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Volume 87, Issue 9

May 1 1996

In this Issue

REVIEW
ARTICLES
PHOTOGRAPHS
LETTER

REVIEW

Inherited thrombophilia: pathogenesis, clinical syndromes, and management [see comments]

V De Stefano,G Finazzi,PM Mannucci

View Articletitled, Inherited thrombophilia: pathogenesis, clinical syndromes, and management [see comments]

ARTICLES

Single-chain urokinase-type plasminogen activator bound to its receptor is relatively resistant to plasminogen activator inhibitor type 1

AA Higazi,A Mazar,J Wang,R Reilly,J Henkin,D Kniss,D Cines

View Articletitled, Single-chain urokinase-type plasminogen activator bound to its receptor is relatively resistant to plasminogen activator inhibitor type 1

CD34-deficient mice have reduced eosinophil accumulation after allergen exposure and show a novel crossreactive 90-kD protein

A Suzuki,DP Andrew,JA Gonzalo,M Fukumoto,J Spellberg,M Hashiyama,H Takimoto,N Gerwin,I Webb,G Molineux,R Amakawa,Y Tada,A Wakeham,J Brown,I McNiece,K Ley,EC Butcher,T Suda,JC Gutierrez-Ramos,TW Mak

View Articletitled, CD34-deficient mice have reduced eosinophil accumulation after allergen exposure and show a novel crossreactive 90-kD protein

Flt3 ligand induces proliferation of quiescent human bone marrow CD34+CD38- cells and maintains progenitor cells in vitro

AJ Shah,EM Smogorzewska,C Hannum,GM Crooks

View Articletitled, Flt3 ligand induces proliferation of quiescent human bone marrow CD34+CD38- cells and maintains progenitor cells in vitro

Factor V Quebec revisited

CM Janeway,GE Rivard,PB Tracy,KG Mann

View Articletitled, Factor V Quebec revisited

Molecular definition of a narrow interval at 7q22.1 associated with myelodysplasia

EJ Johnson,SW Scherer,L Osborne,LC Tsui,D Oscier,S Mould,FE Cotter

View Articletitled, Molecular definition of a narrow interval at 7q22.1 associated with myelodysplasia

Specific human cellular immunity to bcr-abl oncogene-derived peptides

M Bocchia,T Korontsvit,Q Xu,S Mackinnon,SY Yang,A Sette,DA Scheinberg

View Articletitled, Specific human cellular immunity to bcr-abl oncogene-derived peptides

FcR gamma-chain is essential for both surface expression and function of human Fc gamma RI (CD64) in vivo

MJ van Vugt,IA Heijnen,PJ Capel,SY Park,C Ra,T Saito,JS Verbeek,JG van de Winkel

View Articletitled, FcR gamma-chain is essential for both surface expression and function of human Fc gamma RI (CD64) in vivo

Glycosylphosphatidylinositol-anchor-deficient mice: implications for clonal dominance of mutant cells in paroxysmal nocturnal hemoglobinuria

K Kawagoe,D Kitamura,M Okabe,I Taniuchi,M Ikawa,T Watanabe,T Kinoshita,J Takeda

View Articletitled, Glycosylphosphatidylinositol-anchor-deficient mice: implications for clonal dominance of mutant cells in paroxysmal nocturnal hemoglobinuria

A randomized placebo-controlled trial of recombinant human interleukin- 11 in cancer patients with severe thrombocytopenia due to chemotherapy

I Tepler,L Elias,JW 2nd Smith,M Hussein,G Rosen,AY Chang,JO Moore,MS Gordon,B Kuca,KJ Beach,JW Loewy,MB Garnick,JA Kaye

View Articletitled, A randomized placebo-controlled trial of recombinant human interleukin- 11 in cancer patients with severe thrombocytopenia due to chemotherapy

A phase I trial of recombinant human interleukin-11 (neumega rhIL-11 growth factor) in women with breast cancer receiving chemotherapy

MS Gordon,WJ McCaskill-Stevens,LA Battiato,J Loewy,D Loesch,E Breeden,R Hoffman,KJ Beach,B Kuca,J Kaye,GW Jr Sledge

View Articletitled, A phase I trial of recombinant human interleukin-11 (neumega rhIL-11 growth factor) in women with breast cancer receiving chemotherapy

Second malignancies after treatment for laparotomy staged IA-IIIB Hodgkin's disease: long-term analysis of risk factors and outcome

PM Mauch,LA Kalish,KC Marcus,CN Coleman,LN Shulman,E Krill,S Come,B Silver,GP Canellos,NJ Tarbell

View Articletitled, Second malignancies after treatment for laparotomy staged IA-IIIB Hodgkin's disease: long-term analysis of risk factors and outcome

Malignant neoplasms following bone marrow transplantation

S Bhatia,NK Ramsay,M Steinbuch,KE Dusenbery,RS Shapiro,DJ Weisdorf,LL Robison,JS Miller,JP Neglia

View Articletitled, Malignant neoplasms following bone marrow transplantation

Radioimmunotherapy of relapsed B-cell lymphoma with yttrium 90 anti- idiotype monoclonal antibodies

CA White,SE Halpern,BA Parker,RA Miller,HB Hupf,DL Shawler,HA Collins,I Royston

View Articletitled, Radioimmunotherapy of relapsed B-cell lymphoma with yttrium 90 anti- idiotype monoclonal antibodies

Alterations in tretinoin pharmacokinetics following administration of liposomal all-trans retinoic acid

E Estey,PF Thall,K Mehta,M Rosenblum,T Jr Brewer,V Simmons,F Cabanillas,R Kurzrock,G Lopez-Berestein

View Articletitled, Alterations in tretinoin pharmacokinetics following administration of liposomal all-trans retinoic acid

Signaling pathways activated in a unique mast cell line where interleukin-3 supports survival and stem cell factor is required for a proliferative response

AM O'Farrell,M Ichihara,AL Mui,A Miyajima

View Articletitled, Signaling pathways activated in a unique mast cell line where interleukin-3 supports survival and stem cell factor is required for a proliferative response

The role of MAP kinase kinase in interleukin-3 stimulation of proliferation

GR Perkins,CJ Marshall,MK Collins

View Articletitled, The role of MAP kinase kinase in interleukin-3 stimulation of proliferation

CD98: a type II transmembrane glycoprotein expressed from the beginning of primitive and definitive hematopoiesis may play a critical role in the development of hematopoietic cells

AP Warren,K Patel,DJ McConkey,R Palacios

View Articletitled, CD98: a type II transmembrane glycoprotein expressed from the beginning of primitive and definitive hematopoiesis may play a critical role in the development of hematopoietic cells

JAK2 is associated with the c-kit proto-oncogene product and is phosphorylated in response to stem cell factor

SR Weiler,S Mou,CS DeBerry,JR Keller,FW Ruscetti,DK Ferris,DL Longo,D Linnekin

View Articletitled, JAK2 is associated with the c-kit proto-oncogene product and is phosphorylated in response to stem cell factor

Adjacent, cooperative elements form a strong, constitutive enhancer in the human granulocyte-macrophage colony-stimulating factor gene [published erratum appears in Blood 1996 Oct 1;88(7):2818]

SD Nimer,W Zhang,K Kwan,Y Whang,J Zhang,Y] Wang Y [corrected to Whang

View Articletitled, Adjacent, cooperative elements form a strong, constitutive enhancer in the human granulocyte-macrophage colony-stimulating factor gene [published erratum appears in Blood 1996 Oct 1;88(7):2818]

Macrophage-stimulating protein activates STK receptor tyrosine kinase on osteoclasts and facilitates bone resorption by osteoclast-like cells

N Kurihara,A Iwama,J Tatsumi,K Ikeda,T Suda

View Articletitled, Macrophage-stimulating protein activates STK receptor tyrosine kinase on osteoclasts and facilitates bone resorption by osteoclast-like cells

Constitutive expression of GATA-1 interferes with the cell-cycle regulation

A Dubart,PH Romeo,W Vainchenker,D Dumenil

View Articletitled, Constitutive expression of GATA-1 interferes with the cell-cycle regulation

Efficient retroviral transduction of human bone marrow progenitor and long-term culture-initiating cells: partial reconstitution of cells from patients with X-linked chronic granulomatous disease by gp91-phox expression

CD Porter,MH Parkar,MK Collins,RJ Levinsky,C Kinnon

View Articletitled, Efficient retroviral transduction of human bone marrow progenitor and long-term culture-initiating cells: partial reconstitution of cells from patients with X-linked chronic granulomatous disease by gp91-phox expression

Severe perinatal thrombosis in double and triple heterozygous offspring of a family segregating two independent protein S mutations and a protein C mutation

CJ Formstone,PJ Hallam,EG Tuddenham,J Voke,M Layton,K Nicolaides,IM Hann,DN Cooper

View Articletitled, Severe perinatal thrombosis in double and triple heterozygous offspring of a family segregating two independent protein S mutations and a protein C mutation

Studies of the activation of factor VII bound to tissue factor [see comments]

LV Rao,T Williams,SI Rapaport

View Articletitled, Studies of the activation of factor VII bound to tissue factor [see comments]

Regulation of type I plasminogen activator inhibitor by fibrin degradation products in rat lung fibroblasts

JS Hagood,MA Olman,JA Godoy,KE Rivera,GM Fuller

View Articletitled, Regulation of type I plasminogen activator inhibitor by fibrin degradation products in rat lung fibroblasts

Inhibition of platelet function by A02131-1, a novel inhibitor of cGMP- specific phosphodiesterase, in vitro and in vivo

SM Yu,SY Tsai,SC Kuo,JT Ou

View Articletitled, Inhibition of platelet function by A02131-1, a novel inhibitor of cGMP- specific phosphodiesterase, in vitro and in vivo

Monocyte procoagulant activity induced by in vivo administration of the OKT3 monoclonal antibody

O Pradier,M Surquin,P Stordeur,L De Pauw,P Kinnaert,P Vereerstraeten,P Capel,M Goldman,D Abramowicz

View Articletitled, Monocyte procoagulant activity induced by in vivo administration of the OKT3 monoclonal antibody

Changes in cytosolic calcium concentrations and cell morphology in single platelets adhered to fibrinogen-coated surface under flow

CJ Jen,HI Chen,KC Lai,S Usami

View Articletitled, Changes in cytosolic calcium concentrations and cell morphology in single platelets adhered to fibrinogen-coated surface under flow

Signal transduction and glycophosphatidylinositol-linked proteins (lyn, lck, CD4, CD45, G proteins, and CD55) selectively localize in Triton- insoluble plasma membrane domains of human leukemic cell lines and normal granulocytes

I Parolini,M Sargiacomo,MP Lisanti,C Peschle

View Articletitled, Signal transduction and glycophosphatidylinositol-linked proteins (lyn, lck, CD4, CD45, G proteins, and CD55) selectively localize in Triton- insoluble plasma membrane domains of human leukemic cell lines and normal granulocytes

Persistent clonal excess and skewed T-cell repertoire in T cells from patients with hairy cell leukemia

JC Kluin-Nelemans,MG Kester,JJ Melenhorst,JE Landegent,L van de Corput,R Willemze,JH Falkenburg

View Articletitled, Persistent clonal excess and skewed T-cell repertoire in T cells from patients with hairy cell leukemia

HLA class II as potential target antigen on malignant B cells for therapy with bispecific antibodies in combination with granulocyte colony-stimulating factor

D Elsasser,T Valerius,R Repp,GJ Weiner,Y Deo,JR Kalden,JG van de Winkel,GT Stevenson,MJ Glennie,M Gramatzki

View Articletitled, HLA class II as potential target antigen on malignant B cells for therapy with bispecific antibodies in combination with granulocyte colony-stimulating factor

Bispecific-armed, interferon gamma-primed macrophage-mediated phagocytosis of malignant non-Hodgkin's lymphoma

P Ely,PK Wallace,AL Givan,RF Graziano,PM Guyre,MW Fanger

View Articletitled, Bispecific-armed, interferon gamma-primed macrophage-mediated phagocytosis of malignant non-Hodgkin's lymphoma

A new method of "in-cell reverse transcriptase-polymerase chain reaction" for the detection of BCR/ABL transcript in chronic myeloid leukemia patients

N Testoni,G Martinelli,P Farabegoli,A Zaccaria,M Amabile,D Raspadori,S Pelliconi,E Zuffa,C Carboni,S Tura

View Articletitled, A new method of "in-cell reverse transcriptase-polymerase chain reaction" for the detection of BCR/ABL transcript in chronic myeloid leukemia patients

The consistent association between Epstein-Barr virus and Hodgkin's disease in children in Kenya

M Weinreb,PJ Day,F Niggli,EK Green,AO Nyong'o,NA Othieno-Abinya,MS Riyat,F Raafat,JR Mann

View Articletitled, The consistent association between Epstein-Barr virus and Hodgkin's disease in children in Kenya

Apoptosis induced by erythroid differentiation of human leukemia cell lines is inhibited by Bcl-XL

A Benito,M Silva,D Grillot,G Nunez,JL Fernandez-Luna

View Articletitled, Apoptosis induced by erythroid differentiation of human leukemia cell lines is inhibited by Bcl-XL

Analysis of major histocompatibility complex class I expression on Reed- Sternberg cells in relation to the cytotoxic T-cell response in Epstein- Barr virus-positive and -negative Hodgkin's disease

JJ Oudejans,NM Jiwa,JA Kummer,A Horstman,W Vos,JP Baak,PM Kluin,P van der Valk,JM Walboomers,CJ Meijer

View Articletitled, Analysis of major histocompatibility complex class I expression on Reed- Sternberg cells in relation to the cytotoxic T-cell response in Epstein- Barr virus-positive and -negative Hodgkin's disease

Interleukin-9 stimulates the proliferation of human myeloid leukemic cells

RM Lemoli,A Fortuna,A Tafuri,M Fogli,M Amabile,A Grande,MR Ricciardi,MT Petrucci,L Bonsi,G Bagnara,G Visani,G Martinelli,S Ferrari,S Tura

View Articletitled, Interleukin-9 stimulates the proliferation of human myeloid leukemic cells

Occurrence of the t(2;5)(p23;q35) in non-Hodgkin's lymphoma

DD Weisenburger,BG Gordon,JM Vose,MA Bast,WC Chan,TC Greiner,JR Anderson,WG Sanger

View Articletitled, Occurrence of the t(2;5)(p23;q35) in non-Hodgkin's lymphoma

Restricted immunoglobulin VH region repertoire in chronic lymphocytic leukemia patients with autoimmune hemolytic anemia

DG Efremov,M Ivanovski,N Siljanovski,G Pozzato,L Cevreska,F Fais,N Chiorazzi,FD Batista,OR Burrone

View Articletitled, Restricted immunoglobulin VH region repertoire in chronic lymphocytic leukemia patients with autoimmune hemolytic anemia

Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10

C Sgadari,AL Angiolillo,G Tosato

View Articletitled, Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10

Interferon-alpha restores normal beta 1 integrin-mediated inhibition of hematopoietic progenitor proliferation by the marrow microenvironment in chronic myelogenous leukemia

R Bhatia,JB McCarthy,CM Verfaillie

View Articletitled, Interferon-alpha restores normal beta 1 integrin-mediated inhibition of hematopoietic progenitor proliferation by the marrow microenvironment in chronic myelogenous leukemia

Cure of multidrug-resistant human B-cell lymphoma xenografts by combinations of anti-B4-blocked ricin and chemotherapeutic drugs

C Liu,JM Lambert,BA Teicher,WA Blattler,R O'Connor

View Articletitled, Cure of multidrug-resistant human B-cell lymphoma xenografts by combinations of anti-B4-blocked ricin and chemotherapeutic drugs

Routine bone marrow exam during first remission of acute myeloid leukemia

E Estey,S Pierce

View Articletitled, Routine bone marrow exam during first remission of acute myeloid leukemia

Human herpesvirus-8 DNA sequences in human immunodeficiency virus- negative angioimmunoblastic lymphadenopathy and benign lymphadenopathy with giant germinal center hyperplasia and increased vascularity

M Luppi,P Barozzi,A Maiorana,T Artusi,R Trovato,R Marasca,M Savarino,L Ceccherini-Nelli,G Torelli

View Articletitled, Human herpesvirus-8 DNA sequences in human immunodeficiency virus- negative angioimmunoblastic lymphadenopathy and benign lymphadenopathy with giant germinal center hyperplasia and increased vascularity

Subcellular localization of transforming growth factor-alpha in human eosinophil granulocytes

A Egesten,J Calafat,EF Knol,H Janssen,TM Walz

View Articletitled, Subcellular localization of transforming growth factor-alpha in human eosinophil granulocytes

Induction of the chemotactic S100 protein, CP-10, in monocyte/macrophages by lipopolysaccharide

SP Hu,C Harrison,K Xu,CJ Cornish,CL Geczy

View Articletitled, Induction of the chemotactic S100 protein, CP-10, in monocyte/macrophages by lipopolysaccharide

Total cell content of CR3 (CD11b/CD18) and LFA-1 (CD11a/CD18) in neonatal neutrophils: relationship to gestational age

LT McEvoy,H Zakem-Cloud,MF Tosi

View Articletitled, Total cell content of CR3 (CD11b/CD18) and LFA-1 (CD11a/CD18) in neonatal neutrophils: relationship to gestational age

Asynchronous regulation of splicing events within protein 4.1 pre-mRNA during erythroid differentiation

F Baklouti,SC Huang,TK Tang,J Delaunay,VT Marchesi,EJ Jr Benz

View Articletitled, Asynchronous regulation of splicing events within protein 4.1 pre-mRNA during erythroid differentiation

Human red blood cell Wright antigens: a genetic and evolutionary perspective on glycophorin A-band 3 interaction

CH Huang,ME Reid,SS Xie,OO Blumenfeld

View Articletitled, Human red blood cell Wright antigens: a genetic and evolutionary perspective on glycophorin A-band 3 interaction

Catalysis of soluble hemoglobin oxidation by free iron on sickle red cell membranes

O Shalev,RP Hebbel

View Articletitled, Catalysis of soluble hemoglobin oxidation by free iron on sickle red cell membranes

Multiple G6PD mutations are associated with a clinical and biochemical phenotype similar to that of G6PD Mediterranean

MD Cappellini,F Martinez di Montemuros,G De Bellis,S Debernardi,C Dotti,G Fiorelli

View Articletitled, Multiple G6PD mutations are associated with a clinical and biochemical phenotype similar to that of G6PD Mediterranean

The effect of lymphocytotoxic antibody reactivity on the results of single antigen mismatched platelet transfusions to alloimmunized patients

MA Hussein,EJ Lee,R Fletcher,CA Schiffer

View Articletitled, The effect of lymphocytotoxic antibody reactivity on the results of single antigen mismatched platelet transfusions to alloimmunized patients

Quantitation of mafosfamide-resistant pre-colony-forming units in allogeneic bone marrow transplantation: relationship with rate of engraftment and evidence for long-lasting reduction in stem cell numbers

MA Kirkland,A Spencer,RJ Davidson,C McDonald,JM Goldman

View Articletitled, Quantitation of mafosfamide-resistant pre-colony-forming units in allogeneic bone marrow transplantation: relationship with rate of engraftment and evidence for long-lasting reduction in stem cell numbers

Detection of empty HLA class II molecules on cord blood B cells

F Garban,M Ericson,C Roucard,C Rabian-Herzog,H Teisserenc,E Sauvanet,D Charron,N Mooney

View Articletitled, Detection of empty HLA class II molecules on cord blood B cells

Newborn blood can engraft adult mice without inducing graft-versus-host disease across non H-2 antigens

V de La Selle,E Gluckman,M Bruley-Rosset

View Articletitled, Newborn blood can engraft adult mice without inducing graft-versus-host disease across non H-2 antigens

Analysis of T-cell repopulation after allogeneic bone marrow transplantation: significant differences between recipients of T-cell depleted and unmanipulated grafts

E Roux,C Helg,F Dumont-Girard,B Chapuis,M Jeannet,E Roosnek

View Articletitled, Analysis of T-cell repopulation after allogeneic bone marrow transplantation: significant differences between recipients of T-cell depleted and unmanipulated grafts

Natural killer (NK)-cell function and antileukemic activity of a large population of CD3+/CD8+ T cells expressing NK receptors for major histocompatibility complex class I after "three-loci" HLA-incompatible bone marrow transplantation

N Albi,L Ruggeri,F Aversa,C Merigiola,A Tosti,R Tognellini,CE Grossi,MF Martelli,A Velardi

View Articletitled, Natural killer (NK)-cell function and antileukemic activity of a large population of CD3+/CD8+ T cells expressing NK receptors for major histocompatibility complex class I after "three-loci" HLA-incompatible bone marrow transplantation

In vivo inhibition of cytokine responsiveness and graft-versus-host disease mortality by rapamycin leads to a clinical-pathological syndrome discrete from that observed with cyclosporin A

BR Blazar,PA Taylor,A Panoskaltsis-Mortari,S Sehgal,DA Vallera

View Articletitled, In vivo inhibition of cytokine responsiveness and graft-versus-host disease mortality by rapamycin leads to a clinical-pathological syndrome discrete from that observed with cyclosporin A

PHOTOGRAPHS

Photograph

J. C. Kluin-Nelemans,P. Brederoo

View Articletitled, Photograph

LETTER

The first clinical use of donor leukocyte infusions for the treatment of leukemia relapsing after allogeneic bone marrow transplantation [letter]

J Mehta

View Articletitled, The first clinical use of donor leukocyte infusions for the treatment of leukemia relapsing after allogeneic bone marrow transplantation [letter]

Allogeneic cell therapy: the treatment of choice for all hematologic malignancies relapsing post BMT [letter; comment]

S Slavin,E Naparstek,A Nagler,Y Kapelushnik,A Ackerstein,R Or

View Articletitled, Allogeneic cell therapy: the treatment of choice for all hematologic malignancies relapsing post BMT [letter; comment]

Identification of the lineage of mature neutrophils and delineation of lipid body formation and apoptosis therein [letter; comment]

AM Dvorak

View Articletitled, Identification of the lineage of mature neutrophils and delineation of lipid body formation and apoptosis therein [letter; comment]

Utility of fingernail DNA for evaluation of chimerism after bone marrow transplantation and for diagnostic testing for transfusion-associated graft-versus-host disease [letter]

S Uchida,L Wang,Y Yahagi,K Tokunaga,K Tadokoro,T Juji

View Articletitled, Utility of fingernail DNA for evaluation of chimerism after bone marrow transplantation and for diagnostic testing for transfusion-associated graft-versus-host disease [letter]

Serum interleukin-8 (IL-8) and IL-6 concentrations in patients with hematologic malignancies [letter]

Y Denizot,P Fixe,E Liozon,V Praloran

View Articletitled, Serum interleukin-8 (IL-8) and IL-6 concentrations in patients with hematologic malignancies [letter]

Stem cell factor serum levels may not be clinically relevant [letter]

JL Abkowitz,H Hume,SA Yancik,LG Bennett,AM Matsumoto

View Articletitled, Stem cell factor serum levels may not be clinically relevant [letter]

How do antisense oligodeoxynucleotides inhibit the growth of chronic myelogenous leukemia cells? [letter; comment]

R Bergan,L Neckers

View Articletitled, How do antisense oligodeoxynucleotides inhibit the growth of chronic myelogenous leukemia cells? [letter; comment]

Long-term follow-up of 12 pediatric patients with primary myelodysplastic syndrome treated with HLA-identical sibling donor bone marrow transplantation [letter]

K Nichols,SK Parsons,E Guinan

View Articletitled, Long-term follow-up of 12 pediatric patients with primary myelodysplastic syndrome treated with HLA-identical sibling donor bone marrow transplantation [letter]

Effects of interleukin-4 administration on endocrine function and lipid profile of patients with malignant diseases [letter]

R Vassilopoulou-Sellin,D Thielvoldt,AB Markowitz

View Articletitled, Effects of interleukin-4 administration on endocrine function and lipid profile of patients with malignant diseases [letter]

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Follicular lymphoma comprises germinal center-like and memory-like molecular subtypes with prognostic significance

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Asciminib plus dasatinib and prednisone for Philadelphia chromosome-positive acute leukemia

How I treat Blastic Plasmacytoid Dendritic Cell Neoplasm

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