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Volume 89, Issue 2

January 15 1997

In this Issue

REVIEW ARTICLES
RAPID COMMUNICATIONS
CLINICAL INTERVENTION AND THERAPEUTIC TRIALS
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
TRANSPLANTATION
CORRESPONDENCE
ERRATA

REVIEW ARTICLES

Activating Mutations in Cytokine Receptors: Implications for Receptor Function and Role in Disease

Thomas J. Gonda,Richard J. D'Andrea

View Articletitled, Activating Mutations in Cytokine Receptors: Implications for Receptor Function and Role in Disease

RAPID COMMUNICATIONS

FcγRIIA H/R¹³¹ Polymorphism, Subclass-Specific IgG Anti-Heparin/Platelet Factor 4 Antibodies and Clinical Course in Patients With Heparin-Induced Thrombocytopenia and Thrombosis

Gowthami Arepally,Steven E. McKenzie,Xiao-Ming Jiang,Mortimer Poncz,Douglas B. Cines

View Articletitled, FcγRIIA H/R131 Polymorphism, Subclass-Specific IgG Anti-Heparin/Platelet Factor 4 Antibodies and Clinical Course in Patients With Heparin-Induced Thrombocytopenia and Thrombosis

Altered Myeloid Development and Acute Leukemia in Transgenic Mice Expressing PML-RARα Under Control of Cathepsin G Regulatory Sequences

Jay L. Grisolano,Robin L. Wesselschmidt,Pier Giuseppe Pelicci,Timothy J. Ley

View Articletitled, Altered Myeloid Development and Acute Leukemia in Transgenic Mice Expressing PML-RARα Under Control of Cathepsin G Regulatory Sequences

Differential Activation of the Tyrosine Kinases ZAP-70 and Syk After FcγRI Stimulation

Naomi Taylor,Thomas Jahn,Susan Smith,Thomas Lamkin,Lisa Uribe,Yenbou Liu,Donald L. Durden,Kenneth Weinberg

View Articletitled, Differential Activation of the Tyrosine Kinases ZAP-70 and Syk After FcγRI Stimulation

A Single Genetic Origin for a Common Caucasian Risk Factor for Venous Thrombosis

Ariella Zivelin,John H. Griffin,Xiao Xu,Ingrid Pabinger,Michel Samama,Jacqueline Conard,Benjamin Brenner,Amiram Eldor,Uri Seligsohn

View Articletitled, A Single Genetic Origin for a Common Caucasian Risk Factor for Venous Thrombosis

CLINICAL INTERVENTION AND THERAPEUTIC TRIALS

A Phase-I Study of an Anti-CD25 Ricin A-Chain Immunotoxin (RFT5-SMPT-dgA) in Patients With Refractory Hodgkin's Lymphoma

Andreas Engert,Volker Diehl,Roland Schnell,Andrea Radszuhn,Maria-Theresia Hatwig,Silke Drillich,Gisela Schön,Heribert Bohlen,Hans Tesch,Martin-Leo Hansmann,Stefan Barth,John Schindler,Victor Ghetie,Jonathan Uhr,Ellen Vitetta

View Articletitled, A Phase-I Study of an Anti-CD25 Ricin A-Chain Immunotoxin (RFT5-SMPT-dgA) in Patients With Refractory Hodgkin's Lymphoma

Avoidance of Allogeneic Blood Transfusions by Treatment With Epoetin Beta (Recombinant Human Erythropoietin) in Patients Undergoing Open-Heart Surgery

Olaf Sowade,Harry Warnke,Paul Scigalla,Birgit Sowade,Werner Franke,Diethelm Messinger,Johann Gross

View Articletitled, Avoidance of Allogeneic Blood Transfusions by Treatment With Epoetin Beta (Recombinant Human Erythropoietin) in Patients Undergoing Open-Heart Surgery

3′-Azido 3′-Deoxythymidine + Methotrexate as a Novel Antineoplastic Combination in the Treatment of Human Immunodeficiency Virus-Related Non-Hodgkin's Lymphomas

Patrizia Tosi,Filippo Gherlinzoni,Patrizio Mazza,Giuseppe Visani,Olga Coronado,Paolo Costigliola,Enzo Raise,Magda Mazzetti,Francesco Gritti,Francesco Chiodo,Sante Tura

View Articletitled, 3′-Azido 3′-Deoxythymidine + Methotrexate as a Novel Antineoplastic Combination in the Treatment of Human Immunodeficiency Virus-Related Non-Hodgkin's Lymphomas

HEMATOPOIESIS

The Development of Human Megakaryocytes: III. Development of Mature Megakaryocytes From Highly Purified Committed Progenitors in Synthetic Culture Media and Inhibition of Thrombopoietin-Induced Polyploidization by Interleukin-3

Alexandr Dolzhanskiy,Ross S. Basch,Simon Karpatkin

View Articletitled, The Development of Human Megakaryocytes: III. Development of Mature Megakaryocytes From Highly Purified Committed Progenitors in Synthetic Culture Media and Inhibition of Thrombopoietin-Induced Polyploidization by Interleukin-3

Ectopic Expression of the Erythropoietin Receptor in a Murine Interleukin-6–Dependent Plasmacytoma Cell Line (TEPC-2027) Confers Proliferative Responsiveness to Erythropoietin

Frédéric Féger,Anne Dubart,Catherine Lacout,Isabelle Dusanter-Fourt,Patrick Mayeux,William Vainchenker,Dominique Duménil

View Articletitled, Ectopic Expression of the Erythropoietin Receptor in a Murine Interleukin-6–Dependent Plasmacytoma Cell Line (TEPC-2027) Confers Proliferative Responsiveness to Erythropoietin

FLT3 Ligand Preserves the Ability of Human CD34⁺ Progenitors to Sustain Long-Term Hematopoiesis in Immune-Deficient Mice After Ex Vivo Retroviral-Mediated Transduction

Mo A. Dao,Charles H. Hannum,Donald B. Kohn,Jan A. Nolta

View Articletitled, FLT3 Ligand Preserves the Ability of Human CD34+ Progenitors to Sustain Long-Term Hematopoiesis in Immune-Deficient Mice After Ex Vivo Retroviral-Mediated Transduction

Upregulation of Cortactin Expression During the Maturation of Megakaryocytes

Xi Zhan,Christian C. Haudenschild,Yangson Ni,Elizabeth Smith,Cai Huang

View Articletitled, Upregulation of Cortactin Expression During the Maturation of Megakaryocytes

The Unexpected G0/G1 Cell Cycle Status of Mobilized Hematopoietic Stem Cells From Peripheral Blood

Nobuko Uchida,Dongping He,Annabelle M. Friera,Michael Reitsma,Dennis Sasaki,Ben Chen,Ann Tsukamoto

View Articletitled, The Unexpected G0/G1 Cell Cycle Status of Mobilized Hematopoietic Stem Cells From Peripheral Blood

Homodimerization of Erythropoietin Receptor by a Bivalent Monoclonal Antibody Triggers Cell Proliferation and Differentiation of Erythroid Precursors

Helmut Schneider,Warak Chaovapong,David J. Matthews,Cyrus Karkaria,Robert T. Cass,Hangjun Zhan,Mark Boyle,Tony Lorenzini,Steve G. Elliott,Lutz B. Giebel

View Articletitled, Homodimerization of Erythropoietin Receptor by a Bivalent Monoclonal Antibody Triggers Cell Proliferation and Differentiation of Erythroid Precursors

Thrombopoietin Signal Transduction in Purified Murine Megakaryocytes

Jonathan G. Drachman,Diana F. Sabath,Norma E. Fox,Kenneth Kaushansky

View Articletitled, Thrombopoietin Signal Transduction in Purified Murine Megakaryocytes

Mapping of the Active Site of Recombinant Human Erythropoietin

Steve Elliott,Tony Lorenzini,David Chang,Jack Barzilay,Evelyne Delorme

View Articletitled, Mapping of the Active Site of Recombinant Human Erythropoietin

Induction of Hypoxia-Inducible Factor-1, Erythropoietin, Vascular Endothelial Growth Factor, and Glucose Transporter-1 by Hypoxia: Evidence Against a Regulatory Role for Src Kinase

Jonathan M. Gleadle,Peter J. Ratcliffe

View Articletitled, Induction of Hypoxia-Inducible Factor-1, Erythropoietin, Vascular Endothelial Growth Factor, and Glucose Transporter-1 by Hypoxia: Evidence Against a Regulatory Role for Src Kinase

Exocytotic Competence and Intergranular Fusion in Cord Blood-Derived Eosinophils During Differentiation

Susanne Scepek,Manfred Lindau

View Articletitled, Exocytotic Competence and Intergranular Fusion in Cord Blood-Derived Eosinophils During Differentiation

Interactions Between c-kit and Stem Cell Factor Are Not Required for B-Cell Development In Vivo

Shunichi Takeda,Takeyuki Shimizu,Hans-Reimer Rodewald

View Articletitled, Interactions Between c-kit and Stem Cell Factor Are Not Required for B-Cell Development In Vivo

Tumor Necrosis Factor-α– and Interleukin-6–Triggered Mast Cell Development From Mouse Spleen Cells

Zhi-Qing Hu,Kazuo Kobayashi,Naoko Zenda,Tadakatsu Shimamura

View Articletitled, Tumor Necrosis Factor-α– and Interleukin-6–Triggered Mast Cell Development From Mouse Spleen Cells

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Antithrombotic Efficacy in the Guinea Pig of a Derivative of Human Protein C With Enhanced Activation by Thrombin

Ken D. Kurz,Tommy Smith,Alexander Wilson,Bruce Gerlitz,Mark A. Richardson,Brian W. Grinnell

View Articletitled, Antithrombotic Efficacy in the Guinea Pig of a Derivative of Human Protein C With Enhanced Activation by Thrombin

Monocytes Upregulate Endothelial Cell Expression of Tissue Factor: A Role for Cell-Cell Contact and Cross-Talk

Emanuela Napoleone,Angelomaria Di Santo,Roberto Lorenzet

View Articletitled, Monocytes Upregulate Endothelial Cell Expression of Tissue Factor: A Role for Cell-Cell Contact and Cross-Talk

IMMUNOBIOLOGY

A Cysteine Protease Inhibitor Prevents Activation-Induced T-Cell Apoptosis and Death of Peripheral Blood Cells From Human Immunodeficiency Virus-Infected Individuals by Inhibiting Upregulation of Fas Ligand

Yili Yang,Zhi-Hong Liu,Carl F. Ware,Jonathan D. Ashwell

View Articletitled, A Cysteine Protease Inhibitor Prevents Activation-Induced T-Cell Apoptosis and Death of Peripheral Blood Cells From Human Immunodeficiency Virus-Infected Individuals by Inhibiting Upregulation of Fas Ligand

Differential Susceptibility to HIV-GP120–Sensitized Apoptosis in CD4⁺ T-Cell Clones With Different T-Helper Phenotypes: Role of CD95/CD95L Interactions

Paola Accornero,Marina Radrizzani,Domenico Delia,Franca Gerosa,Roland Kurrle,Mario P. Colombo

View Articletitled, Differential Susceptibility to HIV-GP120–Sensitized Apoptosis in CD4+ T-Cell Clones With Different T-Helper Phenotypes: Role of CD95/CD95L Interactions

Interleukin-12 (IL-12) Production in Whole Blood Cultures From Human Immunodeficiency Virus-Infected Individuals Studied in Relation to IL-10 and Prostaglandin E₂ Production

Linde Meyaard,Egbert Hovenkamp,Nadine Pakker,Tineke C.T.M. van der Pouw Kraan,Frank Miedema

View Articletitled, Interleukin-12 (IL-12) Production in Whole Blood Cultures From Human Immunodeficiency Virus-Infected Individuals Studied in Relation to IL-10 and Prostaglandin E2 Production

The Role of Hyperuricemia in the Increased Cytokine Production After Lipopolysaccharide Challenge in Neutropenic Mice

Mihai G. Netea,Bart Jan Kullberg,Willem L. Blok,Romana T. Netea,Jos W.M. Van der Meer

View Articletitled, The Role of Hyperuricemia in the Increased Cytokine Production After Lipopolysaccharide Challenge in Neutropenic Mice

Bone Marrow and Thymus Expression of Interferon-γ Results in Severe B-Cell Lineage Reduction, T-Cell Lineage Alterations, and Hematopoietic Progenitor Deficiencies

Howard A. Young,Dennis M. Klinman,Della A. Reynolds,Krzysztof J. Grzegorzewski,Aisuke Nii,Jerrold M. Ward,Robin T. Winkler-Pickett,John R. Ortaldo,James J. Kenny,Kristin L. Komschlies

View Articletitled, Bone Marrow and Thymus Expression of Interferon-γ Results in Severe B-Cell Lineage Reduction, T-Cell Lineage Alterations, and Hematopoietic Progenitor Deficiencies

NEOPLASIA

Frequent Jumping Translocations of Chromosomal Segments Involving the ABL Oncogene Alone or in Combination With CD3-MLL Genes in Secondary Leukemias

Kimio Tanaka,Mansyur Arif,Mariko Eguchi,Taiichi Kyo,Hiroo Dohy,Nanao Kamada

View Articletitled, Frequent Jumping Translocations of Chromosomal Segments Involving the ABL Oncogene Alone or in Combination With CD3-MLL Genes in Secondary Leukemias

Relationship of p53, bcl-2, and Tumor Proliferation to Clinical Drug Resistance in Non-Hodgkin's Lymphomas

Wyndham H. Wilson,Julie Teruya-Feldstein,Thierry Fest,Cynthia Harris,Seth M. Steinberg,Elaine S. Jaffe,Mark Raffeld

View Articletitled, Relationship of p53, bcl-2, and Tumor Proliferation to Clinical Drug Resistance in Non-Hodgkin's Lymphomas

Evidence for the Participation of Interleukin-2 (IL-2) and IL-4 in the Regulation of Autonomous Growth and Tumorigenesis of Transformed Cells of Lymphoid Origin

Mona R. Hassuneh,Prakash S. Nagarkatti,Mitzi Nagarkatti

View Articletitled, Evidence for the Participation of Interleukin-2 (IL-2) and IL-4 in the Regulation of Autonomous Growth and Tumorigenesis of Transformed Cells of Lymphoid Origin

Minimally Differentiated Acute Myeloid Leukemia (AML-M0): Comparison of 25 Cases With Other French-American-British Subtypes

Adriano Venditti,Giovanni Del Poeta,Francesco Buccisano,Anna Tamburini,M. Christina Cox,Roberto Stasi,Antonio Bruno,Germano Aronica,Laura Maffei,Giovanna Suppo,Maria Domenica Simone,Laura Forte,Valeria Cordero,Massimiliano Postorino,Vincenza Tufilli,Giancarlo Isacchi,Mario Masi,Giuseppe Papa,Sergio Amadori

View Articletitled, Minimally Differentiated Acute Myeloid Leukemia (AML-M0): Comparison of 25 Cases With Other French-American-British Subtypes

Mcl-1, a Bcl-2 Family Member, Delays the Death of Hematopoietic Cells Under a Variety of Apoptosis-Inducing Conditions

Ping Zhou,Liping Qian,Karen M. Kozopas,Ruth W. Craig

View Articletitled, Mcl-1, a Bcl-2 Family Member, Delays the Death of Hematopoietic Cells Under a Variety of Apoptosis-Inducing Conditions

Primary Non-Hodgkin's Lymphoma of the Intestine: High Prevalence of Epstein-Barr Virus in Mexican Lymphomas as Compared With European Cases

Leticia Quintanilla-Martı́nez,Carmen Lome-Maldonado,German Ott,Andreas Gschwendtner,Evelyn Gredler,Edgardo Reyes,Arturo Angeles-Angeles,Falko Fend

View Articletitled, Primary Non-Hodgkin's Lymphoma of the Intestine: High Prevalence of Epstein-Barr Virus in Mexican Lymphomas as Compared With European Cases

PHAGOCYTES

The Amino Terminal Lectin-Like Domain of Thrombomodulin Is Required for Constitutive Endocytosis

Edward M. Conway,Saskia Pollefeyt,Desiré Collen,Marta Steiner-Mosonyi

View Articletitled, The Amino Terminal Lectin-Like Domain of Thrombomodulin Is Required for Constitutive Endocytosis

Formation of Multinucleated Giant Cells In Vitro Is Dependent on the Stage of Monocyte to Macrophage Maturation

Johannes Möst,Ludwig Spötl,Gertraud Mayr,Annette Gasser,Alessandra Sarti,Manfred P. Dierich

View Articletitled, Formation of Multinucleated Giant Cells In Vitro Is Dependent on the Stage of Monocyte to Macrophage Maturation

p15s (15-kD Antimicrobial Proteins) Are Stored in the Secondary Granules of Rabbit Granulocytes: Implications for Antibacterial Synergy With the Bactericidal/Permeability-Increasing Protein in Inflammatory Fluids

Kol Zarember,Peter Elsbach,Kwang Shin-Kim,Jerrold Weiss

View Articletitled, p15s (15-kD Antimicrobial Proteins) Are Stored in the Secondary Granules of Rabbit Granulocytes: Implications for Antibacterial Synergy With the Bactericidal/Permeability-Increasing Protein in Inflammatory Fluids

RED CELLS

Regulation of Cellular Iron Metabolism by Erythropoietin: Activation of Iron-Regulatory Protein and Upregulation of Transferrin Receptor Expression in Erythroid Cells

Günter Weiss,Tracey Houston,Stefan Kastner,Karin Jöhrer,Kurt Grünewald,Jeremy H. Brock

View Articletitled, Regulation of Cellular Iron Metabolism by Erythropoietin: Activation of Iron-Regulatory Protein and Upregulation of Transferrin Receptor Expression in Erythroid Cells

Characterization of Adult α- and β-Globin Genes in the Zebrafish

Fung-Yee Chan,Judith Robinson,Alison Brownlie,Ramesh A. Shivdasani,Adriana Donovan,Carlos Brugnara,John Kim,Bing-Chuen Lau,H. Ewa Witkowska,Leonard I. Zon

View Articletitled, Characterization of Adult α- and β-Globin Genes in the Zebrafish

Detection of Duffy Antigen in the Plasma Membranes and Caveolae of Vascular Endothelial and Epithelial Cells of Nonerythroid Organs

Asok Chaudhuri,Søren Nielsen,Marie-Louise Elkjaer,Valerie Zbrzezna,Fang Fang,A. Oscar Pogo

View Articletitled, Detection of Duffy Antigen in the Plasma Membranes and Caveolae of Vascular Endothelial and Epithelial Cells of Nonerythroid Organs

Globin Gene Switching in Transgenic Mice Carrying HS2-Globin Gene Constructs

N.A. Roberts,J.A. Sloane-Stanley,J.A. Sharpe,S.J. Stanworth,W.G. Wood

View Articletitled, Globin Gene Switching in Transgenic Mice Carrying HS2-Globin Gene Constructs

TRANSPLANTATION

Molecular Monitoring of Minimal Residual Disease in Follicular and Mantle Cell Non-Hodgkin's Lymphomas Treated With High-Dose Chemotherapy and Peripheral Blood Progenitor Cell Autografting

Paolo Corradini,Monica Astolfi,Cristina Cherasco,Marco Ladetto,Claudia Voena,Daniele Caracciolo,Alessandro Pileri,Corrado Tarella

View Articletitled, Molecular Monitoring of Minimal Residual Disease in Follicular and Mantle Cell Non-Hodgkin's Lymphomas Treated With High-Dose Chemotherapy and Peripheral Blood Progenitor Cell Autografting

CORRESPONDENCE

Milder Clinical Course of Sickle Cell Disease in Patients With α Thalassemia in the Indian Subcontinent

M.B. Mukherjee,R.B. Colah,K. Ghosh,D. Mohanty,R. Krishnamoorthy

View Articletitled, Milder Clinical Course of Sickle Cell Disease in Patients With α Thalassemia in the Indian Subcontinent

Developmental Outcome of Unrelated Donor Bone Marrow Transplantation in Children With Hurler Syndrome

Sean Phipps,Raymond Mulhern

View Articletitled, Developmental Outcome of Unrelated Donor Bone Marrow Transplantation in Children With Hurler Syndrome

Deletion of 13q14.3 and Not 13q12 Is the Most Common Genetic Abnormality Detected in Chronic Lymphocytic Leukemia Cells

P. Panayiotidis,K. Ganeshaguru,A.V. Hoffbrand,C. Rowntree,S.A.B. Jabbar,L. Foroni

View Articletitled, Deletion of 13q14.3 and Not 13q12 Is the Most Common Genetic Abnormality Detected in Chronic Lymphocytic Leukemia Cells

ERRATA

ERRATUM

View Articletitled, ERRATUM

ERRATUM

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BRD4 inhibition sensitizes diffuse large B-cell lymphoma cells to ferroptosis

Lipid Nanoparticles Allow Efficient and Harmless Ex Vivo Gene Editing of Human Hematopoietic Cells

Safety and efficacy of anti-human activated protein C antibody SR604 for prophylaxis of congenital factor deficiencies

Infectious Neutrophil deployment is regulated by Resolvin D4

Macrophage checkpoint for iron absorption

Issue Archive

Table of Contents

REVIEW ARTICLES

RAPID COMMUNICATIONS

CLINICAL INTERVENTION AND THERAPEUTIC TRIALS

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

IMMUNOBIOLOGY

NEOPLASIA

PHAGOCYTES

RED CELLS

TRANSPLANTATION

CORRESPONDENCE

ERRATA

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American Society of Hematology

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