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Volume 88, Issue 9

November 1 1996

In this Issue

REVIEW
ARTICLES
PHOTOGRAPHS
MULTICENTER STUDY
LETTER

Table of Contents

REVIEW

Selectins and their ligands: current concepts and controversies

GS Kansas

ARTICLES

Administration of pegylated recombinant human megakaryocyte growth and development factor to humans stimulates the production of functional platelets that show no evidence of in vivo activation

CJ O'Malley,JE Rasko,RL Basser,KM McGrath,J Cebon,AP Grigg,W Hopkins,B Cohen,J O'Byrne,MD Green,RM Fox,MC Berndt,CG Begley

Human eosinophils express functional CD30 ligand and stimulate proliferation of a Hodgkin's disease cell line

A Pinto,D Aldinucci,A Gloghini,V Zagonel,M Degan,S Improta,S Juzbasic,M Todesco,V Perin,V Gattei,F Herrmann,HJ Gruss,A Carbone

Extended long-term culture reveals a highly quiescent and primitive human hematopoietic progenitor population

QL Hao,FT Thiemann,D Petersen,EM Smogorzewska,GM Crooks

Eradication of polymerase chain reaction detectable immunoglobulin gene rearrangement in non-Hodgkin's lymphoma is associated with decreased relapse after autologous bone marrow transplantation

CS Zwicky,AB Maddocks,N Andersen,JG Gribben

Increased numbers of long-term culture-initiating cells in the apheresis product of patients randomized to receive increasing doses of stem cell factor administered in combination with chemotherapy and a standard dose of granulocyte colony-stimulating factor

A Weaver,D Ryder,D Crowther,TM Dexter,NG Testa

Mobilization of CD34+ progenitor cells by granulocyte colony- stimulating factor in human immunodeficiency virus type 1-infected adults

KS Slobod,TA Bennett,PJ Freiden,AM Kechli,N Howlett,PM Flynn,DR Head,DK Srivastava,JM Boyett,MK Brenner,JV Garcia

A cell proliferation-dependent multiprotein complex NC-3A positively regulates the CD34 promoter via a TCATTT-containing element

D Perrotti,T Bellon,R Trotta,R Martinez,B Calabretta

The erythropoietin gene is expressed strongly in the mammalian mesonephric kidney

EM Wintour,A Butkus,L Earnest,S Pompolo

Differential mechanisms in the regulation of endogenous levels of thrombopoietin and interleukin-11 during thrombocytopenia: insight into the regulation of platelet production

M Chang,Y Suen,G Meng,JS Buzby,J Bussel,V Shen,C van de Ven,MS Cairo

Synergistic effects of thrombopoietin and granulocyte colony- stimulating factor on neutrophil recovery in myelosuppressed mice

A Grossmann,J Lenox,TA Deisher,HP Ren,JM Humes,K Kaushansky,KH Sprugel

Biochemical and genetic characterization of multiple splice variants of the Flt3 ligand

T McClanahan,J Culpepper,D Campbell,J Wagner,K Franz-Bacon,J Mattson,S Tsai,J Luh,MJ Guimaraes,MG Mattei,O Rosnet,D Birnbaum,CH Hannum

FLT3 receptor expression on the surface of normal and malignant human hematopoietic cells

AM Turner,NL Lin,S Issarachai,SD Lyman,VC Broudy

Expression of growth factor receptors in unilineage differentiation culture of purified hematopoietic progenitors

U Testa,C Fossati,P Samoggia,R Masciulli,G Mariani,HJ Hassan,NM Sposi,R Guerriero,V Rosato,M Gabbianelli,E Pelosi,M Valtieri,C Peschle

High-dose multidrug resistance in primary human hematopoietic progenitor cells transduced with optimized retroviral vectors

HG Eckert,M Stockschlader,U Just,S Hegewisch-Becker,M Grez,A Uhde,A Zander,W Ostertag,C Baum

Fibrinogen mediates leukocyte-endothelium bridging in vivo at low shear forces

P Sriramarao,LR Languino,DC Altieri

Embryonic stem cells differentiate in vitro to endothelial cells through successive maturation steps

D Vittet,MH Prandini,R Berthier,A Schweitzer,H Martin-Sisteron,G Uzan,E Dejana

Blood clotting in minimally altered whole blood

MD Rand,JB Lock,C van't Veer,DP Gaffney,KG Mann

Further characterization of factor VIII-deficient mice created by gene targeting: RNA and protein studies

L Bi,R Sarkar,T Naas,AM Lawler,J Pain,SL Shumaker,V Bedian,HH Jr Kazazian

A deletion mutation causes hemophilia B in Lhasa Apso dogs

AE Mauser,J Whitlark,KM Whitney,CD Jr Lothrop

High shear stress can initiate both platelet aggregation and shedding of procoagulant containing microparticles

Y Miyazaki,S Nomura,T Miyake,H Kagawa,C Kitada,H Taniguchi,Y Komiyama,Y Fujimura,Y Ikeda,S Fukuhara

Megakaryocytic cell line-specific hyperploidy by cytotoxic necrotizing factor bacterial toxins

KM Hudson,NC Denko,E Schwab,E Oswald,A Weiss,MA Lieberman

Differential regulation of proinflammatory and hematopoietic cytokines in human macrophages after infection with human immunodeficiency virus

R Esser,W Glienke,H von Briesen,H Rubsamen-Waigmann,R Andreesen

Pyrrolidine dithiocarbamate inhibits the production of interleukin-6, interleukin-8, and granulocyte-macrophage colony-stimulating factor by human endothelial cells in response to inflammatory mediators: modulation of NF-kappa B and AP-1 transcription factors activity

C Munoz,D Pascual-Salcedo,MC Castellanos,A Alfranca,J Aragones,A Vara,MJ Redondo,MO de Landazuri

Analysis of Epstein-Barr virus gene polymorphisms in normal donors and in virus-associated tumors from different geographic locations

F Khanim,QY Yao,G Niedobitek,S Sihota,AB Rickinson,LS Young

The protein product of the proto-oncogene c-cbl forms a complex with phosphatidylinositol 3-kinase p85 and CD19 in anti-IgM-stimulated human B-lymphoma cells

M Beckwith,G Jorgensen,DL Longo

Functional comparison of spleen dendritic cells and dendritic cells cultured in vitro from bone marrow precursors

K Garrigan,P Moroni-Rawson,C McMurray,I Hermans,N Abernethy,J Watson,F Ronchese

Heterogeneity of the human CD4+ T-cell population: two distinct CD4+ T- cell subsets characterized by coexpression of CD45RA and CD45RO isoforms

D Hamann,PA Baars,B Hooibrink,RW van Lier

Recognition of BCR-ABL positive leukemic blasts by human CD4+ T cells elicited by primary in vitro immunization with a BCR-ABL breakpoint peptide

GJ Bosch,AM Joosten,JH Kessler,CJ Melief,OC Leeksma

Role of nitric oxide in the anti-tumoral effect of retinoic acid and 1,25-dihydroxyvitamin D3 on human promonocytic leukemic cells

N Dugas,MD Mossalayi,A Calenda,A Leotard,P Becherel,F Mentz,F Ouaaz,M Arock,P Debre,J Dornand,B Dugas

AF10 is split by MLL and HEAB, a human homolog to a putative Caenorhabditis elegans ATP/GTP-binding protein in an invins(10;11)(p12;q23q12)

S Tanabe,SK Bohlander,CV Vignon,R 3rd Espinosa,N Zhao,PL Strissel,NJ Zeleznik-Le,JD Rowley

Functional role of cation-independent mannose 6-phosphate/insulin-like growth factor II receptor in cell adhesion and proliferation of a human myeloma cell line OPM-2

T Nishiura,T Karasuno,H Yoshida,H Nakao,M Ogawa,Y Horikawa,M Yoshimura,Y Okajima,Y Kanakura,Y Kanayama,Y Matsuzawa

Differentiation inhibitory factor nm23 as a new prognostic factor in acute monocytic leukemia

A Yokoyama,J Okabe-Kado,A Sakashita,N Maseki,Y Kaneko,K Hino,S Tomoyasu,N Tsuruoka,T Kasukabe,Y Honma

VH and VL gene analysis in sporadic Burkitt's lymphoma shows somatic hypermutation, intraclonal heterogeneity, and a role for antigen selection

CJ Chapman,JX Zhou,C Gregory,AB Rickinson,FK Stevenson

Activation of A3 adenosine receptors on human eosinophils elevates intracellular calcium

Y Kohno,X Ji,SD Mawhorter,M Koshiba,KA Jacobson

Effect of interleukin-5 exposure during in vitro eosinophilopiesis on MAC-1 adhesion molecule expression and function on cultured human eosinophils

KJ Hamann,SP Neeley,TL Dowling,JA Grant,AR Leff

Immunohistochemical localization of hepatic nitric oxide synthase in normal and transgenic sickle cell mice: the effect of hypoxia

SY Osei,RS Ahima,ME Fabry,RL Nagel,N Bank

Five new mutations in the uroporphyrinogen decarboxylase gene identified in families with cutaneous porphyria

JF McManus,CG Begley,S Sassa,S Ratnaike

Inhibition of binding of anti-PLA1 antibodies to platelets with monoclonal antibody LK-4. Evidence for multiple PLA1 receptor sites on platelet GPIIIa

LX Liu,MA Nardi,JF Casella,S Karpatkin

Oxidative stress and antioxidant status in beta-thalassemia major: iron overload and depletion of lipid-soluble antioxidants

MA Livrea,L Tesoriere,AM Pintaudi,A Calabrese,A Maggio,HJ Freisleben,D D'Arpa,R D'Anna,A Bongiorno

Lymphotropic herpesviruses in allogeneic bone marrow transplantation

FZ Wang,H Dahl,A Linde,M Brytting,A Ehrnst,P Ljungman

Early recurrence or persistence of autoimmune diseases after unmanipulated autologous stem cell transplantation

HH Euler,AM Marmont,A Bacigalupo,S Fastenrath,P Dreger,M Hoffknecht,AR Zander,B Schalke,U Hahn,R Haas,N Schmitz

Posttransplant T-cell lymphoproliferative disorders--an aggressive, late complication of solid-organ transplantation

MN Hanson,VA Morrison,BA Peterson,KT Stieglbauer,VL Kubic,SR McCormick,RC McGlennen,JC Manivel,RD Brunning,CE Litz

Partially differentiated ex vivo expanded cells accelerate hematologic recovery in myeloablated mice transplanted with highly enriched long- term repopulating stem cells

SJ Szilvassy,KP Weller,B Chen,CA Juttner,A Tsukamoto,R Hoffman

Transduction of hematopoietic cells by foamy virus vectors

RK Hirata,AD Miller,RG Andrews,DW Russell

PHOTOGRAPHS

Photograph

A. M. Dvorak

MULTICENTER STUDY

FK506 in combination with methotrexate for the prevention of graft- versus-host disease after marrow transplantation from matched unrelated donors

RA Nash,LA Pineiro,R Storb,HJ Deeg,WE Fitzsimmons,T Furlong,JA Hansen,T Gooley,RM Maher,P Martin,PA McSweeney,KM Sullivan,C Anasetti,JW Fay

LETTER

Itraconazole more bioavailable in solution [letter]

AG Prentice,DW Warnock

Peripheral blood stem cell apheresis in normal donors: the neglected side [letter; comment]

P Anderlini,D Przepiorka,R Champlin,M Korbling

The ability of tissue factor to promote factor VII activation [letter; comment]

JH Morrissey,PF Neuenschwander

The Ser460Pro substitution of the protein S (PS) gene in rare in Italian patients with type IIa PS deficiency [letter]

G Castaman,M Ruggeri,A Tosetto,F Bernardi,F Rodeghiero

Association of endothelial tissue factor and thrombomodulin with caveolae [letter]

AB Mulder,JW Smit,VJ Bom,NR Blom,MR Halie,J van der Meer

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