoshino,Hiroshi Yamasaki,Toshiya Okubo,Hitoshi Suzushima,Kiyoshi Takatsuki,Tomohiko Kanno,Katsuya Shigesada,Yoshiaki Ito

View Articletitled, Biallelic and Heterozygous Point Mutations in the Runt Domain of theAML1/PEBP2B Gene Associated With Myeloblastic Leukemias

Vitronectin Inhibits the Thrombotic Response to Arterial Injury in Mice

William P. Fay,Andrew C. Parker,Maria N. Ansari,Xianxian Zheng,David Ginsburg

View Articletitled, Vitronectin Inhibits the Thrombotic Response to Arterial Injury in Mice

Cytokine-Based Tumor Cell Vaccine Is Equally Effective Against Parental and Isogenic Multidrug-Resistant Myeloma Cells: The Role of Cytotoxic T Lymphocytes

Alexander A. Shtil,Joel G. Turner,John Durfee,William S. Dalton,Hua Yu

View Articletitled, Cytokine-Based Tumor Cell Vaccine Is Equally Effective Against Parental and Isogenic Multidrug-Resistant Myeloma Cells: The Role of Cytotoxic T Lymphocytes

Chemokine and Chemokine Receptor Gene Variants and Risk of Non-Hodgkin’s Lymphoma in Human Immunodeficiency Virus-1–Infected Individuals

Charles S. Rabkin,Quan-en Yang,James J. Goedert,Giao Nguyen,Hiroaki Mitsuya,Shizuko Sei

View Articletitled, Chemokine and Chemokine Receptor Gene Variants and Risk of Non-Hodgkin’s Lymphoma in Human Immunodeficiency Virus-1–Infected Individuals

Human Immunodeficiency Virus-1–Infected Macrophages Induce Inducible Nitric Oxide Synthase and Nitric Oxide (NO) Production in Astrocytes: Astrocytic NO as a Possible Mediator of Neural Damage in Acquired Immunodeficiency Syndrome

Kotaro Hori,Parris R. Burd,Keizo Furuke,Joseph Kutza,Karis A. Weih,Kathleen A. Clouse

View Articletitled, Human Immunodeficiency Virus-1–Infected Macrophages Induce Inducible Nitric Oxide Synthase and Nitric Oxide (NO) Production in Astrocytes: Astrocytic NO as a Possible Mediator of Neural Damage in Acquired Immunodeficiency Syndrome

CHEMOKINES

Human Immunodeficiency Virus Replication Induces Monocyte Chemotactic Protein-1 in Human Macrophages and U937 Promonocytic Cells

Manuela Mengozzi,Camilla De Filippi,Pietro Transidico,Priscilla Biswas,Manuela Cota,Silvia Ghezzi,Elisa Vicenzi,Alberto Mantovani,Silvano Sozzani,Guido Poli

View Articletitled, Human Immunodeficiency Virus Replication Induces Monocyte Chemotactic Protein-1 in Human Macrophages and U937 Promonocytic Cells

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Multicenter Phase III Trial to Evaluate CD34⁺ Selected Versus Unselected Autologous Peripheral Blood Progenitor Cell Transplantation in Multiple Myeloma

Robert Vescio,Gary Schiller,A. Keith Stewart,Oscar Ballester,Stephen Noga,Hope Rugo,Cesar Freytes,Edward Stadtmauer,Stefano Tarantolo,Firoozeh Sahebi,Pat Stiff,Jacinta Meharchard,Robert Schlossman,Randy Brown,Heather Tully,Mark Benyunes,Cindy Jacobs,Ronald Berenson,John DiPersio,Ken Anderson,James Berenson

View Articletitled, Multicenter Phase III Trial to Evaluate CD34+ Selected Versus Unselected Autologous Peripheral Blood Progenitor Cell Transplantation in Multiple Myeloma

Effective Control of Epstein-Barr Virus–Related Hemophagocytic Lymphohistiocytosis With Immunochemotherapy

Shinsaku Imashuku,Shigeyoshi Hibi,Toshio Ohara,Asayuki Iwai,Masahiro Sako,Masahiko Kato,Hirokazu Arakawa,Manabu Sotomatsu,Satoshi Kataoka,Keiko Asami,Daijiro Hasegawa,Yoshiyuki Kosaka,Kimihiko Sano,Noboru Igarashi,Keiko Maruhashi,Ryouji Ichimi,Hajime Kawasaki,Naoko Maeda,Akihiko Tanizawa,Koji Arai,Takanori Abe,Hiroaki Hisakawa,Hidemasa Miyashita,Jan-Inge Henter,for the Histiocyte Society

View Articletitled, Effective Control of Epstein-Barr Virus–Related Hemophagocytic Lymphohistiocytosis With Immunochemotherapy

GENE THERAPY

The Rhesus Macaque as an Animal Model for Hemophilia B Gene Therapy

Jay N. Lozier,Mark E. Metzger,Robert E. Donahue,Richard A. Morgan

View Articletitled, The Rhesus Macaque as an Animal Model for Hemophilia B Gene Therapy

Transduction of Primitive Human Marrow and Cord Blood-Derived Hematopoietic Progenitor Cells With Adeno-Associated Virus Vectors

Saswati Chatterjee,Wei Li,Christie Ann Wong,Grace Fisher-Adams,Di Lu,Mausumee Guha,James A. Macer,Stephen J. Forman,K.K. Wong, Jr

View Articletitled, Transduction of Primitive Human Marrow and Cord Blood-Derived Hematopoietic Progenitor Cells With Adeno-Associated Virus Vectors

Genetically Corrected Autologous Stem Cells Engraft, But Host Immune Responses Limit Their Utility in Canine -L-iduronidase Deficiency

Carolyn Lutzko,Stephen Kruth,Anthony C.G. Abrams-Ogg,Kathy Lau,Liheng Li,Brian R. Clark,Christine Ruedy,Shaherose Nanji,Robert Foster,Donald Kohn,Robert Shull,Ian D. Dubé

View Articletitled, Genetically Corrected Autologous Stem Cells Engraft, But Host Immune Responses Limit Their Utility in Canine -L-iduronidase Deficiency

HEMATOPOIESIS

Human Immunodeficiency Virus Type 1 Vpr Alters Bone Marrow Cell Function

Joseph Kulkosky,Alexey Laptev,Shubhra Shetty,Alagarsamy Srinivasan,Mohamad BouHamdan,Darwin J. Prockop,Roger J. Pomerantz

View Articletitled, Human Immunodeficiency Virus Type 1 Vpr Alters Bone Marrow Cell Function

Hematopoietic Stem Cell Tracking In Vivo: A Comparison of Short-Term and Long-Term Repopulating Cells

Sophie M. Lanzkron,Michael I. Collector,Saul J. Sharkis

View Articletitled, Hematopoietic Stem Cell Tracking In Vivo: A Comparison of Short-Term and Long-Term Repopulating Cells

A Novel Spliced Form of SH2-Containing Inositol Phosphatase Is Expressed During Myeloid Development

David M. Lucas,Larry R. Rohrschneider

View Articletitled, A Novel Spliced Form of SH2-Containing Inositol Phosphatase Is Expressed During Myeloid Development

Cytoplasmic Domains of the Leukemia Inhibitory Factor Receptor Required for STAT3 Activation, Differentiation, and Growth Arrest of Myeloid Leukemic Cells

Mikio Tomida,Toshio Heike,Takashi Yokota

View Articletitled, Cytoplasmic Domains of the Leukemia Inhibitory Factor Receptor Required for STAT3 Activation, Differentiation, and Growth Arrest of Myeloid Leukemic Cells

Deficient Transcription of Mouse Mast Cell Protease 4 Gene in Mutant Mice of mi/mi Genotype

Tomoko Jippo,Young-Mi Lee,Yee Katsu,Kumiko Tsujino,Eiichi Morii,Dae-Ki Kim,Hyung-Min Kim,Yukihiko Kitamura

View Articletitled, Deficient Transcription of Mouse Mast Cell Protease 4 Gene in Mutant Mice of mi/mi Genotype

Influence of Monoclonal Antiplatelet Glycoprotein Antibodies on In Vitro Human Megakaryocyte Colony Formation and Proplatelet Formation

Ryo Takahashi,Nariko Sekine,Toshihiko Nakatake

View Articletitled, Influence of Monoclonal Antiplatelet Glycoprotein Antibodies on In Vitro Human Megakaryocyte Colony Formation and Proplatelet Formation

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Conformational Changes in the A3 Domain of von Willebrand Factor Modulate the Interaction of the A1 Domain With Platelet Glycoprotein Ib

Bernadette Obert,Anne Houllier,Dominique Meyer,Jean-Pierre Girma

View Articletitled, Conformational Changes in the A3 Domain of von Willebrand Factor Modulate the Interaction of the A1 Domain With Platelet Glycoprotein Ib

Inflammatory Cytokines and Vascular Endothelial Growth Factor Stimulate the Release of Soluble Tie Receptor From Human Endothelial Cells Via Metalloprotease Activation

Rachel Yabkowitz,Susanne Meyer,Tabitha Black,Gary Elliott,Lee Anne Merewether,Harvey K. Yamane

View Articletitled, Inflammatory Cytokines and Vascular Endothelial Growth Factor Stimulate the Release of Soluble Tie Receptor From Human Endothelial Cells Via Metalloprotease Activation

IMMUNOBIOLOGY

Interferon- Activates Multiple STAT Proteins and Upregulates Proliferation-Associated IL-2R, c-myc, and pim-1 Genes in Human T Cells

Sampsa Matikainen,Timo Sareneva,Tapani Ronni,Anne Lehtonen,Päivi J. Koskinen,Ilkka Julkunen

View Articletitled, Interferon- Activates Multiple STAT Proteins and Upregulates Proliferation-Associated IL-2R, c-myc, and pim-1 Genes in Human T Cells

CD40-Activated B-Cell Chronic Lymphocytic Leukemia Cells for Tumor Immunotherapy: Stimulation of Allogeneic Versus Autologous T Cells Generates Different Types of Effector Cells

Raymund Buhmann,Annette Nolte,Doreen Westhaus,Bertold Emmerich,Michael Hallek

View Articletitled, CD40-Activated B-Cell Chronic Lymphocytic Leukemia Cells for Tumor Immunotherapy: Stimulation of Allogeneic Versus Autologous T Cells Generates Different Types of Effector Cells

Involvement of Wiskott-Aldrich Syndrome Protein in B-Cell Cytoplasmic Tyrosine Kinase Pathway

Yoshihiro Baba,Shigeaki Nonoyama,Masato Matsushita,Tomoki Yamadori,Shoji Hashimoto,Kohsuke Imai,Shigeyuki Arai,Toshio Kunikata,Masashi Kurimoto,Tomohiro Kurosaki,Hans D. Ochs,Jun-ichi Yata,Tadamitsu Kishimoto,Satoshi Tsukada

View Articletitled, Involvement of Wiskott-Aldrich Syndrome Protein in B-Cell Cytoplasmic Tyrosine Kinase Pathway

Cloning and Characterization of a Lymphoid-Specific, Inducible Human Protein Tyrosine Phosphatase, Lyp

Shai Cohen,Harjit Dadi,Ester Shaoul,Nigel Sharfe,Chaim M. Roifman

View Articletitled, Cloning and Characterization of a Lymphoid-Specific, Inducible Human Protein Tyrosine Phosphatase, Lyp

Tandem Amino Acid Repeats From Trypanosoma cruzi Shed Antigens Increase the Half-Life of Proteins in Blood

Carlos A. Buscaglia,Julieta Alfonso,Oscar Campetella,Alberto C.C. Frasch

View Articletitled, Tandem Amino Acid Repeats From Trypanosoma cruzi Shed Antigens Increase the Half-Life of Proteins in Blood

Long-Term Fetal Microchimerism in Peripheral Blood Mononuclear Cell Subsets in Healthy Women and Women With Scleroderma

Paul C. Evans,Nathalie Lambert,Sean Maloney,Dan E. Furst,James M. Moore,J. Lee Nelson

View Articletitled, Long-Term Fetal Microchimerism in Peripheral Blood Mononuclear Cell Subsets in Healthy Women and Women With Scleroderma

PHOTOGRAPH

Photograph

View Articletitled, Photograph

NEOPLASIA

Spectral Karyotype Analysis of T-Cell Acute Leukemia

Janet D. Rowley,Shalini Reshmi,Katrin Carlson,Diane Roulston

View Articletitled, Spectral Karyotype Analysis of T-Cell Acute Leukemia

Mutant N-ras Induces Myeloproliferative Disorders and Apoptosis in Bone Marrow Repopulated Mice

K.L. MacKenzie,A. Dolnikov,M. Millington,Y. Shounan,G. Symonds

View Articletitled, Mutant N-ras Induces Myeloproliferative Disorders and Apoptosis in Bone Marrow Repopulated Mice

Effects of Novel RAR- and RXR-Selective Retinoids on Myeloid Leukemic Proliferation and Differentiation In Vitro

Masaaki Shiohara,Marcia I. Dawson,Peter D. Hobbs,Nobukuni Sawai,Tsukasa Higuchi,Kenichi Koike,Atsushi Komiyama,H. Phillip Koeffler

View Articletitled, Effects of Novel RAR- and RXR-Selective Retinoids on Myeloid Leukemic Proliferation and Differentiation In Vitro

Cyclin A1 Expression in Leukemia and Normal Hematopoietic Cells

Rong Yang,Tsuyoshi Nakamaki,Michael Lübbert,Jonathan Said,Akiko Sakashita,Bettina S. Freyaldenhoven,Susan Spira,Vong Huynh,Carsten Müller,H. Phillip Koeffler

View Articletitled, Cyclin A1 Expression in Leukemia and Normal Hematopoietic Cells

Methylation of the ABL1 Promoter in Chronic Myelogenous Leukemia: Lack of Prognostic Significance

Jean-Pierre J. Issa,Hagop Kantarjian,Avinash Mohan,Susan O’Brien,Jorge Cortes,Sherry Pierce,Moshe Talpaz

View Articletitled, Methylation of the ABL1 Promoter in Chronic Myelogenous Leukemia: Lack of Prognostic Significance

PHAGOCYTES

Immunosurveillance of Alglucerase Enzyme Therapy for Gaucher Patients: Induction of Humoral Tolerance in Seroconverted Patients After Repeat Administration

Mireille Rosenberg,Wytske Kingma,Mary Anne Fitzpatrick,Susan M. Richards

View Articletitled, Immunosurveillance of Alglucerase Enzyme Therapy for Gaucher Patients: Induction of Humoral Tolerance in Seroconverted Patients After Repeat Administration

The Intracellular Serpin Proteinase Inhibitor 6 Is Expressed in Monocytes and Granulocytes and Is a Potent Inhibitor of the Azurophilic Granule Protease, Cathepsin G

Fiona L. Scott,Claire E. Hirst,Jiuru Sun,Catherina H. Bird,Stephen P. Bottomley,Phillip I. Bird

View Articletitled, The Intracellular Serpin Proteinase Inhibitor 6 Is Expressed in Monocytes and Granulocytes and Is a Potent Inhibitor of the Azurophilic Granule Protease, Cathepsin G

Missense Mutations in the gp91-phox Gene Encoding Cytochromeb₅₅₈ in Patients With Cytochrome b Positive and Negative X-Linked Chronic Granulomatous Disease

Mizuho Kaneda,Hitoshi Sakuraba,Akira Ohtake,Akira Nishida,Chika Kiryu,Katsuko Kakinuma

View Articletitled, Missense Mutations in the gp91-phox Gene Encoding Cytochromeb558 in Patients With Cytochrome b Positive and Negative X-Linked Chronic Granulomatous Disease

RED CELLS

Inheritance in Erythropoietic Protoporphyria: A Common Wild-Type Ferrochelatase Allelic Variant With Low Expression Accounts for Clinical Manifestation

Laurent Gouya,Herve Puy,Jerôme Lamoril,Vasco Da Silva,Bernard Grandchamp,Yves Nordmann,Jean-Charles Deybach

View Articletitled, Inheritance in Erythropoietic Protoporphyria: A Common Wild-Type Ferrochelatase Allelic Variant With Low Expression Accounts for Clinical Manifestation

Identification of the Poly(C) Binding Protein in the Complex Associated With the 3′ Untranslated Region of Erythropoietin Messenger RNA

Maria F. Czyzyk-Krzeska,Amy C. Bendixen

View Articletitled, Identification of the Poly(C) Binding Protein in the Complex Associated With the 3′ Untranslated Region of Erythropoietin Messenger RNA

Structural and Functional Consequences of Antigenic Modulation of Red Blood Cells With Methoxypoly(Ethylene Glycol)

Kari L. Murad,Kathleen L. Mahany,Carlo Brugnara,Frans A. Kuypers,John W. Eaton,Mark D. Scott

View Articletitled, Structural and Functional Consequences of Antigenic Modulation of Red Blood Cells With Methoxypoly(Ethylene Glycol)

CORRESPONDENCE

Dynamic Association of Moesin With the Membrane Skeleton of Thrombin-Activated Platelets

Anna Shcherbina,Dianne M. Kenney,Anthony Bretscher,Eileen Remold-O’Donnell

View Articletitled, Dynamic Association of Moesin With the Membrane Skeleton of Thrombin-Activated Platelets

Ex Vivo Factors Affecting Contact Phase Activation in Negatively Charged Medical Devices

Jean-Louis Renaux,Larry J. Dumont

View Articletitled, Ex Vivo Factors Affecting Contact Phase Activation in Negatively Charged Medical Devices

Hereditary Spherocytosis Due to a Novel Frameshift Mutation in AE1 Cytoplasmic COOH Terminal Tail: Band 3 Vesuvio

Silverio Perrotta,Raffaella Polito,Maria Luisa Conte,Bruno Nobili,Stefano Cutillo,Emanuele Miraglia del Giudice,Vincenzo Nigro,Achille Iolascon,Giovanni Amendola

View Articletitled, Hereditary Spherocytosis Due to a Novel Frameshift Mutation in AE1 Cytoplasmic COOH Terminal Tail: Band 3 Vesuvio

Splenectomy in Agnogenic Myeloid Metaplasia

Pierluigi Porcu,Richard S. Neiman,Attilio Orazi

View Articletitled, Splenectomy in Agnogenic Myeloid Metaplasia

Dehydrated Hereditary Stomatocytosis Is Not Linked to the hIK1 Locus, a Gardos Channel Candidate, on Chromosome 19q13.2

Patrick G. Gallagher,Brian D. Smith

View Articletitled, Dehydrated Hereditary Stomatocytosis Is Not Linked to the hIK1 Locus, a Gardos Channel Candidate, on Chromosome 19q13.2

C282Y Hemochromatosis Mutation Does Not Contribute to Hypercoagulability in a Factor V Leiden Population Referred for Venous Thrombosis

Franck Lellouche,Ian Dorval,Jean Marc Corvisier,Pascal Jézéquel,Loı̈c Campion

View Articletitled, C282Y Hemochromatosis Mutation Does Not Contribute to Hypercoagulability in a Factor V Leiden Population Referred for Venous Thrombosis

Comparative Analysis of Autografting in Chronic Myelogenous Leukemia: Effect of Priming Regimen and Marrow or Blood Origin of Stem Cells

Angelo Michele Carella

View Articletitled, Comparative Analysis of Autografting in Chronic Myelogenous Leukemia: Effect of Priming Regimen and Marrow or Blood Origin of Stem Cells

ERRATA

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Issue Archive

Table of Contents

INTRODUCTION: FOCUS ON HEMATOLOGY

FOCUS ON HEMATOLOGY

REVIEW ARTICLES

RAPID COMMUNICATIONS

CHEMOKINES

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

GENE THERAPY

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

IMMUNOBIOLOGY

PHOTOGRAPH

NEOPLASIA

PHAGOCYTES

RED CELLS

CORRESPONDENCE

ERRATA

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ASH Publications

American Society of Hematology

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