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Volume 92, Issue 2

July 15 1998

In this Issue

CONTROVERSIES IN HEMATOLOGY
RAPID COMMUNICATIONS
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSPLANTATION
CORRESPONDENCE

CONTROVERSIES IN HEMATOLOGY

A New Feature: Controversies in Hematology

Kenneth Kaushansky

View Articletitled, A New Feature: Controversies in Hematology

Lineage Commitment and Maturation in Hematopoietic Cells: The Case for Extrinsic Regulation

Donald Metcalf

View Articletitled, Lineage Commitment and Maturation in Hematopoietic Cells: The Case for Extrinsic Regulation

Do Stem Cells Play Dice?

T. Enver,C.M. Heyworth,T.M. Dexter

View Articletitled, Do Stem Cells Play Dice?

Rebuttal to Enver, Heyworth, and Dexter

View Articletitled, Rebuttal to Enver, Heyworth, and Dexter

Rebuttal to Metcalf

View Articletitled, Rebuttal to Metcalf

RAPID COMMUNICATIONS

Specific Signals Generated by the Cytoplasmic Domain of the Granulocyte Colony-Stimulating Factor (G-CSF) Receptor Are Not Required for G-CSF–Dependent Granulocytic Differentiation

Jason Jacob,Jeffery S. Haug,Sofia Raptis,Daniel C. Link

View Articletitled, Specific Signals Generated by the Cytoplasmic Domain of the Granulocyte Colony-Stimulating Factor (G-CSF) Receptor Are Not Required for G-CSF–Dependent Granulocytic Differentiation

Evidence for Circulating Bone Marrow-Derived Endothelial Cells

Qun Shi,Shahin Rafii,Moses Hong-De Wu,Errol S. Wijelath,Cong Yu,Atsushi Ishida,Yuji Fujita,Sudesh Kothari,Robert Mohle,Lester R. Sauvage,Malcom A.S. Moore,Rainer F. Storb,William P. Hammond

View Articletitled, Evidence for Circulating Bone Marrow-Derived Endothelial Cells

Transgenic Mice for MTCP1 Develop T-Cell Prolymphocytic Leukemia

Catherine Gritti,Hélène Dastot,Jean Soulier,Anne Janin,Marie-Thérèse Daniel,Ali Madani,Gisèle Grimber,Pascale Briand,François Sigaux,Marc-Henri Stern

View Articletitled, Transgenic Mice for MTCP1 Develop T-Cell Prolymphocytic Leukemia

Mutations in the E-Domain of RARα Portion of the PML/RARα Chimeric Gene May Confer Clinical Resistance to All-transRetinoic Acid in Acute Promyelocytic Leukemia

Masue Imaizumi,Hoshiro Suzuki,Miyako Yoshinari,Atsushi Sato,Toshiaki Saito,Akira Sugawara,Shigeru Tsuchiya,Yoshiro Hatae,Takeo Fujimoto,Akira Kakizuka,Tasuke Konno,Kazuie Iinuma

View Articletitled, Mutations in the E-Domain of RARα Portion of the PML/RARα Chimeric Gene May Confer Clinical Resistance to All-transRetinoic Acid in Acute Promyelocytic Leukemia

Loss of Function of the Homeobox Gene Hoxa-9 Perturbs Early T-Cell Development and Induces Apoptosis in Primitive Thymocytes

David J. Izon,Sofia Rozenfeld,Stephen T. Fong,László Kömüves,Corey Largman,H. Jeffrey Lawrence

View Articletitled, Loss of Function of the Homeobox Gene Hoxa-9 Perturbs Early T-Cell Development and Induces Apoptosis in Primitive Thymocytes

Association Between Pretransplant Interferon-α and Outcome After Unrelated Donor Marrow Transplantation for Chronic Myelogenous Leukemia in Chronic Phase

A. James Morton,Ted Gooley,John A. Hansen,Frederick R. Appelbaum,Barbara Bruemmer,Jean W. Bjerke,Reg Clift,Paul J. Martin,Effie W. Petersdorf,Jean E. Sanders,Rainer Storb,Keith M. Sullivan,Ann Woolfrey,Claudio Anasetti

View Articletitled, Association Between Pretransplant Interferon-α and Outcome After Unrelated Donor Marrow Transplantation for Chronic Myelogenous Leukemia in Chronic Phase

Blood Dendritic Cells From Myeloma Patients Are Not Infected With Kaposi's Sarcoma-Associated Herpesvirus (KSHV/HHV-8)

Qing Yi,Marianne Ekman,Doina Anton,Susanne Bergenbrant,Anders Österborg,Patrik Georgii-Hemming,Göran Holm,Kenneth Nilsson,Peter Biberfeld

View Articletitled, Blood Dendritic Cells From Myeloma Patients Are Not Infected With Kaposi's Sarcoma-Associated Herpesvirus (KSHV/HHV-8)

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

A Risk Model for Thrombocytopenia Requiring Platelet Transfusion After Cytotoxic Chemotherapy

J.Y. Blay,A. Le Cesne,C. Mermet,C. Maugard,A. Ravaud,C. Chevreau,C. Sebban,J.-P. Guastalla,P. Biron,I. Ray-Coquard,for the ELYPSE1 Study Group

View Articletitled, A Risk Model for Thrombocytopenia Requiring Platelet Transfusion After Cytotoxic Chemotherapy

Early Intensification of Intrathecal Chemotherapy Virtually Eliminates Central Nervous System Relapse in Children With Acute Lymphoblastic Leukemia

Ching-Hon Pui,Hazem H. Mahmoud,Gaston K. Rivera,Michael L. Hancock,John T. Sandlund,Frederick G. Behm,David R. Head,Mary V. Relling,Raul C. Ribeiro,Jeffrey E. Rubnitz,Larry E. Kun,William E. Evans

View Articletitled, Early Intensification of Intrathecal Chemotherapy Virtually Eliminates Central Nervous System Relapse in Children With Acute Lymphoblastic Leukemia

HEMATOPOIESIS

Granulocyte-Macrophage Colony-Stimulating Factor Rescues TF-1 Leukemia Cells From Ionizing Radiation-Induced Apoptosis Through a Pathway Mediated by Protein Kinase Cα

Mary L. Kelly,Yan Tang,Nitsa Rosensweig,Sanda Clejan,Barbara S. Beckman

View Articletitled, Granulocyte-Macrophage Colony-Stimulating Factor Rescues TF-1 Leukemia Cells From Ionizing Radiation-Induced Apoptosis Through a Pathway Mediated by Protein Kinase Cα

The Hyperresponsiveness of Cells Expressing Truncated Erythropoietin Receptors Is Contingent on Insulin-Like Growth Factor-1 in Fetal Calf Serum

Jacqueline E. Damen,Jana Krosl,Donna Morrison,Steven Pelech,Gerald Krystal

View Articletitled, The Hyperresponsiveness of Cells Expressing Truncated Erythropoietin Receptors Is Contingent on Insulin-Like Growth Factor-1 in Fetal Calf Serum

Role of GATA-1 in Proliferation and Differentiation of Definitive Erythroid and Megakaryocytic Cells In Vivo

Satoru Takahashi,Takuya Komeno,Naruyoshi Suwabe,Keigyo Yoh,Osamu Nakajima,Sigeko Nishimura,Takashi Kuroha,Toshiro Nagasawa,Masayuki Yamamoto

View Articletitled, Role of GATA-1 in Proliferation and Differentiation of Definitive Erythroid and Megakaryocytic Cells In Vivo

Erythropoietin Induces Tyrosine Phosphorylation of Jak2, STAT5A, and STAT5B in Primary Cultured Human Erythroid Precursors

Atsushi Oda,Kenichi Sawada,Brian J. Druker,Katsutoshi Ozaki,Hina Takano,Kazuki Koizumi,Yoshikazu Fukada,Makoto Handa,Takao Koike,Yasuo Ikeda

View Articletitled, Erythropoietin Induces Tyrosine Phosphorylation of Jak2, STAT5A, and STAT5B in Primary Cultured Human Erythroid Precursors

Thrombopoietin Promotes the Survival of Murine Hematopoietic Long-Term Reconstituting Cells: Comparison With the Effects of FLT3/FLK-2 Ligand and Interleukin-6

Takuya Matsunaga,Takashi Kato,Hiroshi Miyazaki,Makio Ogawa

View Articletitled, Thrombopoietin Promotes the Survival of Murine Hematopoietic Long-Term Reconstituting Cells: Comparison With the Effects of FLT3/FLK-2 Ligand and Interleukin-6

A Novel Function of Stat1α and Stat3 Proteins in Erythropoietin-Induced Erythroid Differentiation of a Human Leukemia Cell Line

Keita Kirito,Mie Uchida,Masaaki Takatoku,Koichi Nakajima,Toshio Hirano,Yasusada Miura,Norio Komatsu

View Articletitled, A Novel Function of Stat1α and Stat3 Proteins in Erythropoietin-Induced Erythroid Differentiation of a Human Leukemia Cell Line

The Induction of Megakaryocyte Differentiation Is Accompanied by Selective Ser¹³³ Phosphorylation of the Transcription Factor CREB in Both HEL Cell Line and Primary CD34⁺Cells

Giorgio Zauli,Davide Gibellini,Marco Vitale,Paola Secchiero,Claudio Celeghini,Alessandra Bassini,Sabina Pierpaoli,Marco Marchisio,Lia Guidotti,Silvano Capitani

View Articletitled, The Induction of Megakaryocyte Differentiation Is Accompanied by Selective Ser133 Phosphorylation of the Transcription Factor CREB in Both HEL Cell Line and Primary CD34+Cells

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

A Novel Asn344 Deletion in the Core Domain of Coagulation Factor XIII A Subunit: Its Effects on Protein Structure and Function

Sasichai Kangsadalampai,Gareth Chelvanayagam,Rohan T. Baker,Pa-thai Yenchitsomanus,Parichat Pung-amritt,Chularatana Mahasandana,Philip G. Board

View Articletitled, A Novel Asn344 Deletion in the Core Domain of Coagulation Factor XIII A Subunit: Its Effects on Protein Structure and Function

In Vivo Expression of Murine Platelet Glycoprotein Ibα

Hiroyuki Fujita,Yoshimi Hashimoto,Susan Russell,Barbara Zieger,Jerry Ware

View Articletitled, In Vivo Expression of Murine Platelet Glycoprotein Ibα

Mechanism and Kinetics of Factor VIII Inactivation: Study With an IgG4 Monoclonal Antibody Derived From a Hemophilia A Patient With Inhibitor

Marc G. Jacquemin,Benoı̂t G. Desqueper,Abdellah Benhida,Luc Vander Elst,Marc F. Hoylaerts,Marleen Bakkus,Kris Thielemans,Jef Arnout,Kathelijne Peerlinck,Jean Guy G. Gilles,Jos Vermylen,Jean-Marie R. Saint-Remy

View Articletitled, Mechanism and Kinetics of Factor VIII Inactivation: Study With an IgG4 Monoclonal Antibody Derived From a Hemophilia A Patient With Inhibitor

Platelet-Endothelial Cell Interactions During Ischemia/Reperfusion: The Role of P-Selectin

Steffen Massberg,Georg Enders,Rosmarie Leiderer,Simone Eisenmenger,Dietmar Vestweber,Fritz Krombach,Konrad Messmer

View Articletitled, Platelet-Endothelial Cell Interactions During Ischemia/Reperfusion: The Role of P-Selectin

High Prevalence of Serum Cryoglobulins in Multitransfused Hemophilic Patients With Chronic Hepatitis C

E. Santagostino,M. Colombo,D. Cultraro,M. Muça-Perja,A. Gringeri,P.M. Mannucci

View Articletitled, High Prevalence of Serum Cryoglobulins in Multitransfused Hemophilic Patients With Chronic Hepatitis C

Expression of P-Selectin on Hepatic Endothelia and Platelets Promoting Neutrophil Removal by Liver Macrophages

Jialan Shi,Yoshihiro Kokubo,Kenjiro Wake

View Articletitled, Expression of P-Selectin on Hepatic Endothelia and Platelets Promoting Neutrophil Removal by Liver Macrophages

Binding of Factor VIII to von Willebrand Factor Is Enabled by Cleavage of the von Willebrand Factor Propeptide and Enhanced by Formation of Disulfide-Linked Multimers

Ana Victoria Bendetowicz,Jill A. Morris,Robert J. Wise,Gary E. Gilbert,Randal J. Kaufman

View Articletitled, Binding of Factor VIII to von Willebrand Factor Is Enabled by Cleavage of the von Willebrand Factor Propeptide and Enhanced by Formation of Disulfide-Linked Multimers

IMMUNOBIOLOGY

Ig Receptor Binding Protein 1 (α4) Is Associated With a Rapamycin-Sensitive Signal Transduction in Lymphocytes Through Direct Binding to the Catalytic Subunit of Protein Phosphatase 2A

Seiji Inui,Hideki Sanjo,Kazuhiko Maeda,Hideyuki Yamamoto,Eishichi Miyamoto,Nobuo Sakaguchi

View Articletitled, Ig Receptor Binding Protein 1 (α4) Is Associated With a Rapamycin-Sensitive Signal Transduction in Lymphocytes Through Direct Binding to the Catalytic Subunit of Protein Phosphatase 2A

Role for Tyrosine Phosphorylation and Lyn Tyrosine Kinase in Fas Receptor-Mediated Apoptosis in Eosinophils

Hans-Uwe Simon,Shida Yousefi,Birgit Dibbert,Holger Hebestreit,Martina Weber,Donald R. Branch,Kurt Blaser,Francesca Levi-Schaffer,Gary P. Anderson

View Articletitled, Role for Tyrosine Phosphorylation and Lyn Tyrosine Kinase in Fas Receptor-Mediated Apoptosis in Eosinophils

Shiga Toxin Type 1 Activates Tumor Necrosis Factor-α Gene Transcription and Nuclear Translocation of the Transcriptional Activators Nuclear Factor-κB and Activator Protein-1

Ramesh Sakiri,Belakere Ramegowda,Vernon L. Tesh

View Articletitled, Shiga Toxin Type 1 Activates Tumor Necrosis Factor-α Gene Transcription and Nuclear Translocation of the Transcriptional Activators Nuclear Factor-κB and Activator Protein-1

NEOPLASIA

Telomerase Activity in Hodgkin's Disease

Karl-Fredrik Norrback,Gunilla Enblad,Martin Erlanson,Christer Sundström,Göran Roos

View Articletitled, Telomerase Activity in Hodgkin's Disease

Multiplex Reverse Transcription-Polymerase Chain Reaction for Simultaneous Screening of 29 Translocations and Chromosomal Aberrations in Acute Leukemia

Niels Pallisgaard,Peter Hokland,Dorthe C. Riishøj,Bent Pedersen,Poul Jørgensen

View Articletitled, Multiplex Reverse Transcription-Polymerase Chain Reaction for Simultaneous Screening of 29 Translocations and Chromosomal Aberrations in Acute Leukemia

Malignant Progenitors From Patients With Acute Myelogenous Leukemia Are Sensitive to a Diphtheria Toxin–Granulocyte-Macrophage Colony-Stimulating Factor Fusion Protein

Donna E. Hogge,Cheryl L. Willman,Robert J. Kreitman,Marc Berger,Philip D. Hall,Kenneth J. Kopecky,Chris McLain,Edward P. Tagge,Connie J. Eaves,Arthur E. Frankel

View Articletitled, Malignant Progenitors From Patients With Acute Myelogenous Leukemia Are Sensitive to a Diphtheria Toxin–Granulocyte-Macrophage Colony-Stimulating Factor Fusion Protein

The Reliability and Specificity of c-kit for the Diagnosis of Acute Myeloid Leukemias and Undifferentiated Leukemias

M.C. Bene,M. Bernier,R.O. Casasnovas,G. Castoldi,W. Knapp,F. Lanza,W.D. Ludwig,E. Matutes,A. Orfao,C. Sperling,M.B. van't Veer,for the European Group for the Immunological Classification of Leukemias (EGIL)

View Articletitled, The Reliability and Specificity of c-kit for the Diagnosis of Acute Myeloid Leukemias and Undifferentiated Leukemias

Epstein-Barr Virus in Nasal Lymphomas Contains Multiple Ongoing Mutations in the EBNA-1 Gene

M.I. Gutiérrez,G. Spangler,D. Kingma,M. Raffeld,I. Guerrero,O. Misad,E.S. Jaffe,I.T. Magrath,K. Bhatia

View Articletitled, Epstein-Barr Virus in Nasal Lymphomas Contains Multiple Ongoing Mutations in the EBNA-1 Gene

Impaired Granulocytic Differentiation In Vitro in Hematopoietic Cells Lacking Retinoic Acid Receptors α1 and γ

Jean Labrecque,Deborah Allan,Pierre Chambon,Norman N. Iscove,David Lohnes,Trang Hoang

View Articletitled, Impaired Granulocytic Differentiation In Vitro in Hematopoietic Cells Lacking Retinoic Acid Receptors α1 and γ

PHAGOCYTES

Lack of Clinically Significant Contact System Activation During Platelet Concentrate Filtration by Leukocyte Removal Filters

Cheryl F. Scott,Harvey Brandwein,John Whitbread,Robert W. Colman

View Articletitled, Lack of Clinically Significant Contact System Activation During Platelet Concentrate Filtration by Leukocyte Removal Filters

Regulation and Processing of a Precursor Form of Eosinophil Granule Major Basic Protein (ProMBP) in Differentiating Eosinophils

Pamela Popken-Harris,James Checkel,David Loegering,Benjamin Madden,Margaret Springett,Gail Kephart,Gerald J. Gleich

View Articletitled, Regulation and Processing of a Precursor Form of Eosinophil Granule Major Basic Protein (ProMBP) in Differentiating Eosinophils

RED CELLS

The Iron Chelator L1 Potentiates Oxidative DNA Damage in Iron-Loaded Liver Cells

Louise Cragg,Robert P. Hebbel,Wesley Miller,Alex Solovey,Scott Selby,Helen Enright

View Articletitled, The Iron Chelator L1 Potentiates Oxidative DNA Damage in Iron-Loaded Liver Cells

Molecular Defects of the RHCE Gene in Rh-Deficient Individuals of the Amorph Type

Baya Chérif-Zahar,Giorgio Matassi,Virginie Raynal,Pierre Gane,Wolfgang Mempel,Carmen Perez,Jean-Pierre Cartron

View Articletitled, Molecular Defects of the RHCE Gene in Rh-Deficient Individuals of the Amorph Type

Six Previously Undescribed Pyruvate Kinase Mutations Causing Enzyme Deficiency

Anna Demina,Kottayil I. Varughese,José Barbot,Linda Forman,Ernest Beutler

View Articletitled, Six Previously Undescribed Pyruvate Kinase Mutations Causing Enzyme Deficiency

Full Activity From Human β-Globin Locus Control Region Transgenes Requires 5′HS1, Distal β-Globin Promoter, and 3′ β-Globin Sequences

Peter Pasceri,Dylan Pannell,Xiumei Wu,James Ellis

View Articletitled, Full Activity From Human β-Globin Locus Control Region Transgenes Requires 5′HS1, Distal β-Globin Promoter, and 3′ β-Globin Sequences

Rh_null Disease: The Amorph Type Results From a Novel Double Mutation in RhCe Gene on D-Negative Background

Cheng-Han Huang,Ying Chen,Marion E. Reid,Christine Seidl

View Articletitled, Rhnull Disease: The Amorph Type Results From a Novel Double Mutation in RhCe Gene on D-Negative Background

TRANSPLANTATION

Cytosine Deaminase Adenoviral Vector and 5-Fluorocytosine Selectively Reduce Breast Cancer Cells 1 Million-Fold When They Contaminate Hematopoietic Cells: A Potential Purging Method for Autologous Transplantation

F. Garcia-Sanchez,G. Pizzorno,S.Q. Fu,T. Nanakorn,D.S. Krause,J. Liang,E. Adams,J.J. Leffert,L.H. Yin,M.R. Cooperberg,E. Hanania,W.L. Wang,J.H. Won,X.Y. Peng,R. Cote,R. Brown,B. Burtness,R. Giles,R. Crystal,A.B. Deisseroth

View Articletitled, Cytosine Deaminase Adenoviral Vector and 5-Fluorocytosine Selectively Reduce Breast Cancer Cells 1 Million-Fold When They Contaminate Hematopoietic Cells: A Potential Purging Method for Autologous Transplantation

Detection of Microchimerism After Allogeneic Blood Transfusion Using Nested Polymerase Chain Reaction Amplification With Sequence-Specific Primers (PCR-SSP): A Cautionary Tale

Anthony S. Carter,Mike Bunce,Lucia Cerundolo,Ken I. Welsh,Peter J. Morris,Susan V. Fuggle

View Articletitled, Detection of Microchimerism After Allogeneic Blood Transfusion Using Nested Polymerase Chain Reaction Amplification With Sequence-Specific Primers (PCR-SSP): A Cautionary Tale

Role of Class-II Major Histocompatibility Complex (MHC)-Antigen–Positive Donor Leukocytes in Transfusion-Induced Alloimmunization to Donor Class-I MHC Antigens

K.J. Kao,M.L.U. del Rosario

View Articletitled, Role of Class-II Major Histocompatibility Complex (MHC)-Antigen–Positive Donor Leukocytes in Transfusion-Induced Alloimmunization to Donor Class-I MHC Antigens

CORRESPONDENCE

Prognostic Value of Cytogenetics and Multidrug Resistance (MDR1) in Elderly Patients With Acute Myeloid Leukemia

Roberto Stasi,Giovanni Del Poeta,Adriano Venditti,Mario Masi,Elisa Stipa,Maria Christina Cox,Sergio Amadori

View Articletitled, Prognostic Value of Cytogenetics and Multidrug Resistance (MDR1) in Elderly Patients With Acute Myeloid Leukemia

Biological Features of Acute Myeloid Leukemia in the Elderly

Adriano Venditti,Giovanni Del Poeta,Francesco Buccisano,Anna Tamburini,Maria Christina Cox-Froncillo,Antonio Bruno,Beatrice Del Moro,Anna Maria Epiceno,M. Masi,Sergio Amadori,Roberto Stasi

View Articletitled, Biological Features of Acute Myeloid Leukemia in the Elderly

A Case of Wiskott-Aldrich Syndrome With Dual Mutations in Exon 10 of the WASP Gene: An Additional De Novo One-Base Insertion, Which Restores Frame Shift Due to an Inherent One-Base Deletion, Detected in the Major Population of the Patient's Peripheral Blood Lymphocytes

Tadashi Ariga,Masafumi Yamada,Yukio Sakiyama,Osamu Tatsuzawa

View Articletitled, A Case of Wiskott-Aldrich Syndrome With Dual Mutations in Exon 10 of the WASP Gene: An Additional De Novo One-Base Insertion, Which Restores Frame Shift Due to an Inherent One-Base Deletion, Detected in the Major Population of the Patient's Peripheral Blood Lymphocytes

c-kit Activating Mutations and Mast Cell Proliferation in Human Leukemia

A. Beghini,L. Larizza,R. Cairoli,E. Morra

View Articletitled, c-kit Activating Mutations and Mast Cell Proliferation in Human Leukemia

The Role of Factor XII in Contact System Activation

C. Erik Hack

View Articletitled, The Role of Factor XII in Contact System Activation

The Prothrombin G20210A Mutation and Factor V Leiden Mutation in Patients With Cerebrovascular Disease

Wolfgang Lalouschek,Susanne Aull,Wolfgang Series,Karl Zeiler,Christine Mannhalter

View Articletitled, The Prothrombin G20210A Mutation and Factor V Leiden Mutation in Patients With Cerebrovascular Disease

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