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Volume 93, Issue 10

May 15 1999

In this Issue

CONTROVERSIES IN HEMATOLOGY
REVIEW ARTICLES
RAPID COMMUNICATIONS
CHEMOKINES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSPLANTATION
CORRESPONDENCE
RETRACTIONS

CONTROVERSIES IN HEMATOLOGY

HHV-8 Is Present in Multiple Myeloma Patients

James R. Berenson,Robert A. Vescio

View Articletitled, HHV-8 Is Present in Multiple Myeloma Patients

Kaposi’s Sarcoma-Associated Herpesvirus and Multiple Myeloma: Lack of Criteria for Causality

Karin Tarte,Yuan Chang,Bernard Klein

View Articletitled, Kaposi’s Sarcoma-Associated Herpesvirus and Multiple Myeloma: Lack of Criteria for Causality

Rebuttal to Tarte, Chang, and Klein

View Articletitled, Rebuttal to Tarte, Chang, and Klein

Rebuttal to Berenson and Vescio

View Articletitled, Rebuttal to Berenson and Vescio

REVIEW ARTICLES

Deconstructing a Disease: RAR, Its Fusion Partners, and Their Roles in the Pathogenesis of Acute Promyelocytic Leukemia

Ari Melnick,Jonathan D. Licht

View Articletitled, Deconstructing a Disease: RAR, Its Fusion Partners, and Their Roles in the Pathogenesis of Acute Promyelocytic Leukemia

RAPID COMMUNICATIONS

Transcriptional Inhibition of p53 by the MLL/MEN Chimeric Protein Found in Myeloid Leukemia

Kazuhiro Maki,Kinuko Mitani,Tetsuya Yamagata,Mineo Kurokawa,Yoshinobu Kanda,Yoshio Yazaki,Hisamaru Hirai

View Articletitled, Transcriptional Inhibition of p53 by the MLL/MEN Chimeric Protein Found in Myeloid Leukemia

CHEMOKINES

Chemotactic Response Toward Chemokines and Its Regulation by Transforming Growth Factor-β1 of Murine Bone Marrow Hematopoietic Progenitor Cell-Derived Different Subset of Dendritic Cells

Masafumi Ogata,Yi Zhang,Yong Wang,Meiji Itakura,Yan-yun Zhang,Akihisa Harada,Shin-ichi Hashimoto,Kouji Matsushima

View Articletitled, Chemotactic Response Toward Chemokines and Its Regulation by Transforming Growth Factor-β1 of Murine Bone Marrow Hematopoietic Progenitor Cell-Derived Different Subset of Dendritic Cells

Human Thymocytes Express CCR-3 and Are Activated by Eotaxin

Karin Franz-Bacon,Daniel J. Dairaghi,Stefen A. Boehme,Susan K. Sullivan,Thomas J. Schall,Paul J. Conlon,Naomi Taylor,Kevin B. Bacon

View Articletitled, Human Thymocytes Express CCR-3 and Are Activated by Eotaxin

NF-κB Activation Is Required for C5a-Induced Interleukin-8 Gene Expression in Mononuclear Cells

Matthew H. Hsu,Meiying Wang,Darren D. Browning,Naofumi Mukaida,Richard D. Ye

View Articletitled, NF-κB Activation Is Required for C5a-Induced Interleukin-8 Gene Expression in Mononuclear Cells

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Abrogation of the Hematological and Biological Activities of the Interleukin-3/Granulocyte-Macrophage Colony-Stimulating Factor Fusion Protein PIXY321 by Neutralizing Anti-PIXY321 Antibodies in Cancer Patients Receiving High-Dose Carboplatin

Langdon L. Miller,Edward L. Korn,Diane S. Stevens,John E. Janik,Barry L. Gause,William C. Kopp,Jon T. Holmlund,Brendan D. Curti,Mario Sznol,John W. Smith, II,Walter J. Urba,Sarah E. Donegan,Thelma M. Watson,Dan L. Longo

View Articletitled, Abrogation of the Hematological and Biological Activities of the Interleukin-3/Granulocyte-Macrophage Colony-Stimulating Factor Fusion Protein PIXY321 by Neutralizing Anti-PIXY321 Antibodies in Cancer Patients Receiving High-Dose Carboplatin

Cirrhosis of the Liver in Long-Term Marrow Transplant Survivors

Simone I. Strasser,Keith M. Sullivan,David Myerson,Catherine L. Spurgeon,Barry Storer,H. Gary Schoch,Carol S. Murakami,George B. McDonald

View Articletitled, Cirrhosis of the Liver in Long-Term Marrow Transplant Survivors

Influence of Intestinal Bacterial Decontamination Using Metronidazole and Ciprofloxacin or Ciprofloxacin Alone on the Development of Acute Graft-Versus-Host Disease After Marrow Transplantation in Patients With Hematologic Malignancies: Final Results and Long-Term Follow-Up of an Open-Label Prospective Randomized Trial

Dietrich W. Beelen,Ahmet Elmaagacli,Karl-Dieter Müller,Herbert Hirche,Ulrich W. Schaefer

View Articletitled, Influence of Intestinal Bacterial Decontamination Using Metronidazole and Ciprofloxacin or Ciprofloxacin Alone on the Development of Acute Graft-Versus-Host Disease After Marrow Transplantation in Patients With Hematologic Malignancies: Final Results and Long-Term Follow-Up of an Open-Label Prospective Randomized Trial

GENE THERAPY

Transcriptional Targeting of Retroviral Vectors to the Erythroblastic Progeny of Transduced Hematopoietic Stem Cells

Alexis Grande,Bianca Piovani,Alessandro Aiuti,Sergio Ottolenghi,Fulvio Mavilio,Giuliana Ferrari

View Articletitled, Transcriptional Targeting of Retroviral Vectors to the Erythroblastic Progeny of Transduced Hematopoietic Stem Cells

HEMATOPOIESIS

The Effect of Recombinant Human Erythropoietin on Platelet Counts Is Strongly Modulated by the Adequacy of Iron Supply

Martine Loo,Yves Beguin

View Articletitled, The Effect of Recombinant Human Erythropoietin on Platelet Counts Is Strongly Modulated by the Adequacy of Iron Supply

Dynamic Changes in Mouse Hematopoietic Stem Cell Numbers During Aging

Gerald de Haan,Gary Van Zant

View Articletitled, Dynamic Changes in Mouse Hematopoietic Stem Cell Numbers During Aging

An Essential Role for NF-κB in Human CD34⁺ Bone Marrow Cell Survival

David W. Pyatt,Wayne S. Stillman,Yanzhu Yang,Sherilyn Gross,Jia hua Zheng,Richard D. Irons

View Articletitled, An Essential Role for NF-κB in Human CD34+ Bone Marrow Cell Survival

Interferon γ Induces Upregulation and Activation of Caspases 1, 3, and 8 to Produce Apoptosis in Human Erythroid Progenitor Cells

Chunhua Dai,Sanford B. Krantz

View Articletitled, Interferon γ Induces Upregulation and Activation of Caspases 1, 3, and 8 to Produce Apoptosis in Human Erythroid Progenitor Cells

Modulation of Integrin Function in Hematopoietic Progenitor Cells by CD43 Engagement: Possible Involvement of Protein Tyrosine Kinase and Phospholipase C-γ

Naoyuki Anzai,Akihiko Gotoh,Hirohiko Shibayama,Hal E. Broxmeyer

View Articletitled, Modulation of Integrin Function in Hematopoietic Progenitor Cells by CD43 Engagement: Possible Involvement of Protein Tyrosine Kinase and Phospholipase C-γ

C/EBPɛ Directly Interacts With the DNA Binding Domain of c-myb and Cooperatively Activates Transcription of Myeloid Promoters

Walter Verbeek,Adrian F. Gombart,Alexey M. Chumakov,Carsten Müller,Alan D. Friedman,H. Phillip Koeffler

View Articletitled, C/EBPɛ Directly Interacts With the DNA Binding Domain of c-myb and Cooperatively Activates Transcription of Myeloid Promoters

Characterization of Mast Cell-Committed Progenitors Present in Human Umbilical Cord Blood

Duraisamy Kempuraj,Hirohisa Saito,Azusa Kaneko,Kazumi Fukagawa,Masaharu Nakayama,Hano Toru,Morimitsu Tomikawa,Hiroshi Tachimoto,Motohiro Ebisawa,Akira Akasawa,Toko Miyagi,Hiromitsu Kimura,Toshiharu Nakajima,Kohichiro Tsuji,Tatsutoshi Nakahata

View Articletitled, Characterization of Mast Cell-Committed Progenitors Present in Human Umbilical Cord Blood

Activation of Hematopoietic Progenitor Kinase-1 by Erythropoietin

Yuka Nagata,Friedemann Kiefer,Takeshi Watanabe,Kazuo Todokoro

View Articletitled, Activation of Hematopoietic Progenitor Kinase-1 by Erythropoietin

Unicellular-Unilineage Erythropoietic Cultures: Molecular Analysis of Regulatory Gene Expression at Sibling Cell Level

Benedikt L. Ziegler,Robert Müller,Mauro Valtieri,Christa P. Lamping,Christian A. Thomas,Marco Gabbianelli,Christina Giesert,Hans-Jörg Bühring,Lothar Kanz,Cesare Peschle

View Articletitled, Unicellular-Unilineage Erythropoietic Cultures: Molecular Analysis of Regulatory Gene Expression at Sibling Cell Level

Regulated Expression and Functional Role of the Transcription Factor CHOP (GADD153) in Erythroid Growth and Differentiation

Margaret Coutts,Kunyuan Cui,Kerry L. Davis,Joan Cleves Keutzer,Arthur J. Sytkowski

View Articletitled, Regulated Expression and Functional Role of the Transcription Factor CHOP (GADD153) in Erythroid Growth and Differentiation

Growth Factors and Cytokines Upregulate Gelatinase Expression in Bone Marrow CD34⁺ Cells and Their Transmigration Through Reconstituted Basement Membrane

Anna Janowska-Wieczorek,Leah A. Marquez,Jean-Marc Nabholtz,Maria L. Cabuhat,Jencet Montaño,Hung Chang,Jacob Rozmus,James A. Russell,Dylan R. Edwards,A. Robert Turner

View Articletitled, Growth Factors and Cytokines Upregulate Gelatinase Expression in Bone Marrow CD34+ Cells and Their Transmigration Through Reconstituted Basement Membrane

Characterization of HOX Gene Expression During Myelopoiesis: Role of HOX A5 in Lineage Commitment and Maturation

John F. Fuller,Jeanne McAdara,Yifah Yaron,Mark Sakaguchi,John K. Fraser,Judith C. Gasson

View Articletitled, Characterization of HOX Gene Expression During Myelopoiesis: Role of HOX A5 in Lineage Commitment and Maturation

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Ongoing Prothrombotic State in Patients With Antiphospholipid Antibodies: A Role for Increased Lipid Peroxidation

Domenico Praticò,Domenico Ferro,Luigi Iuliano,Joshua Rokach,Fabrizio Conti,Guido Valesini,Garret A. FitzGerald,Francesco Violi

View Articletitled, Ongoing Prothrombotic State in Patients With Antiphospholipid Antibodies: A Role for Increased Lipid Peroxidation

Agonist-Induced Regulation of Myosin Phosphatase Activity in Human Platelets Through Activation of Rho-Kinase

Yoshinori Suzuki,Masatoshi Yamamoto,Hideo Wada,Masaaki Ito,Takeshi Nakano,Yasuharu Sasaki,Shuh Narumiya,Hiroshi Shiku,Masakatsu Nishikawa

View Articletitled, Agonist-Induced Regulation of Myosin Phosphatase Activity in Human Platelets Through Activation of Rho-Kinase

Vascular Endothelial Genes That Are Responsive to Tumor Necrosis Factor- In Vitro Are Expressed in Atherosclerotic Lesions, Including Inhibitor of Apoptosis Protein-1, Stannin, and Two Novel Genes

Anton J.G. Horrevoets,Ruud D. Fontijn,Anton Jan van Zonneveld,Carlie J.M. de Vries,Jan Wouter ten Cate,Hans Pannekoek

View Articletitled, Vascular Endothelial Genes That Are Responsive to Tumor Necrosis Factor- In Vitro Are Expressed in Atherosclerotic Lesions, Including Inhibitor of Apoptosis Protein-1, Stannin, and Two Novel Genes

Two Common Functional Polymorphisms in the Promoter Region of the Coagulation Factor VII Gene Determining Plasma Factor VII Activity and Mass Concentration

Ferdinand M. van ’t Hooft,Angela Silveira,Per Tornvall,Anastasia Iliadou,Ewa Ehrenborg,Per Eriksson,Anders Hamsten

View Articletitled, Two Common Functional Polymorphisms in the Promoter Region of the Coagulation Factor VII Gene Determining Plasma Factor VII Activity and Mass Concentration

Structure-Function Analyses of Thrombomodulin by Gene-Targeting in Mice: The Cytoplasmic Domain Is Not Required for Normal Fetal Development

Edward M. Conway,Saskia Pollefeyt,Jan Cornelissen,Inky DeBaere,Marta Steiner-Mosonyi,Jeffrey I. Weitz,Hartmut Weiler-Guettler,Peter Carmeliet,Désiré Collen

View Articletitled, Structure-Function Analyses of Thrombomodulin by Gene-Targeting in Mice: The Cytoplasmic Domain Is Not Required for Normal Fetal Development

Elevated Levels of Circulating Procoagulant Microparticles in Patients With Paroxysmal Nocturnal Hemoglobinuria and Aplastic Anemia

Bénédicte Hugel,Gérard Socié,Thi Vu,Florence Toti,Eliane Gluckman,Jean-Marie Freyssinet,Marie-Lorraine Scrobohaci

View Articletitled, Elevated Levels of Circulating Procoagulant Microparticles in Patients With Paroxysmal Nocturnal Hemoglobinuria and Aplastic Anemia

Compound-Heterozygous Mutations in the Plasminogen Gene Predispose to the Development of Ligneous Conjunctivitis: Presented in part on the XIVth International Congress on Fibrinolysis and Thrombolysis, Ljubljana, June 22-26, 1998; Fibrinolysis & Proteolysis 12:20, 1998 (abstr 54, suppl 1)

Volker Schuster,Silvia Seidenspinner,Petra Zeitler,Cornelia Escher,Uwe Pleyer,Wolfgang Bernauer,E. Richard Stiehm,Sherwin Isenberg,Stefan Seregard,Thomas Olsson,Anne-Marie Mingers,Christian Schambeck,Hans Wolfgang Kreth

View Articletitled, Compound-Heterozygous Mutations in the Plasminogen Gene Predispose to the Development of Ligneous Conjunctivitis: Presented in part on the XIVth International Congress on Fibrinolysis and Thrombolysis, Ljubljana, June 22-26, 1998; Fibrinolysis & Proteolysis 12:20, 1998 (abstr 54, suppl 1)

IMMUNOBIOLOGY

Additive Effects of Human Recombinant Interleukin-11 and Granulocyte Colony-Stimulating Factor in Experimental Gram-Negative Sepsis: Presented in part at the 37th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy, held in Toronto, Ontario, Canada, September 30, 1997.

Steven M. Opal,Jhung W. Jhung,James C. Keith, Jr,Samuel J. Goldman,John E. Palardy,Nicolas A. Parejo

View Articletitled, Additive Effects of Human Recombinant Interleukin-11 and Granulocyte Colony-Stimulating Factor in Experimental Gram-Negative Sepsis: Presented in part at the 37th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy, held in Toronto, Ontario, Canada, September 30, 1997.

A Novel Function for Transforming Growth Factor-β₁: Upregulation of the Expression and the IgE-Independent Extracellular Release of a Mucosal Mast Cell Granule-Specific β-Chymase, Mouse Mast Cell Protease-1

Hugh R.P. Miller,Steven H. Wright,Pamela A. Knight,Elisabeth M. Thornton

View Articletitled, A Novel Function for Transforming Growth Factor-β1: Upregulation of the Expression and the IgE-Independent Extracellular Release of a Mucosal Mast Cell Granule-Specific β-Chymase, Mouse Mast Cell Protease-1

NEOPLASIA

The T-Cell Activation Markers CD30 and OX40/CD134 Are Expressed in Nonoverlapping Subsets of Peripheral T-Cell Lymphoma

Dan Jones,Christopher D.M. Fletcher,Karen Pulford,Aliakbar Shahsafaei,David M. Dorfman

View Articletitled, The T-Cell Activation Markers CD30 and OX40/CD134 Are Expressed in Nonoverlapping Subsets of Peripheral T-Cell Lymphoma

Interferon-γ Prevents Apoptosis in Epstein-Barr Virus-Infected Natural Killer Cell Leukemia in an Autocrine Fashion

Shin-ichi Mizuno,Koichi Akashi,Koichi Ohshima,Hiromi Iwasaki,Toshihiro Miyamoto,Naoyuki Uchida,Tsunefumi Shibuya,Mine Harada,Masahiro Kikuchi,Yoshiyuki Niho

View Articletitled, Interferon-γ Prevents Apoptosis in Epstein-Barr Virus-Infected Natural Killer Cell Leukemia in an Autocrine Fashion

PHAGOCYTES

Monoclonal Lym-1 Antibody-Dependent Cytolysis by Neutrophils Exposed to Granulocyte-Macrophage Colony-Stimulating Factor: Intervention of FcγR_II (CD32), CD11b-CD18 Integrins, and CD66b Glycoproteins

L. Ottonello,A.L. Epstein,P. Dapino,P. Barbera,P. Morone,F. Dallegri

View Articletitled, Monoclonal Lym-1 Antibody-Dependent Cytolysis by Neutrophils Exposed to Granulocyte-Macrophage Colony-Stimulating Factor: Intervention of FcγRII (CD32), CD11b-CD18 Integrins, and CD66b Glycoproteins

Elf-1 and PU.1 Induce Expression of gp91^phox Via a Promoter Element Mutated in a Subset of Chronic Granulomatous Disease Patients

Kui Shin Voo,David G. Skalnik

View Articletitled, Elf-1 and PU.1 Induce Expression of gp91phox Via a Promoter Element Mutated in a Subset of Chronic Granulomatous Disease Patients

Transient Association of the Nicotinamide Adenine Dinucleotide Phosphate Oxidase Subunits p47phox and p67phox With Phagosomes in Neutrophils From Patients With X-Linked Chronic Granulomatous Disease

Lee-Ann H. Allen,Frank R. DeLeo,Annabelle Gallois,Satoshi Toyoshima,Kensuke Suzuki,William M. Nauseef

View Articletitled, Transient Association of the Nicotinamide Adenine Dinucleotide Phosphate Oxidase Subunits p47phox and p67phox With Phagosomes in Neutrophils From Patients With X-Linked Chronic Granulomatous Disease

Human Monocytes Constitutively Express Membrane-Bound, Biologically Active, and Interferon-γ–Upregulated Interleukin-15

Tiziana Musso,Liliana Calosso,Mario Zucca,Maura Millesimo,Daniela Ravarino,Mirella Giovarelli,Fabio Malavasi,Alessandro Negro Ponzi,Ralf Paus,Silvia Bulfone-Paus

View Articletitled, Human Monocytes Constitutively Express Membrane-Bound, Biologically Active, and Interferon-γ–Upregulated Interleukin-15

RED CELLS

Analysis of Linked Human ɛ and γ Transgenes: Effect of Locus Control Region Hypersensitive Sites 2 and 3 or a Distal YY1 Mutation on Stage-Specific Expression Patterns

Wei Zhu,Catherine TomHon,Marsha Mason,Thomas Campbell,Eric Shelden,Neil Richards,Morris Goodman,Deborah L. Gumucio

View Articletitled, Analysis of Linked Human ɛ and γ Transgenes: Effect of Locus Control Region Hypersensitive Sites 2 and 3 or a Distal YY1 Mutation on Stage-Specific Expression Patterns

TRANSPLANTATION

Depletion of Alloreactive T Cells by a Specific Anti–Interleukin-2 Receptor p55 Chain Immunotoxin Does Not Impair In Vitro Antileukemia and Antiviral Activity

Daniela Montagna,Eric Yvon,Valeria Calcaterra,Patrizia Comoli,Franco Locatelli,Rita Maccario,Alain Fisher,Marina Cavazzana-Calvo

View Articletitled, Depletion of Alloreactive T Cells by a Specific Anti–Interleukin-2 Receptor p55 Chain Immunotoxin Does Not Impair In Vitro Antileukemia and Antiviral Activity

Prevention of Graft-Versus-Host Disease by Induction of Immune Tolerance With Ultraviolet B-Irradiated Leukocytes in H-2 Disparate Bone Marrow Donor

M.L.U. del Rosario,James R. Zucali,K.J. Kao

View Articletitled, Prevention of Graft-Versus-Host Disease by Induction of Immune Tolerance With Ultraviolet B-Irradiated Leukocytes in H-2 Disparate Bone Marrow Donor

CORRESPONDENCE

Is Filgrastim as Useless After Peripheral Blood Stem Cell Transplantation for Adults as It Could Be for Children?

E. Ojeda,J. Garcia-Bustos,M.J. Aguado,E. Quevedo,R. Arrieta,V. Jimenez,M. Canales,F. Hernandez-Navarro

View Articletitled, Is Filgrastim as Useless After Peripheral Blood Stem Cell Transplantation for Adults as It Could Be for Children?

Intracytoplasmic Detection of Cytokines in Neonatal Lymphocytes and Monocytes by Flow Cytometry

Christian Schultz,Christina Rott,Nina Richter,Peter Bucsky,Irwin Reiss,Ludwig Gortner

View Articletitled, Intracytoplasmic Detection of Cytokines in Neonatal Lymphocytes and Monocytes by Flow Cytometry

Healing of Chronic Leg Ulcers in the Hemoglobinopathies With Perilesional Injections of Granulocyte-Macrophage Colony-Stimulating Factor

Ersi Voskaridou,Maria-Christina Kyrtsonis,Aphrodite Loutradi-Anagnostou,Dimitris Loukopoulos

View Articletitled, Healing of Chronic Leg Ulcers in the Hemoglobinopathies With Perilesional Injections of Granulocyte-Macrophage Colony-Stimulating Factor

TT Virus: A Mother-to-Child Transmitted Rather Than Bloodborne Virus

Shoichi Yokozaki,Yoshihide Fukuda,Isao Nakano,Yoshiaki Katano,Makoto Okamura,Masayuki Naruse

View Articletitled, TT Virus: A Mother-to-Child Transmitted Rather Than Bloodborne Virus

RETRACTIONS

Correction for vol. 78, p. 2070

View Articletitled, Correction for vol. 78, p. 2070

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One hundred thirty-four germ line PU.1 variants and the agammaglobulinemic patients carrying them

DDAVP response and its determinants in bleeding disorders: a systematic review and meta-analysis

The Fit Older Adult with Acute Myeloid Leukemia: Clinical Challenges to Providing Evidence-Based Frontline Treatment

“Complementing” hemolytic anemias: what’s next?

Another cryo-EM success: structure of FXIII