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Volume 91, Issue 2

January 15 1998

In this Issue

REVIEW ARTICLES
RAPID COMMUNICATIONS
CLINICAL INTERVENTION AND THERAPEUTIC TRIALS
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSFUSION MEDICINE
TRANSPLANTATION
CORRESPONDENCE

REVIEW ARTICLES

The Therapeutic Potential of Ribozymes

Helen A. James,Ian Gibson

View Articletitled, The Therapeutic Potential of Ribozymes

RAPID COMMUNICATIONS

Physical and Functional Association of FcαR With Protein Tyrosine Kinase Lyn

Heinz Gulle,Aysen Samstag,Martha M. Eibl,Hermann M. Wolf

View Articletitled, Physical and Functional Association of FcαR With Protein Tyrosine Kinase Lyn

High Efficiency Adenovirus-Mediated Gene Transfer to Human Dendritic Cells

Allan B. Dietz,Stanimir Vuk-Pavlovic

View Articletitled, High Efficiency Adenovirus-Mediated Gene Transfer to Human Dendritic Cells

CLINICAL INTERVENTION AND THERAPEUTIC TRIALS

Phase I Trial of a Ligand Fusion-Protein (DAB₃₈₉IL-2) in Lymphomas Expressing the Receptor for Interkeukin-2

C.F. LeMaistre,Mansoor N. Saleh,Timothy M. Kuzel,Francine Foss,Leonidas C. Platanias,Gary Schwartz,Mark Ratain,Alain Rook,Cesar O. Freytes,Fiona Craig,James Reuben,Jean C. Nichols

View Articletitled, Phase I Trial of a Ligand Fusion-Protein (DAB389IL-2) in Lymphomas Expressing the Receptor for Interkeukin-2

HEMATOPOIESIS

The SH3 Domain Contributes to BCR/ABL-Dependent Leukemogenesis In Vivo: Role in Adhesion, Invasion, and Homing

Tomasz Skorski,Malgorzata Nieborowska-Skorska,Pawel Wlodarski,Mariusz Wasik,Rossana Trotta,Palanisamy Kanakaraj,Paolo Salomoni,Mark Antonyak,Robert Martinez,Miroslaw Majewski,Albert Wong,Bice Perussia,Bruno Calabretta

View Articletitled, The SH3 Domain Contributes to BCR/ABL-Dependent Leukemogenesis In Vivo: Role in Adhesion, Invasion, and Homing

Transcriptional Regulation of vav, a Gene Expressed Throughout the Hematopoietic Compartment

Sarah Ogilvy,Andrew G. Elefanty,Jane Visvader,Mary L. Bath,Alan W. Harris,Jerry M. Adams

View Articletitled, Transcriptional Regulation of vav, a Gene Expressed Throughout the Hematopoietic Compartment

Retrovirally Transduced CD34⁺⁺ Human Cord Blood Cells Generate T Cells Expressing High Levels of the Retroviral Encoded Green Fluorescent Protein Marker In Vitro

Bruno Verhasselt,Magda De Smedt,Rita Verhelst,Evelien Naessens,Jean Plum

View Articletitled, Retrovirally Transduced CD34++ Human Cord Blood Cells Generate T Cells Expressing High Levels of the Retroviral Encoded Green Fluorescent Protein Marker In Vitro

The Tetrapeptide Acetyl-N-Ser-Asp-Lys-Pro (Goralatide) Protects From Doxorubicin-Induced Toxicity: Improvement in Mice Survival and Protection of Bone Marrow Stem Cells and Progenitors

A. Massé,L.H. Ramirez,G. Bindoula,C. Grillon,J. Wdzieczak-Bakala,K. Raddassi,E. Deschamps de Paillette,J.M. Mencia-Huerta,S. Koscielny,P. Potier,F. Sainteny,P. Carde

View Articletitled, The Tetrapeptide Acetyl-N-Ser-Asp-Lys-Pro (Goralatide) Protects From Doxorubicin-Induced Toxicity: Improvement in Mice Survival and Protection of Bone Marrow Stem Cells and Progenitors

Forced GATA-1 Expression in the Murine Myeloid Cell Line M1: Induction of c-Mpl Expression and Megakaryocytic/Erythroid Differentiation

Yuji Yamaguchi,Leonard I. Zon,Steven J. Ackerman,Masayuki Yamamoto,Toshio Suda

View Articletitled, Forced GATA-1 Expression in the Murine Myeloid Cell Line M1: Induction of c-Mpl Expression and Megakaryocytic/Erythroid Differentiation

Early Induction of Apoptosis in Hematopoietic Cell Lines After Exposure to Flavopiridol

Bernard W. Parker,Gurmeet Kaur,Wilberto Nieves-Neira,Mohammed Taimi,Glenda Kohlhagen,Tsunehiro Shimizu,Michael D. Losiewicz,Yves Pommier,Edward A. Sausville,Adrian M. Senderowicz

View Articletitled, Early Induction of Apoptosis in Hematopoietic Cell Lines After Exposure to Flavopiridol

A Single Intravenous Dose of Murine Megakaryocyte Growth and Development Factor Potently Stimulates Platelet Production, Challenging the Necessity for Daily Administration

Najat C. Daw,Julie T. Arnold,Basel A. Abushullaih,Paula E. Stenberg,Melanie M. White,Deepthi Jayawardene,Deo Kumar Srivastava,Carl W. Jackson

View Articletitled, A Single Intravenous Dose of Murine Megakaryocyte Growth and Development Factor Potently Stimulates Platelet Production, Challenging the Necessity for Daily Administration

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Sialyl Lewis^x (sLe^x) and an sLe^xMimetic, CGP69669A, Disrupt E-Selectin–Dependent Leukocyte Rolling In Vivo

Keith E. Norman,Gary P. Anderson,Hartmut C. Kolb,Klaus Ley,Beat Ernst

View Articletitled, Sialyl Lewisx (sLex) and an sLexMimetic, CGP69669A, Disrupt E-Selectin–Dependent Leukocyte Rolling In Vivo

Hydrogen Peroxide Is Involved in Collagen-Induced Platelet Activation

Pasquale Pignatelli,Fabio M. Pulcinelli,Luisa Lenti,Pier Paolo Gazzaniga,Francesco Violi

View Articletitled, Hydrogen Peroxide Is Involved in Collagen-Induced Platelet Activation

Glycoprotein VI Is a Major Collagen Receptor for Platelet Activation: It Recognizes the Platelet-Activating Quaternary Structure of Collagen, Whereas CD36, Glycoprotein IIb/IIIa, and von Willebrand Factor Do Not

Beate Kehrel,Sonja Wierwille,Kenneth J. Clemetson,Olaf Anders,Michael Steiner,C. Graham Knight,Richard W. Farndale,Minoru Okuma,Michael J. Barnes

View Articletitled, Glycoprotein VI Is a Major Collagen Receptor for Platelet Activation: It Recognizes the Platelet-Activating Quaternary Structure of Collagen, Whereas CD36, Glycoprotein IIb/IIIa, and von Willebrand Factor Do Not

Platelet/Endothelial Cell Adhesion Molecule-1 Serves as a Costimulatory Agonist Receptor That Modulates Integrin-Dependent Adhesion and Aggregation of Human Platelets

David Varon,Denise E. Jackson,Boris Shenkman,Rima Dardik,Ilya Tamarin,Naphtali Savion,Peter J. Newman

View Articletitled, Platelet/Endothelial Cell Adhesion Molecule-1 Serves as a Costimulatory Agonist Receptor That Modulates Integrin-Dependent Adhesion and Aggregation of Human Platelets

Atherogenic Lipoproteins Support Assembly of the Prothrombinase Complex and Thrombin Generation: Modulation by Oxidation and Vitamin E

Simin Rota,Nicola A. McWilliam,Trevor P. Baglin,Christopher D. Byrne

View Articletitled, Atherogenic Lipoproteins Support Assembly of the Prothrombinase Complex and Thrombin Generation: Modulation by Oxidation and Vitamin E

High Molecular Weight Kininogen Regulates Prekallikrein Assembly and Activation on Endothelial Cells: A Novel Mechanism for Contact Activation

Guacyara Motta,Rasmus Rojkjaer,Ahmed A.K. Hasan,Douglas B. Cines,Alvin H. Schmaier

View Articletitled, High Molecular Weight Kininogen Regulates Prekallikrein Assembly and Activation on Endothelial Cells: A Novel Mechanism for Contact Activation

Evidence of a Local Mechanism for Desmopressin-Induced Tissue-Type Plasminogen Activator Release in Human Forearm

Ulrika Wall,Sverker Jern,Lilian Tengborn,Christina Jern

View Articletitled, Evidence of a Local Mechanism for Desmopressin-Induced Tissue-Type Plasminogen Activator Release in Human Forearm

The Molecular Basis for Cross-Reacting Material–Positive Hemophilia A Due to Missense Mutations Within the A2-Domain of Factor VIII

Kagehiro Amano,Rita Sarkar,Susan Pemberton,Geoffrey Kemball-Cook,Haig H. Kazazian, Jr,Randal J. Kaufman

View Articletitled, The Molecular Basis for Cross-Reacting Material–Positive Hemophilia A Due to Missense Mutations Within the A2-Domain of Factor VIII

Adenosine Diphosphate (ADP) and ADP Receptor Play a Major Role in Platelet Activation/Aggregation Induced by Sera From Heparin-Induced Thrombocytopenia Patients

János Polgár,Petra Eichler,Andreas Greinacher,Kenneth J. Clemetson

View Articletitled, Adenosine Diphosphate (ADP) and ADP Receptor Play a Major Role in Platelet Activation/Aggregation Induced by Sera From Heparin-Induced Thrombocytopenia Patients

The Low-Density Lipoprotein Receptor-Related Protein (LRP) Mediates Clearance of Coagulation Factor Xa In Vivo

Masaaki Narita,Amy E. Rudolph,Joseph P. Miletich,Alan L. Schwartz

View Articletitled, The Low-Density Lipoprotein Receptor-Related Protein (LRP) Mediates Clearance of Coagulation Factor Xa In Vivo

IMMUNOBIOLOGY

The Upregulation of p27^Kip1 by Rapamycin Results in G1 Arrest in Exponentially Growing T-Cell Lines

Shin Kawamata,Hitoshi Sakaida,Toshiyuki Hori,Michiyuki Maeda,Takashi Uchiyama

View Articletitled, The Upregulation of p27Kip1 by Rapamycin Results in G1 Arrest in Exponentially Growing T-Cell Lines

Interferon-α Resistance in a Cutaneous T-Cell Lymphoma Cell Line Is Associated With Lack of STAT1 Expression

Wenn H. Sun,Carlos Pabon,Yazan Alsayed,Paul P. Huang,Sara Jandeska,Shahab Uddin,Leonidas C. Platanias,Steven T. Rosen

View Articletitled, Interferon-α Resistance in a Cutaneous T-Cell Lymphoma Cell Line Is Associated With Lack of STAT1 Expression

Lipopolysaccharide Activates Caspase-1 (Interleukin-1–Converting Enzyme) in Cultured Monocytic and Endothelial Cells

Ralf R. Schumann,Claus Belka,Dirk Reuter,Norbert Lamping,Carsten J. Kirschning,Joerg R. Weber,Dagmar Pfeil

View Articletitled, Lipopolysaccharide Activates Caspase-1 (Interleukin-1–Converting Enzyme) in Cultured Monocytic and Endothelial Cells

Circulating CD8 T Lymphocytes in Human Immunodeficiency Virus-Infected Individuals Have Impaired Function and Downmodulate CD3ζ, the Signaling Chain of the T-Cell Receptor Complex

Linda A. Trimble,Judy Lieberman

View Articletitled, Circulating CD8 T Lymphocytes in Human Immunodeficiency Virus-Infected Individuals Have Impaired Function and Downmodulate CD3ζ, the Signaling Chain of the T-Cell Receptor Complex

Deficient Expression of Bruton's Tyrosine Kinase in Monocytes From X-Linked Agammaglobulinemia as Evaluated by a Flow Cytometric Analysis and Its Clinical Application to Carrier Detection

Takeshi Futatani,Toshio Miyawaki,Satoshi Tsukada,Shoji Hashimoto,Toshio Kunikata,Shigeyuki Arai,Masashi Kurimoto,Yo Niida,Hiroshi Matsuoka,Yukio Sakiyama,Tsutomu Iwata,Shigeru Tsuchiya,Osamu Tatsuzawa,Kazuyuki Yoshizaki,Tadamitsu Kishimoto

View Articletitled, Deficient Expression of Bruton's Tyrosine Kinase in Monocytes From X-Linked Agammaglobulinemia as Evaluated by a Flow Cytometric Analysis and Its Clinical Application to Carrier Detection

NEOPLASIA

Heterologous Promoters Fused to BCL6 by Chromosomal Translocations Affecting Band 3q27 Cause Its Deregulated Expression During B-Cell Differentiation

Weiyi Chen,Shinsuke Iida,Diane C. Louie,Riccardo Dalla-Favera,R.S.K. Chaganti

View Articletitled, Heterologous Promoters Fused to BCL6 by Chromosomal Translocations Affecting Band 3q27 Cause Its Deregulated Expression During B-Cell Differentiation

Distinctive Demography, Biology, and Outcome of Acute Myeloid Leukemia and Myelodysplastic Syndrome in Children With Down Syndrome: Children's Cancer Group Studies 2861 and 2891

Beverly J. Lange,Nathan Kobrinsky,Dorothy R. Barnard,Diane C. Arthur,Jonathan D. Buckley,William B. Howells,Stuart Gold,Jean Sanders,Steven Neudorf,Franklin O. Smith,William G. Woods

View Articletitled, Distinctive Demography, Biology, and Outcome of Acute Myeloid Leukemia and Myelodysplastic Syndrome in Children With Down Syndrome: Children's Cancer Group Studies 2861 and 2891

Acute Myeloid Leukemia and Myelodysplastic Syndromes Following Essential Thrombocythemia Treated With Hydroxyurea: High Proportion of Cases With 17p Deletion

Yvon Sterkers,Claude Preudhomme,Jean-Luc Laı̈,Jean-Loup Demory,Marie-Thérèse Caulier,Eric Wattel,Dominique Bordessoule,Francis Bauters,Pierre Fenaux

View Articletitled, Acute Myeloid Leukemia and Myelodysplastic Syndromes Following Essential Thrombocythemia Treated With Hydroxyurea: High Proportion of Cases With 17p Deletion

The Metastatic Characteristics of Murine Lymphoma Cell Lines In Vivo Are Manifested After Target Organ Invasion

Fawzi Aoudjit,Edouard F. Potworowski,Yves St-Pierre

View Articletitled, The Metastatic Characteristics of Murine Lymphoma Cell Lines In Vivo Are Manifested After Target Organ Invasion

Establishment of a Reproducible Model of Chronic-Phase Chronic Myeloid Leukemia in NOD/SCID Mice Using Blood-Derived Mononuclear or CD34⁺ Cells

Ian D. Lewis,Louise A. McDiarmid,Leanne M. Samels,L. Bik To,Timothy P. Hughes

View Articletitled, Establishment of a Reproducible Model of Chronic-Phase Chronic Myeloid Leukemia in NOD/SCID Mice Using Blood-Derived Mononuclear or CD34+ Cells

Suppression of Cell Proliferation and the Expression of abcr-abl Fusion Gene and Apoptotic Cell Death in a New Human Chronic Myelogenous Leukemia Cell Line, KT-1, by Interferon-α

Kohsuke Yanagisawa,Hayato Yamauchi,Masahiko Kaneko,Hidehisa Kohno,Hitoshi Hasegawa,Shigeru Fujita

View Articletitled, Suppression of Cell Proliferation and the Expression of abcr-abl Fusion Gene and Apoptotic Cell Death in a New Human Chronic Myelogenous Leukemia Cell Line, KT-1, by Interferon-α

PHAGOCYTES

Acute Regulation of Glucose Transport After Activation of Human Peripheral Blood Neutrophils by Phorbol Myristate Acetate, fMLP, and Granulocyte-Macrophage Colony-Stimulating Factor

An S. Tan,Nuzhat Ahmed,Michael V. Berridge

View Articletitled, Acute Regulation of Glucose Transport After Activation of Human Peripheral Blood Neutrophils by Phorbol Myristate Acetate, fMLP, and Granulocyte-Macrophage Colony-Stimulating Factor

A Naturally Occurring Mutation in FcγRIIA: A Q to K¹²⁷ Change Confers Unique IgG Binding Properties to the R¹³¹ Allelic Form of the Receptor

Cynthia F. Norris,Luminita Pricop,Sean S. Millard,Scott M. Taylor,Saul Surrey,Elias Schwartz,Jane E. Salmon,Steven E. McKenzie

View Articletitled, A Naturally Occurring Mutation in FcγRIIA: A Q to K127 Change Confers Unique IgG Binding Properties to the R131 Allelic Form of the Receptor

Mice Transgenic for the Human CGM6 Gene Express Its Product, the Granulocyte Marker CD66b, Exclusively in Granulocytes

Anne-Marie Eades-Perner,John Thompson,Herman van der Putten,Wolfgang Zimmermann

View Articletitled, Mice Transgenic for the Human CGM6 Gene Express Its Product, the Granulocyte Marker CD66b, Exclusively in Granulocytes

FcγRIIIB Gene Duplication: Evidence for Presence and Expression of Three Distinct FcγRIIIB Genes in NA(1+,2+)SH(+) Individuals

Harry R. Koene,Marion Kleijer,Dirk Roos,Masja de Haas,Albert E.G.Kr. Von dem Borne

View Articletitled, FcγRIIIB Gene Duplication: Evidence for Presence and Expression of Three Distinct FcγRIIIB Genes in NA(1+,2+)SH(+) Individuals

RED CELLS

Molecular Cloning and Characterization of Decay-Accelerating Factor Deficiency in Cromer Blood Group Inab Phenotype

Li Wang,Makoto Uchikawa,Hatsue Tsuneyama,Katsushi Tokunaga,Kenji Tadokoro,Takeo Juji

View Articletitled, Molecular Cloning and Characterization of Decay-Accelerating Factor Deficiency in Cromer Blood Group Inab Phenotype

Dominantly Transmitted β-Thalassemia Arising From the Production of Several Aberrant mRNA Species and One Abnormal Peptide

Paula Faustino,Leonor Osório-Almeida,Luı́sa Romão,José Barbot,Berta Fernandes,Benvindo Justiça,João Lavinha

View Articletitled, Dominantly Transmitted β-Thalassemia Arising From the Production of Several Aberrant mRNA Species and One Abnormal Peptide

Fetal Hemoglobin in Starvation Ketosis of Young Women

Achim Peters,Dagmar Rohloff,Thomas Kohlmann,Florian Renner,Günther Jantschek,Wolfgang Kerner,Horst Lorenz Fehm

View Articletitled, Fetal Hemoglobin in Starvation Ketosis of Young Women

Developmental Expression of Mouse Erythrocyte Protein 4.2 mRNA: Evidence for Specific Expression in Erythroid Cells

Lingyun Zhu,Samir B. Kahwash,Long-Sheng Chang

View Articletitled, Developmental Expression of Mouse Erythrocyte Protein 4.2 mRNA: Evidence for Specific Expression in Erythroid Cells

Mortality in a Cohort of Men Expressing the Glucose-6-Phosphate Dehydrogenase Deficiency

Pierluigi Cocco,Pierfelice Todde,Susanna Fornera,Maria Bonaria Manca,Pierina Manca,Ana Rosa Sias

View Articletitled, Mortality in a Cohort of Men Expressing the Glucose-6-Phosphate Dehydrogenase Deficiency

TRANSFUSION MEDICINE

Absence of Immunogenicity of Diaspirin Cross-Linked Hemoglobin in Humans

Mehul J. Patel,Edwin J. Webb,Tina E. Shelbourn,Cynthia Mattia-Goldberg,Andrew J.T. George,Feng Zhang,Edwin G. Moore,Deanna J. Nelson

View Articletitled, Absence of Immunogenicity of Diaspirin Cross-Linked Hemoglobin in Humans

TRANSPLANTATION

Primary Diffuse Large B-Cell Lymphoma of the Mediastinum: Outcome Following High-Dose Chemotherapy and Autologous Hematopoietic Cell Transplantation

Laurie H. Sehn,Joseph H. Antin,Lawrence N. Shulman,Peter Mauch,Anthony Elias,Marshall E. Kadin,Catherine Wheeler

View Articletitled, Primary Diffuse Large B-Cell Lymphoma of the Mediastinum: Outcome Following High-Dose Chemotherapy and Autologous Hematopoietic Cell Transplantation

CORRESPONDENCE

Seroprevalence of Kaposi's Sarcoma-Associated Herpes Virus Antibody in Young Adult Hodgkin's Disease

Wendy Cozen,Rizwan Masood,Thomas Mack,Parkash S. Gill,Dharam V. Ablashi

View Articletitled, Seroprevalence of Kaposi's Sarcoma-Associated Herpes Virus Antibody in Young Adult Hodgkin's Disease

A Retinoic Acid Receptor-α (RARα) Selective Agonist Modulates Procoagulant Activity of Acute Promyelocytic Cells and Induces Their Differentiation Into Neutrophils

Misako Shibakura,Takatoshi Koyama,Mai Ohsawa,Ryuichi Kamiyama,Shinsaku Hirosawa

View Articletitled, A Retinoic Acid Receptor-α (RARα) Selective Agonist Modulates Procoagulant Activity of Acute Promyelocytic Cells and Induces Their Differentiation Into Neutrophils

Plasma Levels of Endothelial Cell Protein C Receptor Are Elevated in Patients With Sepsis and Systemic Lupus Erythematosus: Lack of Correlation With Thrombomodulin Suggests Involvement of Different Pathological Processes

Shinichiro Kurosawa,D.J. Stearns-Kurosawa,Craig W. Carson,Armando D' Angelo,Patrizia Della Valle,Charles T. Esmon

View Articletitled, Plasma Levels of Endothelial Cell Protein C Receptor Are Elevated in Patients With Sepsis and Systemic Lupus Erythematosus: Lack of Correlation With Thrombomodulin Suggests Involvement of Different Pathological Processes

High-Dose and Long-Term Therapy of α Interferon in Hemophiliac Patients With Chronic C Virus Hepatitis

Javier Pinilla,Manuel Quintana,Manuel Magallon

View Articletitled, High-Dose and Long-Term Therapy of α Interferon in Hemophiliac Patients With Chronic C Virus Hepatitis

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