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Volume 89, Issue 3

February 1 1997

In this Issue

REVIEW ARTICLES
RAPID COMMUNICATIONS
CLINICAL INTERVENTION AND THERAPEUTIC TRIALS
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSPLANTATION
CORRESPONDENCE

REVIEW ARTICLES

Iron-Chelating Therapy and the Treatment of Thalassemia

Nancy F. Olivieri,Gary M. Brittenham

View Articletitled, Iron-Chelating Therapy and the Treatment of Thalassemia

RAPID COMMUNICATIONS

Identification of the cDNA for Human Red Blood Cell–Specific Hexokinase Isozyme

Koko Murakami,Sergio Piomelli

View Articletitled, Identification of the cDNA for Human Red Blood Cell–Specific Hexokinase Isozyme

A Novel Specific Immunoassay for Plasma Two-Chain Factor VIIa: Investigation of FVIIa Levels in Normal Individuals and in Patients With Acute Coronary Syndromes

Helen Philippou,Antonella Adami,Rajiv A. Amersey,Peter J. Stubbs,David A. Lane

View Articletitled, A Novel Specific Immunoassay for Plasma Two-Chain Factor VIIa: Investigation of FVIIa Levels in Normal Individuals and in Patients With Acute Coronary Syndromes

Development of Antibodies to Fetal Calf Serum With Arthus-Like Reactions in Human Immunodeficiency Virus–Infected Patients Given Syngeneic Lymphocyte Infusions

Thomas A. Selvaggi,Robert E. Walker,Thomas A. Fleisher

View Articletitled, Development of Antibodies to Fetal Calf Serum With Arthus-Like Reactions in Human Immunodeficiency Virus–Infected Patients Given Syngeneic Lymphocyte Infusions

CLINICAL INTERVENTION AND THERAPEUTIC TRIALS

Granulocyte Colony-Stimulating Factor (Filgrastim) Accelerates Granulocyte Recovery After Intensive Postremission Chemotherapy for Acute Myeloid Leukemia With Aziridinyl Benzoquinone and Mitoxantrone: Cancer and Leukemia Group B Study 9022

Joseph O. Moore,Richard K. Dodge,Philip C. Amrein,Jonathan Kolitz,Edward J. Lee,Bayard Powell,Scott Godfrey,Francisco Robert,Charles A. Schiffer

View Articletitled, Granulocyte Colony-Stimulating Factor (Filgrastim) Accelerates Granulocyte Recovery After Intensive Postremission Chemotherapy for Acute Myeloid Leukemia With Aziridinyl Benzoquinone and Mitoxantrone: Cancer and Leukemia Group B Study 9022

Superiority of Tandem Autologous Transplantation Over Standard Therapy for Previously Untreated Multiple Myeloma

Bart Barlogie,Sundar Jagannath,David H. Vesole,Sally Naucke,Bruce Cheson,Sandy Mattox,Dwayne Bracy,Sydney Salmon,Joth Jacobson,John Crowley,Guido Tricot

View Articletitled, Superiority of Tandem Autologous Transplantation Over Standard Therapy for Previously Untreated Multiple Myeloma

Frequency and Severity of Central Nervous System Lesions in Hemophagocytic Lymphohistiocytosis

Elie Haddad,Maria-Luisa Sulis,Nada Jabado,Stephane Blanche,Alain Fischer,Marc Tardieu

View Articletitled, Frequency and Severity of Central Nervous System Lesions in Hemophagocytic Lymphohistiocytosis

High-Dose Therapy and Autologous Hematopoietic Progenitor Cell Transplantation for Recurrent or Refractory Hodgkin's Disease: Analysis of the Stanford University Results and Prognostic Indices

Sandra J. Horning,Nelson J. Chao,Robert S. Negrin,Richard T. Hoppe,Gwynn D. Long,Wendy W. Hu,Ruby M. Wong,Byron W. Brown,Karl G. Blume

View Articletitled, High-Dose Therapy and Autologous Hematopoietic Progenitor Cell Transplantation for Recurrent or Refractory Hodgkin's Disease: Analysis of the Stanford University Results and Prognostic Indices

Comparison Between Conventional Salvage Therapy and High-Dose Therapy With Autografting for Recurrent or Refractory Hodgkin's Disease

Alan R. Yuen,Saul A. Rosenberg,Richard T. Hoppe,Jerry D. Halpern,Sandra J. Horning

View Articletitled, Comparison Between Conventional Salvage Therapy and High-Dose Therapy With Autografting for Recurrent or Refractory Hodgkin's Disease

HEMATOPOIESIS

A Single Injection of Pegylated Murine Megakaryocyte Growth and Development Factor (MGDF ) Into Mice Is Sufficient to Produce a Profound Stimulation of Megakaryocyte Frequency, Size, and Ploidization

Julie T. Arnold,Najat C. Daw,Paula E. Stenberg,Deepthi Jayawardene,Deo Kumar Srivastava,Carl W. Jackson

View Articletitled, A Single Injection of Pegylated Murine Megakaryocyte Growth and Development Factor (MGDF ) Into Mice Is Sufficient to Produce a Profound Stimulation of Megakaryocyte Frequency, Size, and Ploidization

Population Size and Radiosensitivity of Murine Hematopoietic Endogenous Long-Term Repopulating Cells

Kenneth F. McCarthy

View Articletitled, Population Size and Radiosensitivity of Murine Hematopoietic Endogenous Long-Term Repopulating Cells

Roles of the N and C Terminal Domains of the Interleukin-3 Receptor α Chain in Receptor Function

S.C. Barry,E. Korpelainen,Q. Sun,F.C. Stomski,P.A.B. Moretti,H. Wakao,R.J. D'Andrea,M.A. Vadas,A.F. Lopez,G.J. Goodall

View Articletitled, Roles of the N and C Terminal Domains of the Interleukin-3 Receptor α Chain in Receptor Function

Role of bcl-2 in the Development of Lymphoid Cells From the Hematopoietic Stem Cell

Yumi Matsuzaki,Kei-ichi Nakayama,Keiko Nakayama,Takashi Tomita,Miu Isoda,Dennis Y. Loh,Hiromitsu Nakauchi

View Articletitled, Role of bcl-2 in the Development of Lymphoid Cells From the Hematopoietic Stem Cell

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Activation of JAK2 in Human Vascular Endothelial Cells by Granulocyte-Macrophage Colony-Stimulating Factor

Raffaella Soldi,Luca Primo,Maria Felice Brizzi,Fiorella Sanavio,Massimo Aglietta,Nadia Polentarutti,Luigi Pegoraro,Alberto Mantovani,Federico Bussolino

View Articletitled, Activation of JAK2 in Human Vascular Endothelial Cells by Granulocyte-Macrophage Colony-Stimulating Factor

Induction of Fibrinogen Biosynthesis and Secretion From Cultured Pulmonary Epithelial Cells

Patricia J. Simpson Haidaris

View Articletitled, Induction of Fibrinogen Biosynthesis and Secretion From Cultured Pulmonary Epithelial Cells

Thrombopoietin Enhances the α_IIbβ₃-Dependent Adhesion of Megakaryocytic Cells to Fibrinogen or Fibronectin Through PI 3 Kinase

Giorgio Zauli,Alessandra Bassini,Marco Vitale,Davide Gibellini,Claudio Celeghini,Elisabetta Caramelli,Sabina Pierpaoli,Lia Guidotti,Silvano Capitani

View Articletitled, Thrombopoietin Enhances the αIIbβ3-Dependent Adhesion of Megakaryocytic Cells to Fibrinogen or Fibronectin Through PI 3 Kinase

IMMUNOBIOLOGY

P-Selectin Glycoprotein Ligand-1 Is Essential for Adhesion to P-Selectin But Not E-Selectin in Stably Transfected Hematopoietic Cell Lines

Karen R. Snapp,Amy J. Wagers,Ron Craig,Lloyd M. Stoolman,Geoffrey S. Kansas

View Articletitled, P-Selectin Glycoprotein Ligand-1 Is Essential for Adhesion to P-Selectin But Not E-Selectin in Stably Transfected Hematopoietic Cell Lines

Missense Mutations in the Fas Gene Resulting in Autoimmune Lymphoproliferative Syndrome: A Molecular and Immunological Analysis

Alessandra Bettinardi,Duilio Brugnoni,Eugenia Quiròs-Roldan,Alberto Malagoli,Stefania La Grutta,Antonio Correra,Luigi D. Notarangelo

View Articletitled, Missense Mutations in the Fas Gene Resulting in Autoimmune Lymphoproliferative Syndrome: A Molecular and Immunological Analysis

Cytokine-Induced Apoptosis of Human Natural Killer Cells Identifies a Novel Mechanism to Regulate the Innate Immune Response

Mary E. Ross,Michael A. Caligiuri

View Articletitled, Cytokine-Induced Apoptosis of Human Natural Killer Cells Identifies a Novel Mechanism to Regulate the Innate Immune Response

Maintenance of Human Germinal Center B Cells In Vitro

John D. Pound,John Gordon

View Articletitled, Maintenance of Human Germinal Center B Cells In Vitro

Expression of Interleukin-7 Receptor by Lineage-Negative Human Bone Marrow Progenitors With Enhanced Lymphoid Proliferative Potential and B-Lineage Differentiation Capacity

Daniel H. Ryan,Bonnie L. Nuccie,Ion Ritterman,Jane L. Liesveld,Camille N. Abboud,Richard A. Insel

View Articletitled, Expression of Interleukin-7 Receptor by Lineage-Negative Human Bone Marrow Progenitors With Enhanced Lymphoid Proliferative Potential and B-Lineage Differentiation Capacity

NEOPLASIA

Chronic Lymphocytic Leukemia B Cells Are Resistant to the Apoptotic Effects of Transforming Growth Factor-β

Raymond S. Douglas,Renold J. Capocasale,Roberta J. Lamb,Peter C. Nowell,Jonni S. Moore

View Articletitled, Chronic Lymphocytic Leukemia B Cells Are Resistant to the Apoptotic Effects of Transforming Growth Factor-β

Integration Patterns of HTLV-I Provirus in Relation to the Clinical Course of ATL: Frequent Clonal Change at Crisis From Indolent Disease

Kunihiro Tsukasaki,Hideki Tsushima,Masaomi Yamamura,Tomoko Hata,Ken Murata,Takahiro Maeda,Sunao Atogami,Hisashi Sohda,Saburo Momita,Shuichi Ideda,Sigeru Katamine,Yasuaki Yamada,Shimeru Kamihira,Masao Tomonaga

View Articletitled, Integration Patterns of HTLV-I Provirus in Relation to the Clinical Course of ATL: Frequent Clonal Change at Crisis From Indolent Disease

Involvement of Fas-Mediated Apoptosis in the Inhibitory Effects of Interferon-α in Chronic Myelogenous Leukemia

Carmine Selleri,Tadatsugu Sato,Luigi Del Vecchio,Luigia Luciano,A. John Barrett,Bruno Rotoli,Neal S. Young,Jaroslaw P. Maciejewski

View Articletitled, Involvement of Fas-Mediated Apoptosis in the Inhibitory Effects of Interferon-α in Chronic Myelogenous Leukemia

Detection of Cyclin D1 (bcl-1, PRAD1) Overexpression by a Simple Competitive Reverse Transcription-Polymerase Chain Reaction Assay in t(11; 14)(q13; q32)-Bearing B-Cell Malignancies and/or Mantle Cell Lymphoma

Kaoru Uchimaru,Toshiyasu Taniguchi,Miwa Yoshikawa,Shigetaka Asano,Andrew Arnold,Toshiro Fujita,Toru Motokura

View Articletitled, Detection of Cyclin D1 (bcl-1, PRAD1) Overexpression by a Simple Competitive Reverse Transcription-Polymerase Chain Reaction Assay in t(11; 14)(q13; q32)-Bearing B-Cell Malignancies and/or Mantle Cell Lymphoma

Microsatellite Instability Is Rare in B-Cell Non-Hodgkin's Lymphomas

Barbara Gamberi,Gianluca Gaidano,Nasser Parsa,Antonino Carbone,Silvio Roncella,Daniel M. Knowles,Diane C. Louie,Darryl Shibata,R.S.K. Chaganti,Riccardo Dalla-Favera

View Articletitled, Microsatellite Instability Is Rare in B-Cell Non-Hodgkin's Lymphomas

Cytotoxic Cell Antigen Expression in Anaplastic Large Cell Lymphomas of T- and Null-Cell Type and Hodgkin's Disease: Evidence for Distinct Cellular Origin

Laszlo Krenacs,Axel Wellmann,Lynn Sorbara,Andreas W. Himmelmann,Eniko Bagdi,Elaine S. Jaffe,Mark Raffeld

View Articletitled, Cytotoxic Cell Antigen Expression in Anaplastic Large Cell Lymphomas of T- and Null-Cell Type and Hodgkin's Disease: Evidence for Distinct Cellular Origin

Hepatocyte Growth Factor/Scatter Factor Promotes Adhesion of Lymphoma Cells to Extracellular Matrix Molecules Via α₄β₁ and α₅β₁ Integrins

Iris S. Weimar,Daphne de Jong,Egbert J. Muller,Toshikazu Nakamura,Joost M.H.H. van Gorp,Gijsbert C. de Gast,Winald R. Gerritsen

View Articletitled, Hepatocyte Growth Factor/Scatter Factor Promotes Adhesion of Lymphoma Cells to Extracellular Matrix Molecules Via α4β1 and α5β1 Integrins

Stat1 Is Induced and Activated by All-Trans Retinoic Acid in Acute Promyelocytic Leukemia Cells

Maurizio Gianni,Mineko Terao,Ida Fortino,Marco LiCalzi,Vincenzo Viggiano,Tiziano Barbui,Alessandro Rambaldi,Enrico Garattini

View Articletitled, Stat1 Is Induced and Activated by All-Trans Retinoic Acid in Acute Promyelocytic Leukemia Cells

Defective Transport Is a Common Mechanism of Acquired Methotrexate Resistance in Acute Lymphocytic Leukemia and Is Associated With Decreased Reduced Folate Carrier Expression

Richard Gorlick,Erdem Goker,Tanya Trippett,Peter Steinherz,Yaroslav Elisseyeff,Madhu Mazumdar,Wayne F. Flintoff,Joseph R. Bertino

View Articletitled, Defective Transport Is a Common Mechanism of Acquired Methotrexate Resistance in Acute Lymphocytic Leukemia and Is Associated With Decreased Reduced Folate Carrier Expression

PHAGOCYTES

Inactivation of Recombinant Monocyte cAMP-Specific Phosphodiesterase by cAMP Analog, 8-[(4-Bromo-2,3-Dioxobutyl)thio]Adenosine 3′,5′-Cyclic Monophosphate

George A. Omburo,Theodore J. Torphy,Gilbert Scott,Susanne Jacobitz,Roberta F. Colman,Robert W. Colman

View Articletitled, Inactivation of Recombinant Monocyte cAMP-Specific Phosphodiesterase by cAMP Analog, 8-[(4-Bromo-2,3-Dioxobutyl)thio]Adenosine 3′,5′-Cyclic Monophosphate

Characterization of a New Alloantigen (SH) on the Human Neutrophil Fcγreceptor IIIb

Juergen Bux,Ernst-Ludwig Stein,Philippe Bierling,Patricia Fromont,Mary Clay,David Stroncek,Sentot Santoso

View Articletitled, Characterization of a New Alloantigen (SH) on the Human Neutrophil Fcγreceptor IIIb

Granulocyte-Macrophage Colony-Stimulating Factor–Activated Signaling Pathways in Human Neutrophils. I. Tyrosine Phosphorylation-Dependent Stimulation of Phosphatidylinositol 3-Kinase and Inhibition by Phorbol Esters

Amin Al-Shami,Sylvain G. Bourgoin,Paul H. Naccache

View Articletitled, Granulocyte-Macrophage Colony-Stimulating Factor–Activated Signaling Pathways in Human Neutrophils. I. Tyrosine Phosphorylation-Dependent Stimulation of Phosphatidylinositol 3-Kinase and Inhibition by Phorbol Esters

RED CELLS

Protoporphyria Induced by the Orally Active Iron Chelator 1,2-diethyl-3-hydroxypyridin-4-one in C57BL/10ScSn Mice

Andrew G. Smith,Bruce Clothier,Jean E. Francis,Anthony H. Gibbs,Francesco De Matteis,Robert C. Hider

View Articletitled, Protoporphyria Induced by the Orally Active Iron Chelator 1,2-diethyl-3-hydroxypyridin-4-one in C57BL/10ScSn Mice

Serum Transferrin Receptor and Its Ratio to Serum Ferritin in the Diagnosis of Iron Deficiency

Kari Punnonen,Kerttu Irjala,Allan Rajamäki

View Articletitled, Serum Transferrin Receptor and Its Ratio to Serum Ferritin in the Diagnosis of Iron Deficiency

Altered Erythrocytes and a Leaky Block in B-Cell Development in CD24/HSA-Deficient Mice

P.J. Nielsen,B. Lorenz,A.M. Müller,R.H. Wenger,F. Brombacher,M. Simon,T. von der Weid,J. Langhorne,H. Mossmann,G. Köhler

View Articletitled, Altered Erythrocytes and a Leaky Block in B-Cell Development in CD24/HSA-Deficient Mice

The Primate Erythrocyte Complement Receptor (CR1) as a Privileged Site: Binding of Immunoglobulin G to Erythrocyte CR1 Does Not Target Erythrocytes for Phagocytosis

Michele L. Reinagel,Murat Gezen,Polly J. Ferguson,Susan Kuhn,Edward N. Martin,Ronald P. Taylor

View Articletitled, The Primate Erythrocyte Complement Receptor (CR1) as a Privileged Site: Binding of Immunoglobulin G to Erythrocyte CR1 Does Not Target Erythrocytes for Phagocytosis

Fetal Hemoglobin in Sickle Cell Anemia: Determinants of Response to Hydroxyurea

Martin H. Steinberg,Zhi-Hong Lu,Franca B. Barton,Michael L. Terrin,Samuel Charache,George J. Dover,the Multicenter Study of Hydroxyurea

View Articletitled, Fetal Hemoglobin in Sickle Cell Anemia: Determinants of Response to Hydroxyurea

TRANSPLANTATION

A Murine Model for Human Cord Blood Transplantation: Near-Term Fetal and Neonatal Peripheral Blood Cells Can Achieve Long-Term Bone Marrow Engraftment in Sublethally Irradiated Adult Recipients

Andromachi Scaradavou,Luis Isola,Pablo Rubinstein,Yelena Galperin,Vesna Najfeld,David Berlin,Jon Gordon,Rona S. Weinberg

View Articletitled, A Murine Model for Human Cord Blood Transplantation: Near-Term Fetal and Neonatal Peripheral Blood Cells Can Achieve Long-Term Bone Marrow Engraftment in Sublethally Irradiated Adult Recipients

Donor γδ T Lymphocytes Promote Allogeneic Engraftment Across the Major Histocompatibility Barrier in Mice

William R. Drobyski,David Majewski

View Articletitled, Donor γδ T Lymphocytes Promote Allogeneic Engraftment Across the Major Histocompatibility Barrier in Mice

CORRESPONDENCE

Interferon-α Upregulates Both Interleukin-10 and Interferon-γ Production by Human CD4⁺ T Cells

Liliane Schandené,Elie Cogan,Alain Crusiaux,Michel Goldman

View Articletitled, Interferon-α Upregulates Both Interleukin-10 and Interferon-γ Production by Human CD4+ T Cells

In Vitro Hypersensitivity to Oxygen of Fanconi Anemia (FA) Cells Is Linked to Ex Vivo Evidence for Oxidative Stress in FA Homozygotes and Heterozygotes

Giovanni Pagano,Ludmila G. Korkina,Paolo Degan,Domenico Del Principe,Barbara Lindau-Shepard,Adriana Zatterale,Claudio Franceschi

View Articletitled, In Vitro Hypersensitivity to Oxygen of Fanconi Anemia (FA) Cells Is Linked to Ex Vivo Evidence for Oxidative Stress in FA Homozygotes and Heterozygotes

Platelet Antibody Testing in Idiopathic Thrombocytopenic Purpura

Thomas J. Raife,John D. Olson,Steven R. Lentz

View Articletitled, Platelet Antibody Testing in Idiopathic Thrombocytopenic Purpura

Microsatellite Instability in Natural Killer Cell–Like T-Cell Lymphomas in Immunocompromised and Immunocompetent Individuals

Richard S. Larson,Suzanne Manning,William R. Macon,Cindy Vnencak-Jones

View Articletitled, Microsatellite Instability in Natural Killer Cell–Like T-Cell Lymphomas in Immunocompromised and Immunocompetent Individuals

Nephrotic Syndrome as a Complication of Immune Tolerance in Hemophilia B

B.M. Ewenstein,C. Takemoto,I. Warrier,J. Lusher,P. Saidi,J. Eisele,L. J. Ettinger,D. DiMichele

View Articletitled, Nephrotic Syndrome as a Complication of Immune Tolerance in Hemophilia B

Transient Increase of Leukocytes After Transplantation of Expanded and Nonexpanded Allogeneic CD34⁺ Blood Cells Is of Host Origin

Lubomir Arseniev,Hartmut Link,Gerdt Hübner,Jürgen Novotny,Arnold Ganser,Bernd Hertenstein

View Articletitled, Transient Increase of Leukocytes After Transplantation of Expanded and Nonexpanded Allogeneic CD34+ Blood Cells Is of Host Origin

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Loss of BCL7A Permits IRF4 Transcriptional Activity and Cellular Growth in Multiple Myeloma

Genetic and epigenetic mechanisms of GPRC5D loss after anti-GPRC5D CAR T-cell therapy in multiple myeloma

Blunted CD40-responsive enhancer activation in CREBBP-mutant lymphomas can be restored by enforced CD4 T-cell engagement

HLA-haploidentical stem cell transplantation for chronic granulomatous disease: an EBMT-IEWP retrospective study

Safety and efficacy of rilzabrutinib vs placebo in adults with immune thrombocytopenia: the phase 3 LUNA3 study