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Issue Archive

Volume 93, Issue 5
March 1 1999
Blood Cover Image for Volume 93, Issue 5

Table of Contents

EDITORIAL

Evolution in BLOOD
Kenneth Kaushansky, MD
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INTRODUCTION: FOCUS ON HEMATOLOGY

Resolving Conflicting Signals: Cross Inhibition of Cytokine Signaling Pathways
C.G. Begley,N.A. Nicola
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FOCUS ON HEMATOLOGY

Downregulation of Interleukin-12 (IL-12) Responsiveness in Human T Cells by Transforming Growth Factor-β: Relationship With IL-12 Signaling
Cécile Pardoux,Xiaojing Ma,Stéphanie Gobert,Sandra Pellegrini,Patrick Mayeux,Françoise Gay,Giorgio Trinchieri,Salem Chouaib
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Interleukin-10 Inhibits Expression of Both Interferon – and Interferon γ– Induced Genes by Suppressing Tyrosine Phosphorylation of STAT1
Satoshi Ito,Parswa Ansari,Minoru Sakatsume,Harold Dickensheets,Nancy Vazquez,Raymond P. Donnelly,Andrew C. Larner,David S. Finbloom
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REVIEW ARTICLES

NADPH Oxidase: An Update
Bernard M. Babior
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RAPID COMMUNICATIONS

Constitutive Degradation of PML/RAR Through the Proteasome Pathway Mediates Retinoic Acid Resistance
Mirco Fanelli,Saverio Minucci,Vania Gelmetti,Clara Nervi,Carlo Gambacorti-Passerini,Pier Giuseppe Pelicci
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Detection of Kaposi’s Sarcoma Herpesvirus DNA Sequences in Multiple Myeloma Bone Marrow Stromal Cells
Dharminder Chauhan,Ajit Bharti,Noopur Raje,Eric Gustafson,Geraldine S. Pinkus,Jack L. Pinkus,Gerrard Teoh,Teru Hideshima,Steve P. Treon,Joyce D. Fingeroth,Kenneth C. Anderson
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Bone Marrow and Peripheral Blood Dendritic Cells From Patients With Multiple Myeloma Are Phenotypically and Functionally Normal Despite the Detection of Kaposi’s Sarcoma Herpesvirus Gene Sequences
Noopur Raje,Jianlin Gong,Dharminder Chauhan,Gerrard Teoh,David Avigan,Zekui Wu,Dongshu Chen,Steven P. Treon,Iain J. Webb,Donald W. Kufe,Kenneth C. Anderson
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Susceptibility to Childhood Acute Lymphoblastic Leukemia: Influence of CYP1A1, CYP2D6, GSTM1, and GSTT1 Genetic Polymorphisms
Maja Krajinovic,Damian Labuda,Chantal Richer,Sepideh Karimi,Daniel Sinnett
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A Prospective Study on TT Virus Infection in Transfusion-Dependent Patients With β-Thalassemia
Daniele Prati,Yu-Huei Lin,Claudia De Mattei,Jen-Kuei Liu,Elena Farma,Latha Ramaswamy,Alberto Zanella,Helen Lee,Paolo Rebulla,Jean-Pierre Allain,Girolamo Sirchia,Benjamin Chen,for the Cooleycare Cooperative Group
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Rapid Death of Adoptively Transferred T Cells in Acquired Immunodeficiency Syndrome
Rusung Tan,Xiaoning Xu,Graham S. Ogg,Pokrath Hansasuta,Tao Dong,Tim Rostron,Graz Luzzi,Christopher P. Conlon,Gavin R. Screaton,Andrew J. McMichael,Sarah Rowland-Jones
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CHEMOKINES

Phenotypic and Functional Evidence for the Expression of CXCR4 Receptor During Megakaryocytopoiesis
Christel Rivière,Frédéric Subra,Karine Cohen-Solal,Véronique Cordette-Lagarde,Remi Letestu,Christian Auclair,William Vainchenker,Fawzia Louache
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Enhanced Myeloid Progenitor Cell Cycling and Apoptosis in Mice Lacking the Chemokine Receptor, CCR2
Suzanna Reid,Alec Ritchie,Landin Boring,Jennifa Gosling,Scott Cooper,Giao Hangoc,Israel F. Charo,Hal E. Broxmeyer
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CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Autografting With Philadelphia Chromosome–Negative Mobilized Hematopoietic Progenitor Cells in Chronic Myelogenous Leukemia
Angelo M. Carella,Enrica Lerma,Maria T. Corsetti,Anna Dejana,Palmina Basta,Franca Vassallo,Monica Abate,Monica Soracco,Federica Benvenuto,Osvaldo Figari,Marina Podestà,Giovanna Piaggio,Raimondo Ferrara,Mario Sessarego,Caterina Parodi,Michele Pizzuti,Alessandra Rubagotti,Domenico Occhini,Francesco Frassoni
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HEMATOPOIESIS

H-Ras Is Involved in the Inside-out Signaling Pathway of Interleukin-3–Induced Integrin Activation
Hirohiko Shibayama,Naoyuki Anzai,Stephen E. Braun,Seiji Fukuda,Charlie Mantel,Hal E. Broxmeyer
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In Vitro Hematopoietic and Endothelial Cell Development From Cells Expressing TEK Receptor in Murine Aorta-Gonad-Mesonephros Region
Isao Hamaguchi,Xu-Ling Huang,Nobuyuki Takakura,Jun-ichi Tada,Yuji Yamaguchi,Hiroaki Kodama,Toshio Suda
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Organ-Selective Homing Defines Engraftment Kinetics of Murine Hematopoietic Stem Cells and Is Compromised by Ex Vivo Expansion
Stephen J. Szilvassy,Michael J. Bass,Gary Van Zant,Barry Grimes
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Role of Cytokine Signaling Molecules in Erythroid Differentiation of Mouse Fetal Liver Hematopoietic Cells: Functional Analysis of Signaling Molecules by Retrovirus-Mediated Expression
Dai Chida,Osamu Miura,Akihiko Yoshimura,Atsushi Miyajima
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Receptor Clearance Obscures the Magnitude of Granulocyte-Macrophage Colony-Stimulating Factor Responses in Mice to Endotoxin or Local Infections
Donald Metcalf,Nicos A. Nicola,Sandra Mifsud,Ladina Di Rago
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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Structural and Functional Abnormalities in the Spleen of anmFtz-F1 Gene–Disrupted Mouse
Ken-ichirou Morohashi,Hisae Tsuboi-Asai,Sumie Matsushita,Masahiro Suda,Manabu Nakashima,Hironobu Sasano,Yoshiaki Hataba,Chun-Lin Li,Junichi Fukata,Junji Irie,Takeshi Watanabe,Hiroshi Nagura,En Li
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Prospective Evaluation of the Thrombotic Risk in Children With Acute Lymphoblastic Leukemia Carrying the MTHFR TT 677 Genotype, the Prothrombin G20210A Variant, and Further Prothrombotic Risk Factors
Ulrike Nowak-Göttl,Cornelia Wermes,Ralf Junker,Hans-Georg Koch,Rosmarie Schobess,Gudrun Fleischhack,Dirk Schwabe,Silke Ehrenforth
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The Megakaryocyte/Platelet-Specific Enhancer of the 2β1 Integrin Gene: Two Tandem AP1 Sites and the Mitogen-Activated Protein Kinase Signaling Cascade
Mary M. Zutter,Audrey D. Painter,Xun Yang
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Contribution of Natural Killer Cells to Inhibition of Angiogenesis by Interleukin-12
Lei Yao,Cecilia Sgadari,Keizo Furuke,Eda T. Bloom,Julie Teruya-Feldstein,Giovanna Tosato
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Labeling of the Internal Pool of GP IIb-IIIa in Platelets by c7E3 Fab Fragments (abciximab): Flow and Endocytic Mechanisms Contribute to the Transport
Paquita Nurden,Christel Poujol,Catherine Durrieu-Jais,Joëlle Winckler,Robert Combrié,Laurent Macchi,Claude Bihour,Carrie Wagner,Robert Jordan,Alan T. Nurden
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IMMUNOBIOLOGY

Interleukin-10–Treated Human Dendritic Cells Induce a Melanoma-Antigen–Specific Anergy in CD8+ T Cells Resulting in a Failure to Lyse Tumor Cells
Kerstin Steinbrink,Helmut Jonuleit,Gabriele Müller,Gerold Schuler,Jürgen Knop,Alexander H. Enk
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NEOPLASIA

Reduced Folate Carrier Expression in Acute Lymphoblastic Leukemia: A Mechanism for Ploidy but not Lineage Differences in Methotrexate Accumulation
Vladimir M. Belkov,Eugene Y. Krynetski,John D. Schuetz,Yuri Yanishevski,Eric Masson,Susan Mathew,Susana Raimondi,Ching-Hon Pui,Mary V. Relling,William E. Evans
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Clonality of Isolated Eosinophils in the Hypereosinophilic Syndrome
Hsiao-Wen Chang,Kah-Hoo Leong,Dow-Rhoon Koh,Szu-Hee Lee
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Cell Adhesion Mediated Drug Resistance (CAM-DR): Role of Integrins and Resistance to Apoptosis in Human Myeloma Cell Lines
Jason S. Damiano,Anne E. Cress,Lori A. Hazlehurst,Alexander A. Shtil,William S. Dalton
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Expression and Function of Leptin Receptor Isoforms in Myeloid Leukemia and Myelodysplastic Syndromes: Proliferative and Anti-Apoptotic Activities
Marina Konopleva,Adel Mikhail,Zeev Estrov,Shourong Zhao,David Harris,Gisela Sanchez-Williams,Steven M. Kornblau,Joan Dong,Kay-Oliver Kliche,Shuwei Jiang,H. Ralph Snodgrass,Elihu H. Estey,Michael Andreeff
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Role of Folylpolyglutamate Synthetase and Folylpolyglutamate Hydrolase in Methotrexate Accumulation and Polyglutamylation in Childhood Leukemia
Marianne G. Rots,Rob Pieters,Godefridus J. Peters,Paul Noordhuis,Christina H. van Zantwijk,Gertjan J.L. Kaspers,Karel Hählen,Ursula Creutzig,Anjo J.P. Veerman,Gerrit Jansen
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Overexpression of the Receptor for Hyaluronan-Mediated Motility (RHAMM) Characterizes the Malignant Clone in Multiple Myeloma: Identification of Three Distinct RHAMM Variants
Mary Crainie,Andrew R. Belch,Michael J. Mant,Linda M. Pilarski
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Ibandronate Reduces Osteolytic Lesions but not Tumor Burden in a Murine Model of Myeloma Bone Disease
Sarah L. Dallas,I. Ross Garrett,Babatunde O. Oyajobi,Mark R. Dallas,Brendan F. Boyce,Frieder Bauss,Jiri Radl,Gregory R. Mundy
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TEL/PDGFβR Induces Hematologic Malignancies in Mice That Respond to a Specific Tyrosine Kinase Inhibitor
Michael H. Tomasson,Ifor R. Williams,Robert Hasserjian,Chirayu Udomsakdi,Shannon M. McGrath,Juerg Schwaller,Brian Druker,D. Gary Gilliland
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Heparin-Binding Epidermal Growth Factor–Like Growth Factor/Diphtheria Toxin Receptor Expression by Acute Myeloid Leukemia Cells
Fabrizio Vinante,Antonella Rigo,Emanuele Papini,Marco A. Cassatella,Giovanni Pizzolo
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The Somatostatin Analog Octreotide Inhibits Growth of Interleukin-6 (IL-6)–Dependent and IL-6–Independent Human Multiple Myeloma Cell Lines
Patrik Georgii-Hemming,Thomas Strömberg,Eva Tiensuu Janson,Mats Stridsberg,Helena Jernberg Wiklund,Kenneth Nilsson
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Elevated Serum Thymidine Kinase Levels Identify a Subgroup at High Risk of Disease Progression in Early, Nonsmoldering Chronic Lymphocytic Leukemia
Michael Hallek,Irmgard Langenmayer,Christoph Nerl,Wolfgang Knauf,Hermann Dietzfelbinger,Dagmar Adorf,Marianne Ostwald,Raymonde Busch,Ingrid Kuhn-Hallek,Eckhard Thiel,Bertold Emmerich
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PHAGOCYTES

Cell-Specific Peptide Binding by Human Neutrophils
Luca Mazzucchelli,James B. Burritt,Algirdas J. Jesaitis,Asma Nusrat,Tony W. Liang,Andrew T. Gewirtz,Frederick J. Schnell,Charles A. Parkos
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RED CELLS

Resistance of Paroxysmal Nocturnal Hemoglobinuria Cells to the Glycosylphosphatidylinositol-Binding Toxin Aerolysin
Robert A. Brodsky,Galina L. Mukhina,Kim L. Nelson,Tracy S. Lawrence,Richard J. Jones,J. Thomas Buckley
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Four New Mutations in the Erythroid-Specific 5-Aminolevulinate Synthase (ALAS2) Gene Causing X-Linked Sideroblastic Anemia: Increased Pyridoxine Responsiveness After Removal of Iron Overload by Phlebotomy and Coinheritance of Hereditary Hemochromatosis
Philip D. Cotter,Alison May,Liping Li,A.I. Al-Sabah,Edward J. Fitzsimons,Mario Cazzola,David F. Bishop
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TRANSFUSION MEDICINE

Soluble HLA Class I, HLA Class II, and Fas Ligand in Blood Components: A Possible Key to Explain the Immunomodulatory Effects of Allogeneic Blood Transfusions
M. Ghio,P. Contini,C. Mazzei,S. Brenci,G. Barberis,G. Filaci,F. Indiveri,F. Puppo
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CORRESPONDENCE

Hepatitis C Virus Infection in Patients With Overt B-Cell Non-Hodgkin’s Lymphoma in a French Center
Georgios Germanidis,Corinne Haioun,Jérôme Pourquier,Philippe Gaulard,Jean-Michel Pawlotsky,Daniel Dhumeaux,Félix Reyes
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The Adverse Influence of Pretransplant Interferon- (IFN-) on Transplant Outcome After Marrow Transplantation for Chronic Phase Chronic Myelogenous Leukemia Increases With the Duration of IFN- Exposure
Dietrich W. Beelen,Ahmet H. Elmaagacli,Prof. Ulrich W. Schaefer
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Successful Modification of a pp65 Antigenemia-Based Early Treatment Strategy for Prevention of Cytomegalovirus Disease in Allogeneic Marrow Transplant Recipients
Michael Boeckh,Raleigh A. Bowden,Ted Gooley,David Myerson,Lawrence Corey
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Cimetidine Activates Interleukin-12, Which Enhances Cellular Immunity
Hiroyasu Ishikura,Hisanori Fukui,Naoshi Takeyama,Takaya Tanaka
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ERRATA

Erratum for vol. 92, p. 3309
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Erratum for vol. 91, p. 1152
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