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Issue Archive

Volume 92, Issue 3
August 1 1998
Blood Cover Image for Volume 92, Issue 3

Table of Contents

COMMENTARY

What Significance Should We Attribute to the Detection ofMLL Fusion Transcripts?
Stephen P. Hunger,Michael L. Cleary
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REVIEW ARTICLES

Nucleic Acid Therapeutics: State of the Art and Future Prospects
Alan M. Gewirtz,Deborah L. Sokol,Mariusz Z. Ratajczak
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RAPID COMMUNICATIONS

Treatment of Severe Veno-Occlusive Disease With Defibrotide: Compassionate Use Results in Response Without Significant Toxicity in a High-Risk Population
Paul G. Richardson,Anthony D. Elias,Amrita Krishnan,Catherine Wheeler,Raj Nath,Debra Hoppensteadt,Nancy M. Kinchla,Donna Neuberg,Edmund K. Waller,Joseph H. Antin,Robert Soiffer,James Vredenburgh,Michael Lill,Ann E. Woolfrey,Scott I. Bearman,Massimo Iacobelli,Jawed Fareed,Eva C. Guinan
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Neutralization of Tumor Necrosis Factor Activity Shortly After the Onset of Dendritic Cell Hematopoiesis Reveals a Novel Mechanism for the Selective Expansion of the CD14-Dependent Dendritic Cell Pathway
Frances Santiago-Schwarz,Marguerite McCarthy,John Tucci,Steven E. Carsons
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The α-Chemokine Receptor CXCR4 Is Expressed on the Megakaryocytic Lineage From Progenitor to Platelets and Modulates Migration and Adhesion
Jian-Feng Wang,Zhong-Ying Liu,Jerome E. Groopman
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FLT-3 Ligand Provides Hematopoietic Protection From Total Body Irradiation in Rabbits
A. Gratwohl,L. John,H. Baldomero,J. Roth,A. Tichelli,C. Nissen,S.D. Lyman,A. Wodnar-Filipowicz
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Expression of Cyclin E and the Cyclin-Dependent Kinase Inhibitor p27 in Malignant Lymphomas—Prognostic Implications
Martin Erlanson,Cajsa Portin,Barbro Linderholm,Jack Lindh,Göran Roos,Göran Landberg
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Role for Bcl-xL in Delayed Eosinophil Apoptosis Mediated by Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-5
Birgit Dibbert,Isabelle Daigle,Doris Braun,Corinna Schranz,Martina Weber,Kurt Blaser,Uwe Zangemeister-Wittke,Arne N. Akbar,Hans-Uwe Simon
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CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Early Detection of Relapse by Prospective Reverse Transcriptase-Polymerase Chain Reaction Analysis of the PML/RARα Fusion Gene in Patients With Acute Promyelocytic Leukemia Enrolled in the GIMEMA-AIEOP Multicenter “AIDA” Trial
Daniela Diverio,Vincenzo Rossi,Giuseppe Avvisati,Silvia DeSantis,Alessandra Pistilli,Fabrizio Pane,Giuseppe Saglio,Giovanni Martinelli,Maria Concetta Petti,Alessandra Santoro,Pier Giuseppe Pelicci,Franco Mandelli,Andrea Biondi,Francesco Lo Coco,for the GIMEMA and AIEOP Cooperative Groups
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Anaplastic Large Cell Lymphoma Hodgkin's-Like: A Randomized Trial of ABVD Versus MACOP-B With and Without Radiation Therapy
Pier Luigi Zinzani,Maurizio Martelli,Massimo Magagnoli,Alfonso Zaccaria,Fioravante Ronconi,Maria Cantonetti,Monica Bocchia,Roberto Marra,Marco Gobbi,Brunangelo Falini,Filippo Gherlinzoni,Luciano Moretti,Amalia De Renzo,Patrizio Mazza,Enzo Pavone,Elena Sabattini,Angela Amendola,Maurizio Bendandi,Stefano A. Pileri,Franco Mandelli,Sante Tura
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Expression of Myeloid Markers Lacks Prognostic Impact in Children Treated for Acute Lymphoblastic Leukemia: Italian Experience in AIEOP-ALL 88-91 Studies
Maria Caterina Putti,Roberto Rondelli,Maria Grazia Cocito,Maurizio Aricó,Laura Sainati,Valentino Conter,Cesare Guglielmi,Angelo Cantú-Rajnoldi,Rita Consolini,Andrea Pession,Luigi Zanesco,Giuseppe Masera,Andrea Biondi,Giuseppe Basso
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Presence of a p53 Gene Deletion in Patients With Multiple Myeloma Predicts for Short Survival After Conventional-Dose Chemotherapy
Johannes Drach,Jutta Ackermann,Elke Fritz,Elisabeth Krömer,Rudolf Schuster,Heinz Gisslinger,Maria DeSantis,Niklas Zojer,Michael Fiegl,Sebastian Roka,Judith Schuster,Renate Heinz,Heinz Ludwig,Heinz Huber
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Clinical Significance of MLL-AF4 Fusion Transcript Expression in the Absence of a Cytogenetically Detectable t(4;11)(q21;q23) Chromosomal Translocation
Fatih M. Uckun,Kim Herman-Hatten,Mya-Lisa Crotty,Martha G. Sensel,Harland N. Sather,Lisa Tuel-Ahlgren,Mireille B. Sarquis,Bruce Bostrom,James B. Nachman,Peter G. Steinherz,Paul S. Gaynon,Nyla Heerema
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GENE THERAPY

Intermittent, Repetitive Corticosteroid-Induced Upregulation of Platelet Levels After Adenovirus-Mediated Transfer to the Liver of a Chimeric Glucocorticoid-Responsive Promoter Controlling the Thrombopoietin cDNA
Ko Narumi,Motoyoshi Suzuki,Wenru Song,Malcolm A.S. Moore,Ronald G. Crystal
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HEMATOPOIESIS

Mutual Education Between Hematopoietic Cells and Bone Marrow Stromal Cells Through Direct Cell-to-Cell Contact: Factors That Determine the Growth of Bone Marrow Stroma-Dependent Leukemic (HB-1) Cells
Huijie Jiang,Kenkichi Sugimoto,Hitoshi Sawada,Emi Takashita,Maki Tohma,Hiroyuki Gonda,Kazuhiro John Mori
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Different Adhesive Characteristics and VLA-4 Expression of CD34+ Progenitors in G0/G1 Versus S+G2/M Phases of the Cell Cycle
Miki Yamaguchi,Kenji Ikebuchi,Fumiya Hirayama,Norihiro Sato,Yuko Mogi,Jun-ichi Ohkawara,Yoshihiro Yoshikawa,Ken-ichi Sawada,Takao Koike,Sadayoshi Sekiguchi
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CD164, a Novel Sialomucin on CD34+ and Erythroid Subsets, Is Located on Human Chromosome 6q21
Suzanne M. Watt,Hans-Jörg Bühring,Irene Rappold,James Yi-Hsin Chan,Jane Lee-Prudhoe,Tania Jones,Andrew C.W. Zannettino,Paul J. Simmons,Regis Doyonnas,Denise Sheer,Lisa H. Butler
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Characterization of the Role of the Human Granulocyte-Macrophage Colony-Stimulating Factor Receptor α Subunit in the Activation of JAK2 and STAT5
Sean E. Doyle,Judith C. Gasson
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Overexpression of HOX11 Leads to the Immortalization of Embryonic Precursors With Both Primitive and Definitive Hematopoietic Potential
Gordon Keller,Charles Wall,Andrew Z.C. Fong,Teresa S. Hawley,Robert G. Hawley
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Stomach Implant for Long-Term Erythropoietin Expression in Rats
Daniel V. Lejnieks,N. Ramesh,Stella Lau,William R.A. Osborne
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Role of Adhesion Molecules in the Homing and Mobilization of Murine Hematopoietic Stem and Progenitor Cells
Monica Vermeulen,Françoise Le Pesteur,Marie-Claude Gagnerault,Jean-Yves Mary,Françoise Sainteny,Françoise Lepault
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Negative Regulation by Interleukin-3 (IL-3) of Mouse Early B-Cell Progenitors and Stem Cells in Culture: Transduction of the Negative Signals by βc and βIL-3 Proteins of IL-3 Receptor and Absence of Negative Regulation by Granulocyte-Macrophage Colony-Stimulating Factor
Takuya Matsunaga,Fumiya Hirayama,Yuji Yonemura,Richard Murray,Makio Ogawa
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Hematopoietic Stem Cell Maintenance and Differentiation Are Supported by Embryonic Aorta-Gonad-Mesonephros Region–Derived Endothelium
Osamu Ohneda,Christopher Fennie,Zhong Zheng,Christopher Donahue,Hank La,Ricardo Villacorta,Belinda Cairns,Laurence A. Lasky
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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Exclusion of the First EGF Domain of Factor VII by a Splice Site Mutation Causes Lethal Factor VII Deficiency
John H. McVey,Emma J. Boswell,Osamu Takamiya,Gabriel Tamagnini,Victor Valente,Teresa Fidalgo,Mark Layton,Edward G.D. Tuddenham
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Effect of Steroid Hormones and Retinoids on the Formation of Capillary-Like Tubular Structures of Human Microvascular Endothelial Cells in Fibrin Matrices Is Related to Urokinase Expression
Mirian Lansink,Pieter Koolwijk,Victor van Hinsbergh,Teake Kooistra
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Apposition-Dependent Induction of Plasminogen Activator Inhibitor Type 1 Expression: A Mechanism for Balancing Pericellular Proteolysis During Angiogenesis
Eran Bacharach,Ahuva Itin,Eli Keshet
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IMMUNOBIOLOGY

Adenosine Triphosphate–Induced Shedding of CD23 and L-Selectin (CD62L) From Lymphocytes Is Mediated by the Same Receptor but Different Metalloproteases
B. Gu,L.J. Bendall,J.S. Wiley
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Clonal Diversity of Ig and T-Cell–Receptor Gene Rearrangements Identifies a Subset of Childhood B-Precursor Acute Lymphoblastic Leukemia With Increased Risk of Relapse
Elaine Green,Carmel M. McConville,Judith E. Powell,Jillian R. Mann,Philip J. Darbyshire,A. Malcolm R. Taylor,Tatjana Stankovic
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NEOPLASIA

MDM2 Protein Overexpression Inhibits Apoptosis of TF-1 Granulocyte-Macrophage Colony-Stimulating Factor–Dependent Acute Myeloblastic Leukemia Cells
Mitsuyoshi Urashima,Gerrard Teoh,Dharminder Chauhan,Atsushi Ogata,Shuya Shirahama,Chiharu Kaihara,Masaharu Matsuzaki,Hiroshi Matsushima,Masaharu Akiyama,Youki Yuza,Kihei Maekawa,Kenneth C. Anderson
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Use of the Microculture Kinetic Assay of Apoptosis to Determine Chemosensitivities of Leukemias
Vladimir D. Kravtsov,John P. Greer,James A. Whitlock,Mark J. Koury
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Fas-Mediated Modulation of Bcr/Abl in Chronic Myelogenous Leukemia Results in Differential Effects on Apoptosis
Carmine Selleri,Jaroslaw P. Maciejewski,Fabrizio Pane,Luigia Luciano,Anna Maria Raiola,Ilaria Mostarda,Francesco Salvatore,Bruno Rotoli
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Triggering of CD40 Antigen Inhibits Fludarabine-Induced Apoptosis in B Chronic Lymphocytic Leukemia Cells
Maria Fiammetta Romano,Annalisa Lamberti,Pierfrancesco Tassone,Fiorella Alfinito,Silvia Costantini,Federico Chiurazzi,Thierry Defrance,Patrizio Bonelli,Franca Tuccillo,Maria Caterina Turco,Salvatore Venuta
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Chemopreventive Agent Resveratrol, a Natural Product Derived From Grapes, Triggers CD95 Signaling-Dependent Apoptosis in Human Tumor Cells
Marie-Véronique Clément,Jayshreekumari L. Hirpara,Sanaul-Haq Chawdhury,Shazib Pervaiz
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Distinct Apoptotic Responses Imparted by c-myc and max
Chadd E. Nesbit,Saijun Fan,Hong Zhang,Edward V. Prochownik
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The Molecular and Phenotypic Profile of Primary Central Nervous System Lymphoma Identifies Distinct Categories of the Disease and Is Consistent With Histogenetic Derivation From Germinal Center–Related B Cells
Luigi Maria Larocca,Daniela Capello,Alessandro Rinelli,Simonetta Nori,Andrea Antinori,Annunziata Gloghini,Antonella Cingolani,Anna Migliazza,Giuseppe Saglio,Sophie Cammilleri-Broet,Martine Raphael,Antonino Carbone,Gianluca Gaidano
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Antigen Presenting Phenotype of Hodgkin Reed-Sternberg Cells: Analysis of the HLA Class I Processing Pathway and the Effects of Interleukin-10 on Epstein-Barr Virus-Specific Cytotoxic T-Cell Recognition
Steven P. Lee,Christothea M. Constandinou,Wendy A. Thomas,Debbie Croom-Carter,Neil W. Blake,Paul G. Murray,John Crocker,Alan B. Rickinson
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B-Cell Chronic Lymphocytic Leukemia Cells Express a Functional Inducible Nitric Oxide Synthase Displaying Anti-Apoptotic Activity
Haixia Zhao,Nathalie Dugas,Claire Mathiot,Alain Delmer,Bernard Dugas,François Sigaux,Jean-Pierre Kolb
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PHAGOCYTES

Entry and Trafficking of Granzyme B in Target Cells During Granzyme B-Perforin–Mediated Apoptosis
Michael J. Pinkoski,Marita Hobman,Jeffrey A. Heibein,Kevin Tomaselli,Feng Li,Prem Seth,Christopher J. Froelich,R. Chris Bleackley
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Stem Cell Factor Influences Mast Cell Mediator Release in Response to Eosinophil-Derived Granule Major Basic Protein
Glenn T. Furuta,Steven J. Ackerman,Lei Lu,Rachel E. Williams,Barry K. Wershil
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TRANSPLANTATION

Release of Polymorphonuclear Leukocytes From the Bone Marrow by Interleukin-8
Takeshi Terashima,Dean English,James C. Hogg,Stephan F. vanEeden
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