Skip Nav Destination

Issue Archive

Select Decade

Select Year

Issue

Volume 90, Issue 11

December 1 1997

In this Issue

COMMENTARY
REVIEW ARTICLES
RAPID COMMUNICATIONS
CLINICAL INTERVENTION AND THERAPEUTIC TRIALS
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSFUSION MEDICINE
TRANSPLANTATION
ERRATA

COMMENTARY

Fifty Years of Studies of the Biology and Therapy of Childhood Leukemia

John H. Kersey

View Articletitled, Fifty Years of Studies of the Biology and Therapy of Childhood Leukemia

REVIEW ARTICLES

Evolving Views of the Major Histocompatibility Complex

Jeffrey R. Gruen,Sherman M. Weissman

View Articletitled, Evolving Views of the Major Histocompatibility Complex

RAPID COMMUNICATIONS

Mutations in the Fas Antigen in Patients With Multiple Myeloma

Terry H. Landowski,Ning Qu,Ibrahim Buyuksal,Jeffrey S. Painter,William S. Dalton

View Articletitled, Mutations in the Fas Antigen in Patients With Multiple Myeloma

Fusion of the Platelet-Derived Growth Factor Receptor β to a Novel Gene CEV14 in Acute Myelogenous Leukemia After Clonal Evolution

Akihiro Abe,Nobuhiko Emi,Mitsune Tanimoto,Hiroshi Terasaki,Toru Marunouchi,Hidehiko Saito

View Articletitled, Fusion of the Platelet-Derived Growth Factor Receptor β to a Novel Gene CEV14 in Acute Myelogenous Leukemia After Clonal Evolution

Localization of Kaposi's Sarcoma–Associated Herpesvirus in Bone Marrow Biopsy Samples From Patients With Multiple Myeloma

Jonathan W. Said,Matthew R. Rettig,Karen Heppner,Robert A. Vescio,Gary Schiller,Hong J. Ma,Daniel Belson,Alison Savage,I. Peter Shintaku,H. Phillip Koeffler,Hiroya Asou,Geraldine Pinkus,Jack Pinkus,Matthew Schrage,Eric Green,James R. Berenson

View Articletitled, Localization of Kaposi's Sarcoma–Associated Herpesvirus in Bone Marrow Biopsy Samples From Patients With Multiple Myeloma

Comparison of Caspase Activation and Subcellular Localization in HL-60 and K562 Cells Undergoing Etoposide-Induced Apoptosis

Luis M. Martins,Peter W. Mesner,Timothy J. Kottke,Guriqbal S. Basi,Sukanto Sinha,Jay S. Tung,Phyllis A. Svingen,Benjamin J. Madden,Atsushi Takahashi,Daniel J. McCormick,William C. Earnshaw,Scott H. Kaufmann

View Articletitled, Comparison of Caspase Activation and Subcellular Localization in HL-60 and K562 Cells Undergoing Etoposide-Induced Apoptosis

In Vivo Expression of B7-1 and B7-2 By Follicular Lymphoma Cells Can Prevent Induction of T-Cell Anergy But Is Insufficient to Induce Significant T-Cell Proliferation

David M. Dorfman,Joachim L. Schultze,Aliakbar Shahsafaei,Sabine Michalak,John G. Gribben,Gordon J. Freeman,Geraldine S. Pinkus,Lee M. Nadler

View Articletitled, In Vivo Expression of B7-1 and B7-2 By Follicular Lymphoma Cells Can Prevent Induction of T-Cell Anergy But Is Insufficient to Induce Significant T-Cell Proliferation

The Novel Cyclin-Dependent Kinase Inhibitor Flavopiridol Downregulates Bcl-2 and Induces Growth Arrest and Apoptosis in Chronic B-Cell Leukemia Lines

Andrea König,Gary K. Schwartz,Ramzi M. Mohammad,Ayad Al-Katib,Janice L. Gabrilove

View Articletitled, The Novel Cyclin-Dependent Kinase Inhibitor Flavopiridol Downregulates Bcl-2 and Induces Growth Arrest and Apoptosis in Chronic B-Cell Leukemia Lines

CLINICAL INTERVENTION AND THERAPEUTIC TRIALS

A Prospective Randomized Trial of Buffy Coat Versus CD34-Selected Autologous Bone Marrow Support in High-Risk Breast Cancer Patients Receiving High-Dose Chemotherapy

Elizabeth J. Shpall,C. Fred LeMaistre,Kent Holland,Edward Ball,Roy B. Jones,Rein Saral,Cindy Jacobs,Shelly Heimfeld,Ronald Berenson,Richard Champlin

View Articletitled, A Prospective Randomized Trial of Buffy Coat Versus CD34-Selected Autologous Bone Marrow Support in High-Risk Breast Cancer Patients Receiving High-Dose Chemotherapy

HEMATOPOIESIS

Bidirectional Effect of Interleukin-10 on Early Murine B-Cell Development: Stimulation of flt3-Ligand Plus Interleukin-7–Dependent Generation of CD19⁻ ProB Cells From Uncommitted Bone Marrow Progenitor Cells and Growth Inhibition of CD19⁺ ProB Cells

Ole P. Veiby,Ole J. Borge,Annica Mårtensson,Eric X. Beck,Andrew E. Schade,Krzysztof Grzegorzewski,Stewart D. Lyman,Inga-Lill Mårtensson,Sten E.W. Jacobsen

View Articletitled, Bidirectional Effect of Interleukin-10 on Early Murine B-Cell Development: Stimulation of flt3-Ligand Plus Interleukin-7–Dependent Generation of CD19− ProB Cells From Uncommitted Bone Marrow Progenitor Cells and Growth Inhibition of CD19+ ProB Cells

Predominant Expression of Murine Bmx Tyrosine Kinase in the Granulo-Monocytic Lineage

Dominique Weil,Mary-Anne Power,Shirley I. Smith,Chung Leung Li

View Articletitled, Predominant Expression of Murine Bmx Tyrosine Kinase in the Granulo-Monocytic Lineage

The Bmx Tyrosine Kinase Induces Activation of the Stat Signaling Pathway, Which Is Specifically Inhibited by Protein Kinase Cδ

Pipsa Saharinen,Niklas Ekman,Krista Sarvas,Peter Parker,Kari Alitalo,Olli Silvennoinen

View Articletitled, The Bmx Tyrosine Kinase Induces Activation of the Stat Signaling Pathway, Which Is Specifically Inhibited by Protein Kinase Cδ

Hydroxyurea Can Be Used to Increase Mouse c-kit⁺Thy-1.1^loLin^−/loSca-1⁺ Hematopoietic Cell Number and Frequency in Cell Cycle In Vivo

Nobuko Uchida,Annabelle M. Friera,Dongping He,Michael J. Reitsma,Ann S. Tsukamoto,Irving L. Weissman

View Articletitled, Hydroxyurea Can Be Used to Increase Mouse c-kit+Thy-1.1loLin−/loSca-1+ Hematopoietic Cell Number and Frequency in Cell Cycle In Vivo

Synergistic Action of Flt3 and gp130 Signalings in Human Hematopoiesis

Yasuhiro Ebihara,Kohichiro Tsuji,Stewart D. Lyman,Xingwei Sui,Makoto Yoshida,Kenji Muraoka,Kaoru Yamada,Ryuhei Tanaka,Tatsutoshi Nakahata

View Articletitled, Synergistic Action of Flt3 and gp130 Signalings in Human Hematopoiesis

High Thrombopoietin Production by Hematopoietic Cells Induces a Fatal Myeloproliferative Syndrome in Mice

Jean-Luc Villeval,Karine Cohen-Solal,Micheline Tulliez,Stéphane Giraudier,Josette Guichard,Samuel A. Burstein,Elisabeth M. Cramer,William Vainchenker,Françoise Wendling

View Articletitled, High Thrombopoietin Production by Hematopoietic Cells Induces a Fatal Myeloproliferative Syndrome in Mice

Functional Heterogeneity of Human CD34⁺ Cells Isolated in Subcompartments of the G₀ /G₁ Phase of the Cell Cycle

André Gothot,Robert Pyatt,Jon McMahel,Susan Rice,Edward F. Srour

View Articletitled, Functional Heterogeneity of Human CD34+ Cells Isolated in Subcompartments of the G0 /G1 Phase of the Cell Cycle

Thrombopoietin Upregulates the Promoter Conformation of p53 in a Proliferation-Independent Manner Coincident With a Decreased Expression of Bax: Potential Mechanisms for Survival Enhancing Effects

Alec Ritchie,Akihiko Gotoh,Jay Gaddy,Stephen E. Braun,Hal E. Broxmeyer

View Articletitled, Thrombopoietin Upregulates the Promoter Conformation of p53 in a Proliferation-Independent Manner Coincident With a Decreased Expression of Bax: Potential Mechanisms for Survival Enhancing Effects

Recombinant Soluble Interleukin-11 (IL-11) Receptor α-Chain Can Act as an IL-11 Antagonist

David J. Curtis,Douglas J. Hilton,Bronwyn Roberts,Leecia Murray,Nicos Nicola,C. Glenn Begley

View Articletitled, Recombinant Soluble Interleukin-11 (IL-11) Receptor α-Chain Can Act as an IL-11 Antagonist

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Analysis of the Involvement of the von Willebrand Factor–Glycoprotein Ib Interaction in Platelet Adhesion to a Collagen-Coated Surface Under Flow Conditions

Masaaki Moroi,Stephanie M. Jung,Shosaku Nomura,Sadayoshi Sekiguchi,Antonio Ordinas,Maribel Diaz-Ricart

View Articletitled, Analysis of the Involvement of the von Willebrand Factor–Glycoprotein Ib Interaction in Platelet Adhesion to a Collagen-Coated Surface Under Flow Conditions

Activation of Human Platelets by the Membrane-Expressed A1 Domain of von Willebrand Factor

Jan Schulte am Esch, II,Miguel A. Cruz,Jonathan B. Siegel,Josef Anrather,Simon C. Robson

View Articletitled, Activation of Human Platelets by the Membrane-Expressed A1 Domain of von Willebrand Factor

IMMUNOBIOLOGY

The c-kit Ligand Stem Cell Factor and Anti-IgE Promote Expression of Monocyte Chemoattractant Protein-1 in Human Lung Mast Cells

Mehrdad Baghestanian,Roland Hofbauer,Hans P. Kiener,Hans C. Bankl,Friedrich Wimazal,Martin Willheim,Otto Scheiner,Wolfgang Füreder,Michael R. Müller,Dorian Bevec,Klaus Lechner,Peter Valent

View Articletitled, The c-kit Ligand Stem Cell Factor and Anti-IgE Promote Expression of Monocyte Chemoattractant Protein-1 in Human Lung Mast Cells

Neoexpression of the c-met/Hepatocyte Growth Factor-Scatter Factor Receptor Gene in Activated Monocytes

Mario Beilmann,Margarete Odenthal,Waltraud Jung,George F. Vande Woude,Hans-Peter Dienes,Peter Schirmacher

View Articletitled, Neoexpression of the c-met/Hepatocyte Growth Factor-Scatter Factor Receptor Gene in Activated Monocytes

E- and P-Selectin Are Not Involved in the Recruitment of Inflammatory Cells Across the Blood-Brain Barrier in Experimental Autoimmune Encephalomyelitis

Britta Engelhardt,Dietmar Vestweber,Rupert Hallmann,Martina Schulz

View Articletitled, E- and P-Selectin Are Not Involved in the Recruitment of Inflammatory Cells Across the Blood-Brain Barrier in Experimental Autoimmune Encephalomyelitis

Protective Effect of a Single Interleukin-12 (IL-12) Predose Against the Toxicity of Subsequent Chronic IL-12 in Mice: Role of Cytokines and Glucocorticoids

Silvano Sacco,Hubertine Heremans,Berndt Echtenacher,Wim A. Buurman,Zoulikha Amraoui,Michel Goldman,Pietro Ghezzi

View Articletitled, Protective Effect of a Single Interleukin-12 (IL-12) Predose Against the Toxicity of Subsequent Chronic IL-12 in Mice: Role of Cytokines and Glucocorticoids

Methylation of the Epstein-Barr Virus Genome in Normal Lymphocytes

Keith D. Robertson,Richard F. Ambinder

View Articletitled, Methylation of the Epstein-Barr Virus Genome in Normal Lymphocytes

FcαRI (CD89) as a Novel Trigger Molecule for Bispecific Antibody Therapy

Thomas Valerius,Bernhard Stockmeyer,Annemiek B. van Spriel,Robert F. Graziano,Ingrid E. van den Herik-Oudijk,Roland Repp,Yashwant M. Deo,John Lund,Joachim R. Kalden,Martin Gramatzki,Jan G.J. van de Winkel

View Articletitled, FcαRI (CD89) as a Novel Trigger Molecule for Bispecific Antibody Therapy

Recombinant Tumor Necrosis Factor Enhances the Locomotion of Memory and Naive B Lymphocytes From Human Tonsils Through the Selective Engagement of the Type II Receptor

Anna Corcione,Luciano Ottonello,Giuseppe Tortolina,Paola Tasso,Fabio Ghiotto,Irma Airoldi,Giuseppe Taborelli,Fabio Malavasi,Franco Dallegri,Vito Pistoia

View Articletitled, Recombinant Tumor Necrosis Factor Enhances the Locomotion of Memory and Naive B Lymphocytes From Human Tonsils Through the Selective Engagement of the Type II Receptor

Human Herpesvirus 7 Induces CD4⁺ T-Cell Death by Two Distinct Mechanisms: Necrotic Lysis in Productively Infected Cells and Apoptosis in Uninfected or Nonproductively Infected Cells

Paola Secchiero,Louis Flamand,Davide Gibellini,Elisabetta Falcieri,Iole Robuffo,Silvano Capitani,Robert C. Gallo,Giorgio Zauli

View Articletitled, Human Herpesvirus 7 Induces CD4+ T-Cell Death by Two Distinct Mechanisms: Necrotic Lysis in Productively Infected Cells and Apoptosis in Uninfected or Nonproductively Infected Cells

The Role of Interleukin-10 (IL-10) in IL-15–Mediated T-Cell Responses

Dieter Körholz,Ursula Banning,Halvard Bönig,Markus Grewe,Marion Schneider,Christine Mauz-Körholz,Anne Klein-Vehne,Jean Krutmann,Stephan Burdach

View Articletitled, The Role of Interleukin-10 (IL-10) in IL-15–Mediated T-Cell Responses

NEOPLASIA

Growth and Dissemination of Lewis Lung Carcinoma in Plasminogen-Deficient Mice

Thomas H. Bugge,Keith W. Kombrinck,Qing Xiao,Kenn Holmbäck,Cynthia C. Daugherty,Dave P. Witte,Jay L. Degen

View Articletitled, Growth and Dissemination of Lewis Lung Carcinoma in Plasminogen-Deficient Mice

Adult Patients With De Novo Acute Myeloid Leukemia and t(9; 11)(p22; q23) Have a Superior Outcome to Patients With Other Translocations Involving Band 11q23: A Cancer and Leukemia Group B Study

Krzysztof Mrózek,Kristiina Heinonen,David Lawrence,Andrew J. Carroll,Prasad R.K. Koduru,Kathleen W. Rao,Matthew P. Strout,Robert E. Hutchison,Joseph O. Moore,Robert J. Mayer,Charles A. Schiffer,Clara D. Bloomfield

View Articletitled, Adult Patients With De Novo Acute Myeloid Leukemia and t(9; 11)(p22; q23) Have a Superior Outcome to Patients With Other Translocations Involving Band 11q23: A Cancer and Leukemia Group B Study

Expression of Constitutively Activated Human c-Kit in Myb Transformed Early Myeloid Cells Leads to Factor Independence, Histiocytic Differentiation, and Tumorigenicity

Petranel Ferrao,Thomas J. Gonda,Leonie K. Ashman

View Articletitled, Expression of Constitutively Activated Human c-Kit in Myb Transformed Early Myeloid Cells Leads to Factor Independence, Histiocytic Differentiation, and Tumorigenicity

Regulation of a Graft-Versus-Leukemia Effect by Major Histocompatibility Complex Class II Molecules on Leukemia Cells: HLA-DR1 Expression Renders K562 Cell Tumors Resistant to Adoptively Transferred Lymphocytes in Severe Combined Immunodeficiency Mice/Nonobese Diabetic Mice

Frank F. Weichold,Yin-zheng Jiang,Daniel E. Dunn,Michael Bloom,Vera Malkovska,Nancy F. Hensel,A. John Barrett

View Articletitled, Regulation of a Graft-Versus-Leukemia Effect by Major Histocompatibility Complex Class II Molecules on Leukemia Cells: HLA-DR1 Expression Renders K562 Cell Tumors Resistant to Adoptively Transferred Lymphocytes in Severe Combined Immunodeficiency Mice/Nonobese Diabetic Mice

12p Abnormalities and the TEL Gene (ETV6) in Childhood Acute Lymphoblastic Leukemia

S.C. Raimondi,S.A. Shurtleff,J.R. Downing,J. Rubnitz,S. Mathew,M. Hancock,C-H. Pui,G.K. Rivera,G.C. Grosveld,F.G. Behm

View Articletitled, 12p Abnormalities and the TEL Gene (ETV6) in Childhood Acute Lymphoblastic Leukemia

Mitochondrial Antisense RNA for Cytochrome C Oxidase (MARCO) Can Induce Morphologic Changes and Cell Death in Human Hematopoietic Cell Lines

Naoki Shirafuji,Satoshi Takahashi,Satoru Matsuda,Shigetaka Asano

View Articletitled, Mitochondrial Antisense RNA for Cytochrome C Oxidase (MARCO) Can Induce Morphologic Changes and Cell Death in Human Hematopoietic Cell Lines

Modulation of Idarubicin-Induced Apoptosis in Human Acute Myeloid Leukemia Blasts by All-Trans Retinoic Acid, 1,25(OH)₂ Vitamin D3, and Granulocyte-Macrophage Colony-Stimulating Factor

Nicolas J. Ketley,Paul D. Allen,Stephen M. Kelsey,Adrian C. Newland

View Articletitled, Modulation of Idarubicin-Induced Apoptosis in Human Acute Myeloid Leukemia Blasts by All-Trans Retinoic Acid, 1,25(OH)2 Vitamin D3, and Granulocyte-Macrophage Colony-Stimulating Factor

PHAGOCYTES

The CXC-Chemokine Neutrophil-Activating Peptide-2 Induces Two Distinct Optima of Neutrophil Chemotaxis by Differential Interaction With Interleukin-8 Receptors CXCR-1 and CXCR-2

Andreas Ludwig,Frank Petersen,Stefan Zahn,Otto Götze,Jens-Michael Schröder,Hans-Dieter Flad,Ernst Brandt

View Articletitled, The CXC-Chemokine Neutrophil-Activating Peptide-2 Induces Two Distinct Optima of Neutrophil Chemotaxis by Differential Interaction With Interleukin-8 Receptors CXCR-1 and CXCR-2

Granulocyte Colony-Stimulating Factor Upregulates the Vacuolar Proton ATPase in Human Neutrophils

Hans Niessen,Grant W. Meisenholder,Hai-Ling Li,Stephen L. Gluck,Beth S. Lee,Barry Bowman,Robert L. Engler,Bernard M. Babior,Roberta A. Gottlieb

View Articletitled, Granulocyte Colony-Stimulating Factor Upregulates the Vacuolar Proton ATPase in Human Neutrophils

RED CELLS

The Human β Globin Locus Introduced by YAC Transfer Exhibits a Specific and Reproducible Pattern of Developmental Regulation in Transgenic Mice

Susanna Porcu,Michael Kitamura,Ewa Witkowska,Zemin Zhang,Annick Mutero,Chin Lin,Judy Chang,Karin M.L. Gaensler

View Articletitled, The Human β Globin Locus Introduced by YAC Transfer Exhibits a Specific and Reproducible Pattern of Developmental Regulation in Transgenic Mice

Thrombosis and Secondary Hemochromatosis Play Major Roles in the Pathogenesis of Jaundiced and Spherocytic Mice, Murine Models for Hereditary Spherocytosis

Tamma M. Kaysser,Nancy J. Wandersee,Rod T. Bronson,Jane E. Barker

View Articletitled, Thrombosis and Secondary Hemochromatosis Play Major Roles in the Pathogenesis of Jaundiced and Spherocytic Mice, Murine Models for Hereditary Spherocytosis

Systematic Enhancement of Polymerization of Recombinant Sickle Hemoglobin Mutants: Implications for Transgenic Mouse Model for Sickle Cell Anemia

Xianfeng Li,Urooj A. Mirza,Brian T. Chait,James M. Manning

View Articletitled, Systematic Enhancement of Polymerization of Recombinant Sickle Hemoglobin Mutants: Implications for Transgenic Mouse Model for Sickle Cell Anemia

TRANSFUSION MEDICINE

Prevalence and Natural History of Hepatitis C Infection in Patients Cured of Childhood Leukemia

Anna Locasciulli,Marina Testa,Patrizia Pontisso,Luisa Benvegnù,Donatella Fraschini,Adele Corbetta,Franco Noventa,Giuseppe Masera,Alfredo Alberti

View Articletitled, Prevalence and Natural History of Hepatitis C Infection in Patients Cured of Childhood Leukemia

High Rates of Hepatitis G Virus Infection in Multitransfused Patients With Hemophilia

Francesca De Filippi,M. Colombo,Maria Grazia Rumi,F. Tradati,D. Prati,A. Zanella,P.M. Mannucci

View Articletitled, High Rates of Hepatitis G Virus Infection in Multitransfused Patients With Hemophilia

TRANSPLANTATION

Gene Transfer into Marrow Repopulating Cells: Comparison Between Amphotropic and Gibbon Ape Leukemia Virus Pseudotyped Retroviral Vectors in a Competitive Repopulation Assay in Baboons

Hans-Peter Kiem,Scott Heyward,Aaron Winkler,Jennifer Potter,James M. Allen,A. Dusty Miller,Robert G. Andrews

View Articletitled, Gene Transfer into Marrow Repopulating Cells: Comparison Between Amphotropic and Gibbon Ape Leukemia Virus Pseudotyped Retroviral Vectors in a Competitive Repopulation Assay in Baboons

Synchronized Cell-Cycle Induction of Engrafting Long-Term Repopulating Stem Cells

Susan K. Nilsson,Mark S. Dooner,Peter J. Quesenberry

View Articletitled, Synchronized Cell-Cycle Induction of Engrafting Long-Term Repopulating Stem Cells

Interleukin-12 Preserves the Graft-Versus-Leukemia Effect of Allogeneic CD8 T Cells While Inhibiting CD4-Dependent Graft-Versus-Host Disease in Mice

Yong-Guang Yang,Justin J. Sergio,Denise A. Pearson,Gregory L. Szot,Akira Shimizu,Megan Sykes

View Articletitled, Interleukin-12 Preserves the Graft-Versus-Leukemia Effect of Allogeneic CD8 T Cells While Inhibiting CD4-Dependent Graft-Versus-Host Disease in Mice

ERRATA

Cover Image

Cover Image
Table of Contents

All Issues

Advertisement intended for health care professionals

Email alerts

First Edition Alert

Latest Issue Alert

Latest
Most Read
Most Cited

HLA-I aberrations in cutaneous T-cell lymphoma

Daratumumab for maintenance in myeloma

Combined targeted modality in cHL: a risky bet?

Is it time to screen for multiple myeloma?

B-1 B cells lose self-control in SCD