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Volume 89, Issue 7

April 1 1997

In this Issue

REVIEW ARTICLES
RAPID COMMUNICATIONS
CLINICAL INTERVENTION AND THERAPEUTIC TRIALS
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSPLANTATION
CORRESPONDENCE
ERRATA

REVIEW ARTICLES

The Biology and Clinical Uses of Blood Stem Cells

L.B. To,D.N. Haylock,P.J. Simmons,C.A. Juttner

View Articletitled, The Biology and Clinical Uses of Blood Stem Cells

RAPID COMMUNICATIONS

Inhibition of Human Immunodeficiency Virus-1 (HIV-1) Replication After Transduction of Granulocyte Colony-Stimulating Factor–Mobilized CD34⁺ Cells From HIV-1–Infected Donors Using Retroviral Vectors Containing Anti–HIV-1 Genes

Gerhard Bauer,Penelope Valdez,Karen Kearns,Ingrid Bahner,Sui Fang Wen,John A. Zaia,Donald B. Kohn

View Articletitled, Inhibition of Human Immunodeficiency Virus-1 (HIV-1) Replication After Transduction of Granulocyte Colony-Stimulating Factor–Mobilized CD34+ Cells From HIV-1–Infected Donors Using Retroviral Vectors Containing Anti–HIV-1 Genes

Enhanced Host Defense After Gene Transfer in the Murine p47^phox-Deficient Model of Chronic Granulomatous Disease

Michael Mardiney, III,Sharon H. Jackson,S. Kaye Spratt,Fei Li,Steven M. Holland,Harry L. Malech

View Articletitled, Enhanced Host Defense After Gene Transfer in the Murine p47phox-Deficient Model of Chronic Granulomatous Disease

Defects of the Mismatch Repair Gene MSH2 Are Implicated in the Development of Murine and Human Lymphoblastic Lymphomas and Are Associated With the Aberrant Expression of Rhombotin-2 (Lmo-2) and Tal-1 (SCL)

Robert Lowsky,John F. DeCoteau,Armin H. Reitmair,Ryo Ichinohasama,Wei-Feng Dong,Yi Xu,Tak W. Mak,Marshall E. Kadin,Mark D. Minden

View Articletitled, Defects of the Mismatch Repair Gene MSH2 Are Implicated in the Development of Murine and Human Lymphoblastic Lymphomas and Are Associated With the Aberrant Expression of Rhombotin-2 (Lmo-2) and Tal-1 (SCL)

CLINICAL INTERVENTION AND THERAPEUTIC TRIALS

Hematopoietic Stem Cell–Based Gene Therapy for Acquired Immunodeficiency Syndrome: Efficient Transduction and Expression of RevM10 in Myeloid Cells In Vivo and In Vitro

Lishan Su,Robert Lee,Mark Bonyhadi,Hajime Matsuzaki,Sean Forestell,Sonia Escaich,Ernst Böhnlein,Hideto Kaneshima

View Articletitled, Hematopoietic Stem Cell–Based Gene Therapy for Acquired Immunodeficiency Syndrome: Efficient Transduction and Expression of RevM10 in Myeloid Cells In Vivo and In Vitro

Subclassification of Diffuse Large B-Cell Lymphomas According to the Kiel Classification: Distinction of Centroblastic and Immunoblastic Lymphomas Is a Significant Prognostic Risk Factor

Marianne Engelhard,Günter Brittinger,Dieter Huhn,Heinrich H. Gerhartz,Peter Meusers,Wolfgang Siegert,Eckhard Thiel,Wolfgang Wilmanns,Ülker Aydemir,Stefan Bierwolf,Henrik Griesser,Markus Tiemann,Karl Lennert

View Articletitled, Subclassification of Diffuse Large B-Cell Lymphomas According to the Kiel Classification: Distinction of Centroblastic and Immunoblastic Lymphomas Is a Significant Prognostic Risk Factor

Treatment of Chronic Graft-Versus-Host Disease With Clofazimine

Stephanie J. Lee,Scott A. Wegner,Carol J. McGarigle,Barbara E. Bierer,Joseph H. Antin

View Articletitled, Treatment of Chronic Graft-Versus-Host Disease With Clofazimine

Radiotherapy-Associated Neutropenia and Thrombocytopenia: Analysis of Risk Factors and Development of a Predictive Model

Michael Mac Manus,Kathleen Lamborn,Waqqar Khan,Anna Varghese,Lorin Graef,Susan Knox

View Articletitled, Radiotherapy-Associated Neutropenia and Thrombocytopenia: Analysis of Risk Factors and Development of a Predictive Model

Randomized Comparison of DAT Versus ADE as Induction Chemotherapy in Children and Younger Adults With Acute Myeloid Leukemia. Results of the Medical Research Council's 10th AML Trial (MRC AML10)

Ian M. Hann,Richard F. Stevens,Anthony H. Goldstone,John K.H. Rees,Keith Wheatley,Richard G. Gray,Alan K. Burnett,on behalf of the Adult and Childhood Leukaemia Working Parties of the Medical Research Council

View Articletitled, Randomized Comparison of DAT Versus ADE as Induction Chemotherapy in Children and Younger Adults With Acute Myeloid Leukemia. Results of the Medical Research Council's 10th AML Trial (MRC AML10)

Treatment of Polycythemia Vera: Use of ³²P Alone or in Combination With Maintenance Therapy Using Hydroxyurea in 461 Patients Greater Than 65 Years of Age

Yves Najean,Jean-Didier Rain,for The French Polycythemia Study Group

View Articletitled, Treatment of Polycythemia Vera: Use of 32P Alone or in Combination With Maintenance Therapy Using Hydroxyurea in 461 Patients Greater Than 65 Years of Age

HEMATOPOIESIS

Platelet Factor 4 and Other CXC Chemokines Support the Survival of Normal Hematopoietic Cells and Reduce the Chemosensitivity of Cells to Cytotoxic Agents

Zhong Chao Han,Min Lu,Junmin Li,Mai Defard,Bernadette Boval,Nicole Schlegel,Jacques P. Caen

View Articletitled, Platelet Factor 4 and Other CXC Chemokines Support the Survival of Normal Hematopoietic Cells and Reduce the Chemosensitivity of Cells to Cytotoxic Agents

Ultrastructure of Platelet Formation by Human Megakaryocytes Cultured With the Mpl Ligand

Elisabeth M. Cramer,Françoise Norol,Josette Guichard,Janine Breton-Gorius,William Vainchenker,Jean-Marc Massé,Najet Debili

View Articletitled, Ultrastructure of Platelet Formation by Human Megakaryocytes Cultured With the Mpl Ligand

Frequency of Fetal Cells in Sorted Subpopulations of Nucleated Erythroid and CD34⁺ Hematopoietic Progenitor Cells From Maternal Peripheral Blood

Marie-Térèse Little,Sylvie Langlois,R. Douglas Wilson,Peter M. Lansdorp

View Articletitled, Frequency of Fetal Cells in Sorted Subpopulations of Nucleated Erythroid and CD34+ Hematopoietic Progenitor Cells From Maternal Peripheral Blood

Lineage- and Stage-Specific Expression of Runt Box Polypeptides in Primitive and Definitive Hematopoiesis

Maria Teresa Corsetti,Franco Calabi

View Articletitled, Lineage- and Stage-Specific Expression of Runt Box Polypeptides in Primitive and Definitive Hematopoiesis

Clinical Relevance of Point Mutations in the Cytoplasmic Domain of the Granulocyte Colony-Stimulating Factor Receptor Gene in Patients With Severe Congenital Neutropenia

N. Tidow,C. Pilz,B. Teichmann,A. Müller-Brechlin,M. Germeshausen,B. Kasper,P. Rauprich,K.-W. Sykora,K. Welte

View Articletitled, Clinical Relevance of Point Mutations in the Cytoplasmic Domain of the Granulocyte Colony-Stimulating Factor Receptor Gene in Patients With Severe Congenital Neutropenia

Host Conditioning With 5-Fluorouracil and kit-Ligand to Provide for Long-Term Bone Marrow Engraftment

Ronald van Os,Donald Dawes,John M.K. Mislow,Alice Witsell,Peter M. Mauch

View Articletitled, Host Conditioning With 5-Fluorouracil and kit-Ligand to Provide for Long-Term Bone Marrow Engraftment

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

The Src Family Kinases, Fgr, Fyn, Lck, and Lyn, Colocalize With Coated Membranes in Platelets

Paula E. Stenberg,Tamara I. Pestina,Rosemary J. Barrie,Carl W. Jackson

View Articletitled, The Src Family Kinases, Fgr, Fyn, Lck, and Lyn, Colocalize With Coated Membranes in Platelets

Regulation of Plasminogen Gene Expression by Interleukin-6

G. Ronald Jenkins,Dietmar Seiffert,Robert J. Parmer,Lindsey A. Miles

View Articletitled, Regulation of Plasminogen Gene Expression by Interleukin-6

Missense Mutations of the Glycoprotein (GP) Ibβ Gene Impairing the GPIb α/β Disulfide Linkage in a Family With Giant Platelet Disorder

Shinji Kunishima,Jose A. Lopez,Sentaro Kobayashi,Nobuaki Imai,Tadashi Kamiya,Hidehiko Saito,Tomoki Naoe

View Articletitled, Missense Mutations of the Glycoprotein (GP) Ibβ Gene Impairing the GPIb α/β Disulfide Linkage in a Family With Giant Platelet Disorder

A Molecular Model for the Triplicated A Domains of Human Factor VIII Based on the Crystal Structure of Human Ceruloplasmin

S. Pemberton,P. Lindley,V. Zaitsev,G. Card,E.G.D. Tuddenham,G. Kemball-Cook

View Articletitled, A Molecular Model for the Triplicated A Domains of Human Factor VIII Based on the Crystal Structure of Human Ceruloplasmin

HPA-10w^b (La^a): Genetic Determination of a New Platelet-Specific Alloantigen on Glycoprotein IIIa and Its Expression in COS-7 Cells

O. Peyruchaud,F. Bourre,M.-C. Morel-Kopp,D. Reviron,P. Mercier,A. Nurden,C. Kaplan

View Articletitled, HPA-10wb (Laa): Genetic Determination of a New Platelet-Specific Alloantigen on Glycoprotein IIIa and Its Expression in COS-7 Cells

Apoptotic Vascular Endothelial Cells Become Procoagulant

Thomas Bombeli,Aly Karsan,Jonathan F. Tait,John M. Harlan

View Articletitled, Apoptotic Vascular Endothelial Cells Become Procoagulant

IMMUNOBIOLOGY

Human Cytomegalovirus-Associated Immunosuppression Is Mediated Through Interferon-α

Nelly Noraz,Janet L. Lathey,Stephen A. Spector

View Articletitled, Human Cytomegalovirus-Associated Immunosuppression Is Mediated Through Interferon-α

Upregulation of Intracellular Glutathione by Fibroblast-Derived Factor(s): Enhanced Survival of Activated T Cells in the Presence of Low Bcl-2

Helena Hyde,Nicola J. Borthwick,George Janossy,Michael Salmon,Arne N. Akbar

View Articletitled, Upregulation of Intracellular Glutathione by Fibroblast-Derived Factor(s): Enhanced Survival of Activated T Cells in the Presence of Low Bcl-2

Vascular Cell Adhesion Molecule-1 Is Expressed by Cortical Thymic Epithelial Cells and Mediates Thymocyte Adhesion. Implications for the Function of α4β1 (VLA4) Integrin in T-Cell Development

Daniel R. Salomon,Laura Crisa,Christopher F. Mojcik,Jennifer K. Ishii,George Klier,Ethan M. Shevach

View Articletitled, Vascular Cell Adhesion Molecule-1 Is Expressed by Cortical Thymic Epithelial Cells and Mediates Thymocyte Adhesion. Implications for the Function of α4β1 (VLA4) Integrin in T-Cell Development

Endogenous Tumor Necrosis Factor as a Predictor of Doxorubicin Sensitivity in Leukemic Patients

Daisuke Kobayashi,Naoki Watanabe,Naofumi Yamauchi,Naoki Tsuji,Tsutomu Sato,Yoshiro Niitsu

View Articletitled, Endogenous Tumor Necrosis Factor as a Predictor of Doxorubicin Sensitivity in Leukemic Patients

NEOPLASIA

Possible Roles of an Adult T-Cell Leukemia (ATL)-Derived Factor/Thioredoxin in the Drug Resistance of ATL to Adriamycin

Jingxin Wang,Masanobu Kobayashi,Keisuke Sakurada,Masahiro Imamura,Tetsuya Moriuchi,Masuo Hosokawa

View Articletitled, Possible Roles of an Adult T-Cell Leukemia (ATL)-Derived Factor/Thioredoxin in the Drug Resistance of ATL to Adriamycin

Clinical Features and Treatment Outcome of Children With Biphenotypic CD2⁺CD19⁺ Acute Lymphoblastic Leukemia: A Children's Cancer Group Study

Fatih M. Uckun,Paul Gaynon,Harland Sather,Diane Arthur,Michael Trigg,David Tubergen,James Nachman,Peter Steinherz,Martha G. Sensel,Gregory R. Reaman

View Articletitled, Clinical Features and Treatment Outcome of Children With Biphenotypic CD2+CD19+ Acute Lymphoblastic Leukemia: A Children's Cancer Group Study

Molecular Mechanism of Antifolate Transport-Deficiency in a Methotrexate-Resistant MOLT-3 Human Leukemia Cell Line

Maokai Gong,James Yess,Tatiana Connolly,S. Percy Ivy,Takao Ohnuma,Kenneth H. Cowan,Jeffrey A. Moscow

View Articletitled, Molecular Mechanism of Antifolate Transport-Deficiency in a Methotrexate-Resistant MOLT-3 Human Leukemia Cell Line

Frequent Hypermethylation of p16 and p15 Genes in Multiple Myeloma

M.H.L. Ng,Y.F. Chung,K.W. Lo,N.W.R. Wickham,J.C.K. Lee,D.P. Huang

View Articletitled, Frequent Hypermethylation of p16 and p15 Genes in Multiple Myeloma

Downregulation of RARα in Mice by Antisense Transgene Leads to a Compensatory Increase in RARβ and RARγ and Development of Lymphoma

Taghi Manshouri,Yun Yang,Huai Lin,Sanford A. Stass,Armand B. Glassman,Michael J. Keating,Maher Albitar

View Articletitled, Downregulation of RARα in Mice by Antisense Transgene Leads to a Compensatory Increase in RARβ and RARγ and Development of Lymphoma

11q Deletions Identify a New Subset of B-Cell Chronic Lymphocytic Leukemia Characterized by Extensive Nodal Involvement and Inferior Prognosis

Hartmut Döhner,Stephan Stilgenbauer,Michael R. James,Axel Benner,Traudel Weilguni,Martin Bentz,Konstanze Fischer,Werner Hunstein,Peter Lichter

View Articletitled, 11q Deletions Identify a New Subset of B-Cell Chronic Lymphocytic Leukemia Characterized by Extensive Nodal Involvement and Inferior Prognosis

Human Non-Hodgkin's Lymphomas Overexpress a Wild-Type Form of p53 Which Is a Functional Transcriptional Activator of the Cyclin-Dependent Kinase Inhibitor p21

Roberta Maestro,Annunziata Gloghini,Claudio Doglioni,Sara Piccinin,Tamara Vukosavljevic,Daniela Gasparotto,Antonino Carbone,Mauro Boiocchi

View Articletitled, Human Non-Hodgkin's Lymphomas Overexpress a Wild-Type Form of p53 Which Is a Functional Transcriptional Activator of the Cyclin-Dependent Kinase Inhibitor p21

Adoptive Transfer of Anti-CD3–Activated CD4⁺ T Cells Plus Cyclophosphamide and Liposome-Encapsulated Interleukin-2 Cure Murine MC-38 and 3LL Tumors and Establish Tumor-Specific Immunity

Mark L. Saxton,Dan L. Longo,Holly E. Wetzel,Henry Tribble,W. Gregory Alvord,Larry W. Kwak,Arnold S. Leonard,Claudio Dansky Ullmann,Brendan D. Curti,Augusto C. Ochoa

View Articletitled, Adoptive Transfer of Anti-CD3–Activated CD4+ T Cells Plus Cyclophosphamide and Liposome-Encapsulated Interleukin-2 Cure Murine MC-38 and 3LL Tumors and Establish Tumor-Specific Immunity

Increased Circulating Colony-Stimulating Factor-1 (CSF-1) in SJL/J Mice With Radiation-Induced Acute Myeloid Leukemia (AML) Is Associated With Autocrine Regulation of AML Cells by CSF-1

Nechama Haran-Ghera,Rita Krautghamer,Tsvee Lapidot,Alpha Peled,Melissa G. Dominguez,E. Richard Stanley

View Articletitled, Increased Circulating Colony-Stimulating Factor-1 (CSF-1) in SJL/J Mice With Radiation-Induced Acute Myeloid Leukemia (AML) Is Associated With Autocrine Regulation of AML Cells by CSF-1

PHAGOCYTES

Inappropriately High Iron Regulatory Protein Activity in Monocytes of Patients With Genetic Hemochromatosis

Gaetano Cairo,Stefania Recalcati,Giuliana Montosi,Elisa Castrusini,Dario Conte,Antonello Pietrangelo

View Articletitled, Inappropriately High Iron Regulatory Protein Activity in Monocytes of Patients With Genetic Hemochromatosis

RED CELLS

Decrease of Very Late Activation Antigen-4 and CD36 on Reticulocytes in Sickle Cell Patients Treated With Hydroxyurea

Lori A. Styles,Bertram Lubin,Elliott Vichinsky,Sandy Lawrence,Mandy Hua,Samuel Test,Frans Kuypers

View Articletitled, Decrease of Very Late Activation Antigen-4 and CD36 on Reticulocytes in Sickle Cell Patients Treated With Hydroxyurea

Inhibition of Sickle Erythrocyte Adhesion to Immobilized Thrombospondin by von Willebrand Factor Under Dynamic Flow Conditions

Gilda A. Barabino,Robert J. Wise,Valerie A. Woodbury,Beibing Zhang,Kenneth A. Bridges,Robert P. Hebbel,Jack Lawler,Bruce M. Ewenstein

View Articletitled, Inhibition of Sickle Erythrocyte Adhesion to Immobilized Thrombospondin by von Willebrand Factor Under Dynamic Flow Conditions

Evidence of Genetic Diversity Underlying Rh D⁻, Weak D (D^u), and Partial D Phenotypes as Determined by Multiplex Polymerase Chain Reaction Analysis of the RHD Gene

Neil D. Avent,Peter G. Martin,Sylvia S. Armstrong-Fisher,Wendy Liu,Kirstin M. Finning,Deborah Maddocks,Stanislaw J. Urbaniak

View Articletitled, Evidence of Genetic Diversity Underlying Rh D−, Weak D (Du), and Partial D Phenotypes as Determined by Multiplex Polymerase Chain Reaction Analysis of the RHD Gene

TRANSPLANTATION

Stem Cell Transplantation for Secondary Acute Myeloid Leukemia: Evaluation of Transplantation as Initial Therapy or Following Induction Chemotherapy

Jeanne E. Anderson,Ted A. Gooley,Gary Schoch,Claudio Anasetti,William I. Bensinger,Reginald A. Clift,John A. Hansen,Jean E. Sanders,Rainer Storb,Frederick R. Appelbaum

View Articletitled, Stem Cell Transplantation for Secondary Acute Myeloid Leukemia: Evaluation of Transplantation as Initial Therapy or Following Induction Chemotherapy

Granulocyte Colony-Stimulating Factor–Induced Comobilization of CD4⁻CD8⁻ T Cells and Hematopoietic Progenitor Cells (CD34⁺) in the Blood of Normal Donors

Claus R. Kusnierz-Glaz,Beverley J. Still,Masahiko Amano,Jazil D. Zukor,Robert S. Negrin,Karl G. Blume,Samuel Strober

View Articletitled, Granulocyte Colony-Stimulating Factor–Induced Comobilization of CD4−CD8− T Cells and Hematopoietic Progenitor Cells (CD34+) in the Blood of Normal Donors

Specific Tolerance Induction and Transplantation: A Single-Day Protocol

Anneke de Vries-van der Zwan,Arit C. Besseling,Leo P. de Waal,Claire J.P. Boog

View Articletitled, Specific Tolerance Induction and Transplantation: A Single-Day Protocol

Detection of bcr-abl Transcripts in Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia After Marrow Transplantation

Jerald Radich,Gene Gehly,Arthur Lee,Rachel Avery,Eileen Bryant,Scott Edmands,Ted Gooley,Peter Kessler,Judy Kirk,Paula Ladne,E.D. Thomas,Frederick R. Appelbaum

View Articletitled, Detection of bcr-abl Transcripts in Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia After Marrow Transplantation

CORRESPONDENCE

Allogeneic Bone Marrow Transplant for Multiple Myeloma

N. H. Russell,G. Miflin,C. Stainer,J. G. Mc Quaker,N. Bienz,A. P. Haynes,E. M. Bessell

View Articletitled, Allogeneic Bone Marrow Transplant for Multiple Myeloma

Can Ferritin Provide Iron for Hemoglobin Synthesis?

Prem Ponka,Des R. Richardson

View Articletitled, Can Ferritin Provide Iron for Hemoglobin Synthesis?

Association Between ACP₁ and Favism: A Possible Biochemical Mechanism

E. Bottini,F. Gloria Bottini,P. Borgiani,L. Businco

View Articletitled, Association Between ACP1 and Favism: A Possible Biochemical Mechanism

Autologous Stem Cell Transplantation: Exogenous Granulocyte Colony-Stimulating Factor or Granulocyte-Macrophage Colony-Stimulating Factor Modulate the Endogenous Cytokine Levels

Ugo Testa,Robert Martucci,Giovanni Scambia,Pierluigi Benedetti Panici,Salvatore Mancuso,Antonio Camagna,G. Mastroberardino,Luca Pierelli,Giacomo Menichella,Cesare Peschle

View Articletitled, Autologous Stem Cell Transplantation: Exogenous Granulocyte Colony-Stimulating Factor or Granulocyte-Macrophage Colony-Stimulating Factor Modulate the Endogenous Cytokine Levels

ERRATA

Addendum

View Articletitled, Addendum

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