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Volume 92, Issue 11

December 1 1998

In this Issue

REVIEW ARTICLES
RAPID COMMUNICATIONS
CHEMOKINES
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
PHOTOGRAPH
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSFUSION MEDICINE
TRANSPLANTATION
CORRESPONDENCE

REVIEW ARTICLES

The Life Cycle of Coagulation Factor VIII in View of Its Structure and Function

Peter J. Lenting,Jan A. van Mourik,Koen Mertens

View Articletitled, The Life Cycle of Coagulation Factor VIII in View of Its Structure and Function

RAPID COMMUNICATIONS

FcγRIII (CD16)-Deficient Mice Show IgG Isotype-Dependent Protection to Experimental Autoimmune Hemolytic Anemia

Dirk Meyer,Carsten Schiller,Jürgen Westermann,Shozo Izui,Wouter L. W. Hazenbos,J. Sjef Verbeek,Reinhold E. Schmidt,J. Engelbert Gessner

View Articletitled, FcγRIII (CD16)-Deficient Mice Show IgG Isotype-Dependent Protection to Experimental Autoimmune Hemolytic Anemia

The t(3;21) Fusion Product, AML1/Evi-1, Interacts With Smad3 and Blocks Transforming Growth Factor-β–Mediated Growth Inhibition of Myeloid Cells

Mineo Kurokawa,Kinuko Mitani,Yoichi Imai,Seishi Ogawa,Yoshio Yazaki,Hisamaru Hirai

View Articletitled, The t(3;21) Fusion Product, AML1/Evi-1, Interacts With Smad3 and Blocks Transforming Growth Factor-β–Mediated Growth Inhibition of Myeloid Cells

Highly Efficient Transduction of the Green Fluorescent Protein Gene in Human Umbilical Cord Blood Stem Cells Capable of Cobblestone Formation in Long-Term Cultures and Multilineage Engraftment of Immunodeficient Mice

Paula B. van Hennik,Monique M.A. Verstegen,Marti F.A. Bierhuizen,Ana Limón,Albertus W. Wognum,José A. Cancelas,Jordi Barquinero,Rob E. Ploemacher,Gerard Wagemaker

View Articletitled, Highly Efficient Transduction of the Green Fluorescent Protein Gene in Human Umbilical Cord Blood Stem Cells Capable of Cobblestone Formation in Long-Term Cultures and Multilineage Engraftment of Immunodeficient Mice

Thrombopoietin Production Is Inhibited by a Translational Mechanism

Nico Ghilardi,Adrian Wiestner,Radek C. Skoda

View Articletitled, Thrombopoietin Production Is Inhibited by a Translational Mechanism

Molecular Cytogenetic Characterization of a Critical Region in Bands 7q35-q36 Commonly Deleted in Malignant Myeloid Disorders

Konstanze Döhner,Jill Brown,Ute Hehmann,Claudia Hetzel,Janet Stewart,Gordon Lowther,Claudia Scholl,Stefan Fröhling,Antonio Cuneo,Lap C. Tsui,Peter Lichter,Stephen W. Scherer,Hartmut Döhner

View Articletitled, Molecular Cytogenetic Characterization of a Critical Region in Bands 7q35-q36 Commonly Deleted in Malignant Myeloid Disorders

CHEMOKINES

The Viral Chemokine Macrophage Inflammatory Protein-II Is a Selective Th2 Chemoattractant

S. Sozzani,W. Luini,G. Bianchi,P. Allavena,T.N.C. Wells,M. Napolitano,G. Bernardini,A. Vecchi,D. D’Ambrosio,D. Mazzeo,F. Sinigaglia,A. Santoni,E. Maggi,S. Romagnani,A. Mantovani

View Articletitled, The Viral Chemokine Macrophage Inflammatory Protein-II Is a Selective Th2 Chemoattractant

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Marginal Benefit/Disadvantage of Granulocyte Colony-Stimulating Factor Therapy After Autologous Blood Stem Cell Transplantation in Children: Results of a Prospective Randomized Trial

Yoshifumi Kawano,Yoichi Takaue,Junichi Mimaya,Yasuo Horikoshi,Tsutomu Watanabe,Takanori Abe,Yukitoshi Shimizu,Takeji Matsushita,Atsushi Kikuta,Arata Watanabe,Asayuki Iwai,Etsuro Ito,Mikiya Endo,Nobuyuki Kodani,Shigeru Ohta,Kazuo Gushi,Hiroshi Azuma,Takao Etoh,Yasuhiro Okamoto,Koji Amano,Hiroyoshi Hattori,Haruhiko Eguchi,Yasuhiro Kuroda,for the Japanese Cooperative Study Group of PBSCT

View Articletitled, Marginal Benefit/Disadvantage of Granulocyte Colony-Stimulating Factor Therapy After Autologous Blood Stem Cell Transplantation in Children: Results of a Prospective Randomized Trial

The Costs and Cost-Effectiveness of Unrelated Donor Bone Marrow Transplantation for Chronic Phase Chronic Myelogenous Leukemia

Stephanie J. Lee,Claudio Anasetti,Karen M. Kuntz,Jonathan Patten,Joseph H. Antin,Jane C. Weeks

View Articletitled, The Costs and Cost-Effectiveness of Unrelated Donor Bone Marrow Transplantation for Chronic Phase Chronic Myelogenous Leukemia

Congenital Erythropoietic Porphyria Successfully Treated by Allogeneic Bone Marrow Transplantation

I. Tezcan,W. Xu,A. Gurgey,M. Tuncer,M. Cetin,C. Öner,S. Yetgin,F. Ersoy,G. Aizencang,K.H. Astrin,R.J. Desnick

View Articletitled, Congenital Erythropoietic Porphyria Successfully Treated by Allogeneic Bone Marrow Transplantation

Response at Three Months Is a Good Predictive Factor for Newly Diagnosed Chronic Myeloid Leukemia Patients Treated by Recombinant Interferon-: Presented in part at the 38th annual meeting of the American Society of Hematology, Orlando, FL, December 6-10, 1996.

F.X. Mahon,C. Fabères,S. Pueyo,P. Cony-Makhoul,R. Salmi,J.M. Boiron,G. Marit,C. Bilhou-Nabera,A. Carrère,M. Montastruc,A. Pigneux,Ph. Bernard,J. Reiffers

View Articletitled, Response at Three Months Is a Good Predictive Factor for Newly Diagnosed Chronic Myeloid Leukemia Patients Treated by Recombinant Interferon-: Presented in part at the 38th annual meeting of the American Society of Hematology, Orlando, FL, December 6-10, 1996.

A Phase II Study of BTI-322, a Monoclonal Anti-CD2 Antibody, for Treatment of Steroid-Resistant Acute Graft-Versus-Host Disease

Donna Przepiorka,Gordon L. Phillips,Voravit Ratanatharathorn,Michele Cottler-Fox,Laurie H. Sehn,Joseph H. Antin,Donna LeBherz,Michel Awwad,James Hope,J. Bruce McClain

View Articletitled, A Phase II Study of BTI-322, a Monoclonal Anti-CD2 Antibody, for Treatment of Steroid-Resistant Acute Graft-Versus-Host Disease

Minimal Residual Disease Status Before Allogeneic Bone Marrow Transplantation Is an Important Determinant of Successful Outcome for Children and Adolescents With Acute Lymphoblastic Leukemia

Christopher J.C. Knechtli,Nicholas J. Goulden,Jeremy P. Hancock,Victoria L.G. Grandage,Emma L. Harris,Russell J. Garland,Claire G. Jones,Anthony W. Rowbottom,Linda P. Hunt,Ann F. Green,Emer Clarke,Alan W. Lankester,Jacqueline M. Cornish,Derwood H. Pamphilon,Colin G. Steward,Anthony Oakhill

View Articletitled, Minimal Residual Disease Status Before Allogeneic Bone Marrow Transplantation Is an Important Determinant of Successful Outcome for Children and Adolescents With Acute Lymphoblastic Leukemia

PHOTOGRAPH

Photograph

View Articletitled, Photograph

GENE THERAPY

Enhanced Retroviral Transduction of 5-Fluorouracil–Resistant Human Bone Marrow (Stem) Cells Using a Genetically Modified Packaging Cell Line

Joanna Povey,Nishanthi Weeratunge,Chloe Marden,Amita Sehgal,Adrian Thrasher,Colin Casimir

View Articletitled, Enhanced Retroviral Transduction of 5-Fluorouracil–Resistant Human Bone Marrow (Stem) Cells Using a Genetically Modified Packaging Cell Line

γc Gene Transfer in the Presence of Stem Cell Factor, FLT-3L, Interleukin-7 (IL-7), IL-1, and IL-15 Cytokines Restores T-Cell Differentiation From γc(−) X-Linked Severe Combined Immunodeficiency Hematopoietic Progenitor Cells in Murine Fetal Thymic Organ Cultures

S. Hacein-Bey,G. De Saint Basile,J. Lemerle,A. Fischer,M. Cavazzana-Calvo

View Articletitled, γc Gene Transfer in the Presence of Stem Cell Factor, FLT-3L, Interleukin-7 (IL-7), IL-1, and IL-15 Cytokines Restores T-Cell Differentiation From γc(−) X-Linked Severe Combined Immunodeficiency Hematopoietic Progenitor Cells in Murine Fetal Thymic Organ Cultures

HEMATOPOIESIS

Influence of Cytokines on the Growth Kinetics and Immunophenotype of Daughter Cells Resulting From the First Division of Single CD34⁺Thy-1⁺lin⁻ Cells

Julie P. Goff,Donna S. Shields,Joel S. Greenberger

View Articletitled, Influence of Cytokines on the Growth Kinetics and Immunophenotype of Daughter Cells Resulting From the First Division of Single CD34+Thy-1+lin− Cells

GATA-1 Regulates Growth and Differentiation of Definitive Erythroid Lineage Cells During In Vitro ES Cell Differentiation

Naruyoshi Suwabe,Satoru Takahashi,Toru Nakano,Masayuki Yamamoto

View Articletitled, GATA-1 Regulates Growth and Differentiation of Definitive Erythroid Lineage Cells During In Vitro ES Cell Differentiation

Functional Analysis of Mature Hematopoietic Cells From Mice Lacking the βc Chain of the Granulocyte-Macrophage Colony-Stimulating Factor Receptor

C.L. Scott,D.A. Hughes,D. Cary,N.A. Nicola,C.G. Begley,L. Robb

View Articletitled, Functional Analysis of Mature Hematopoietic Cells From Mice Lacking the βc Chain of the Granulocyte-Macrophage Colony-Stimulating Factor Receptor

Cooperative Effects of Growth Factors Involved in the Induction of Hematopoietic Mesoderm

Tara L. Huber,Yi Zhou,Paul E. Mead,Leonard I. Zon

View Articletitled, Cooperative Effects of Growth Factors Involved in the Induction of Hematopoietic Mesoderm

Selective Sp1 Binding Is Critical for Maximal Activity of the Human c-kit Promoter

Gyeong H. Park,Howard K. Plummer, III,Geoffrey W. Krystal

View Articletitled, Selective Sp1 Binding Is Critical for Maximal Activity of the Human c-kit Promoter

Vascular Endothelial Growth Factor Inhibits the Development of Dendritic Cells and Dramatically Affects the Differentiation of Multiple Hematopoietic Lineages In Vivo: Presented in part at the Keystone Symposium “Cellular and Molecular Biology of Dendritic Cells,” Santa Fe, NM, March 3-9, 1998, and at the annual meeting of the American Association for Cancer Research, March 28-April 1, 1998.

Dmitry Gabrilovich,Tadao Ishida,Tsunehiro Oyama,Sophia Ran,Vladimir Kravtsov,Sorena Nadaf,David P. Carbone

View Articletitled, Vascular Endothelial Growth Factor Inhibits the Development of Dendritic Cells and Dramatically Affects the Differentiation of Multiple Hematopoietic Lineages In Vivo: Presented in part at the Keystone Symposium “Cellular and Molecular Biology of Dendritic Cells,” Santa Fe, NM, March 3-9, 1998, and at the annual meeting of the American Association for Cancer Research, March 28-April 1, 1998.

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Role of Tissue Factor in Adhesion of Mononuclear Phagocytes to and Trafficking Through Endothelium In Vitro

Gwendalyn J. Randolph,Thomas Luther,Sybille Albrecht,Viktor Magdolen,William A. Muller

View Articletitled, Role of Tissue Factor in Adhesion of Mononuclear Phagocytes to and Trafficking Through Endothelium In Vitro

R to Q Amino Acid Substitution in the GFFKR Sequence of the Cytoplasmic Domain of the Integrin _IIb Subunit in a Patient With a Glanzmann’s Thrombasthenia-Like Syndrome

O. Peyruchaud,A.T. Nurden,S. Milet,L. Macchi,A. Pannochia,P.F. Bray,N. Kieffer,F. Bourre

View Articletitled, R to Q Amino Acid Substitution in the GFFKR Sequence of the Cytoplasmic Domain of the Integrin IIb Subunit in a Patient With a Glanzmann’s Thrombasthenia-Like Syndrome

Intravascular Coagulation Activation in a Murine Model of Thrombomodulin Deficiency: Effects of Lesion Size, Age, and Hypoxia on Fibrin Deposition

Aileen M. Healy,Wayne W. Hancock,Patricia D. Christie,Helen B. Rayburn,Robert D. Rosenberg

View Articletitled, Intravascular Coagulation Activation in a Murine Model of Thrombomodulin Deficiency: Effects of Lesion Size, Age, and Hypoxia on Fibrin Deposition

The Second Exon-Encoded Factor XII Region Is Involved in the Interaction of Factor XII With Factor XI and Does Not Contribute to the Binding Site for Negatively Charged Surfaces

Franca Citarella,Giorgio Fedele,Dorina Roem,Antonio Fantoni,C. Erik Hack

View Articletitled, The Second Exon-Encoded Factor XII Region Is Involved in the Interaction of Factor XII With Factor XI and Does Not Contribute to the Binding Site for Negatively Charged Surfaces

Identification of Peptides, Selected by Phage Display Technology, That Inhibit von Willebrand Factor Binding to Collagen

H. Depraetere,A. Viaene,S. Deroo,S. Vauterin,H. Deckmyn

View Articletitled, Identification of Peptides, Selected by Phage Display Technology, That Inhibit von Willebrand Factor Binding to Collagen

IMMUNOBIOLOGY

Interleukin-6 (IL-6) Prevents Activation-Induced Cell Death: IL-2–Independent Inhibition of Fas/fasL Expression and Cell Death

Emira Ayroldi,Ornella Zollo,Lorenza Cannarile,Francesca D’ Adamio,Ursula Grohmann,Domenico V. Delfino,Carlo Riccardi

View Articletitled, Interleukin-6 (IL-6) Prevents Activation-Induced Cell Death: IL-2–Independent Inhibition of Fas/fasL Expression and Cell Death

Proteasome Inhibitors Induce Apoptosis in Glucocorticoid-Resistant Chronic Lymphocytic Leukemic Lymphocytes

Joya Chandra,Irina Niemer,Joyce Gilbreath,Kay-Oliver Kliche,Michael Andreeff,Emil J. Freireich,Michael Keating,David J. McConkey

View Articletitled, Proteasome Inhibitors Induce Apoptosis in Glucocorticoid-Resistant Chronic Lymphocytic Leukemic Lymphocytes

Immunophenotypic Analysis of Peripheral Blood Mononuclear Cells Undergoing In Vitro Apoptosis After Isolation From Human Immunodeficiency Virus–Infected Children

Thomas W. McCloskey,Saroj Bakshi,Soe Than,Parisa Arman,Savita Pahwa

View Articletitled, Immunophenotypic Analysis of Peripheral Blood Mononuclear Cells Undergoing In Vitro Apoptosis After Isolation From Human Immunodeficiency Virus–Infected Children

Generation of Functional Human Dendritic Cells From Adherent Peripheral Blood Monocytes by CD40 Ligation in the Absence of Granulocyte-Macrophage Colony-Stimulating Factor

Peter Brossart,Frank Grünebach,Gernot Stuhler,Volker L. Reichardt,Robert Möhle,Lothar Kanz,Wolfram Brugger

View Articletitled, Generation of Functional Human Dendritic Cells From Adherent Peripheral Blood Monocytes by CD40 Ligation in the Absence of Granulocyte-Macrophage Colony-Stimulating Factor

Role of Spontaneous and Interleukin-2–Induced Natural Killer Cell Activity in the Cytotoxicity and Rejection of Fas⁺and Fas⁻ Tumor Cells

Mike Bradley,Ahmet Zeytun,Asimah Rafi-Janajreh,Prakash S. Nagarkatti,Mitzi Nagarkatti

View Articletitled, Role of Spontaneous and Interleukin-2–Induced Natural Killer Cell Activity in the Cytotoxicity and Rejection of Fas+and Fas− Tumor Cells

Interleukin-10 Abrogates the Inhibition of Epstein-Barr Virus–Induced B-Cell Transformation by Memory T-Cell Responses

M.T. Bejarano,M.G. Masucci

View Articletitled, Interleukin-10 Abrogates the Inhibition of Epstein-Barr Virus–Induced B-Cell Transformation by Memory T-Cell Responses

NEOPLASIA

Modulation of Granulocyte-Macrophage Colony-Stimulating Factor Gene Expression by a Tumor Necrosis Factor  Specific Ribozyme in Juvenile Myelomonocytic Leukemic Cells

Per Ole Iversen,Mouldy Sioud

View Articletitled, Modulation of Granulocyte-Macrophage Colony-Stimulating Factor Gene Expression by a Tumor Necrosis Factor  Specific Ribozyme in Juvenile Myelomonocytic Leukemic Cells

Identification of New Nonrandom Translocations in Multiple Myeloma With Multicolor Spectral Karyotyping

Jeffrey R. Sawyer,Janet L. Lukacs,Nikhil Munshi,K. Raman Desikan,Seema Singhal,Jayesh Mehta,David Siegel,John Shaughnessy,Bart Barlogie

View Articletitled, Identification of New Nonrandom Translocations in Multiple Myeloma With Multicolor Spectral Karyotyping

Diphtheria Toxin Fused to Granulocyte-Macrophage Colony-Stimulating Factor Is Toxic to Blasts From Patients With Juvenile Myelomonocytic Leukemia and Chronic Myelomonocytic Leukemia

Arthur E. Frankel,Michael Lilly,Robert Kreitman,Donna Hogge,Miloslav Beran,Melvin H. Freedman,Peter D. Emanuel,Chris McLain,Philip Hall,Edward Tagge,Marc Berger,Connie Eaves

View Articletitled, Diphtheria Toxin Fused to Granulocyte-Macrophage Colony-Stimulating Factor Is Toxic to Blasts From Patients With Juvenile Myelomonocytic Leukemia and Chronic Myelomonocytic Leukemia

Generation of Cells With Hodgkin’s and Reed-Sternberg Phenotype Through Downregulation of CD99 (Mic2)

Soon Ha Kim,Eun Young Choi,Young Kee Shin,Tae Jin Kim,Doo Hyun Chung,Sung Ik Chang,Noe Kyeong Kim,Seong Hoe Park

View Articletitled, Generation of Cells With Hodgkin’s and Reed-Sternberg Phenotype Through Downregulation of CD99 (Mic2)

Hypomethylation Status of CpG Sites at the Promoter Region and Overexpression of the Human MDR1 Gene in Acute Myeloid Leukemias

Masaharu Nakayama,Morimasa Wada,Taishi Harada,Jun Nagayama,Hitoshi Kusaba,Koichi Ohshima,Mitsuo Kozuru,Hirokazu Komatsu,Ryuzo Ueda,Michihiko Kuwano

View Articletitled, Hypomethylation Status of CpG Sites at the Promoter Region and Overexpression of the Human MDR1 Gene in Acute Myeloid Leukemias

Trivalent Antimonials Induce Degradation of the PML-RAR Oncoprotein and Reorganization of the Promyelocytic Leukemia Nuclear Bodies in Acute Promyelocytic Leukemia NB4 Cells

Stefan Müller,Wilson H. Miller, Jr,Anne Dejean

View Articletitled, Trivalent Antimonials Induce Degradation of the PML-RAR Oncoprotein and Reorganization of the Promyelocytic Leukemia Nuclear Bodies in Acute Promyelocytic Leukemia NB4 Cells

Flow Cytometric Diagnosis of the Cell Lineage and Developmental Stage of Acute Lymphoblastic Leukemia by Novel Monoclonal Antibodies Specific to Human Pre–B-Cell Receptor

Keiko Tsuganezawa,Nobutaka Kiyokawa,Yoshinobu Matsuo,Fujiko Kitamura,Noriko Toyama-Sorimachi,Keisuke Kuida,Junichiro Fujimoto,Hajime Karasuyama

View Articletitled, Flow Cytometric Diagnosis of the Cell Lineage and Developmental Stage of Acute Lymphoblastic Leukemia by Novel Monoclonal Antibodies Specific to Human Pre–B-Cell Receptor

Most Acute Myeloid Leukemia Progenitor Cells With Long-Term Proliferative Ability In Vitro and In Vivo Have the Phenotype CD34⁺/CD71⁻/HLA-DR⁻

A. Blair,D.E. Hogge,H.J. Sutherland

View Articletitled, Most Acute Myeloid Leukemia Progenitor Cells With Long-Term Proliferative Ability In Vitro and In Vivo Have the Phenotype CD34+/CD71−/HLA-DR−

2′,5′-Oligoadenylate-Antisense Chimeras Cause RNase L to Selectively Degrade bcr/abl mRNA in Chronic Myelogenous Leukemia Cells

Avudaiappan Maran,Cornelius F. Waller,Jayashree M. Paranjape,Guiying Li,Wei Xiao,Kerry Zhang,Matt E. Kalaycio,Ratan K. Maitra,Alan E. Lichtin,Wolfram Brugger,Paul F. Torrence,Robert H. Silverman

View Articletitled, 2′,5′-Oligoadenylate-Antisense Chimeras Cause RNase L to Selectively Degrade bcr/abl mRNA in Chronic Myelogenous Leukemia Cells

CBFβ-SMMHC, Expressed in M4eo Acute Myeloid Leukemia, Reduces p53 Induction and Slows Apoptosis in Hematopoietic Cells Exposed to DNA-Damaging Agents

Martin Britos-Bray,Manuel Ramirez,Wangsen Cao,Xinping Wang,P. Paul Liu,Curt I. Civin,Alan D. Friedman

View Articletitled, CBFβ-SMMHC, Expressed in M4eo Acute Myeloid Leukemia, Reduces p53 Induction and Slows Apoptosis in Hematopoietic Cells Exposed to DNA-Damaging Agents

PHAGOCYTES

Autocrine Signals Control CCAAT/Enhancer Binding Protein β Expression, Localization, and Activity in Macrophages

Mark Baer,Simon C. Williams,Allan Dillner,Richard C. Schwartz,Peter F. Johnson

View Articletitled, Autocrine Signals Control CCAAT/Enhancer Binding Protein β Expression, Localization, and Activity in Macrophages

In Vivo Treatment With Granulocyte Colony-Stimulating Factor Results in Divergent Effects on Neutrophil Functions Measured In Vitro

Patrick J. Leavey,Karen S. Sellins,Gail Thurman,David Elzi,Andrew Hiester,Christopher C. Silliman,Gary Zerbe,J. John Cohen,Daniel R. Ambruso

View Articletitled, In Vivo Treatment With Granulocyte Colony-Stimulating Factor Results in Divergent Effects on Neutrophil Functions Measured In Vitro

RED CELLS

HbS-Oman Heterozygote: A New Dominant Sickle Syndrome

Ronald L. Nagel,Shahina Daar,Jose R. Romero,Sandra M. Suzuka,David Gravell,Eric Bouhassira,Robert S. Schwartz,Mary E. Fabry,Rajagopal Krishnamoorthy

View Articletitled, HbS-Oman Heterozygote: A New Dominant Sickle Syndrome

Coinduction of Embryonic and Adult-Type Globin mRNAs by Sodium Butyrate and Trichostatin A in Two Murine Interleukin-3–Dependent Bone Marrow–Derived Cell Lines

Kimiko Ishiguro,Alan C. Sartorelli

View Articletitled, Coinduction of Embryonic and Adult-Type Globin mRNAs by Sodium Butyrate and Trichostatin A in Two Murine Interleukin-3–Dependent Bone Marrow–Derived Cell Lines

Description and Targeted Deletion of 5′ Hypersensitive Site 5 and 6 of the Mouse β-Globin Locus Control Region

M.A. Bender,Andreas Reik,Jennie Close,Agnes Telling,Elliot Epner,Steven Fiering,Ross Hardison,Mark Groudine

View Articletitled, Description and Targeted Deletion of 5′ Hypersensitive Site 5 and 6 of the Mouse β-Globin Locus Control Region

Characterization of Multiple Isoforms of Protein 4.1R Expressed During Erythroid Terminal Differentiation

P. Gascard,G. Lee,L. Coulombel,I. Auffray,M. Lum,M. Parra,J.G. Conboy,N. Mohandas,J.A. Chasis

View Articletitled, Characterization of Multiple Isoforms of Protein 4.1R Expressed During Erythroid Terminal Differentiation

Recombination Breakpoints in the Human β-Globin Gene Cluster

Rachelle A. Smith,P. Joy Ho,John B. Clegg,Judith R. Kidd,Swee Lay Thein

View Articletitled, Recombination Breakpoints in the Human β-Globin Gene Cluster

High Adenosine Deaminase Level Among Healthy Probands of Diamond Blackfan Anemia (DBA) Cosegregates With the DBA Gene Region on Chromosome 19q13

T.N. Willig,J.L. Pérignon,P. Gustavsson,P. Gane,N. Draptchinskaya,H. Testard,R. Girot,M. Debré,J.L. Stéphan,C. Chenel,J.P. Cartron,N. Dahl,G. Tchernia,on behalf of the DBA Working Group of Sociétéd’Hématologie et d’Immunologie Pédiatrique (SHIP)

View Articletitled, High Adenosine Deaminase Level Among Healthy Probands of Diamond Blackfan Anemia (DBA) Cosegregates With the DBA Gene Region on Chromosome 19q13

Functional Cell Surface Expression of Band 3, the Human Red Blood Cell Anion Exchange Protein (AE1), in K562 Erythroleukemia Cells: Band 3 Enhances the Cell Surface Reactivity of Rh Antigens

Roland Beckmann,Jonathan S. Smythe,David J. Anstee,Michael J.A. Tanner

View Articletitled, Functional Cell Surface Expression of Band 3, the Human Red Blood Cell Anion Exchange Protein (AE1), in K562 Erythroleukemia Cells: Band 3 Enhances the Cell Surface Reactivity of Rh Antigens

TRANSFUSION MEDICINE

Correction of the PNH Defect by GPI-Anchored Protein Transfer

Elaine M. Sloand,Jaroslaw P. Maciejewski,Daniel Dunn,Joel Moss,Bryan Brewer,Martha Kirby,Neal S. Young

View Articletitled, Correction of the PNH Defect by GPI-Anchored Protein Transfer

P-Selectin and Platelet Clearance

Gaëtan Berger,Daqing W. Hartwell,Denisa D. Wagner

View Articletitled, P-Selectin and Platelet Clearance

TRANSPLANTATION

A Critical Role for CD48 Antigen in Regulating Alloengraftment and Lymphohematopoietic Recovery After Bone Marrow Transplantation

Bruce R. Blazar,Patricia A. Taylor,Angela Panoskaltsis-Mortari,Hideo Yagita,Jonathan S. Bromberg,Daniel A. Vallera

View Articletitled, A Critical Role for CD48 Antigen in Regulating Alloengraftment and Lymphohematopoietic Recovery After Bone Marrow Transplantation

Reconstitution of the T-Cell Compartment After Bone Marrow Transplantation: Restoration of the Repertoire by Thymic Emigrants

Florence Dumont-Girard,Etienne Roux,René A. van Lier,Geoff Hale,Claudine Helg,Bernard Chapuis,Michel Starobinski,Eddy Roosnek

View Articletitled, Reconstitution of the T-Cell Compartment After Bone Marrow Transplantation: Restoration of the Repertoire by Thymic Emigrants

Recombinant CD40L Treatment Protects Allogeneic Murine Bone Marrow Transplant Recipients From Death Caused by Herpes Simplex Virus-1 Infection

Janice L. Beland,Heiko Adler,Nadia C. Del-Pan,Wende Kozlow,Janice Sung,William Fanslow,Ilonna J. Rimm

View Articletitled, Recombinant CD40L Treatment Protects Allogeneic Murine Bone Marrow Transplant Recipients From Death Caused by Herpes Simplex Virus-1 Infection

CORRESPONDENCE

Nontransfusional Iron Overload in Thalassemia Intermedia: Role of the Hemochromatosis Allele

M.D. Cappellini,S.R. Fargion,M. Sampietro,G. Graziadei,G. Fiorelli

View Articletitled, Nontransfusional Iron Overload in Thalassemia Intermedia: Role of the Hemochromatosis Allele

Coinheritance of Alleles Associated With Hemochromatosis and Hereditary Hyperferritinemia-Cataract Syndrome

James C. Barton,Ernest Beutler,Terri Gelbart

View Articletitled, Coinheritance of Alleles Associated With Hemochromatosis and Hereditary Hyperferritinemia-Cataract Syndrome

Coinheritance of α- and β-Spectrin Gene Mutations in a Case of Hereditary Elliptocytosis

Didier Dhermy,Colette Galand,Odile Bournier,May-Jean King,Thérèse Cynober,Irene Roberts,Frederick Kanyike,Adekunle Adekile

View Articletitled, Coinheritance of α- and β-Spectrin Gene Mutations in a Case of Hereditary Elliptocytosis

Nerve Growth Factor Released by CD40 Ligand-Transfected L Cells: Implications for Functional and Phenotypic Studies on CD40⁺Cells

Angelo De Milito,Noemi Nagy,Astrid Samuelsson,Francesca Chiodi,Eva Rajnavölgyi

View Articletitled, Nerve Growth Factor Released by CD40 Ligand-Transfected L Cells: Implications for Functional and Phenotypic Studies on CD40+Cells

Low-Dose Interleukin-2 for Treating Postautologous Transplant Cytogenetic Abnormality Recurrency in a Case of Acute Myeloid Leukemia With Hyperdiploidy

G. De Rosa,L. Pezzullo,C. Selleri,A.M. Raiola,L. Luciano,M. Picardi,B. Rotoli

View Articletitled, Low-Dose Interleukin-2 for Treating Postautologous Transplant Cytogenetic Abnormality Recurrency in a Case of Acute Myeloid Leukemia With Hyperdiploidy

Expression of AC133, a Novel Stem Cell Marker, on Human Leukemic Blasts Lacking CD34⁻ Antigen and on a Human CD34⁺ Leukemic Cell Line: MUTZ-2

Karsten Kratz-Albers,Michael Zühlsdorf,Regine Leo,Wolfgang E. Berdel,Thomas Büchner,Hubert Serve

View Articletitled, Expression of AC133, a Novel Stem Cell Marker, on Human Leukemic Blasts Lacking CD34− Antigen and on a Human CD34+ Leukemic Cell Line: MUTZ-2

Deletions in the Long Arm of Chromosome 10 in Lymphomas With t(14;18): A Pathogenetic Role of the Tumor Suppressor Genes PTEN/MMAC1 and MXI1?

Reiner Siebert,Stefan Gesk,Svetlana Harder,Sebastian Plötz,Peter Matthiesen,Werner Grote,Brigitte Schlegelberger,Burkhard Jandrig,Unn-Hilde Grasmo-Wendler,Siegfried Scherneck,Andreas Rosenwald,German Ott

View Articletitled, Deletions in the Long Arm of Chromosome 10 in Lymphomas With t(14;18): A Pathogenetic Role of the Tumor Suppressor Genes PTEN/MMAC1 and MXI1?

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