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Issue Archive

Volume 92, Issue 9
November 1 1998
Blood Cover Image for Volume 92, Issue 9

Table of Contents

REVIEW ARTICLES

Inside the Neutrophil Phagosome: Oxidants, Myeloperoxidase, and Bacterial Killing
Mark B. Hampton,Anthony J. Kettle,Christine C. Winterbourn
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RAPID COMMUNICATIONS

Somatic Fas Mutations in Non-Hodgkin’s Lymphoma: Association With Extranodal Disease and Autoimmunity
Kirsten Grønbæk,Per thor Straten,Elisabeth Ralfkiaer,Vibeke Ahrenkiel,Mette Klarskov Andersen,Niels Ebbe Hansen,Jesper Zeuthen,Klaus Hou-Jensen,Per Guldberg
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The t(4;14) Translocation in Myeloma Dysregulates Both FGFR3and a Novel Gene, MMSET, Resulting in IgH/MMSET Hybrid Transcripts
Marta Chesi,Elena Nardini,Robert S.C. Lim,Kerrington D. Smith,W. Michael Kuehl,P. Leif Bergsagel
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Secretable Human Platelet-Derived Factor V Originates From the Plasma Pool
Rodney M. Camire,Eleanor S. Pollak,Kenneth Kaushansky,Paula B. Tracy
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Phosphorylated Forms of Activated Caspases Are Present in Cytosol From HL-60 Cells During Etoposide-Induced Apoptosis
Luis M. Martins,Timothy J. Kottke,Scott H. Kaufmann,William C. Earnshaw
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Abnormal Microsomal Detoxification Implicated in Fanconi Anemia Group C by Interaction of the FAC Protein With NADPH Cytochrome P450 Reductase
Frank A.E. Kruyt,Taizo Hoshino,Johnson M. Liu,Pius Joseph,Anil K. Jaiswal,Hagop Youssoufian
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Reversal of Lethal - and β-Thalassemias in Mice by Expression of Human Embryonic Globins
J. Eric Russell,Stephen A. Liebhaber
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CHEMOKINES

Endothelin-1 Induces Production of the Neutrophil Chemotactic Factor Interleukin-8 by Human Brain-Derived Endothelial Cells
F.M. Hofman,P. Chen,R. Jeyaseelan,F. Incardona,M. Fisher,R. Zidovetzki
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Expression of Macrophage Inflammatory Protein-1 Receptors in Human CD34+ Hematopoietic Cells and Their Modulation by Tumor Necrosis Factor- and Interferon-γ
Jan Dürig,Erika A. de Wynter,Christoph Kasper,Michael A. Cross,James Chang,Nydia G. Testa,Clare M. Heyworth
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CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Beneficial Effect of Intravenous Dexamethasone in Children With Mild to Moderately Severe Acute Chest Syndrome Complicating Sickle Cell Disease
Juan Carlos Bernini,Zora R. Rogers,Eric S. Sandler,Joan S. Reisch,Charles T. Quinn,George R. Buchanan
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Caspase 2 and Caspase 3 Protein Levels as Predictors of Survival in Acute Myelogenous Leukemia
Zeev Estrov,Peter F. Thall,Moshe Talpaz,Elihu H. Estey,Hagop M. Kantarjian,Michael Andreeff,David Harris,Quin Van,Monika Walterscheid,Steven M. Kornblau
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Successful Use of Extracorporeal Photochemotherapy in the Treatment of Severe Acute and Chronic Graft-Versus-Host Disease
Hildegard T. Greinix,Beatrix Volc-Platzer,Werner Rabitsch,Bernd Gmeinhart,Carlos Guevara-Pineda,Peter Kalhs,Jean Krutmann,Herbert Hönigsmann,Marina Ciovica,Robert M. Knobler
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Virological and Immunological Features of Long-Term Human Immunodeficiency Virus–Infected Individuals Who Have Remained Asymptomatic Compared With Those Who Have Progressed to Acquired Immunodeficiency Syndrome
Edward Barker,Carl E. Mackewicz,Gustavo Reyes-Terán,Akihiko Sato,Sharon A. Stranford,Sue H. Fujimura,Cindy Christopherson,Sheng-Yung Chang,Jay A. Levy
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Relationship Between Cleaved L-Selectin Levels and the Outcome of Acute Myeloid Leukemia
M. Extermann,M. Bacchi,N. Monai,M. Fopp,M. Fey,A. Tichelli,M. Schapira,O. Spertini,for the Swiss Group for Clinical Cancer Research (SAKK)
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Partially Mismatched Pediatric Transplants With Allogeneic CD34+ Blood Cells From a Related Donor
Yoshifumi Kawano,Yoichi Takaue,Arata Watanabe,Osamu Takeda,Kohji Arai,Etsuro Itoh,Yuhju Ohno,Takanori Teshima,Mine Harada,Tsutomu Watanabe,Yasuhiro Okamoto,Takanori Abe,Teruyuki Kajiume,Takeji Matsushita,Kazuma Ikeda,Mikiya Endo,Yasuhiro Kuroda,Shigetaka Asano,Ryuji Tanosaki,Ken Yamaguchi,Ping Law,John D. McMannis
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High-Dose Therapy and Autologous Peripheral Blood Stem Cell Transplantation in Multiple Myeloma: Up-front or Rescue Treatment? Results of a Multicenter Sequential Randomized Clinical Trial
Jean-Paul Fermand,Philippe Ravaud,Sylvie Chevret,Marine Divine,Véronique Leblond,Coralie Belanger,Margaret Macro,Edouard Pertuiset,François Dreyfus,Xavier Mariette,Catherine Boccacio,Jean-Claude Brouet,for the Group “Myélome Autogreffe”*
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Anti–B-Cell Monoclonal Antibody Treatment of Severe Posttransplant B-Lymphoproliferative Disorder: Prognostic Factors and Long-Term Outcome
Malika Benkerrou,Jean-Philippe Jais,Véronique Leblond,Anne Durandy,Laurent Sutton,Pierre Bordigoni,Jane Luce Garnier,Jérôme Le Bidois,Françoise Le Deist,Stéphane Blanche,Alain Fischer
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Serum Levels of Substance P Are Elevated in Patients With Sickle Cell Disease and Increase Further During Vaso-Occlusive Crisis
Lisa A. Michaels,Kwaku Ohene-Frempong,Huaqing Zhao,Steven D. Douglas
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Clinical Relevance of BCL2, BCL6, and MYC Rearrangements in Diffuse Large B-Cell Lymphoma
M.H.H. Kramer,J. Hermans,E. Wijburg,K. Philippo,E. Geelen,J.H.J.M. van Krieken,D. de Jong,E. Maartense,E. Schuuring,P.M. Kluin
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GENE THERAPY

High Efficiency Gene Transfer to Human Hematopoietic SCID-Repopulating Cells Under Serum-Free Conditions
Andrea J. Schilz,Gaby Brouns,Heike Knöβ,Oliver G. Ottmann,Dieter Hoelzer,Axel A. Fauser,Adrian J. Thrasher,Manuel Grez
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Gene Transfer in Dendritic Cells, Induced by Oral DNA Vaccination With Salmonellatyphimurium, Results in Protective Immunity Against a Murine Fibrosarcoma
Paola Paglia,Eva Medina,Ivano Arioli,Carlos A. Guzman,Mario P. Colombo
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HEMATOPOIESIS

Effect of FLT3 Ligand and Granulocyte Colony-Stimulating Factor on Expansion and Mobilization of Facilitating Cells and Hematopoietic Stem Cells in Mice: Kinetics and Repopulating Potential
Michael Neipp,Tatiana Zorina,Michele A. Domenick,Beate G. Exner,Suzanne T. Ildstad
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Role of Members of the Wnt Gene Family in Human Hematopoiesis
David J. Van Den Berg,Arun K. Sharma,Edward Bruno,Ron Hoffman
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Four-Color Flow Cytometric Investigation of Terminal Deoxynucleotidyl Transferase–Positive Lymphoid Precursors in Pediatric Bone Marrow: CD79a Expression Precedes CD19 in Early B-Cell Ontogeny
Michael N. Dworzak,Gerhard Fritsch,Gertraud Fröschl,Dieter Printz,Helmut Gadner
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Long-Term Contribution to the Myeloid Compartment by Lineage-Committed Stem Cells
Chiann-Chyi Chen,Amariliz Rivera,Naomi Ron,Natalie Sutkowski,Joseph P. Dougherty,Yacov Ron
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Erythropoietin mRNA Expression in Human Fetal and Neonatal Tissue
Christof Dame,Hubert Fahnenstich,Patricia Freitag,Dietmar Hofmann,Thair Abdul-Nour,Peter Bartmann,Joachim Fandrey
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Mcl-1 in Transgenic Mice Promotes Survival in a Spectrum of Hematopoietic Cell Types and Immortalization in the Myeloid Lineage
Ping Zhou,Liping Qian,Christine K. Bieszczad,Randolph Noelle,Michael Binder,Norman B. Levy,Ruth W. Craig
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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Induction of Fibrinogen Binding and Platelet Aggregation as a Potential Intrinsic Property of Various Glycoprotein IIb/IIIa (IIbβ3) Inhibitors
Karlheinz Peter,Meike Schwarz,Jari Ylänne,Benedikt Kohler,Martin Moser,Thomas Nordt,Peter Salbach,Wolfgang Kübler,Christoph Bode
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Defining an Antigenic Epitope on Platelet Factor 4 Associated With Heparin-Induced Thrombocytopenia
L. Ziporen,Z.Q. Li,K.S. Park,P. Sabnekar,W.Y. Liu,G. Arepally,Y. Shoenfeld,T. Kieber-Emmons,D.B. Cines,M. Poncz
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Adhesive and Signaling Properties of a Naturally Occurring Allele of Glycoprotein IIIa With an Amino Acid Substitution Within the Ligand Binding Domain—The Pena/PenbPlatelet Alloantigenic Epitopes
Ronggang Wang,Peter J. Newman
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Accutin, a New Disintegrin, Inhibits Angiogenesis In Vitro and In Vivo by Acting as Integrin vβ3 Antagonist and Inducing Apoptosis
Chia Hsin Yeh,Hui-Chin Peng,Tur-Fu Huang
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Three Complement-Type Repeats of the Low-Density Lipoprotein Receptor-Related Protein Define a Common Binding Site for RAP, PAI-1, and Lactoferrin
Brian Vash,Neil Phung,Sima Zein,Dianne DeCamp
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Detection of a Complex That Associates With the Bβ Fibrinogen G−455-A Polymorphism
Erika T. Brown,Gerald M. Fuller
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Activation of Clotting Factor XI Without Detectable Contact Activation in Experimental Human Endotoxemia
M.C. Minnema,D. Pajkrt,W.A. Wuillemin,D. Roem,W.K. Bleeker,M. Levi,S.J.H. van Deventer,C.E. Hack,H. ten Cate
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Formation of the Human Fibrinogen Subclass Fib420: Disulfide Bonds and Glycosylation in Its Unique (EChain) Domains
Yiping Fu,Jian-Zhong Zhang,Colvin M. Redman,Gerd Grieninger
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Identification of Mutations and Polymorphisms in the Factor XI Genes of an African American Family by Dideoxyfingerprinting
Danko Martincic,Sherri A. Zimmerman,Russell E. Ware,Mao-Fu Sun,James A. Whitlock,David Gailani
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IMMUNOBIOLOGY

Expansion of Philadelphia Chromosome–Negative CD3+CD56+ Cytotoxic Cells From Chronic Myeloid Leukemia Patients: In Vitro and In Vivo Efficacy in Severe Combined Immunodeficiency Disease Mice
Christine Hoyle,Charles D. Bangs,Pearl Chang,Onsi Kamel,Bela Mehta,Robert S. Negrin
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Hepatitis C Virus Infection Involves CD34+Hematopoietic Progenitor Cells in Hepatitis C Virus Chronic Carriers
Domenico Sansonno,Claudio Lotesoriere,Vito Cornacchiulo,Massimo Fanelli,Pietro Gatti,Giuseppe Iodice,Vito Racanelli,Franco Dammacco
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OX40 Costimulation Enhances Interleukin-4 (IL-4) Expression at Priming and Promotes the Differentiation of Naive Human CD4+ T Cells Into High IL-4–Producing Effectors
Yusei Ohshima,Liang-Peng Yang,Takashi Uchiyama,Yuetsu Tanaka,Peter Baum,Martin Sergerie,Patrice Hermann,Guy Delespesse
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Alloantigen-Stimulated Anti-HIV Activity
Ligia A. Pinto,Sandra Sharpe,David I. Cohen,Gene M. Shearer
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CD4+ Cytotoxic T-Cell Clones Specific for bcr-abl b3a2 Fusion Peptide Augment Colony Formation by Chronic Myelogenous Leukemia Cells in a b3a2-Specific and HLA-DR–Restricted Manner
Masaki Yasukawa,Hideki Ohminami,Shin Kaneko,Yoshihiro Yakushijin,Yasuharu Nishimura,Koiti Inokuchi,Tsuyoshi Miyakuni,Shinji Nakao,Kenji Kishi,Ichiro Kubonishi,Kazuo Dan,Shigeru Fujita
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NEOPLASIA

The Presence of Typical and Atypical BCR-ABL Fusion Genes in Leukocytes of Normal Individuals: Biologic Significance and Implications for the Assessment of Minimal Residual Disease
Shikha Bose,Michael Deininger,Joanna Gora-Tybor,John M. Goldman,Junia V. Melo
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Human Monocytoid Leukemia Cells Are Highly Sensitive to Apoptosis Induced by 2′-Deoxycoformycin and 2′-Deoxyadenosine: Association With dATP-Dependent Activation of Caspase-3
Nozomi Niitsu,Yuri Yamaguchi,Masanori Umeda,Yoshio Honma
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Prognostic Significance of a Polymerase Chain Reaction–Detectable Dominant T-Lymphocyte Clone in Cutaneous Lesions of Patients With Mycosis Fungoides
Marie-Hélène Delfau-Larue,Sophie Dalac,Eric Lepage,Tony Petrella,Janine Wechsler,Jean-Pierre Farcet,Martine Bagot
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Resistance to Cytotoxic Chemotherapy Induced by CD40 Ligand in Lymphoma Cells
Nathalie Voorzanger-Rousselot,M.-C. Favrot,Jean-Yves Blay
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Coexpression of Erythropoietin and Vascular Endothelial Growth Factor in Nervous System Tumors Associated With von Hippel-Lindau Tumor Suppressor Gene Loss of Function
Marion Krieg,Hugo H. Marti,Karl H. Plate
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Identification of Four Genes in Endothelial Cells Whose Expression Is Affected by Tumor Cells and Host Immune Status—A Study in Ex Vivo–Isolated Endothelial Cells
Birgit Liliensiek,Marian Rocha,Victor Umansky,Axel Benner,Jie Lin,Reinhard Ziegler,Peter P. Nawroth,Volker Schirrmacher
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Chromosome Band 1p36 Contains a Putative Tumor Suppressor Gene Important in the Evolution of Chronic Myelocytic Leukemia
Naoki Mori,Roberta Morosetti,Susanne Spira,Stephen Lee,Dina Ben-Yehuda,Gary Schiller,Raffaele Landolfi,Hideaki Mizoguchi,H. Phillip Koeffler
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PTEN Gene Alterations in Lymphoid Neoplasms
Akira Sakai,Catherine Thieblemont,Axel Wellmann,Elaine S. Jaffe,Mark Raffeld
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RED CELLS

Comparison of Expression of Human Globin Genes Transferred Into Mouse Erythroleukemia Cells and in Transgenic Mice
E. Skarpidi,G. Vassilopoulos,G. Stamatoyannopoulos,Q. Li
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New Somatic Mutation in the PIG-A Gene Emerges at Relapse of Paroxysmal Nocturnal Hemoglobinuria
Khédoudja Nafa,Monica Bessler,H. Joachim Deeg,Lucio Luzzatto
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Unusually Severe Heterozygous β-Thalassemia: Evidence for an Interacting Gene Affecting Globin Translation
P. Joy Ho,Georgina W. Hall,Suzanne Watt,Nicholas C. West,Jennifer W. Wimperis,William G. Wood,Swee Lay Thein
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Differential Regulation of Coproporphyrinogen Oxidase Gene Between Erythroid and Nonerythroid Cells
Shinichiro Takahashi,Shigeru Taketani,Jun-etsu Akasaka,Akira Kobayashi,Norio Hayashi,Masayuki Yamamoto,Tadashi Nagai
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Enhanced Adherence of Sickle Erythrocytes to Thrombin-Treated Endothelial Cells Involves Interendothelial Cell Gap Formation
Annamaria B. Manodori,Neil M. Matsui,James Y. Chen,Stephen H. Embury
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Apolipoprotein E 4 Allele as a Genetic Risk Factor for Left Ventricular Failure in Homozygous β-Thalassemia
Effrosini Economou-Petersen,Athanassios Aessopos,Athina Kladi,Panagiota Flevari,Fotis Karabatsos,Christina Fragodimitri,Peter Nicolaidis,Helen Vrettou,Dimitris Vassilopoulos,Markissia Karagiorga-Lagana,Dimitrios Th. Kremastinos,Michael B. Petersen
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TRANSFUSION MEDICINE

A Multicenter Prospective Study on the Risk of Acquiring Liver Disease in Anti–Hepatitis C Virus Negative Patients Affected From Homozygous β-Thalassemia
Daniele Prati,Alberto Zanella,Elena Farma,Claudia De Mattei,Patrizia Bosoni,Manuela Zappa,Alessandra Picone,Fulvio Mozzi,Paolo Rebulla,Maria Domenica Cappellini,Jean-Pierre Allain,Girolamo Sirchia,for the Cooleycare Cooperative Group
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TRANSPLANTATION

Osteoclast-Mediated Bone Resorption Is Stimulated During Short-Term Administration of Granulocyte Colony-Stimulating Factor But Is Not Responsible for Hematopoietic Progenitor Cell Mobilization
Yasushi Takamatsu,Paul J. Simmons,Robert J. Moore,Howard A. Morris,Luen B. To,Jean-Pierre Lévesque
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CORRESPONDENCE

Absence of a Correlation Between Kaposi’s Sarcoma–Associated Herpesvirus (KSHV/HHV-8) and Multiple Myeloma
G. Schönrich,M. Raftery,P. Schnitzler,U. Rohr,H. Goldschmidt
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Chediak-Higashi–Like Granules in Acute Promyelocytic Leukemia
Nenad Markovic
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An Unusual Cause of Abdominal Pain in Sickle Cell Disease
Roopen Arya,James Wade,Adrian Stephens
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An Even Easier Method for One-Step Detection of Both FV Leiden and FII G20210A Transition
Giansily Muriel,Biron Christine,Jeanjean Philippe,Masmejean Christophe,Schved Jean Francois,Aguilar Martinez Patricia
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Methods for Assessment of Graft-Versus-Host Disease
Paul J. Martin,Gary Schoch,Ted Gooley,Claudio Anasetti,H. Joachim Deeg,Richard Nash,Jean Sanders,Rainer Storb,Fred Appelbaum
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EHT, a New Member of the MTG8/ETO Gene Family, Maps on 20q11 Region and Is Deleted in Acute Myeloid Leukemias
Nicola Stefano Fracchiolla,Gualtiero Colombo,Palma Finelli,Anna Teresa Maiolo,Antonino Neri
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Rapid Regeneration of Normally Functional Naive CD4+ T Cells After Bone Marrow Transplantation From Unrelated Donors for Combined Immunodeficiency
Duilio Brugnoni,Paolo Airò,Alberto Malagoli,Roberto Cattaneo,Marta Pennacchio,Fulvio Porta
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Hepatitis C Virus (HCV) Infection: Serum Rheumatoid Factor Activity and HCV Genotype Correlate With Cryoglobulin Clonality
Cristian Antonescu,Claude Mayerat,Alain Mantegani,Philippe C. Frei,François Spertini,Jean-Daniel Tissot
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Human Herpesvirus-8 and Relatives of Patients With Plasmocytic Diseases
A. Jaccard,M. Touati,C. Sol,D. Bordessoule,J.P. Couty,S. Rogez,F. Trimoreau
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Randomized Trial of Autologous Filgrastim-Primed Bone Marrow Transplantation Versus Filgrastim-Mobilized Peripheral Blood Stem Cell Transplantation in Lymphoma Patients
Martin Gyger,Entezam Sahovic,Mohamed Aslam
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Rituxan in the Treatment of Cold Agglutinin Disease
Edward J. Lee,Brian Kueck
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