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Volume 92, Issue 12

December 15 1998

In this Issue

REVIEW ARTICLES
RAPID COMMUNICATIONS
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
PHOTOGRAPH
TRANSPLANTATION
CORRESPONDENCE

REVIEW ARTICLES

Emerging Applications of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor

James O. Armitage

View Articletitled, Emerging Applications of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor

RAPID COMMUNICATIONS

In Vitro Reconstitution of Human B-Cell Ontogeny: From CD34⁺ Multipotent Progenitors to Ig-Secreting Cells

Anne-Catherine Fluckiger,Eva Sanz,Maria Garcia-Lloret,Thomas Su,Qian-Lin Hao,Roberta Kato,Shirley Quan,Antonio de la Hera,Gay M. Crooks,Owen N. Witte,David J. Rawlings

View Articletitled, In Vitro Reconstitution of Human B-Cell Ontogeny: From CD34+ Multipotent Progenitors to Ig-Secreting Cells

Progressive and Persistent Downregulation of Surface CXCR4 in CD4⁺ T Cells Infected With Human Herpesvirus 7

Paola Secchiero,Davide Zella,Oxana Barabitskaja,Marvin S. Reitz,Silvano Capitani,Robert C. Gallo,Giorgio Zauli

View Articletitled, Progressive and Persistent Downregulation of Surface CXCR4 in CD4+ T Cells Infected With Human Herpesvirus 7

Stat6 Inhibits Human Interleukin-4 Promoter Activity in T Cells

Steve N. Georas,John E. Cumberland,Thomas F. Burke,Rongbing Chen,Ulrike Schindler,Vincenzo Casolaro

View Articletitled, Stat6 Inhibits Human Interleukin-4 Promoter Activity in T Cells

Critical Requirement for Graft Passenger Leukocytes in Allograft Tolerance Induced by Donor Blood Transfusion

Régis Josien,Michèle Heslan,Sophie Brouard,Jean-Paul Soulillou,Maria-Cristina Cuturi

View Articletitled, Critical Requirement for Graft Passenger Leukocytes in Allograft Tolerance Induced by Donor Blood Transfusion

Blood Cells With Reduced Mitochondrial Membrane Potential and Cytosolic Cytochrome C Can Survive and Maintain Clonogenicity Given Appropriate Signals to Suppress Apoptosis

Quan Chen,Naoshi Takeyama,Ged Brady,Alastair J.M. Watson,Caroline Dive

View Articletitled, Blood Cells With Reduced Mitochondrial Membrane Potential and Cytosolic Cytochrome C Can Survive and Maintain Clonogenicity Given Appropriate Signals to Suppress Apoptosis

A Missense Mutation in γ-Glutamyl Carboxylase Gene Causes Combined Deficiency of All Vitamin K-Dependent Blood Coagulation Factors

Benjamin Brenner,Beatriz Sánchez-Vega,Sheue-Mei Wu,Naomi Lanir,Darrel W. Stafford,Jesus Solera

View Articletitled, A Missense Mutation in γ-Glutamyl Carboxylase Gene Causes Combined Deficiency of All Vitamin K-Dependent Blood Coagulation Factors

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Moderate Dose Escalation for Advanced Stage Hodgkin’s Disease Using the Bleomycin, Etoposide, Adriamycin, Cyclophosphamide, Vincristine, Procarbazine, and Prednisone Scheme and Adjuvant Radiotherapy: A Study of the German Hodgkin’s Lymphoma Study Group

H. Tesch,V. Diehl,B. Lathan,D. Hasenclever,M. Sieber,U. Rüffer,A. Engert,J. Franklin,M. Pfreundschuh,K.P. Schalk,G. Schwieder,G. Wulf,G. Dölken,P. Worst,P. Koch,N. Schmitz,U. Bruntsch,C. Tirier,U. Müller,M. Loeffler,for the German Hodgkin’s Lymphoma Study Group (Chairman Prof V. Diehl)

View Articletitled, Moderate Dose Escalation for Advanced Stage Hodgkin’s Disease Using the Bleomycin, Etoposide, Adriamycin, Cyclophosphamide, Vincristine, Procarbazine, and Prednisone Scheme and Adjuvant Radiotherapy: A Study of the German Hodgkin’s Lymphoma Study Group

Norethisterone Treatment, a Major Risk-Factor for Veno-Occlusive Disease in the Liver After Allogeneic Bone Marrow Transplantation

Hans Hägglund,Mats Remberger,Sven Klaesson,Berit Lönnqvist,Per Ljungman,Olle Ringdén

View Articletitled, Norethisterone Treatment, a Major Risk-Factor for Veno-Occlusive Disease in the Liver After Allogeneic Bone Marrow Transplantation

Pregnancy-Associated Thrombocytopenia Revisited: Assessment and Follow-Up of 50 Cases

Nadine Ajzenberg,Marie Dreyfus,Cécile Kaplan,Jeannine Yvart,Bernard Weill,Gil Tchernia

View Articletitled, Pregnancy-Associated Thrombocytopenia Revisited: Assessment and Follow-Up of 50 Cases

Improving the Outcome of Bone Marrow Transplantation by Using CD52 Monoclonal Antibodies to Prevent Graft-Versus-Host Disease and Graft Rejection

Geoff Hale,Mei-Jie Zhang,Donald Bunjes,H. Grant Prentice,David Spence,Mary M. Horowitz,A. John Barrett,Herman Waldmann

View Articletitled, Improving the Outcome of Bone Marrow Transplantation by Using CD52 Monoclonal Antibodies to Prevent Graft-Versus-Host Disease and Graft Rejection

GENE THERAPY

Adenovirus Vector-Based Purging of Multiple Myeloma Cells

Gerrard Teoh,Ling Chen,Mitsuyoshi Urashima,Yu-Tzu Tai,Leo A. Celi,Dongshu Chen,Dharminder Chauhan,Atsushi Ogata,Robert W. Finberg,Iain J. Webb,Donald W. Kufe,Kenneth C. Anderson

View Articletitled, Adenovirus Vector-Based Purging of Multiple Myeloma Cells

HEMATOPOIESIS

The Human Poliovirus Receptor Related 2 Protein Is a New Hematopoietic/Endothelial Homophilic Adhesion Molecule

Marc Lopez,Mustapha Aoubala,François Jordier,Daniel Isnardon,Sophie Gomez,Patrice Dubreuil

View Articletitled, The Human Poliovirus Receptor Related 2 Protein Is a New Hematopoietic/Endothelial Homophilic Adhesion Molecule

Adhesion to Fibronectin Maintains Regenerative Capacity During Ex Vivo Culture and Transduction of Human Hematopoietic Stem and Progenitor Cells

M.A. Dao,K. Hashino,I. Kato,J.A. Nolta

View Articletitled, Adhesion to Fibronectin Maintains Regenerative Capacity During Ex Vivo Culture and Transduction of Human Hematopoietic Stem and Progenitor Cells

Expression Trapping: Identification of Novel Genes Expressed in Hematopoietic and Endothelial Lineages by Gene Trapping in ES Cells

William L. Stanford,Georgina Caruana,Katherine A. Vallis,Maneesha Inamdar,Michihiro Hidaka,Victoria L. Bautch,Alan Bernstein

View Articletitled, Expression Trapping: Identification of Novel Genes Expressed in Hematopoietic and Endothelial Lineages by Gene Trapping in ES Cells

Human Granulocyte Colony-Stimulating Factor (G-CSF) Stimulates the In Vitro and In Vivo Development But Not Commitment of Primitive Multipotential Progenitors From Transgenic Mice Expressing the Human G-CSF Receptor

Feng-Chun Yang,Sumiko Watanabe,Kohichiro Tsuji,Ming-jiang Xu,Azusa Kaneko,Yasuhiro Ebihara,Tatsutoshi Nakahata

View Articletitled, Human Granulocyte Colony-Stimulating Factor (G-CSF) Stimulates the In Vitro and In Vivo Development But Not Commitment of Primitive Multipotential Progenitors From Transgenic Mice Expressing the Human G-CSF Receptor

Structurally Specific Heparan Sulfates Support Primitive Human Hematopoiesis by Formation of a Multimolecular Stem Cell Niche

Pankaj Gupta,Theodore R. Oegema, Jr,Joseph J. Brazil,Arkadiusz Z. Dudek,Arne Slungaard,Catherine M. Verfaillie

View Articletitled, Structurally Specific Heparan Sulfates Support Primitive Human Hematopoiesis by Formation of a Multimolecular Stem Cell Niche

Thrombopoietin Induces Association of Crkl With STAT5 But Not STAT3 in Human Platelets

Katsutoshi Ozaki,Atsushi Oda,Hiroshi Wakao,Jennifer Rhodes,Brian J. Druker,Akaru Ishida,Masatoshi Wakui,Shinichiro Okamoto,Kayo Morita,Makoto Handa,Norio Komatsu,Hideya Ohashi,Atsushi Miyajima,Yasuo Ikeda

View Articletitled, Thrombopoietin Induces Association of Crkl With STAT5 But Not STAT3 in Human Platelets

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

A Novel Mutation in the D3 Domain of von Willebrand Factor Markedly Decreases Its Ability to Bind Factor VIII and Affects Its Multimerization

S. Jorieux,C. Gaucher,J. Goudemand,C. Mazurier

View Articletitled, A Novel Mutation in the D3 Domain of von Willebrand Factor Markedly Decreases Its Ability to Bind Factor VIII and Affects Its Multimerization

Impaired Cotranslational Processing as a Mechanism for Type I Antithrombin Deficiency

Alison C. Fitches,Ruth Appleby,David A. Lane,Valerio De Stefano,Giuseppe Leone,Robin J. Olds

View Articletitled, Impaired Cotranslational Processing as a Mechanism for Type I Antithrombin Deficiency

Cloning of the Promoter Region of Human Endoglin, the Target Gene for Hereditary Hemorrhagic Telangiectasia Type 1

Carlos Rı́us,Joshua D. Smith,Nuria Almendro,Carmen Langa,Luisa M. Botella,Douglas A. Marchuk,Calvin P.H. Vary,Carmelo Bernabéu

View Articletitled, Cloning of the Promoter Region of Human Endoglin, the Target Gene for Hereditary Hemorrhagic Telangiectasia Type 1

Differential Leukocyte Recruitment From Whole Blood Via Endothelial Adhesion Molecules Under Shear Conditions

Paul H. Reinhardt,Paul Kubes

View Articletitled, Differential Leukocyte Recruitment From Whole Blood Via Endothelial Adhesion Molecules Under Shear Conditions

Functional Cooperation of Cyclin C and c-Myc in Mediating Homotypic Cell Adhesion Via Very Late Antigen-4 Activation and Vascular Cell Adhesion Molecule-1 Induction

Zhao-Jun Liu,Yoshiya Tanaka,Shinichiro Mine,Akio Morinobu,Hideo Yagita,Ko Okumura,Tadatsugu Taniguchi,Hirohei Yamamura,Yasuhiro Minami

View Articletitled, Functional Cooperation of Cyclin C and c-Myc in Mediating Homotypic Cell Adhesion Via Very Late Antigen-4 Activation and Vascular Cell Adhesion Molecule-1 Induction

Truncation of Glycoprotein (GP) IIIa (▵ 616-762) Prevents Complex Formation With GPIIb: Novel Mutation in Exon 11 of GPIIIa Associated With Thrombasthenia

Milagros Ferrer,Jianming Tao,Gema Iruı́n,Matilde Sánchez-Ayuso,José González-Rodrı́guez,Roberto Parrilla,Consuelo González-Manchón

View Articletitled, Truncation of Glycoprotein (GP) IIIa (▵ 616-762) Prevents Complex Formation With GPIIb: Novel Mutation in Exon 11 of GPIIIa Associated With Thrombasthenia

Structural Studies of Fibrinolysis by Electron Microscopy

Yuri Veklich,Charles W. Francis,Janice White,John W. Weisel

View Articletitled, Structural Studies of Fibrinolysis by Electron Microscopy

Multiple Forms of Angiostatin Induce Apoptosis in Endothelial Cells

R. Lucas,L. Holmgren,I. Garcia,B. Jimenez,S.J. Mandriota,F. Borlat,B.K.L. Sim,Z. Wu,G.E. Grau,Y. Shing,G.A. Soff,N. Bouck,M.S. Pepper

View Articletitled, Multiple Forms of Angiostatin Induce Apoptosis in Endothelial Cells

IMMUNOBIOLOGY

Interleukin-10 Suppresses IP-10 Gene Transcription by Inhibiting the Production of Class I Interferon

Julie M. Tebo,Hee Sun Kim,Jing Gao,David A. Armstrong,Thomas A. Hamilton

View Articletitled, Interleukin-10 Suppresses IP-10 Gene Transcription by Inhibiting the Production of Class I Interferon

Immunotherapy of B-Cell Lymphoma With CD3x19 Bispecific Antibodies: Costimulation via CD28 Prevents “Veto” Apoptosis of Antibody-Targeted Cytotoxic T Cells

Peter T. Daniel,Arne Kroidl,Joachim Kopp,Isrid Sturm,Gerhard Moldenhauer,Bernd Dörken,Antonio Pezzutto

View Articletitled, Immunotherapy of B-Cell Lymphoma With CD3x19 Bispecific Antibodies: Costimulation via CD28 Prevents “Veto” Apoptosis of Antibody-Targeted Cytotoxic T Cells

NEOPLASIA

Lineage Involvement of Stem Cells Bearing the Philadelphia Chromosome in Chronic Myeloid Leukemia in the Chronic Phase as Shown by a Combination of Fluorescence-Activated Cell Sorting and Fluorescence In Situ Hybridization

Naoto Takahashi,Ikuo Miura,Kohki Saitoh,Akira B. Miura

View Articletitled, Lineage Involvement of Stem Cells Bearing the Philadelphia Chromosome in Chronic Myeloid Leukemia in the Chronic Phase as Shown by a Combination of Fluorescence-Activated Cell Sorting and Fluorescence In Situ Hybridization

Prevalence of Antibodies Against Proteins Derived From Leukemia Cells in Patients With Chronic Myeloid Leukemia

Min Ling,Yue-Jin Wen,Seah H. Lim

View Articletitled, Prevalence of Antibodies Against Proteins Derived From Leukemia Cells in Patients With Chronic Myeloid Leukemia

Dysregulation of CD95/CD95 Ligand-Apoptotic Pathway in CD3⁺ Large Granular Lymphocyte Leukemia

Thierry Lamy,Jin Hong Liu,Terry H. Landowski,William S. Dalton,Thomas P. Loughran, Jr

View Articletitled, Dysregulation of CD95/CD95 Ligand-Apoptotic Pathway in CD3+ Large Granular Lymphocyte Leukemia

Inhibition of the Differentiation of Dendritic Cells From CD34⁺ Progenitors by Tumor Cells: Role of Interleukin-6 and Macrophage Colony-Stimulating Factor

C. Menetrier-Caux,G. Montmain,M.C. Dieu,C. Bain,M.C. Favrot,C. Caux,J.Y. Blay

View Articletitled, Inhibition of the Differentiation of Dendritic Cells From CD34+ Progenitors by Tumor Cells: Role of Interleukin-6 and Macrophage Colony-Stimulating Factor

Incidence of TEL/AML1 Fusion in Children With Relapsed Acute Lymphoblastic Leukemia

Mignon L. Loh,Lewis B. Silverman,Mary L. Young,Donna Neuberg,Todd R. Golub,Stephen E. Sallan,D. Gary Gilliland

View Articletitled, Incidence of TEL/AML1 Fusion in Children With Relapsed Acute Lymphoblastic Leukemia

An Activating Mutation in the Kit Receptor Abolishes the Stroma Requirement for Growth of ELM Erythroleukemia Cells, But Does Not Prevent Their Differentiation in Response to Erythropoietin

Nick R. Leslie,Jim O’Prey,Chris Bartholomew,Paul R. Harrison

View Articletitled, An Activating Mutation in the Kit Receptor Abolishes the Stroma Requirement for Growth of ELM Erythroleukemia Cells, But Does Not Prevent Their Differentiation in Response to Erythropoietin

PHAGOCYTES

Involvement of Caspases in Neutrophil Apoptosis: Regulation by Reactive Oxygen Species

Bengt Fadeel,Anders Åhlin,Jan-Inge Henter,Sten Orrenius,Mark B. Hampton

View Articletitled, Involvement of Caspases in Neutrophil Apoptosis: Regulation by Reactive Oxygen Species

Adhesion-Dependent Release of Elastase From Human Neutrophils in a Novel, Flow-Based Model: Specificity of Different Chemotactic Agents

G. Ed Rainger,Andrew F. Rowley,Gerard B. Nash

View Articletitled, Adhesion-Dependent Release of Elastase From Human Neutrophils in a Novel, Flow-Based Model: Specificity of Different Chemotactic Agents

Interleukin-15 (IL-15) Induces NF-κB Activation and IL-8 Production in Human Neutrophils

Patrick P. McDonald,Maria Pia Russo,Silvano Ferrini,Marco A. Cassatella

View Articletitled, Interleukin-15 (IL-15) Induces NF-κB Activation and IL-8 Production in Human Neutrophils

RED CELLS

Characterization of Seven Low Incidence Blood Group Antigens Carried by Erythrocyte Band 3 Protein: Presented in part at the 49th Annual Meeting of the American Association of Blood Banks, Orlando, FL, October 6-10, 1996.

P. Jarolim,H.L. Rubin,D. Zakova,J. Storry,M.E. Reid

View Articletitled, Characterization of Seven Low Incidence Blood Group Antigens Carried by Erythrocyte Band 3 Protein: Presented in part at the 49th Annual Meeting of the American Association of Blood Banks, Orlando, FL, October 6-10, 1996.

Two Distinct Pathways Mediate the Formation of Intermediate Density Cells and Hyperdense Cells From Normal Density Sickle Red Blood Cells

Robert S. Schwartz,Sylvia Musto,Mary E. Fabry,Ronald L. Nagel

View Articletitled, Two Distinct Pathways Mediate the Formation of Intermediate Density Cells and Hyperdense Cells From Normal Density Sickle Red Blood Cells

Hematopoietic Cells From -Spectrin–Deficient Mice Are Sufficient to Induce Thrombotic Events in Hematopoietically Ablated Recipients

Nancy J. Wandersee,John C. Lee,Tamma M. Kaysser,Roderick T. Bronson,Jane E. Barker

View Articletitled, Hematopoietic Cells From -Spectrin–Deficient Mice Are Sufficient to Induce Thrombotic Events in Hematopoietically Ablated Recipients

PHOTOGRAPH

Photograph

View Articletitled, Photograph

TRANSPLANTATION

Molecular Typing Shows a High Level of HLA Class I Incompatibility in Serologically Well Matched Donor/Patient Pairs: Implications for Unrelated Bone Marrow Donor Selection

Iain Scott,John O’Shea,Mike Bunce,Jean-Marie Tiercy,J. Rafael Argüello,Helen Firman,John Goldman,H. Grant Prentice,Ann-Margaret Little,J. Alejandro Madrigal

View Articletitled, Molecular Typing Shows a High Level of HLA Class I Incompatibility in Serologically Well Matched Donor/Patient Pairs: Implications for Unrelated Bone Marrow Donor Selection

CORRESPONDENCE

Methemoglobinemia Secondary to Clofazimine Treatment for Chronic Graft-Versus-Host Disease

Vaneuza de A. Moreira,Bruno C. De Medeiros,Carmen M.S. Bonfim,Ricardo Pasquini,Carlos R. De Medeiros

View Articletitled, Methemoglobinemia Secondary to Clofazimine Treatment for Chronic Graft-Versus-Host Disease

Bone Marrow Transplantation, Fetal B-Cell Repertoire Development, and the Mechanism of Immune Reconstitution

F.M. Raaphorst

View Articletitled, Bone Marrow Transplantation, Fetal B-Cell Repertoire Development, and the Mechanism of Immune Reconstitution

Distribution of GPIb on and in Resting Platelets

Ginés Escolar,James G. White

View Articletitled, Distribution of GPIb on and in Resting Platelets

TT Virus Viremia and Liver Transplantation: No Significant Increase of the Prevalence

Matthias Schröter,Heinz-Hubert Feucht,Peter Schäfer,Bernhard Zöllner,Rainer Laufs,Lutz Fischer,Bärbel Knödler

View Articletitled, TT Virus Viremia and Liver Transplantation: No Significant Increase of the Prevalence

Quality Issue: Marrow Interpretations

Neil Abramson

View Articletitled, Quality Issue: Marrow Interpretations

Oral Cobalamin Therapy in Patients Who Absorb It Normally

Ralph Carmel

View Articletitled, Oral Cobalamin Therapy in Patients Who Absorb It Normally

Expression of p53, Bcl-2, and Bax in CD34⁺ Cells Recovering After Chemotherapy

Luciana Teofili,Sergio Rutella,Rossana Putzulu,Carlo Rumi,Giuseppe Leone,Luigi Maria Larocca,Nicola Maggiano

View Articletitled, Expression of p53, Bcl-2, and Bax in CD34+ Cells Recovering After Chemotherapy

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